Aliases for ADPRS Gene
- ADP-Ribosylserine Hydrolase 2 3
- ADP-Ribosylhydrolase Like 2 2 3 5
- [Protein ADP-Ribosylarginine] Hydrolase-Like Protein 2 3 4
- [Protein ADP-Ribosylserine] Hydrolase 3 4
- Poly(ADP-Ribose) Glycohydrolase ARH3 3 4
- ADP-Ribosylarginine Hydrolase Like 2 2 3
- O-Acetyl-ADP-Ribose Deacetylase ARH3 3 4
- ADP-Ribose Glycohydrolase ARH3 3 4
External Ids for ADPRS Gene
Previous HGNC Symbols for ADPRS Gene
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
GeneCards Summary for ADPRS Gene
ADPRS (ADP-Ribosylserine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRS include Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures and Hypercholesterolemia, Familial, 4.
UniProtKB/Swiss-Prot Summary for ADPRS Gene
ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30045870, PubMed:29907568, PubMed:30401461). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885).