Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene enco... See more...

Aliases for ADRA1B Gene

Aliases for ADRA1B Gene

  • Adrenoceptor Alpha 1B 2 3 5
  • Adrenergic, Alpha-1B-, Receptor 2 3
  • Alpha-1B Adrenergic Receptor 3 4
  • Alpha-1B Adrenoreceptor 3 4
  • Alpha-1B Adrenoceptor 3 4
  • ALPHA1BAR 3
  • ADRA1B 5
  • ADRA1 3

External Ids for ADRA1B Gene

Previous GeneCards Identifiers for ADRA1B Gene

  • GC05P159198
  • GC05P159853
  • GC05P159324
  • GC05P159276
  • GC05P154438
  • GC05P159343
  • GC05P159916

Summaries for ADRA1B Gene

Entrez Gene Summary for ADRA1B Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1B Gene

ADRA1B (Adrenoceptor Alpha 1B) is a Protein Coding gene. Diseases associated with ADRA1B include Male Reproductive Organ Benign Neoplasm and Prostatic Adenoma. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1D.

UniProtKB/Swiss-Prot Summary for ADRA1B Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1B Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA1B Gene

Genomics for ADRA1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRA1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J159915 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 +52.3 52317 3.6 CTCF ZNF692 ZIC2 REST EZH2 ZNF600 KLF9 SP2 RAD21 SP1 ADRA1B LINC01847 piR-38351-385 TTC1
GH05J159864 Enhancer 0.8 Ensembl dbSUPER 600.7 +0.3 260 0.7 REST PKNOX1 SP1 FOXA2 CEBPB YY1 EP300 CEBPG ZNF384 RAD21 ADRA1B LOC105377689 lnc-ADRA1B-1 KR153235 LINC01847 TTC1
GH05J159772 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 8.8 -91.7 -91669 1.2 PRDM10 ZNF629 CTCF ZNF692 JUND EZH2 GTF2F1 ZNF341 ZFX ZNF561 ADRA1B RF00017-5058 lnc-ADRA1B-2 LINC01847 ENSG00000249738 IL12B
GH05J159786 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.2 -77.4 -77417 1.5 SP1 NR3C1 ZBTB17 NR2F2 POLR2A ADRA1B RF00017-5058 LOC105377689 LINC01847 IL12B ENSG00000249738
GH05J159779 Enhancer 1 Ensembl ENCODE dbSUPER 8.8 -85.3 -85279 2 ZNF629 JUND EGR1 CEBPB NR2C2 FOS FOSL1 NR2F2 ZFHX2 CEBPG ADRA1B RF00017-5058 LOC105377689 LINC01847 IL12B ENSG00000249738
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA1B

Top Transcription factor binding sites by QIAGEN in the ADRA1B gene promoter:
  • AhR
  • Arnt
  • ARP-1
  • E47
  • Hand1
  • HFH-1
  • HOXA9
  • STAT3
  • ZID

Genomic Locations for ADRA1B Gene

Genomic Locations for ADRA1B Gene
chr5:159,865,080-159,989,205
(GRCh38/hg38)
Size:
124,126 bases
Orientation:
Plus strand
chr5:159,343,740-159,400,017
(GRCh37/hg19)
Size:
56,278 bases
Orientation:
Plus strand

Genomic View for ADRA1B Gene

Genes around ADRA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1B Gene

Proteins for ADRA1B Gene

  • Protein details for ADRA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35368-ADA1B_HUMAN
    Recommended name:
    Alpha-1B adrenergic receptor
    Protein Accession:
    P35368
    Secondary Accessions:
    • B0LPE1

    Protein attributes for ADRA1B Gene

    Size:
    520 amino acids
    Molecular mass:
    56836 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).

neXtProt entry for ADRA1B Gene

Post-translational modifications for ADRA1B Gene

  • Glycosylation at Asn10, Asn24, Asn29, and Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1B Gene

Antibody Products

No data available for DME Specific Peptides for ADRA1B Gene

Domains & Families for ADRA1B Gene

Gene Families for ADRA1B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADRA1B Gene

InterPro:
Blocks:
  • Adrenergic receptor signature
  • Alpha-1B adrenergic receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for ADRA1B Gene

GenScript: Design optimal peptide antigens:
  • Alpha-1B adrenoreceptor (ADA1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35368

UniProtKB/Swiss-Prot:

ADA1B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
genes like me logo Genes that share domains with ADRA1B: view

Function for ADRA1B Gene

Molecular function for ADRA1B Gene

UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
GENATLAS Biochemistry:
adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone

Phenotypes From GWAS Catalog for ADRA1B Gene

Gene Ontology (GO) - Molecular Function for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004935 adrenergic receptor activity IBA --
GO:0004937 alpha1-adrenergic receptor activity IBA 21873635
GO:0005515 protein binding IPI 22723743
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1B: view
genes like me logo Genes that share phenotypes with ADRA1B: view

Animal Models for ADRA1B Gene

MGI Knock Outs for ADRA1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1B Gene

Localization for ADRA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1B Gene

Nucleus membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1B gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IDA 22120526
GO:0005737 cytoplasm IEA,IDA 24567387
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
genes like me logo Genes that share ontologies with ADRA1B: view

Pathways & Interactions for ADRA1B Gene

genes like me logo Genes that share pathways with ADRA1B: view

Pathways by source for ADRA1B Gene

2 GeneGo (Thomson Reuters) pathways for ADRA1B Gene
  • Development Activation of ERK by Alpha-1 adrenergic receptors
  • Translation Translation regulation by Alpha-1 adrenergic receptors
5 Qiagen pathways for ADRA1B Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway
  • Signaling Involved in Cardiac Hypertrophy

SIGNOR curated interactions for ADRA1B Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IBA 21873635
GO:0006937 regulation of muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADRA1B: view

