The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014] See more...

Aliases for ADPRH Gene

Aliases for ADPRH Gene

  • ADP-Ribosylarginine Hydrolase 2 3 4 5
  • [Protein ADP-Ribosylarginine] Hydrolase 2 3 4
  • ARH1 2 3 4
  • ADP-Ribose-L-Arginine Cleaving Enzyme 3 4
  • EC 3.2.2.19 4 51
  • HARH1 3 4
  • ADPRH 5

External Ids for ADPRH Gene

Previous GeneCards Identifiers for ADPRH Gene

  • GC03P115940
  • GC03P118926
  • GC03P120579
  • GC03P120619
  • GC03P120781
  • GC03P119298
  • GC03P116674

Summaries for ADPRH Gene

Entrez Gene Summary for ADPRH Gene

  • The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ADPRH Gene

ADPRH (ADP-Ribosylarginine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRH include Tyrosinemia and Mucolipidosis Ii Alpha/Beta. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot Summary for ADPRH Gene

  • Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.

Additional gene information for ADPRH Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADPRH Gene

Genomics for ADPRH Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADPRH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J119578 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 620.9 +0.6 578 2.4 BRCA1 TEAD4 REST POLR2A BACH1 TARDBP LARP7 STAT3 RELA SMAD5 ADPRH ENSG00000272967 CD80 CFAP91 lnc-CD80-5 PLA1A
GH03J119557 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.7 -18.7 -18735 5.8 SP1 CTCF POLR2A BACH1 STAT3 ZNF143 RELA PKNOX1 REST SMAD5 CD80 LOC107986118 lnc-ADPRH-1 ADPRH ARHGAP31 TMEM39A
GH03J119626 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 32.8 +48.9 48890 2.7 RELA IKZF2 PKNOX1 EED ARID3A DPF2 RELB RUNX3 BCLAF1 ZNF592 lnc-POPDC2-5 ADPRH POPDC2 ARHGAP31 CD80 CFAP91 RPL10P7 COX17 PLA1A GPR156
GH03J119321 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 -256.3 -256326 2.8 SP1 CTCF PRDM10 ZNF629 KDM1A POLR2A BACH1 JUND LARP7 ZNF143 ARHGAP31-AS1 ARHGAP31 ADPRH B4GALT4 COX17 CD80 RF00026-729 RNU6-1127P TMEM39A
GH03J119635 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +58.9 58891 4.5 SP1 CREB1 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 POLR2A BACH1 FOS RPL10P7 ADPRH COX17 ARHGAP31 CFAP91 PLA1A GSK3B lnc-POPDC2-2 POPDC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADPRH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADPRH

Top Transcription factor binding sites by QIAGEN in the ADPRH gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myb
  • E47
  • HEN1
  • LCR-F1
  • STAT1
  • Zic1

Genomic Locations for ADPRH Gene

Genomic Locations for ADPRH Gene
chr3:119,579,268-119,589,945
(GRCh38/hg38)
Size:
10,678 bases
Orientation:
Plus strand
chr3:119,298,115-119,308,792
(GRCh37/hg19)
Size:
10,678 bases
Orientation:
Plus strand

Genomic View for ADPRH Gene

Genes around ADPRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRH Gene

Proteins for ADPRH Gene

  • Protein details for ADPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54922-ADPRH_HUMAN
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
    Protein Accession:
    P54922
    Secondary Accessions:
    • B2R8H1
    • D3DN83

    Protein attributes for ADPRH Gene

    Size:
    357 amino acids
    Molecular mass:
    39507 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ADPRH Gene

neXtProt entry for ADPRH Gene

Selected DME Specific Peptides for ADPRH Gene

P54922:
  • WRVSDDT
  • IAGCWWGVM
  • VKERDQFY
  • SGWGGSSGHD

Post-translational modifications for ADPRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ADPRH Gene

Gene Families for ADPRH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADPRH Gene

InterPro:
Blocks:
  • ADP-ribosylglycohydrolase
ProtoNet:

Suggested Antigen Peptide Sequences for ADPRH Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribose-L-arginine cleaving enzyme (ADPRH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54922

UniProtKB/Swiss-Prot:

ADPRH_HUMAN :
  • Belongs to the ADP-ribosylglycohydrolase family.
Family:
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRH: view

Function for ADPRH Gene

Molecular function for ADPRH Gene

UniProtKB/Swiss-Prot Function:
Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]; Xref=Rhea:RHEA:14885, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15377, ChEBI:CHEBI:29965, ChEBI:CHEBI:57967, ChEBI:CHEBI:142554; EC=3.2.2.19; Evidence={ECO:0000269|PubMed:30472116};.

