Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene enco... See more...

Aliases for ADRA1A Gene

Aliases for ADRA1A Gene

  • Adrenoceptor Alpha 1A 2 3 5
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-1C Adrenergic Receptor 3 4
  • Alpha-1A Adrenoreceptor 3 4
  • Alpha-1A Adrenoceptor 3 4
  • ADRA1L1 2 3
  • ADRA1C 3 4
  • Adrenergic, Alpha-1A-, Receptor 2
  • Alpha-Adrenergic Receptor 1c 4
  • G Protein Coupled Receptor 3
  • ADRA1A 5

External Ids for ADRA1A Gene

Previous HGNC Symbols for ADRA1A Gene

  • ADRA1C

Previous GeneCards Identifiers for ADRA1A Gene

  • GC08M026378
  • GC08M027048
  • GC08M026627
  • GC08M026661
  • GC08M025150
  • GC08M026605

Summaries for ADRA1A Gene

Entrez Gene Summary for ADRA1A Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1A Gene

ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include Horner's Syndrome and Prostatic Hypertrophy. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot Summary for ADRA1A Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1A Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA1A Gene

Genomics for ADRA1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRA1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J026865 Promoter 1.7 EPDnew Ensembl CraniofacialAtlas 261.6 +5.2 5193 3.6 ZNF600 ATF2 CEBPA ATF3 NFIC YY1 ZNF639 ZEB1 SIN3A FOXA2 ADRA1A lnc-PNMA2-6 lnc-DPYSL2-3 NONHSAG049814.2 PNMA2
GH08J026839 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 29.4 +30.6 30593 2.4 CEBPA ATF3 YY1 CEBPB EP300 FOXA2 RXRA ZBTB33 JUND HNF4A ADRA1A COX6B1P4 lnc-PNMA2-4 HSALNG0064143 lnc-PNMA2-5 NONHSAG049814.2 PNMA2
GH08J026861 Enhancer 0.8 FANTOM5 Ensembl 21.6 +9.8 9831 0.3 YY1 FOXA2 RXRA JUND RAD21 HNF4A REST MAX ATF3 NR2F2 ADRA1A PTK2B lnc-DPYSL2-3 lnc-PNMA2-6 NONHSAG049814.2 PNMA2
GH08J027033 Enhancer 0.7 Ensembl ENCODE 16.8 -162.7 -162658 0.3 GABPA JUND ATF1 BHLHE40 POLR2A CREM EP300 FOS ADRA1A RF01061-176 LOC100132229 STMN4
GH08J027359 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -495.1 -495149 13.4 BCLAF1 SP1 NCOR1 MYC IKZF1 ZNF592 POLR2A ATF3 NFIC YY1 PTK2B CLU ADRA1A EPHX2 lnc-EPHX2-4 RF00017-6358 HSALNG0064168-001 CHRNA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA1A

Top Transcription factor binding sites by QIAGEN in the ADRA1A gene promoter:
  • AML1a
  • CUTL1
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • Nkx2-5

Genomic Locations for ADRA1A Gene

Latest Assembly
132,882 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
119,129 bases
Minus strand

(GRCh37/hg19 by Ensembl)
119,124 bases
Minus strand

Genomic View for ADRA1A Gene

Genes around ADRA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1A Gene

Proteins for ADRA1A Gene

  • Protein details for ADRA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1A adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • A8K0I3
    • B0ZBD1
    • B0ZBD2
    • B0ZBD4
    • B0ZBD5
    • B0ZBD6
    • B0ZBD8
    • B0ZBD9
    • O60451
    • Q13675
    • Q13729
    • Q4VBM7
    • Q6RUJ4
    • Q6RUJ5
    • Q6RUJ7
    • Q6RUJ8
    • Q6RUJ9
    • Q96RE8
    • Q9UD63
    • Q9UD67

    Protein attributes for ADRA1A Gene

    466 amino acids
    Molecular mass:
    51487 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).
    • [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ADRA1A Gene

neXtProt entry for ADRA1A Gene

Post-translational modifications for ADRA1A Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn7, Asn13, and Asn22
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADRA1A Gene

Domains & Families for ADRA1A Gene

Gene Families for ADRA1A Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADRA1A Gene

  • Adrenergic receptor signature
  • Alpha-1C adrenergic receptor signature

Suggested Antigen Peptide Sequences for ADRA1A Gene

GenScript: Design optimal peptide antigens:
  • Alpha-adrenergic receptor 1c (ADA1A_HUMAN)
  • Adrenergic, alpha-1A-, receptor variant 3 (B0ZBD3_HUMAN)
  • Alpha-1c adrenergic receptor subtype (Q6LD06_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
genes like me logo Genes that share domains with ADRA1A: view

Function for ADRA1A Gene

Molecular function for ADRA1A Gene

UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
GENATLAS Biochemistry:
adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system

Phenotypes From GWAS Catalog for ADRA1A Gene

Gene Ontology (GO) - Molecular Function for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004935 adrenergic receptor activity IEA --
GO:0004937 alpha1-adrenergic receptor activity NAS,TAS 7737411
GO:0005515 protein binding IPI 24567387
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1A: view
genes like me logo Genes that share phenotypes with ADRA1A: view

