This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009] See more...

Aliases for ADPRS Gene

Aliases for ADPRS Gene

  • ADP-Ribosylserine Hydrolase 2 3
  • ADP-Ribosylhydrolase Like 2 2 3 5
  • [Protein ADP-Ribosylarginine] Hydrolase-Like Protein 2 3 4
  • [Protein ADP-Ribosylserine] Hydrolase 3 4
  • Poly(ADP-Ribose) Glycohydrolase ARH3 3 4
  • ADP-Ribosylarginine Hydrolase Like 2 2 3
  • O-Acetyl-ADP-Ribose Deacetylase ARH3 3 4
  • ADP-Ribose Glycohydrolase ARH3 3 4
  • ADP-Ribosylhydrolase 3 3 4
  • EC 3.2.1.143 4 52
  • ADPRHL2 3 5
  • ARH3 3 4
  • Protein ADP-Ribosylarginine Hydrolase-Like Protein 2 3
  • EC 3.5.1.- 4
  • EC 3.2.2.- 4
  • CONDSIAS 3

External Ids for ADPRS Gene

Previous HGNC Symbols for ADPRS Gene

  • ADPRHL2

Summaries for ADPRS Gene

Entrez Gene Summary for ADPRS Gene

  • This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

GeneCards Summary for ADPRS Gene

ADPRS (ADP-Ribosylserine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRS include Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures and Hypercholesterolemia, Familial, 4.

UniProtKB/Swiss-Prot Summary for ADPRS Gene

  • ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30045870, PubMed:29907568, PubMed:30401461). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885).

Gene Wiki entry for ADPRS Gene

Additional gene information for ADPRS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADPRS Gene

Genomics for ADPRS Gene

GeneHancer (GH) Regulatory Elements for ADPRS Gene

Promoters and enhancers for ADPRS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADPRS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADPRS

Genomic Locations for ADPRS Gene

Genomic Locations for ADPRS Gene
chr1:36,088,852-36,093,932
(GRCh38/hg38)
Size:
5,081 bases
Orientation:
Plus strand
chr1:36,554,453-36,559,533
(GRCh37/hg19)
Size:
5,081 bases
Orientation:
Plus strand

Genomic View for ADPRS Gene

Genes around ADPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRS Gene

Proteins for ADPRS Gene

  • Protein details for ADPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX46-ARHL2_HUMAN
    Recommended name:
    ADP-ribose glycohydrolase ARH3
    Protein Accession:
    Q9NX46
    Secondary Accessions:
    • Q53G94
    • Q6IAB8
    • Q9BY47

    Protein attributes for ADPRS Gene

    Size:
    363 amino acids
    Molecular mass:
    38947 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAK14922.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADPRS Gene

neXtProt entry for ADPRS Gene

Selected DME Specific Peptides for ADPRS Gene

Q9NX46:
  • YTDDTAM
  • RFRGCLAGALLGDC
  • GNGGAMR
  • TIATMAGAIAGAYYG
  • SLGYNGA
  • AFESVPTAIY
  • ELGNGIAA

Post-translational modifications for ADPRS Gene

  • Ubiquitination at Lys146
  • Modification sites at PhosphoSitePlus

Other Protein References for ADPRS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADPRS Gene

Gene Families for ADPRS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADPRS Gene

Blocks:
  • ADP-ribosylglycohydrolase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADPRS Gene

GenScript: Design optimal peptide antigens:
  • [Protein ADP-ribosylarginine] hydrolase-like protein 2 (ARHL2_HUMAN)
  • cDNA FLJ51852, highly similar to Homo sapiens ADP-ribosylhydrolase like 2 (ADPRHL2), mRNA (B4DHV5_HUMAN)
  • cDNA, FLJ79248, highly similar to Homo sapiens ADP-ribosylhydrolase like 2 (ADPRHL2), mRNA (B7ZAN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NX46

UniProtKB/Swiss-Prot:

ARHL2_HUMAN :
  • Belongs to the ADP-ribosylglycohydrolase family.
Family:
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRS: view

Function for ADPRS Gene

Molecular function for ADPRS Gene

UniProtKB/Swiss-Prot Function:
ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30045870, PubMed:29907568, PubMed:30401461). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[(1''->2')-ADP-alpha-D-ribose]n + H2O = [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose; Xref=Rhea:RHEA:52216, Rhea:RHEA-COMP:15070, Rhea:RHEA-COMP:15071, ChEBI:CHEBI:15377, ChEBI:CHEBI:57967, ChEBI:CHEBI:142512; EC=3.2.1.143; Evidence={ECO:0000269 PubMed:16278211, ECO:0000269 PubMed:17075046, ECO:0000269 PubMed:22433848}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52217; Evidence={ECO:0000269 PubMed:16278211, ECO:0000269 PubMed:17075046, ECO:0000269 PubMed:22433848};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:58112, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142511; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58113; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]; Xref=Rhea:RHEA:58256, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:57967, ChEBI:CHEBI:142556; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58257; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage (PubMed:29907568). The glutamate flap (Glu-41) blocks substrate entrance to Mg(2+) in the unliganded closed state (PubMed:30045870, PubMed:29907568). In presence of substrate, Glu-41 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O-linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose (PubMed:30045870, PubMed:29907568).

