Aliases for ADNP Gene
External Ids for ADNP Gene
Previous GeneCards Identifiers for ADNP Gene
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADNP Gene
ADNP (Activity Dependent Neuroprotector Homeobox) is a Protein Coding gene. Diseases associated with ADNP include Helsmoortel-Van Der Aa Syndrome and Alacrima, Achalasia, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is ADNP2.
UniProtKB/Swiss-Prot Summary for ADNP Gene
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.