This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by Re... See more...

Aliases for ADM2 Gene

Aliases for ADM2 Gene

  • Adrenomedullin 2 2 3 5
  • Protein ADM2 3 4
  • Intermedin 3 4
  • AM2 3 4
  • DJ579N16.4 3

External Ids for ADM2 Gene

Previous GeneCards Identifiers for ADM2 Gene

  • GC22P049053
  • GC22P049055
  • GC22P049210
  • GC22P049267
  • GC22P050920
  • GC22P033810

Summaries for ADM2 Gene

Entrez Gene Summary for ADM2 Gene

  • This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

GeneCards Summary for ADM2 Gene

ADM2 (Adrenomedullin 2) is a Protein Coding gene. Diseases associated with ADM2 include Anaerobic Pneumonia and Coronary Stenosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is ADM.

UniProtKB/Swiss-Prot Summary for ADM2 Gene

  • [Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
  • [Intermedin-short]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Gene Wiki entry for ADM2 Gene

Additional gene information for ADM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADM2 Gene

Genomics for ADM2 Gene

GeneHancer (GH) Regulatory Elements for ADM2 Gene

Promoters and enhancers for ADM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J050481 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.4 358 1.8 USF1 CLOCK GABPA ZBTB7A MYC EZH2 RAD51 PCBP1 RBM14 CEBPB ADM2 RF00100-082 SBF1 NCAPH2 LMF2 CHKB BRD1 ENSG00000272836 ENSG00000273137 TUBGCP6
GH22J050480 Enhancer 0.3 Ensembl 500.7 -1.2 -1242 0.2 EZH2 ADM2 RF00100-082 SBF1
GH22J050443 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.4 -36.9 -36928 3.2 POLR2G ZNF10 ZIC2 ZBTB10 ZNF740 ZEB1 POLR2A ZBTB17 CEBPG RBM22 PLXNB2 CHKB ALG12 ADM2 SBF1 MIOX ENSG00000273137 BRD1 MAPK8IP2 ENSG00000272836
GH22J050446 Enhancer 0.5 dbSUPER 13.4 -34.5 -34507 0.9 POLR2G ZNF740 BCL11B AGO2 AGO1 RBM39 POLR2A lnc-LMF2-3 PLXNB2 ADM2 SBF1 MIOX CHKB MAPK8IP2 SYCE3 DENND6B ARSA
GH22J050483 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 0.7 +3.1 3131 3.2 POLR2G USF1 CTCF POLR2A CLOCK REST DNMT1 TOE1 TGIF2 ZBTB7A MIOX SBF1 lnc-MIOX-1 CHKB LMF2 NCAPH2 MAPK8IP2 SYCE3 HDAC10 PPP6R2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADM2

Top Transcription factor binding sites by QIAGEN in the ADM2 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • E4BP4
  • Egr-3
  • ER-alpha
  • LCR-F1
  • Pax-2
  • Pax-2a
  • RelA

Genomic Locations for ADM2 Gene

Genomic Locations for ADM2 Gene
chr22:50,481,543-50,486,440
(GRCh38/hg38)
Size:
4,898 bases
Orientation:
Plus strand
chr22:50,919,985-50,924,869
(GRCh37/hg19)
Size:
4,885 bases
Orientation:
Plus strand

Genomic View for ADM2 Gene

Genes around ADM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM2 Gene

Proteins for ADM2 Gene

  • Protein details for ADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H4-ADM2_HUMAN
    Recommended name:
    Protein ADM2
    Protein Accession:
    Q7Z4H4
    Secondary Accessions:
    • Q3LFQ0

    Protein attributes for ADM2 Gene

    Size:
    148 amino acids
    Molecular mass:
    15865 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM2 Gene

neXtProt entry for ADM2 Gene

Post-translational modifications for ADM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADM2 Gene

Domains & Families for ADM2 Gene

Gene Families for ADM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ADM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADM2 Gene

GenScript: Design optimal peptide antigens:
  • Intermedin (ADM2_HUMAN)
  • cDNA: FLJ21135 fis, clone CAS07262 (Q9H794_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4H4

UniProtKB/Swiss-Prot:

