Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADPRH Gene

Aliases for ADPRH Gene

  • ADP-Ribosylarginine Hydrolase 2 3 3 4 5
  • [Protein ADP-Ribosylarginine] Hydrolase 2 3
  • ADP-Ribose-L-Arginine Cleaving Enzyme 3 4
  • ARH1 3 4
  • EC 4

External Ids for ADPRH Gene

Previous GeneCards Identifiers for ADPRH Gene

  • GC03P115940
  • GC03P118926
  • GC03P120579
  • GC03P120619
  • GC03P120781
  • GC03P119298
  • GC03P116674

Summaries for ADPRH Gene

Entrez Gene Summary for ADPRH Gene

  • The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ADPRH Gene

ADPRH (ADP-Ribosylarginine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRH include Glycine N-Methyltransferase Deficiency and Mucolipidosis Ii Alpha/Beta. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot for ADPRH Gene

  • Catalyzes the reverse reaction of mono-ADP-ribosylation.

Additional gene information for ADPRH Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRH Gene

Genomics for ADPRH Gene

GeneHancer (GH) Regulatory Elements for ADPRH Gene

Promoters and enhancers for ADPRH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J119578 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 671 +0.6 578 2.4 HDGF RB1 SIN3A DMAP1 KLF5 YY1 ZNF207 ETV6 ATF7 IKZF2 ADPRH ENSG00000272967 CD80 MAATS1 PLA1A
GH03J119557 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.7 -18.7 -18735 5.8 HDGF PKNOX1 SMAD1 IRF4 TCF12 ZNF766 ZNF207 ZNF143 ATF7 RUNX3 CD80 ADPRH ARHGAP31 TMEM39A
GH03J119635 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +58.9 58891 4.5 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF766 ZNF143 FOS JUNB REST RPL10P7 ADPRH COX17 ARHGAP31 MAATS1 PLA1A GSK3B GC03M119637 POPDC2
GH03J119321 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -256.3 -256290 2.7 HDGF ARID4B SIN3A ZNF2 IRF4 POLR2B ZNF207 ZNF143 FOS SP3 ARHGAP31-AS1 ARHGAP31 ADPRH B4GALT4 COX17 CD80 GC03M119342 RNU6-1127P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADPRH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADPRH gene promoter:
  • STAT1
  • AP-1
  • c-Jun
  • ATF-2
  • E47
  • Zic1
  • HEN1
  • c-Myb
  • LCR-F1

Genomic Locations for ADPRH Gene

Genomic Locations for ADPRH Gene
10,678 bases
Plus strand
10,678 bases
Plus strand

Genomic View for ADPRH Gene

Genes around ADPRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRH Gene

Proteins for ADPRH Gene

  • Protein details for ADPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
    Protein Accession:
    Secondary Accessions:
    • B2R8H1
    • D3DN83

    Protein attributes for ADPRH Gene

    357 amino acids
    Molecular mass:
    39507 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ADPRH Gene

neXtProt entry for ADPRH Gene

Post-translational modifications for ADPRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADPRH Gene

Domains & Families for ADPRH Gene

Gene Families for ADPRH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADPRH Gene

Suggested Antigen Peptide Sequences for ADPRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADP-ribosylglycohydrolase family.
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRH: view

Function for ADPRH Gene

Molecular function for ADPRH Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the reverse reaction of mono-ADP-ribosylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine.
UniProtKB/Swiss-Prot CatalyticActivity:
N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine.

Enzyme Numbers (IUBMB) for ADPRH Gene

Phenotypes From GWAS Catalog for ADPRH Gene

Gene Ontology (GO) - Molecular Function for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 19407395
GO:0003875 ADP-ribosylarginine hydrolase activity IMP 8349667
GO:0005096 NOT GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADPRH: view
genes like me logo Genes that share phenotypes with ADPRH: view

Animal Models for ADPRH Gene

MGI Knock Outs for ADPRH:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADPRH Gene

Localization for ADPRH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADPRH gene
Compartment Confidence
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 NOT endomembrane system IBA --
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADPRH Gene

