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Aliases for ADORA3 Gene

Aliases for ADORA3 Gene

  • Adenosine A3 Receptor 2 3 5
  • Adenosine Receptor A3 3
  • A3AR 3

External Ids for ADORA3 Gene

Previous GeneCards Identifiers for ADORA3 Gene

  • GC01M112458
  • GC01M110913
  • GC01M111144
  • GC01M111340
  • GC01M111326
  • GC01M111739
  • GC01M111827
  • GC01M112025
  • GC01M109897
  • GC01M111484

Summaries for ADORA3 Gene

Entrez Gene Summary for ADORA3 Gene

  • This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

GeneCards Summary for ADORA3 Gene

ADORA3 (Adenosine A3 Receptor) is a Protein Coding gene. Diseases associated with ADORA3 include Ischemia and Reflex Epilepsy. Among its related pathways are GPCRs, Other and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot for ADORA3 Gene

  • Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).

  • Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).

Tocris Summary for ADORA3 Gene

  • The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney and heart.

Gene Wiki entry for ADORA3 Gene

Additional gene information for ADORA3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA3 Gene

Genomics for ADORA3 Gene

GeneHancer (GH) Regulatory Elements for ADORA3 Gene

Promoters and enhancers for ADORA3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111502 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654 -2.7 -2747 8.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ADORA3 C1orf162 RAP1A DDX20 CEPT1 INKA2 DRAM2 TMIGD3
GH01J111591 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 -89.1 -89141 3.2 HDGF HNRNPUL1 SMAD1 ARNT FEZF1 YBX1 ZNF207 ZNF143 FOS KLF13 DDX20 RAP1A DENND2D TMIGD3 ADORA3 C1orf162 INKA2 OVGP1 LINC01160 GC01P111550
GH01J111534 Enhancer 1.1 FANTOM5 ENCODE 12.2 -31.6 -31629 2.5 ELF3 FOXA2 DMAP1 ZNF48 RAD21 RARA ETS1 YY1 ZNF614 CREM TMIGD3 ADORA3 KRT18P57 RNU6-151P LOC105378909 RAP1A
GH01J111595 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -93.3 -93251 3.7 FOXA2 BACH1 EBF1 IRF4 E4F1 RELA EED ATF7 ETV6 RUNX3 RAP1A KRT18P57 RNU6-151P TMIGD3 ADORA3 C1orf162 INKA2 LINC01160 GC01P111550
GH01J111587 Enhancer 0.7 dbSUPER 12.1 -84.1 -84057 2 BCOR LEF1 ZMYM3 EBF1 BATF EGR1 RUNX3 SMARCE1 JUNB MEF2B TMIGD3 ADORA3 KRT18P57 RNU6-151P RAP1A UBE2FP3 LINC01160 GC01P111550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADORA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADORA3 gene promoter:
  • deltaCREB
  • CREB
  • C/EBPalpha
  • Evi-1
  • FOXO4
  • Elk-1
  • FOXF2
  • PPAR-gamma2

Genomic Locations for ADORA3 Gene

Genomic Locations for ADORA3 Gene
4,693 bases
Minus strand
80,628 bases
Minus strand

Genomic View for ADORA3 Gene

Genes around ADORA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA3 Gene

Proteins for ADORA3 Gene

  • Protein details for ADORA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A3
    Protein Accession:
    Secondary Accessions:
    • A2A3P4
    • P33765
    • Q6UWU0
    • Q9BYZ1

    Protein attributes for ADORA3 Gene

    318 amino acids
    Molecular mass:
    36185 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADORA3 Gene

    Alternative splice isoforms for ADORA3 Gene


neXtProt entry for ADORA3 Gene

Post-translational modifications for ADORA3 Gene

  • Glycosylation at Asn12, Asn4, and Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA3 Gene

No data available for DME Specific Peptides for ADORA3 Gene

Domains & Families for ADORA3 Gene

Gene Families for ADORA3 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADORA3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA3: view

Function for ADORA3 Gene

Molecular function for ADORA3 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).
UniProtKB/Swiss-Prot Function:
Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).
GENATLAS Biochemistry:
adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled receptor superfamily,activating adenylate cyclase

