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Aliases for ADPRHL1 Gene

Aliases for ADPRHL1 Gene

  • ADP-Ribosylhydrolase Like 1 2 3 5
  • ADP-Ribosylarginine Hydrolase Like 1 2 3
  • ADP-Ribosylhydrolase 2 3 4
  • ARH2 3 4
  • [Protein ADP-Ribosylarginine] Hydrolase-Like Protein 1 3
  • ADP-Ribosyl-Hydrolase 3
  • EC 3.2.-.- 4

External Ids for ADPRHL1 Gene

Previous GeneCards Identifiers for ADPRHL1 Gene

  • GC13M113162
  • GC13M112024
  • GC13M113124
  • GC13M114076
  • GC13M094515

Summaries for ADPRHL1 Gene

Entrez Gene Summary for ADPRHL1 Gene

  • ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADPRHL1 Gene

ADPRHL1 (ADP-Ribosylhydrolase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRH.

Additional gene information for ADPRHL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRHL1 Gene

Genomics for ADPRHL1 Gene

GeneHancer (GH) Regulatory Elements for ADPRHL1 Gene

Promoters and enhancers for ADPRHL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J113447 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +4.4 4366 2.5 HDGF PKNOX1 ARNT ARID4B SIN3A SLC30A9 ZNF766 E2F8 ZNF143 DEK ADPRHL1 PCID2 TUBGCP3 CDC16 CHAMP1 DCUN1D2 TMCO3 LOC101928841 GC13M113076
GH13J113451 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 +0.2 197 3.4 FEZF1 GLIS2 ZNF366 SCRT2 RCOR1 TSHZ1 ZEB2 ZNF843 ZFP69B PRDM6 ADPRHL1 DCUN1D2 TMCO3 UPF3A LOC101928841 GC13M113076
GH13J113408 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +42.7 42691 4.2 PKNOX1 ZFP64 KLF17 GLI4 ZEB1 GLIS2 ZNF366 FOS CREM EGR2 UPF3A CDC16 ADPRHL1 TUBGCP3 GRTP1 MCF2L LOC101928841 PIR34234 GC13M113076
GH13J113815 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.7 -365.6 -365553 8 ZNF2 ZNF766 GLIS2 ZNF143 FOS RUNX3 RXRA NCOA1 REST GLIS1 LOC105370380 TMEM255B GAS6-AS1 ADPRHL1 GAS6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADPRHL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADPRHL1 gene promoter:
  • TBP
  • AML1a
  • p53
  • LUN-1
  • FOXO1

Genomic Locations for ADPRHL1 Gene

Genomic Locations for ADPRHL1 Gene
53,915 bases
Minus strand
31,580 bases
Minus strand

Genomic View for ADPRHL1 Gene

Genes around ADPRHL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRHL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRHL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRHL1 Gene

Proteins for ADPRHL1 Gene

  • Protein details for ADPRHL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5JUG2
    • Q96GD1

    Protein attributes for ADPRHL1 Gene

    354 amino acids
    Molecular mass:
    40105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADPRHL1 Gene


neXtProt entry for ADPRHL1 Gene

Post-translational modifications for ADPRHL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADPRHL1 Gene

No data available for DME Specific Peptides for ADPRHL1 Gene

Domains & Families for ADPRHL1 Gene

Gene Families for ADPRHL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ADPRHL1 Gene

Suggested Antigen Peptide Sequences for ADPRHL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADP-ribosylglycohydrolase family.
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRHL1: view

Function for ADPRHL1 Gene

Enzyme Numbers (IUBMB) for ADPRHL1 Gene

Gene Ontology (GO) - Molecular Function for ADPRHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003875 ADP-ribosylarginine hydrolase activity IEA --
GO:0005096 GTPase activator activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with ADPRHL1: view
genes like me logo Genes that share phenotypes with ADPRHL1: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADPRHL1 Gene

Localization for ADPRHL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADPRHL1 gene
Compartment Confidence
nucleus 3
plasma membrane 2
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADPRHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005769 early endosome IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with ADPRHL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADPRHL1 Gene

Pathways & Interactions for ADPRHL1 Gene

SuperPathways for ADPRHL1 Gene

No Data Available

Interacting Proteins for ADPRHL1 Gene

Gene Ontology (GO) - Biological Process for ADPRHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0051725 protein de-ADP-ribosylation IEA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with ADPRHL1: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRHL1 Gene

Drugs & Compounds for ADPRHL1 Gene

No Compound Related Data Available

Transcripts for ADPRHL1 Gene

mRNA/cDNA for ADPRHL1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADPRHL1 Gene

ADP-ribosylhydrolase like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP3: -
SP4: - -

Relevant External Links for ADPRHL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADPRHL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADPRHL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADPRHL1 Gene

This gene is overexpressed in Heart - Left Ventricle (x20.4), Heart - Atrial Appendage (x12.1), and Muscle - Skeletal (x11.9).

