Aliases for ADPRHL2 Gene
External Ids for ADPRHL2 Gene
Previous GeneCards Identifiers for ADPRHL2 Gene
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
GeneCards Summary for ADPRHL2 Gene
ADPRHL2 (ADP-Ribosylhydrolase Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include poly(ADP-ribose) glycohydrolase activity.
UniProtKB/Swiss-Prot for ADPRHL2 Gene
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.