Phenotypes From GWAS Catalog for ADORA3 Gene

Gene Ontology (GO) - Molecular Function for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADORA3: view
genes like me logo Genes that share phenotypes with ADORA3: view

Animal Models for ADORA3 Gene

MGI Knock Outs for ADORA3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA3 Gene

Localization for ADORA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADORA3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8399349
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADORA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADORA3 Gene

Pathways & Interactions for ADORA3 Gene

genes like me logo Genes that share pathways with ADORA3: view

Interacting Proteins for ADORA3 Gene

Gene Ontology (GO) - Biological Process for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0006954 inflammatory response TAS 9164961
GO:0007165 signal transduction TAS,IEA 8399349
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007190 activation of adenylate cyclase activity TAS 9380026
genes like me logo Genes that share ontologies with ADORA3: view

No data available for SIGNOR curated interactions for ADORA3 Gene

Drugs & Compounds for ADORA3 Gene

(159) Drugs for ADORA3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist, Channel blocker, agonist, Target 551
Theophylline Approved Pharma Antagonist, antagonist 67
flavone Approved, Experimental Pharma Antagonist 0
Nicardipine Approved, Investigational Pharma Antagonist, blocker 33
Regadenoson Approved, Investigational Pharma Agonist Highly selective and low affinity A2A adenosine agonist 75

(31) Additional Compounds for ADORA3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MRS 5698

(5) Tocris Compounds for ADORA3 Gene

Compound Action Cas Number
2-Cl-IB-MECA Highly selective A3 agonist 163042-96-4
HEMADO High affinity selective A3 agonist 403842-38-6
IB-MECA A3 selective agonist 152918-18-8
MRS 1220 Highly potent, selective hA3 antagonist 183721-15-5
MRS 5698 High affinity and selective A3 adenosine receptor agonist 1377273-00-1

(50) ApexBio Compounds for ADORA3 Gene

Compound Action Cas Number
1,3-Dipropyl-8-phenylxanthine 85872-53-3
1-Deazaadenosine 14432-09-8
2-Chloroadenosine 146-77-0
2-Cl-IB-MECA 163042-96-4
2'-MeCCPA 205171-12-6
8-(3-Chlorostyryl)caffeine 147700-11-6
8-Aminoadenine Adenine receptor agonist 28128-33-8
Adenine HCl Adenine receptor agonist 2922-28-3
CGH 2466 dihydrochloride Antagonist of adenosine A1/A2B/A3 receptor and p38 MAPK inhibitor 1177618-54-0
CGS 15943 104615-18-1
CGS 21680 HCl A2 adenosine receptor agonist 124431-80-7
CV 1808 53296-10-9
DPCPX 102146-07-6
HEMADO 403842-38-6
Istradefylline (KW-6002) Selective A2A receptor antagonist 155270-99-8
KW 3902 136199-02-5
Lu AA 47070 913842-25-8
LUF 5834 333962-91-7
LUF6000 A3 AR modulator 890087-21-5
MRE 3008F20 252979-43-4
MRS 1220 183721-15-5
MRS 1334 192053-05-7
MRS 1706 264622-53-9
MRS 1754 264622-58-4
MRS 3777 hemioxalate
N6-Cyclopentyladenosine 41552-82-3
NECA adenosine receptor agonist, non-selective 35920-39-9
Nicergoline 27848-84-6
PD 81723 132861-87-1
Preladenant Adenosine A2A receptor antagonist 377727-87-2
PSB 0777 ammonium salt
PSB 0788 1027513-54-7
PSB 10 hydrochloride 591771-91-4
PSB 11 hydrochloride 453591-58-7
PSB 1115 152529-79-8
PSB 36 524944-72-7
PSB 603 1092351-10-4
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SCH 442416 316173-57-6
SCH 58261 160098-96-4
SDZ WAG 994 130714-47-5
SLV 320 251945-92-3
TC-G 1004 1061747-72-5
Ticlopidine HCl 53885-35-1
UK 14,304 59803-98-4
Valsartan Angiotensin II AT1 receptor antagonist 137862-53-4
VUF 5574 280570-45-8
XAC 96865-92-8
XCC 96865-83-7
ZM 241385 139180-30-6
genes like me logo Genes that share compounds with ADORA3: view

Drug Products

Transcripts for ADORA3 Gene

mRNA/cDNA for ADORA3 Gene

Unigene Clusters for ADORA3 Gene

Adenosine A3 receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: -

ExUns: 10c ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: -

Relevant External Links for ADORA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADORA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADORA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.5).