Enzyme Numbers (IUBMB) for ADPRS Gene

Phenotypes From GWAS Catalog for ADPRS Gene

Gene Ontology (GO) - Molecular Function for ADPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 30045870
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IDA 30045870
GO:0004649 poly(ADP-ribose) glycohydrolase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADPRS: view
genes like me logo Genes that share phenotypes with ADPRS: view

Human Phenotype Ontology for ADPRS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ADPRS Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADPRS

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ADPRS Gene

Localization for ADPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADPRS Gene

Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites. {ECO:0000269 PubMed:30045870}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADPRS gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 30045870
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA 21873635
genes like me logo Genes that share ontologies with ADPRS: view

Pathways & Interactions for ADPRS Gene

PathCards logo

SuperPathways for ADPRS Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 30045870
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0071451 cellular response to superoxide IMP 30401461
genes like me logo Genes that share ontologies with ADPRS: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRS Gene

Drugs & Compounds for ADPRS Gene

(1) Drugs for ADPRS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0

(1) Additional Compounds for ADPRS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ADPRS: view

Transcripts for ADPRS Gene

mRNA/cDNA for ADPRS Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADPRS

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRS Gene

No ASD Table

Relevant External Links for ADPRS Gene

GeneLoc Exon Structure for
ADPRS

Expression for ADPRS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADPRS

SOURCE GeneReport for Unigene cluster for ADPRS Gene:

Hs.18021

mRNA Expression by UniProt/SwissProt for ADPRS Gene:

Q9NX46-ARHL2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ADPRS Gene

  • Thyroid gland(4.3)
  • Skin(4.2)
  • Nervous system(3.4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADPRS Gene

Orthologs for ADPRS Gene

This gene was present in the common ancestor of animals.

Orthologs for ADPRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPRHL2 31 30
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADPRHL2 31 30
  • 90.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADPRHL2 31 30
  • 89.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adprhl2 17 31 30
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Adprhl2 30
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ADPRHL2 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPRHL2 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADPRHL2 31 30
  • 70.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPRHL2 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adprhl2 30
  • 60.71 (n)
Str.3494 30
zebrafish
(Danio rerio)
Actinopterygii adprhl2 31 30
  • 57.94 (n)
OneToOne
wufj36e06 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002530 30
  • 49.95 (n)
Species where no ortholog for ADPRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRS Gene

ENSEMBL:
Gene Tree for ADPRS (if available)
TreeFam:
Gene Tree for ADPRS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADPRS: view image

Paralogs for ADPRS Gene

No data available for Paralogs for ADPRS Gene

Variants for ADPRS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADPRS Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
590299 Pathogenic: NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES 36,091,625(+) C/T NONSENSE
590302 Pathogenic: NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES 36,091,923(+) C/T MISSENSE_VARIANT
rs1557732234 Pathogenic: NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES 36,089,004(+) G/A MISSENSE_VARIANT
rs1557733311 Pathogenic: NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES 36,091,267(+) A/C MISSENSE_VARIANT
rs1557733367 Pathogenic: NEURODEGENERATION, CHILDHOOD-ONSET, STRESS-INDUCED, WITH VARIABLE ATAXIA AND SEIZURES 36,091,322(+) AG/A FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for ADPRS Gene

Structural Variations from Database of Genomic Variants (DGV) for ADPRS Gene

Variant ID Type Subtype PubMed ID
esv3329704 CNV duplication 20981092
nsv545992 CNV loss 21841781
nsv834691 CNV loss 17160897

Variation tolerance for ADPRS Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADPRS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADPRS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRS Gene

Disorders for ADPRS Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADPRS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADPRS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ARHL2_HUMAN
  • Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures (CONDSIAS) [MIM:618170]: An autosomal recessive neurodegenerative disorder characterized by pediatric onset of progressive brain atrophy, developmental regression, and seizures in association with periods of stress, such as infections. {ECO:0000269 PubMed:30100084, ECO:0000269 PubMed:30401461}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ADPRS

genes like me logo Genes that share disorders with ADPRS: view

No data available for Genatlas for ADPRS Gene

Publications for ADPRS Gene

  1. Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase. (PMID: 16278211) Oka S … Moss J (The Journal of biological chemistry 2006) 2 3 4 23 54
  2. The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. (PMID: 17015823) Mueller-Dieckmann C … Koch-Nolte F (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23 54
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 2 3 4 54
  4. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. (PMID: 30472116) Rack JGM … Ahel I (Cell chemical biology 2018) 2 3 54
  5. Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. (PMID: 30045870) Wang M … Yu X (The Journal of biological chemistry 2018) 3 4 54

Products for ADPRS Gene

Sources for ADPRS Gene