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Aliases for ADM5 Gene

Aliases for ADM5 Gene

  • Adrenomedullin 5 (Putative) 2 3 5
  • Adrenomedullin 5 Homolog (Pig) 2 3
  • C19orf76 3 4
  • Putative Adrenomedullin-5-Like Protein 3
  • Chromosome 19 Open Reading Frame 76 2
  • AM5 3

External Ids for ADM5 Gene

Previous HGNC Symbols for ADM5 Gene

  • C19orf76

Previous GeneCards Identifiers for ADM5 Gene

  • GC19P050197
  • GC19P050198
  • GC19P050205

Summaries for ADM5 Gene

GeneCards Summary for ADM5 Gene

ADM5 (Adrenomedullin 5 (Putative)) is a Protein Coding gene. Diseases associated with ADM5 include Phlebotomus Fever.

UniProtKB/Swiss-Prot for ADM5 Gene

  • Probable non-functional remnant of adrenomedullin-5.

Additional gene information for ADM5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM5 Gene

Genomics for ADM5 Gene

GeneHancer (GH) Regulatory Elements for ADM5 Gene

Promoters and enhancers for ADM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049686 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +1.1 1115 5.6 MZF1 SIN3A STAT5A ZBTB40 RAD21 ZNF121 ZNF143 SP3 REST SP1 CPT1C ADM5 ENSG00000268677 PRMT1
GH19J048751 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.1 -935.5 -935528 2.7 HDGF PKNOX1 ARNT NEUROD1 SIN3A FEZF1 ZBTB7B POLR2B ZNF766 ZNF143 FUT1 GC19P048754 PRR12 GRWD1 SNRNP70 RASIP1 SNORD35A ADM5 IZUMO1 NOP53-AS1
GH19J050022 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 +336.2 336157 4.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZNF473 VRK3 POLD1 NUP62 PTOV1-AS2 SNORD35A IRF3 SNORD35B ALDH16A1 PNKP
GH19J049579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.7 -107.9 -107874 2.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 PRRG2 NOSIP PRR12 NUP62 POLD1 SNORD35A SNORD35B IRF3 PIH1D1 ALDH16A1
GH19J050678 Enhancer 1.2 Ensembl ENCODE 29.1 +990.8 990812 1.2 HDGF PKNOX1 SMAD1 SIN3A YBX1 E2F8 ZNF207 ZNF143 ZNF548 FOS NUP62 POLD1 PTOV1-AS2 ENSG00000268047 ENSG00000267808 CPT1C ADM5 ZNF473 PTOV1 LRRC4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADM5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADM5 Gene

Genomic Locations for ADM5 Gene
chr19:49,688,664-49,690,990
(GRCh38/hg38)
Size:
2,327 bases
Orientation:
Plus strand
chr19:50,191,921-50,194,247
(GRCh37/hg19)
Size:
2,327 bases
Orientation:
Plus strand

Genomic View for ADM5 Gene

Genes around ADM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM5 Gene

Proteins for ADM5 Gene

  • Protein details for ADM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JUS6-ADM5_HUMAN
    Recommended name:
    Putative adrenomedullin-5-like protein
    Protein Accession:
    C9JUS6

    Protein attributes for ADM5 Gene

    Size:
    153 amino acids
    Molecular mass:
    16532 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADM5 Gene

Post-translational modifications for ADM5 Gene

No Post-translational modifications

Other Protein References for ADM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADM5 Gene

Domains & Families for ADM5 Gene

Gene Families for ADM5 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ADM5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ADM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JUS6

UniProtKB/Swiss-Prot:

ADM5_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM5: view

Function for ADM5 Gene

Molecular function for ADM5 Gene

UniProtKB/Swiss-Prot Function:
Probable non-functional remnant of adrenomedullin-5.

Phenotypes From GWAS Catalog for ADM5 Gene

Gene Ontology (GO) - Molecular Function for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ADM5: view

Phenotypes for ADM5 Gene

genes like me logo Genes that share phenotypes with ADM5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADM5 Gene

Localization for ADM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM5 gene
Compartment Confidence
extracellular 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADM5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADM5 Gene

Pathways & Interactions for ADM5 Gene

No Data Available

Interacting Proteins for ADM5 Gene

Gene Ontology (GO) - Biological Process for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ADM5: view

No data available for Pathways by source and SIGNOR curated interactions for ADM5 Gene

Drugs & Compounds for ADM5 Gene

No Compound Related Data Available

Transcripts for ADM5 Gene

mRNA/cDNA for ADM5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(738) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADM5 Gene

Adrenomedullin 5 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADM5 Gene

No ASD Table

Relevant External Links for ADM5 Gene

GeneLoc Exon Structure for
ADM5
ECgene alternative splicing isoforms for
ADM5

Expression for ADM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADM5 Gene:

ADM5

SOURCE GeneReport for Unigene cluster for ADM5 Gene:

Hs.311193
genes like me logo Genes that share expression patterns with ADM5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADM5 Gene

Orthologs for ADM5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM5 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADM5 33
  • 78.87 (n)
dog
(Canis familiaris)
Mammalia ADM5 34 33
  • 76.15 (n)
OneToOne
Species where no ortholog for ADM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADM5 Gene

ENSEMBL:
Gene Tree for ADM5 (if available)
TreeFam:
Gene Tree for ADM5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADM5: view image

Paralogs for ADM5 Gene

No data available for Paralogs for ADM5 Gene

Variants for ADM5 Gene

Sequence variations from dbSNP and Humsavar for ADM5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000163817 -- 49,686,890(+) C/T upstream_transcript_variant
rs1000196752 -- 49,687,133(+) C/T upstream_transcript_variant
rs1000295101 -- 49,688,085(+) C/T upstream_transcript_variant
rs1000388855 -- 49,691,481(+) C/A downstream_transcript_variant
rs1001301276 -- 49,687,051(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADM5 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
nsv953600 CNV deletion 24416366
nsv833865 CNV gain+loss 17160897
nsv833864 CNV gain 17160897
nsv817854 CNV gain 17921354
nsv7308 OTHER inversion 18451855
nsv470150 CNV gain 18288195
nsv469715 CNV gain+loss 16826518
nsv1160655 CNV deletion 26073780

Variation tolerance for ADM5 Gene

Gene Damage Index Score: 1.34; 26.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM5 Gene

Disorders for ADM5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADM5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search ADM5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADM5

genes like me logo Genes that share disorders with ADM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM5 Gene

Publications for ADM5 Gene

  1. Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals. (PMID: 18434369) Takei Y … Ueta Y (The Journal of endocrinology 2008) 2 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ADM5 Gene

Sources for ADM5 Gene

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