Animal Models for ADRA1A Gene

MGI Knock Outs for ADRA1A:

miRNA for ADRA1A Gene

miRTarBase miRNAs that target ADRA1A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1A

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1A Gene

Localization for ADRA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1A Gene

Nucleus membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1A gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22120526
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 24567387
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ADRA1A: view

Pathways & Interactions for ADRA1A Gene

genes like me logo Genes that share pathways with ADRA1A: view

Pathways by source for ADRA1A Gene

2 GeneGo (Thomson Reuters) pathways for ADRA1A Gene
  • Development Activation of ERK by Alpha-1 adrenergic receptors
  • Translation Translation regulation by Alpha-1 adrenergic receptors
6 Qiagen pathways for ADRA1A Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Alpha-Adrenergic Signaling
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway

SIGNOR curated interactions for ADRA1A Gene


Gene Ontology (GO) - Biological Process for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IBA 21873635
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

Drugs & Compounds for ADRA1A Gene

(269) Drugs for ADRA1A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prazosin Approved Pharma Antagonist, Inverse agonist, Target, Target 75
Alfuzosin Approved, Investigational Pharma Target, Target, antagonist 52
Doxazosin Approved Pharma Target, antagonist 69
Terazosin Approved Pharma Target, antagonist α1-adrenergic receptor antagonist 31
Silodosin Approved Pharma Antagonist, Target α1-adrenoceptor antagonist 25

(6) Additional Compounds for ADRA1A Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Promazine 5-sulfoxide
  • Promazine 5-sulphoxide
BMY 7378 dihydrochloride

(5) Tocris Compounds for ADRA1A Gene

Compound Action Cas Number
3-MPPI alpha1 ligand 133399-65-2
A 61603 hydrobromide alpha1A agonist 107756-30-9
BMY 7378 dihydrochloride Selective alpha1D antagonist 21102-95-4
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
Urapidil hydrochloride alpha1 antagonist. Also 5-HT1A receptor agonist 64887-14-5

(113) ApexBio Compounds for ADRA1A Gene

Compound Action Cas Number
(R)-(-)-Niguldipine hydrochloride
(S)-(-)-Propranolol hydrochloride 4199-10-4
(S)-(+)-Niguldipine hydrochloride 113145-69-0
2-MPMDQ α1-adrenoceptor antagonist,potent and selective 149847-77-8
2-PMDQ 139047-55-5
A 61603 hydrobromide Potent α1A-AR agonist 107756-30-9
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Agmatine sulfate 2482-00-0
Alfuzosin 81403-80-7
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Alprenolol hydrochloride 13707-88-5
Atipamezole hydrochloride 104075-48-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Bucindolol 71119-11-4
Carvedilol 72956-09-3
Cimaterol 54239-37-1
Cirazoline hydrochloride 40600-13-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine 76631-46-4
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
Dihydroergocristine mesylate 24730-10-7
DL-Adrenaline 329-65-7
Doxazosin 74191-85-8
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
DSP-4 40616-75-9
Efaroxan hydrochloride 89197-00-2
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Guanfacine 29110-47-2
HEAT hydrochloride 30007-39-7
ICI 89406 53671-71-9
Idazoxan hydrochloride 79944-56-2
Imiloxan hydrochloride 81167-22-8
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
JP 1302 dihydrochloride 1259314-65-2
L-(-)-α-Methyldopa hydrochloride Alpha-adrenergic agonist 884-39-9
L-748,337 244192-94-7
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Succinate 98418-47-4
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxprenolol hydrochloride 6452-73-9
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Pindolol 13523-86-9
Prazosin 19216-56-9
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Procaterol hydrochloride 62929-91-3
Pronethalol hydrochloride 1951-02-5
Propranolol HCl 318-98-9
Rauwolscine hydrochloride 6211-32-1
Rec 15/2615 dihydrochloride 173059-17-1
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
RS 100329 hydrochloride 1215654-26-4
RS 17053 hydrochloride α1A-adrenoceptor antagonist, novel and selective 169505-93-5
RS 79948 hydrochloride 186002-54-0
RWJ 52353 245744-10-9
RX 821002 hydrochloride 109544-45-8
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
SDZ 21009 39731-05-0
Silodosin α1-adrenoceptor antagonist 160970-54-7
SKF 86466 hydrochloride 86129-54-6
SNAP 5089 157066-77-8
Sotalol 959-24-0
Spiroxatrine 1054-88-2
SR 58611A hydrochloride 121524-09-2
SR 59230A hydrochloride 1135278-41-9
ST 91 4749-61-5
Synephrine 1994-07-5
Synephrine HCl 5985-28-4
TC-G 1000 245744-18-7
Terazosin α1-adrenergic receptor antagonist 63590-64-7
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine 51322-75-9
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
WB 4101 hydrochloride 2170-58-3
Xamoterol hemifumarate 73210-73-8
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
ZD 2079 178600-17-4
ZD 7114 hydrochloride 129689-28-7
Zinterol hydrochloride 37000-20-7
genes like me logo Genes that share compounds with ADRA1A: view

