Aliases for ADRA1A Gene
External Ids for ADRA1A Gene
Previous HGNC Symbols for ADRA1A Gene
Previous GeneCards Identifiers for ADRA1A Gene
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA1A Gene
ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include Prostatic Hypertrophy and Horner's Syndrome. Among its related pathways are Endothelin Pathways and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.
UniProtKB/Swiss-Prot for ADRA1A Gene
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.