Drugs & Compounds for ADRA1B Gene

(188) Drugs for ADRA1B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methoxamine Approved, Investigational Pharma Agonist, Full agonist, Target, agonist, stimulator 3
Phenylephrine Approved Pharma Agonist, Full agonist, Target, agonist 566
Prazosin Approved Pharma Antagonist, Inverse agonist, Target, Target, antagonist 70
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 24
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist, Target, antagonist SR-2A inhibitor 532

(14) Additional Compounds for ADRA1B Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
Promazine 5-sulfoxide
3-MPPI
133399-65-2
BMY 7378 dihydrochloride
21102-95-4
Urapidil hydrochloride
64887-14-5

(5) Tocris Compounds for ADRA1B Gene

Compound Action Cas Number
3-MPPI alpha1 ligand 133399-65-2
A 61603 hydrobromide alpha1A agonist 107756-30-9
BMY 7378 dihydrochloride Selective alpha1D antagonist 21102-95-4
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
Urapidil hydrochloride alpha1 antagonist. Also 5-HT1A receptor agonist 64887-14-5

(55) ApexBio Compounds for ADRA1B Gene

Compound Action Cas Number
2-MPMDQ α1-adrenoceptor antagonist,potent and selective 149847-77-8
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
AH 11110 hydrochloride α1B-AR ligand,subtype-selective 179388-65-9
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
genes like me logo Genes that share compounds with ADRA1B: view

Drug Products

Transcripts for ADRA1B Gene

mRNA/cDNA for ADRA1B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1B

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1B Gene

No ASD Table

Relevant External Links for ADRA1B Gene

GeneLoc Exon Structure for
ADRA1B

Expression for ADRA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1B Gene

This gene is overexpressed in Artery - Aorta (x7.3) and Liver (x4.1).

Protein differential expression in normal tissues from HIPED for ADRA1B Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADRA1B Gene



Protein tissue co-expression partners for ADRA1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA1B

SOURCE GeneReport for Unigene cluster for ADRA1B Gene:

Hs.368632

Evidence on tissue expression from TISSUES for ADRA1B Gene

  • Nervous system(4.7)
  • Muscle(3.1)
  • Blood(3.1)
  • Heart(3)
  • Kidney(2.5)
  • Adrenal gland(2.3)
  • Liver(2.2)
  • Spleen(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with ADRA1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1B Gene

Orthologs for ADRA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRA1B 30 31
  • 98.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADRA1B 30 31
  • 93.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADRA1B 30 31
  • 92.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adra1b 30
  • 90.74 (n)
Mouse
(Mus musculus)
Mammalia Adra1b 30 17 31
  • 90.55 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADRA1B 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADRA1B 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADRA1B 30 31
  • 68.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488806 30
  • 64.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii adra1bb 30 31
  • 68.06 (n)
OneToMany
ADRA1B (1 of 2) 31
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7431 32
  • 44 (a)
DopR2 32
  • 43 (a)
5-HT1B 32
  • 39 (a)
CG6919 32
  • 37 (a)
DopR 32
  • 36 (a)
5-HT1A 32
  • 35 (a)
CG6989 32
  • 35 (a)
5-HT7 32
  • 32 (a)
Oamb 31
  • 25 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C52B11.3 32
  • 34 (a)
dop-4 31
  • 27 (a)
OneToMany
Species where no ortholog for ADRA1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRA1B Gene

ENSEMBL:
Gene Tree for ADRA1B (if available)
TreeFam:
Gene Tree for ADRA1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA1B: view image

Paralogs for ADRA1B Gene

(19) SIMAP similar genes for ADRA1B Gene using alignment to 1 proteins:

  • ADA1B_HUMAN
genes like me logo Genes that share paralogs with ADRA1B: view

Variants for ADRA1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA1B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
708372 Benign: not provided 159,972,030(+) C/T SYNONYMOUS_VARIANT
rs8192448 - p.Val51Gly

Additional dbSNP identifiers (rs#s) for ADRA1B Gene

Structural Variations from Database of Genomic Variants (DGV) for ADRA1B Gene

Variant ID Type Subtype PubMed ID
dgv1150e214 CNV gain 21293372
dgv3414e59 CNV duplication 20981092
dgv5825n100 CNV gain 25217958
esv22831 CNV loss 19812545
esv3607354 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1074340 CNV deletion 25765185
nsv1110451 CNV duplication 24896259
nsv1145074 CNV deletion 24896259
nsv462500 CNV loss 19166990
nsv600166 CNV loss 21841781
nsv830531 CNV loss 17160897
nsv969009 CNV duplication 23825009

Variation tolerance for ADRA1B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1B Gene

Disorders for ADRA1B Gene

MalaCards: The human disease database

(15) MalaCards diseases for ADRA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
male reproductive organ benign neoplasm
prostatic adenoma
  • adenoma - prostate
perinephritis
ocular hypotension
  • hypotony of eye
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADRA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1B Gene

Publications for ADRA1B Gene

  1. A genome-wide association study on African-ancestry populations for asthma. (PMID: 19910028) Mathias RA … Barnes KC (The Journal of allergy and clinical immunology 2010) 3 23 41
  2. Genomic organization and expression of the human alpha 1B-adrenergic receptor. (PMID: 1328250) Ramarao CS … Graham RM (The Journal of biological chemistry 1992) 3 4 23
  3. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. (PMID: 24567387) Ogata T … Ueyama T (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4
  4. Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes. (PMID: 22120526) Wright CD … O'Connell TD (Cellular signalling 2012) 3 4
  5. Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. (PMID: 21063774) Parkman HP … Krynetskiy E (Digestive diseases and sciences 2011) 3 41

Products for ADRA1B Gene

Sources for ADRA1B Gene