Enzyme Numbers (IUBMB) for ADPRH Gene

Phenotypes From GWAS Catalog for ADPRH Gene

Gene Ontology (GO) - Molecular Function for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 19407395
GO:0003875 ADP-ribosylarginine hydrolase activity IBA,IMP 8349667
GO:0005096 GTPase activator activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADPRH: view
genes like me logo Genes that share phenotypes with ADPRH: view

Animal Models for ADPRH Gene

MGI Knock Outs for ADPRH:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADPRH

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADPRH Gene

Localization for ADPRH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADPRH gene
Compartment Confidence
extracellular 3
cytosol 3
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005776 autophagosome IBA 21873635
GO:0005829 cytosol IEA --
GO:0055037 recycling endosome IBA 21873635
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADPRH Gene

Pathways & Interactions for ADPRH Gene

PathCards logo

SuperPathways for ADPRH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IBA,IMP 8349667
GO:0006886 intracellular protein transport IBA 21873635
GO:0051725 protein de-ADP-ribosylation IDA 30472116
GO:0090630 activation of GTPase activity IBA 21873635
GO:2000785 regulation of autophagosome assembly IBA 21873635
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRH Gene

Drugs & Compounds for ADPRH Gene

(51) Drugs for ADPRH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Arginine Investigational Nutra Agonist, Full agonist 524

(63) Additional Compounds for ADPRH Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppa
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • a5'pp5RIb
  • Adenosine 5'-diphosphoribose
  • AdoPPRib
20762-30-5
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
ADP-Ribosyl-L-arginine
  • N(Omega)-(ADP-D-ribosyl)-arginine
  • N(Omega)-(ADP-D-ribosyl)-L-arginine
  • N(Omega)-(ADP-delta-ribosyl)-arginine
  • N(Omega)-(ADP-delta-ribosyl)-L-arginine
  • N(W)-(ADP-D-Ribosyl)-arginine
103960-56-1
genes like me logo Genes that share compounds with ADPRH: view

Transcripts for ADPRH Gene

mRNA/cDNA for ADPRH Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADPRH

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for ADPRH Gene

GeneLoc Exon Structure for
ADPRH

Expression for ADPRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADPRH Gene

Protein differential expression in normal tissues from HIPED for ADPRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Spleen (8.7), and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADPRH Gene



Protein tissue co-expression partners for ADPRH Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADPRH

SOURCE GeneReport for Unigene cluster for ADPRH Gene:

Hs.99884

Evidence on tissue expression from TISSUES for ADPRH Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADPRH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADPRH Gene

Orthologs for ADPRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADPRH 30 31
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADPRH 30 31
  • 88.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADPRH 30 31
  • 87.9 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adprh 30 17 31
  • 82.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adprh 30
  • 82.25 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ADPRH 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADPRH 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADPRH 30 31
  • 68.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADPRH 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adprh 30
  • 67.63 (n)
Str.9616 30
Zebrafish
(Danio rerio)
Actinopterygii adprh 31
  • 52 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for ADPRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADPRH Gene

ENSEMBL:
Gene Tree for ADPRH (if available)
TreeFam:
Gene Tree for ADPRH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADPRH: view image

Paralogs for ADPRH Gene

Paralogs for ADPRH Gene

(1) SIMAP similar genes for ADPRH Gene using alignment to 2 proteins:

  • ADPRH_HUMAN
  • C9JZW7_HUMAN
genes like me logo Genes that share paralogs with ADPRH: view

Variants for ADPRH Gene

Additional dbSNP identifiers (rs#s) for ADPRH Gene

Structural Variations from Database of Genomic Variants (DGV) for ADPRH Gene

Variant ID Type Subtype PubMed ID
nsv3963 CNV deletion 18451855
nsv522542 CNV loss 19592680
nsv829695 CNV loss 17160897

Variation tolerance for ADPRH Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADPRH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADPRH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADPRH Gene

Disorders for ADPRH Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADPRH Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tyrosinemia
  • hereditary tyrosinemia
mucolipidosis ii alpha/beta
  • mucolipidosis ii; ml ii
glycine n-methyltransferase deficiency
  • gnmt deficiency
sphingolipidosis
  • sphingolipidoses
chanarin-dorfman syndrome
  • cds
- elite association - COSMIC cancer census association via MalaCards
Search ADPRH in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ADPRH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADPRH Gene

Publications for ADPRH Gene

  1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PMID: 8349667) Takada T … Moss J (The Journal of biological chemistry 1993) 2 3 4 23
  2. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. (PMID: 30472116) Rack JGM … Ahel I (Cell chemical biology 2018) 3 4
  3. Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. (PMID: 19407395) Kernstock S … Mueller-Dieckmann C (Acta crystallographica. Section F, Structural biology and crystallization communications 2009) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 2 3

Products for ADPRH Gene

  • Signalway ELISA kits for ADPRH
  • Signalway Proteins for ADPRH

Sources for ADPRH Gene