Protein differential expression in normal tissues from HIPED for ADPRHL1 Gene

This gene is overexpressed in Heart (47.8) and Fetal heart (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADPRHL1 Gene

Protein tissue co-expression partners for ADPRHL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADPRHL1 Gene:


SOURCE GeneReport for Unigene cluster for ADPRHL1 Gene:


Evidence on tissue expression from TISSUES for ADPRHL1 Gene

  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with ADPRHL1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADPRHL1 Gene

Orthologs for ADPRHL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRHL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADPRHL1 34
  • 100 (a)
(Canis familiaris)
Mammalia ADPRHL1 34 33
  • 81.16 (n)
(Rattus norvegicus)
Mammalia Adprhl1 33
  • 80.64 (n)
(Mus musculus)
Mammalia Adprhl1 16 34 33
  • 79.98 (n)
(Bos Taurus)
Mammalia ADPRHL1 34 33
  • 78.81 (n)
(Ornithorhynchus anatinus)
Mammalia ADPRHL1 34
  • 48 (a)
(Monodelphis domestica)
Mammalia ADPRHL1 34
  • 17 (a)
(Gallus gallus)
Aves ADPRHL1 34
  • 77 (a)
(Anolis carolinensis)
Reptilia ADPRHL1 34
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2412 33
(Danio rerio)
Actinopterygii adprhl1 34 33
  • 67.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Species where no ortholog for ADPRHL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRHL1 Gene

Gene Tree for ADPRHL1 (if available)
Gene Tree for ADPRHL1 (if available)
Evolutionary constrained regions (ECRs) for ADPRHL1: view image

Paralogs for ADPRHL1 Gene

Paralogs for ADPRHL1 Gene

(1) SIMAP similar genes for ADPRHL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADPRHL1: view

Variants for ADPRHL1 Gene

Sequence variations from dbSNP and Humsavar for ADPRHL1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000043345 -- 113,437,957(-) A/C intron_variant
rs1000124456 -- 113,451,861(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000130924 -- 113,448,115(-) C/T intron_variant
rs1000155587 -- 113,451,664(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000572977 -- 113,443,349(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADPRHL1 Gene

Variant ID Type Subtype PubMed ID
esv3433428 CNV duplication 20981092
esv2759970 CNV loss 17122850
esv2748298 CNV deletion 23290073
esv2748296 CNV deletion 23290073
esv2748295 CNV deletion 23290073
esv2677394 CNV deletion 23128226
esv2454485 CNV insertion 19546169
esv22722 CNV gain+loss 19812545
esv1482794 CNV insertion 17803354
esv1314688 CNV deletion 17803354
dgv3449n54 CNV loss 21841781
dgv1744n100 CNV gain 25217958
dgv1132e59 CNV duplication 20981092
nsv958118 CNV deletion 24416366
nsv951928 CNV deletion 24416366
nsv9116 CNV gain 18304495
nsv64762 CNV deletion 16902084
nsv64502 CNV deletion 16902084
nsv64447 CNV deletion 16902084
nsv563379 CNV loss 21841781
nsv563378 CNV loss 21841781
nsv563321 CNV loss 21841781
nsv563318 CNV loss 21841781
nsv513403 CNV insertion 21212237
nsv509522 CNV insertion 20534489
nsv456137 CNV loss 19166990
nsv1195 CNV insertion 18451855
nsv1150562 CNV duplication 26484159
nsv1145875 CNV deletion 26484159
nsv1125191 CNV insertion 24896259
nsv1118525 CNV duplication 24896259
nsv1115719 CNV deletion 24896259
nsv1112267 CNV deletion 24896259
nsv1075856 CNV duplication 25765185
nsv1048814 CNV gain 25217958
nsv1044941 CNV gain 25217958
esv3633609 CNV loss 21293372
esv3580910 CNV loss 25503493

Variation tolerance for ADPRHL1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADPRHL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRHL1 Gene

Disorders for ADPRHL1 Gene

Additional Disease Information for ADPRHL1

No disorders were found for ADPRHL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADPRHL1 Gene

Publications for ADPRHL1 Gene

  1. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 2 3 4 58
  2. The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly. (PMID: 27217161) Smith SJ … Mohun TJ (Developmental biology 2016) 2 3 58
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for ADPRHL1 Gene

Sources for ADPRHL1 Gene

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