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Aliases for ADORA2B Gene

Aliases for ADORA2B Gene

  • Adenosine A2b Receptor 2 3 5
  • Adenosine Receptor A2b 3
  • ADORA2 3

External Ids for ADORA2B Gene

Previous GeneCards Identifiers for ADORA2B Gene

  • GC17P016209
  • GC17P016958
  • GC17P015791
  • GC17P016048
  • GC17P015788
  • GC17P015715
  • GC17P015949

Summaries for ADORA2B Gene

Entrez Gene Summary for ADORA2B Gene

  • This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA2B Gene

ADORA2B (Adenosine A2b Receptor) is a Protein Coding gene. Among its related pathways are C-MYB transcription factor network and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA2A.

UniProtKB/Swiss-Prot for ADORA2B Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for ADORA2B Gene

  • Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels in the lung, blood vessels and eye.

Gene Wiki entry for ADORA2B Gene

Additional gene information for ADORA2B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA2B Gene

Genomics for ADORA2B Gene

GeneHancer (GH) Regulatory Elements for ADORA2B Gene

Promoters and enhancers for ADORA2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J015944 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 651.8 +18.9 18852 4.6 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 TTC19 ADORA2B ZSWIM7 NCOR1 ZNF286A PIGL MEIS3P1 GC17P015935 PIR48319
GH17J015927 Enhancer 0.8 Ensembl ENCODE 650.7 +0.7 680 1.1 SMARCE1 L3MBTL2 CEBPB MAX CEBPG MITF POLR3A POLR2A IKZF1 ADNP ADORA2B TTC19 ENSG00000265519 GC17P015935
GH17J015962 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 45 +37.4 37397 5.8 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A GLIS2 SP5 NFYC MXD4 NFIL3 ZSWIM7 ADORA2B TTC19 RNU6-314P NCOR1 CDRT1 PIR48319
GH17J015892 Enhancer 0.9 Ensembl ENCODE 27.5 -34.8 -34833 1.5 MEIS2 PKNOX1 FOXA2 CEBPG ZNF7 CTBP1 GATA3 POLR2A PRDM10 SMARCE1 ADORA2B TTC19 ZSWIM7 MEIS3P1 GC17P015908 GC17P015909 GC17P015867 SPECC1P1
GH17J015883 Enhancer 1.2 FANTOM5 Ensembl ENCODE 15.6 -43.9 -43863 0.6 MEIS2 ATF1 NFATC3 GTF2E2 INSM2 MAX CEBPG FOSL1 ZNF316 POLR2A ADORA2B MEIS3P1 ZSWIM7 TTC19 GC17P015867 GC17P015908 GC17P015909 SPECC1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADORA2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADORA2B gene promoter:
  • deltaCREB
  • CREB
  • Gfi-1
  • CBF-B
  • ATF-2
  • CRE-BP1
  • CBF(2)
  • CBF-A
  • CBF-C
  • CP1A

Genomic Locations for ADORA2B Gene

Genomic Locations for ADORA2B Gene
48,114 bases
Plus strand
30,980 bases
Plus strand

Genomic View for ADORA2B Gene

Genes around ADORA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA2B Gene

Proteins for ADORA2B Gene

  • Protein details for ADORA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A2b
    Protein Accession:

    Protein attributes for ADORA2B Gene

    332 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADORA2B Gene

Post-translational modifications for ADORA2B Gene

  • Glycosylation at posLast=163163 and posLast=153153
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA2B Gene

No data available for DME Specific Peptides for ADORA2B Gene

Domains & Families for ADORA2B Gene

Gene Families for ADORA2B Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADORA2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA2B: view

Function for ADORA2B Gene

Molecular function for ADORA2B Gene

UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
adenosine receptor B2,G protein coupled receptor superfamily,activating adenylate cyclase,expressed in keratinocytes and fibroblasts,upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)

Phenotypes From GWAS Catalog for ADORA2B Gene

Gene Ontology (GO) - Molecular Function for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADORA2B: view
genes like me logo Genes that share phenotypes with ADORA2B: view

Animal Models for ADORA2B Gene

MGI Knock Outs for ADORA2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADORA2B

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA2B Gene

Localization for ADORA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA2B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADORA2B gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7558011
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADORA2B: view

Pathways & Interactions for ADORA2B Gene

genes like me logo Genes that share pathways with ADORA2B: view

Gene Ontology (GO) - Biological Process for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10101031
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA --
GO:0006968 cellular defense response TAS 10101031
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ADORA2B: view

