Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008] See more...

Aliases for ADO Gene

Aliases for ADO Gene

  • 2-Aminoethanethiol Dioxygenase 2 3 4 5
  • Cysteamine Dioxygenase 2 3 4
  • 2-Aminoethanethiol (Cysteamine) Dioxygenase 2 3
  • C10orf22 3 4
  • Cysteamine (2-Aminoethanethiol) Dioxygenase (ADO) 3
  • Chromosome 10 Open Reading Frame 22 2
  • EC 1.13.11.19 4
  • FLJ14547 2
  • ADO 5

External Ids for ADO Gene

Previous HGNC Symbols for ADO Gene

  • C10orf22

Previous GeneCards Identifiers for ADO Gene

  • GC10P064235
  • GC10P064564
  • GC10P058556

Summaries for ADO Gene

Entrez Gene Summary for ADO Gene

  • Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADO Gene

ADO (2-Aminoethanethiol Dioxygenase) is a Protein Coding gene. Diseases associated with ADO include Ataxia, Sensory, 1, Autosomal Dominant and Adjustment Disorder. Among its related pathways are Metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include cysteamine dioxygenase activity.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADO Gene

Genomics for ADO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADO Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADO

Top Transcription factor binding sites by QIAGEN in the ADO gene promoter:
  • CREB
  • deltaCREB
  • E47
  • Gfi-1
  • HNF-1
  • HNF-1A
  • NF-kappaB
  • NF-kappaB1
  • Tal-1

Genomic Locations for ADO Gene

Latest Assembly
chr10:62,804,720-62,808,479
(GRCh38/hg38)
Size:
3,760 bases
Orientation:
Plus strand

Previous Assembly
chr10:64,564,480-64,568,239
(GRCh37/hg19 by Entrez Gene)
Size:
3,760 bases
Orientation:
Plus strand

chr10:64,564,516-64,568,238
(GRCh37/hg19 by Ensembl)
Size:
3,723 bases
Orientation:
Plus strand

Genomic View for ADO Gene

Genes around ADO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADO Gene

Proteins for ADO Gene

  • Protein details for ADO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ5-AEDO_HUMAN
    Recommended name:
    2-aminoethanethiol dioxygenase
    Protein Accession:
    Q96SZ5
    Secondary Accessions:
    • B1AL29

    Protein attributes for ADO Gene

    Size:
    270 amino acids
    Molecular mass:
    29751 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55123.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADO Gene

Post-translational modifications for ADO Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Other Protein References for ADO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for ADO
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADO

No data available for DME Specific Peptides for ADO Gene

Domains & Families for ADO Gene

Gene Families for ADO Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADO Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1637

Suggested Antigen Peptide Sequences for ADO Gene

GenScript: Design optimal peptide antigens:
  • Cysteamine dioxygenase (AEDO_HUMAN)
genes like me logo Genes that share domains with ADO: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADO Gene

Function for ADO Gene

Molecular function for ADO Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cysteamine + O2 = H(+) + hypotaurine; Xref=Rhea:RHEA:14409, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57853, ChEBI:CHEBI:58029; EC=1.13.11.19; Evidence={ECO:0000269|PubMed:17581819};.

Enzyme Numbers (IUBMB) for ADO Gene

Phenotypes From GWAS Catalog for ADO Gene

Gene Ontology (GO) - Molecular Function for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0016491 oxidoreductase activity IEA --
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA --
GO:0046872 metal ion binding IEA --
GO:0047800 cysteamine dioxygenase activity IEA --
genes like me logo Genes that share ontologies with ADO: view
genes like me logo Genes that share phenotypes with ADO: view

miRNA for ADO Gene

miRTarBase miRNAs that target ADO

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADO

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADO Gene

Localization for ADO Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADO gene
Compartment Confidence
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADO: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ADO Gene

Pathways & Interactions for ADO Gene

genes like me logo Genes that share pathways with ADO: view

Pathways by source for ADO Gene

Gene Ontology (GO) - Biological Process for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADO: view

No data available for SIGNOR curated interactions for ADO Gene

Drugs & Compounds for ADO Gene

(5) Drugs for ADO Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma 459
Cysteamine Approved, Investigational Pharma 29
Oxygen Approved, Vet_approved Pharma 0
Fe2+ Experimental Pharma 0
Hypotaurine Pharma Non-selective endogenous glycine receptor agonist 1
genes like me logo Genes that share compounds with ADO: view

Transcripts for ADO Gene

mRNA/cDNA for ADO Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADO

Alternative Splicing Database (ASD) splice patterns (SP) for ADO Gene

No ASD Table

Relevant External Links for ADO Gene

GeneLoc Exon Structure for
ADO

Expression for ADO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADO Gene

This gene is overexpressed in Uterus (9.0) and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADO Gene



Protein tissue co-expression partners for ADO Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADO

SOURCE GeneReport for Unigene cluster for ADO Gene:

Hs.99821

Evidence on tissue expression from TISSUES for ADO Gene

  • Nervous system(4.7)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with ADO: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADO Gene

Orthologs for ADO Gene

This gene was present in the common ancestor of animals.

Orthologs for ADO Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADO 29 30
  • 99.88 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADO 29 30
  • 92.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADO 29 30
  • 90.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ado 29 16 30
  • 87.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ado 29
  • 85.55 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ADO 30
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADO 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ado 29
  • 65.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii adoa 29 30
  • 60.57 (n)
OneToMany
adob 30
  • 59 (a)
OneToMany
-- 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006807 29
  • 54.78 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7550 29 30
  • 47.72 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y50D4C.6 30
  • 25 (a)
OneToOne
Species where no ortholog for ADO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADO Gene

ENSEMBL:
Gene Tree for ADO (if available)
TreeFam:
Gene Tree for ADO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADO: view image
Alliance of Genome Resources:
Additional Orthologs for ADO

Paralogs for ADO Gene

No data available for Paralogs for ADO Gene

Variants for ADO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADO Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10995311 -- p.Pro39Ala
rs2236295 -- p.Gly25Trp
rs569705 -- p.Pro266Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADO Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADO Gene

Variant ID Type Subtype PubMed ID
dgv249e212 CNV loss 25503493

Variation tolerance for ADO Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.91; 93.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADO
Leiden Open Variation Database (LOVD)
ADO

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADO Gene

Disorders for ADO Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADO Gene - From: COP

Disorder Aliases PubMed IDs
ataxia, sensory, 1, autosomal dominant
  • snax1
adjustment disorder
  • adjustment disease
- elite association - COSMIC cancer census association via MalaCards
Search ADO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADO

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ADO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADO Gene

Publications for ADO Gene

  1. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. (PMID: 17581819) Dominy JE … Stipanuk MH (The Journal of biological chemistry 2007) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ADO Gene

Sources for ADO Gene