Drug products for research

Transcripts for ADRA1A Gene

mRNA/cDNA for ADRA1A Gene

22 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP5: -

Relevant External Links for ADRA1A Gene

GeneLoc Exon Structure for

Expression for ADRA1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1A Gene

This gene is overexpressed in Liver (x18.5) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for ADRA1A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA1A Gene

Protein tissue co-expression partners for ADRA1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA1A

SOURCE GeneReport for Unigene cluster for ADRA1A Gene:


mRNA Expression by UniProt/SwissProt for ADRA1A Gene:

Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Evidence on tissue expression from TISSUES for ADRA1A Gene

  • Liver(4.6)
  • Heart(4.5)
  • Nervous system(4.4)
  • Blood(4.3)
  • Muscle(2.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ADRA1A: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1A Gene

Orthologs for ADRA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADRA1A 29 30
  • 99.29 (n)
(Canis familiaris)
Mammalia ADRA1A 29 30
  • 91.85 (n)
(Bos Taurus)
Mammalia ADRA1A 29 30
  • 90.2 (n)
(Rattus norvegicus)
Mammalia Adra1a 29
  • 87.84 (n)
(Mus musculus)
Mammalia Adra1a 29 16 30
  • 87.12 (n)
(Ornithorhynchus anatinus)
Mammalia ADRA1A 30
  • 82 (a)
(Monodelphis domestica)
Mammalia ADRA1A 30
  • 78 (a)
(Gallus gallus)
Aves ADRA1A 29 30
  • 73.75 (n)
(Anolis carolinensis)
Reptilia ADRA1A 30
  • 68 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492776 29
  • 65.52 (n)
(Danio rerio)
Actinopterygii LOC798498 29
  • 60.48 (n)
ADRA1A (2 of 2) 30
  • 54 (a)
adra1ab 30
  • 52 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Oamb 29 30
  • 55.94 (n)
DopR2 31
  • 44 (a)
CG7431 31
  • 41 (a)
5-HT1B 31
  • 38 (a)
DopR 31
  • 34 (a)
5-HT1A 31
  • 32 (a)
CG6989 31
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPROAR1 29
  • 53.03 (n)
(Caenorhabditis elegans)
Secernentea dop-4 29 30
  • 46.51 (n)
C52B11.3 31
  • 38 (a)
Species where no ortholog for ADRA1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRA1A Gene

Gene Tree for ADRA1A (if available)
Gene Tree for ADRA1A (if available)
Evolutionary constrained regions (ECRs) for ADRA1A: view image
Alliance of Genome Resources:
Additional Orthologs for ADRA1A

Paralogs for ADRA1A Gene

Variants for ADRA1A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA1A Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs142415576 Benign: not provided 26,770,347(-) A/C
NM_000680.4(ADRA1A):c.1203T>G (p.Ser401=)
rs2229124 Benign: not provided 26,864,508(-) G/C
NM_000680.4(ADRA1A):c.462C>G (p.Ser154=)
rs61757007 Benign: not provided 26,864,151(-) C/A
NM_000680.4(ADRA1A):c.819G>T (p.Thr273=)
rs61757009 Benign: not provided 26,864,510(-) A/C
NM_000680.4(ADRA1A):c.460T>G (p.Ser154Ala)
rs7833704 Benign: not provided 26,864,247(-) G/T
NM_000680.4(ADRA1A):c.723C>A (p.Ala241=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADRA1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADRA1A Gene

Variant ID Type Subtype PubMed ID
esv3616666 OTHER inversion 21293372
nsv527478 CNV gain 19592680
nsv610864 CNV loss 21841781

Variation tolerance for ADRA1A Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1A Gene

Disorders for ADRA1A Gene

MalaCards: The human disease database

(15) MalaCards diseases for ADRA1A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
horner's syndrome
  • bernard horner syndrome
prostatic hypertrophy
  • benign prostatic hypertrophy
  • calculus of ureter
complex regional pain syndrome
  • complex regional pain syndromes
arthrogryposis, distal, type 1a
  • da1a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA1A

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ADRA1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1A Gene

Publications for ADRA1A Gene

  1. Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients. (PMID: 19476811) Morris JA … Canter JA (Journal of the American College of Surgeons 2009) 3 22 40
  2. Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. (PMID: 16536786) Mochtar CA … Kiemeney LA (BJU international 2006) 3 22 40
  3. Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension. (PMID: 16685204) Gu D … Qiang B (Journal of hypertension 2006) 2 3 40
  4. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PMID: 16043131) Clark DA … Kerwin RW (Biological psychiatry 2005) 3 22 40
  5. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PMID: 15824464) Matayoshi T … Kawano Y (Hypertension research : official journal of the Japanese Society of Hypertension 2004) 3 22 40

Products for ADRA1A Gene

Sources for ADRA1A Gene