Pathways & Interactions for ADPRH Gene

SuperPathways for ADPRH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IMP 8349667
GO:0006886 NOT intracellular protein transport IBA --
GO:0031338 NOT regulation of vesicle fusion IBA --
GO:0051725 protein de-ADP-ribosylation IEA --
GO:0090630 NOT activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRH Gene

Drugs & Compounds for ADPRH Gene

(47) Drugs for ADPRH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
L-Arginine Approved Nutra Full agonist, Agonist 0

(68) Additional Compounds for ADPRH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppa
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • a5'pp5RIb
  • Adenosine 5'-diphosphoribose
  • AdoPPRib
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • N(Omega)-(ADP-D-ribosyl)-arginine
  • N(Omega)-(ADP-D-ribosyl)-L-arginine
  • N(Omega)-(ADP-delta-ribosyl)-arginine
  • N(Omega)-(ADP-delta-ribosyl)-L-arginine
  • N(W)-(ADP-D-Ribosyl)-arginine
genes like me logo Genes that share compounds with ADPRH: view

Transcripts for ADPRH Gene

Unigene Clusters for ADPRH Gene

ADP-ribosylarginine hydrolase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for ADPRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADPRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADPRH Gene

Protein differential expression in normal tissues from HIPED for ADPRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Spleen (8.7), and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADPRH Gene

Protein tissue co-expression partners for ADPRH Gene

NURSA nuclear receptor signaling pathways regulating expression of ADPRH Gene:


SOURCE GeneReport for Unigene cluster for ADPRH Gene:


Evidence on tissue expression from TISSUES for ADPRH Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ADPRH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADPRH Gene

Orthologs for ADPRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADPRH 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia ADPRH 34 33
  • 88.7 (n)
(Bos Taurus)
Mammalia ADPRH 34 33
  • 87.9 (n)
(Mus musculus)
Mammalia Adprh 16 34 33
  • 82.35 (n)
(Rattus norvegicus)
Mammalia Adprh 33
  • 82.25 (n)
(Ornithorhynchus anatinus)
Mammalia ADPRH 34
  • 79 (a)
(Monodelphis domestica)
Mammalia ADPRH 34
  • 69 (a)
(Gallus gallus)
Aves ADPRH 34 33
  • 68.11 (n)
(Anolis carolinensis)
Reptilia ADPRH 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adprh 33
  • 67.63 (n)
Str.9616 33
(Danio rerio)
Actinopterygii adprh 34
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for ADPRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRH Gene

Gene Tree for ADPRH (if available)
Gene Tree for ADPRH (if available)
Evolutionary constrained regions (ECRs) for ADPRH: view image

Paralogs for ADPRH Gene

Paralogs for ADPRH Gene

(1) SIMAP similar genes for ADPRH Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADPRH: view

Variants for ADPRH Gene

Sequence variations from dbSNP and Humsavar for ADPRH Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000316758 -- 119,588,977(+) C/G 3_prime_UTR_variant
rs1000798660 -- 119,578,864(+) T/C upstream_transcript_variant
rs1001140618 -- 119,585,120(+) G/A/C intron_variant
rs1001464032 -- 119,581,960(+) A/C intron_variant
rs1001581272 -- 119,583,770(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADPRH Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV loss 17160897
nsv522542 CNV loss 19592680
nsv3963 CNV deletion 18451855

Variation tolerance for ADPRH Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADPRH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRH Gene

Disorders for ADPRH Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADPRH Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glycine n-methyltransferase deficiency
  • gnmt deficiency
mucolipidosis ii alpha/beta
  • mucolipidosis ii; ml ii
  • sphingolipidoses
- elite association - COSMIC cancer census association via MalaCards
Search ADPRH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADPRH

genes like me logo Genes that share disorders with ADPRH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADPRH Gene

Publications for ADPRH Gene

  1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PMID: 8349667) Takada T … Moss J (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. (PMID: 19407395) Kernstock S … Mueller-Dieckmann C (Acta crystallographica. Section F, Structural biology and crystallization communications 2009) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ADPRH Gene

Sources for ADPRH Gene

Loading form....