No data available for SIGNOR curated interactions for ADORA2B Gene

Drugs & Compounds for ADORA2B Gene

(124) Drugs for ADORA2B Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, antagonist, Target 67
Adenosine Approved, Investigational Pharma Agonist, Channel blocker, agonist, Target 551
Caffeine Approved Nutra Antagonist, Activator, antagonist 434
Enprofylline Approved, Investigational Pharma Target, antagonist 0
Regadenoson Approved, Investigational Pharma Agonist Highly selective and low affinity A2A adenosine agonist 75

(13) Additional Compounds for ADORA2B Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for ADORA2B Gene

Compound Action Cas Number
BAY 60-6583 Potent A2B receptor agonist; cardioprotective 910487-58-0
CV 1808 Non-selective adenosine A2 receptor agonist 53296-10-9
MRS 1706 Potent and selective A2B inverse agonist 264622-53-9
PSB 1115 Selective human A2B receptor antagonist; water-soluble 152529-79-8
genes like me logo Genes that share compounds with ADORA2B: view

Transcripts for ADORA2B Gene

mRNA/cDNA for ADORA2B Gene

Unigene Clusters for ADORA2B Gene

Adenosine A2b receptor:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA2B Gene

No ASD Table

Relevant External Links for ADORA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADORA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADORA2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA2B Gene

This gene is overexpressed in Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for ADORA2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADORA2B Gene

Protein tissue co-expression partners for ADORA2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADORA2B Gene:


SOURCE GeneReport for Unigene cluster for ADORA2B Gene:


Evidence on tissue expression from TISSUES for ADORA2B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADORA2B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADORA2B Gene

Orthologs for ADORA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADORA2B 34 33
  • 99.3 (n)
(Canis familiaris)
Mammalia ADORA2B 34 33
  • 91.84 (n)
(Mus musculus)
Mammalia Adora2b 16 34 33
  • 87.45 (n)
(Rattus norvegicus)
Mammalia Adora2b 33
  • 85.34 (n)
(Bos Taurus)
Mammalia ADORA2B 34 33
  • 83.48 (n)
(Monodelphis domestica)
Mammalia ADORA2B 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ADORA2B 34
  • 60 (a)
(Gallus gallus)
Aves ADORA2B 34 33
  • 71.28 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
-- 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adora2b 33
  • 67.81 (n)
(Danio rerio)
Actinopterygii adora2b 34 33
  • 66.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 35
  • 32 (a)
AdoR 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea ador-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for ADORA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA2B Gene

Gene Tree for ADORA2B (if available)
Gene Tree for ADORA2B (if available)
Evolutionary constrained regions (ECRs) for ADORA2B: view image

Paralogs for ADORA2B Gene

Paralogs for ADORA2B Gene

(8) SIMAP similar genes for ADORA2B Gene using alignment to 3 proteins:

  • Q2L7J7_HUMAN Pseudogenes for ADORA2B Gene

genes like me logo Genes that share paralogs with ADORA2B: view

Variants for ADORA2B Gene

Sequence variations from dbSNP and Humsavar for ADORA2B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000032711 -- 15,970,611(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000053698 -- 15,961,559(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000193074 -- 15,965,348(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000276378 -- 15,939,916(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000296257 -- 15,931,465(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADORA2B Gene

Variant ID Type Subtype PubMed ID
dgv1425n106 CNV deletion 24896259
dgv3107n100 CNV gain 25217958
dgv3108n100 CNV gain 25217958
esv1683190 CNV deletion 17803354
esv2286288 CNV deletion 18987734
esv2434647 CNV deletion 19546169
esv2660526 CNV deletion 23128226
esv2715702 CNV deletion 23290073
esv3347852 CNV duplication 20981092
esv3554197 CNV deletion 23714750
esv3572431 CNV gain 25503493
esv3892973 CNV gain 25118596
nsv1061987 CNV loss 25217958
nsv1070547 CNV deletion 25765185
nsv1150871 CNV deletion 26484159
nsv478879 CNV novel sequence insertion 20440878
nsv512478 CNV loss 21212237
nsv955424 CNV deletion 24416366

Variation tolerance for ADORA2B Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADORA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA2B Gene

Disorders for ADORA2B Gene

Additional Disease Information for ADORA2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADORA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADORA2B Gene

Publications for ADORA2B Gene

  1. Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. (PMID: 7558011) Jacobson MA … Salvatore CA (Genomics 1995) 2 3 4 22 58
  2. Molecular cloning and expression of an adenosine A2b receptor from human brain. (PMID: 1325798) Pierce KD … Shine J (Biochemical and biophysical research communications 1992) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia. (PMID: 19841638) Yang M … Qu X (Immunology and cell biology 2010) 3 22 58
  5. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 44 58

Products for ADORA2B Gene

Sources for ADORA2B Gene

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