ADM2_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM2: view

Function for ADM2 Gene

Molecular function for ADM2 Gene

UniProtKB/Swiss-Prot Function:
[Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
UniProtKB/Swiss-Prot Function:
[Intermedin-short]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Gene Ontology (GO) - Molecular Function for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0044877 protein-containing complex binding IDA 20596610
genes like me logo Genes that share ontologies with ADM2: view
genes like me logo Genes that share phenotypes with ADM2: view

Animal Models for ADM2 Gene

MGI Knock Outs for ADM2:
  • Adm2 Adm2<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADM2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADM2 Gene

Localization for ADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with ADM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADM2 Gene

Pathways & Interactions for ADM2 Gene

genes like me logo Genes that share pathways with ADM2: view

Gene Ontology (GO) - Biological Process for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006468 protein phosphorylation IDA 20596610
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA --
GO:0007586 digestion IEA --
genes like me logo Genes that share ontologies with ADM2: view

No data available for SIGNOR curated interactions for ADM2 Gene

Drugs & Compounds for ADM2 Gene

(1) Drugs for ADM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ADM2: view

Transcripts for ADM2 Gene

mRNA/cDNA for ADM2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADM2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADM2 Gene

No ASD Table

Relevant External Links for ADM2 Gene

GeneLoc Exon Structure for
ADM2

Expression for ADM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADM2 Gene

mRNA differential expression in normal tissues according to GTEx for ADM2 Gene

This gene is overexpressed in Pancreas (x9.2), Kidney - Cortex (x8.0), and Thyroid (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADM2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADM2

SOURCE GeneReport for Unigene cluster for ADM2 Gene:

Hs.449099

mRNA Expression by UniProt/SwissProt for ADM2 Gene:

Q7Z4H4-ADM2_HUMAN
Tissue specificity: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.

Evidence on tissue expression from TISSUES for ADM2 Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with ADM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADM2 Gene

Orthologs for ADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM2 30
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia ADM2 31 30
  • 81.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADM2 31 30
  • 80.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adm2 17 31 30
  • 75.35 (n)
rat
(Rattus norvegicus)
Mammalia Adm2 30
  • 75.06 (n)
oppossum
(Monodelphis domestica)
Mammalia ADM2 31
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adm2b 31
  • 39 (a)
OneToMany
adm2a 31
  • 34 (a)
OneToMany
Species where no ortholog for ADM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM2 Gene

ENSEMBL:
Gene Tree for ADM2 (if available)
TreeFam:
Gene Tree for ADM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADM2: view image

Paralogs for ADM2 Gene

Paralogs for ADM2 Gene

(1) SIMAP similar genes for ADM2 Gene using alignment to 2 proteins:

  • ADM2_HUMAN
  • Q9H794_HUMAN
genes like me logo Genes that share paralogs with ADM2: view

Variants for ADM2 Gene

Additional dbSNP identifiers (rs#s) for ADM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADM2 Gene

Variant ID Type Subtype PubMed ID
nsv1057656 CNV gain 25217958
nsv1160782 CNV deletion 26073780
nsv3669 CNV insertion 18451855
nsv471224 CNV loss 18288195
nsv829338 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for ADM2 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADM2 Gene

Disorders for ADM2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADM2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADM2

genes like me logo Genes that share disorders with ADM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM2 Gene

Publications for ADM2 Gene

  1. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. (PMID: 14706825) Takei Y … Miyano S (FEBS letters 2004) 2 3 4 23 54
  2. Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. (PMID: 16359754) Takahashi K … Totsune K (Peptides 2006) 3 4 23 54
  3. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. (PMID: 19910445) Cai Y … Qi YF (Cardiovascular research 2010) 3 23 54
  4. Intermedin (adrenomedullin-2): a potential protective role in human aortic endothelial cells. (PMID: 19255504) Pearson LJ … Evans JJ (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009) 3 23 54
  5. Intermedin is a new angiogenic growth factor. (PMID: 19592612) Smith RS … Chao J (American journal of physiology. Heart and circulatory physiology 2009) 3 23 54

Products for ADM2 Gene

Sources for ADM2 Gene