Protein differential expression in normal tissues from HIPED for ADORA3 Gene

This gene is overexpressed in Ovary (35.0) and Testis (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADORA3 Gene

Protein tissue co-expression partners for ADORA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADORA3 Gene:


SOURCE GeneReport for Unigene cluster for ADORA3 Gene:


mRNA Expression by UniProt/SwissProt for ADORA3 Gene:

Tissue specificity: Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

Evidence on tissue expression from TISSUES for ADORA3 Gene

  • Nervous system(4.6)
  • Heart(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ADORA3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADORA3 Gene

Orthologs for ADORA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADORA3 33
  • 99.79 (n)
(Canis familiaris)
Mammalia ADORA3 33
  • 87.69 (n)
(Bos Taurus)
Mammalia ADORA3 33
  • 87.28 (n)
(Mus musculus)
Mammalia Adora3 16 33
  • 78.9 (n)
(Gallus gallus)
Aves ADORA3 33
  • 62.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734629 33
  • 61.04 (n)
(Danio rerio)
Actinopterygii LOC571410 33
  • 56.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 35
  • 32 (a)
Species where no ortholog for ADORA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADORA3 Gene

Gene Tree for ADORA3 (if available)
Gene Tree for ADORA3 (if available)
Evolutionary constrained regions (ECRs) for ADORA3: view image

Paralogs for ADORA3 Gene

Paralogs for ADORA3 Gene

(4) SIMAP similar genes for ADORA3 Gene using alignment to 5 proteins:

  • H0Y6K0_HUMAN
  • H0Y7W7_HUMAN
genes like me logo Genes that share paralogs with ADORA3: view

Variants for ADORA3 Gene

Sequence variations from dbSNP and Humsavar for ADORA3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs746154553 A colorectal cancer sample 111,503,042(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000177935 -- 111,501,179(-) G/A/T intron_variant
rs1000224683 -- 111,502,482(-) ATATATATATAT/ATATATATAT intron_variant
rs1000544344 -- 111,502,806(-) T/C intron_variant
rs1001779681 -- 111,501,789(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADORA3 Gene

Variant ID Type Subtype PubMed ID
esv1401225 CNV insertion 17803354
esv1773706 CNV deletion 17803354
esv2669491 CNV deletion 23128226
esv2716229 CNV deletion 23290073
esv2716240 CNV deletion 23290073
esv2716252 CNV deletion 23290073
esv2716263 CNV deletion 23290073
esv2716274 CNV deletion 23290073
esv3305815 CNV mobile element insertion 20981092
esv3323849 CNV insertion 20981092
esv3587189 CNV loss 21293372
nsv1113156 CNV deletion 24896259
nsv1142068 CNV tandem duplication 24896259
nsv2410 CNV insertion 18451855
nsv2421 CNV deletion 18451855
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781
nsv947443 CNV duplication 23825009

Variation tolerance for ADORA3 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADORA3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA3 Gene

Disorders for ADORA3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADORA3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute coronary syndrome
reflex epilepsy
  • epilepsy, sensory-induced
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADORA3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADORA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADORA3 Gene

Publications for ADORA3 Gene

  1. Molecular cloning and characterization of the human A3 adenosine receptor. (PMID: 8234299) Salvatore CA … Johnson RG (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
  2. cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PMID: 8399349) Sajjadi FG … Firestein GS (Biochimica et biophysica acta 1993) 3 4 22 58
  3. Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. (PMID: 27886186) Iyer SV … Iwakuma T (Nature communications 2016) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58

Products for ADORA3 Gene

Sources for ADORA3 Gene

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