External Ids for ADORA2B Gene
Previous GeneCards Identifiers for ADORA2B Gene
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADORA2B Gene
ADORA2B (Adenosine A2b Receptor) is a Protein Coding gene. Diseases associated with ADORA2B include Cholera and Cystic Fibrosis. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled adenosine receptor activity. An important paralog of this gene is ADORA2A.
UniProtKB/Swiss-Prot Summary for ADORA2B Gene
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels in the lung, blood vessels and eye.