The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacte... See more...

Aliases for ADM Gene

Aliases for ADM Gene

  • Adrenomedullin 2 3 5
  • AM 3 4
  • Proadrenomedullin N-20 Terminal Peptide 3
  • Preproadrenomedullin 3
  • PAMP 3
  • ADM 4

External Ids for ADM Gene

Previous GeneCards Identifiers for ADM Gene

  • GC11P011338
  • GC11P010896
  • GC11P010365
  • GC11P010290
  • GC11P010283
  • GC11P009999
  • GC11P010326

Summaries for ADM Gene

Entrez Gene Summary for ADM Gene

  • The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

GeneCards Summary for ADM Gene

ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include Pheochromocytoma and Malignant Hypertension. Among its related pathways are Signaling by GPCR and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and adrenomedullin receptor binding. An important paralog of this gene is ADM2.

UniProtKB/Swiss-Prot Summary for ADM Gene

  • AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Wiki entry for ADM Gene

Additional gene information for ADM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADM Gene

Genomics for ADM Gene

GeneHancer (GH) Regulatory Elements for ADM Gene

Promoters and enhancers for ADM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADM on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADM

Top Transcription factor binding sites by QIAGEN in the ADM gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA

Genomic Locations for ADM Gene

Genomic Locations for ADM Gene
chr11:10,304,980-10,307,402
(GRCh38/hg38)
Size:
2,423 bases
Orientation:
Plus strand
chr11:10,326,227-10,328,944
(GRCh37/hg19)
Size:
2,718 bases
Orientation:
Plus strand

Genomic View for ADM Gene

Genes around ADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM Gene

Proteins for ADM Gene

  • Protein details for ADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35318-ADML_HUMAN
    Recommended name:
    ADM
    Protein Accession:
    P35318
    Secondary Accessions:
    • B2R793
    • D3DQV3
    • Q6FGW2

    Protein attributes for ADM Gene

    Size:
    185 amino acids
    Molecular mass:
    20420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM Gene

neXtProt entry for ADM Gene

Post-translational modifications for ADM Gene

  • Glycosylation at Ser49, Ser50, Ser51, Thr54, Thr66, Tyr125, Thr128, Thr162, Ser165, Ser178, and Ser180
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADM Gene

Domains & Families for ADM Gene

Gene Families for ADM Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ADM Gene

Blocks:
  • Adrenomedullin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADM Gene

GenScript: Design optimal peptide antigens:
  • ADM (ADML_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35318

UniProtKB/Swiss-Prot:

ADML_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM: view

Function for ADM Gene

Molecular function for ADM Gene

UniProtKB/Swiss-Prot Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
GENATLAS Biochemistry:
adrenomedullin downregulated by cMyc

Phenotypes From GWAS Catalog for ADM Gene

Gene Ontology (GO) - Molecular Function for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8524787
GO:0005179 hormone activity IEA --
GO:0031700 adrenomedullin receptor binding IDA 20074556
genes like me logo Genes that share ontologies with ADM: view
genes like me logo Genes that share phenotypes with ADM: view

Animal Models for ADM Gene

MGI Knock Outs for ADM:
  • Adm Adm<tm1Tfjt>
  • Adm Adm<tm1Hku>
  • Adm Adm<tm1Unc>
  • Adm Adm<tm1.1Mtnz>

Animal Model Products

CRISPR Products

miRNA for ADM Gene

miRTarBase miRNAs that target ADM

Clone Products

  • Addgene plasmids for ADM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADM Gene

Localization for ADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 12379507
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 12379507
genes like me logo Genes that share ontologies with ADM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADM Gene

Pathways & Interactions for ADM Gene

genes like me logo Genes that share pathways with ADM: view

SIGNOR curated interactions for ADM Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IDA 16964401
GO:0001666 response to hypoxia IEA --
GO:0001843 neural tube closure IEA --
GO:0002026 regulation of the force of heart contraction IEA --
GO:0002031 G protein-coupled receptor internalization IDA 10882736
genes like me logo Genes that share ontologies with ADM: view

Drugs & Compounds for ADM Gene

(62) Drugs for ADM Gene - From: PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 252
Benzocaine Approved, Investigational Pharma 2900
tannic acid Approved Pharma Channel blocker 2900
Aldosterone Experimental, Investigational Pharma Agonist 0
Anesthetics Pharma 13788

(56) Additional Compounds for ADM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADM Gene

Compound Action Cas Number
Adrenomedullin (1-12), human Vasodilator
genes like me logo Genes that share compounds with ADM: view

Drug Products

Transcripts for ADM Gene

mRNA/cDNA for ADM Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ADM

Alternative Splicing Database (ASD) splice patterns (SP) for ADM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADM Gene

GeneLoc Exon Structure for
ADM

Expression for ADM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADM Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ADM Gene

This gene is overexpressed in Adipocyte (51.0) and Peripheral blood mononuclear cells (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADM Gene



Protein tissue co-expression partners for ADM Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADM

SOURCE GeneReport for Unigene cluster for ADM Gene:

Hs.441047

mRNA Expression by UniProt/SwissProt for ADM Gene:

P35318-ADML_HUMAN
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Evidence on tissue expression from TISSUES for ADM Gene

  • Nervous system(4.8)
  • Kidney(4.6)
  • Liver(4.5)
  • Heart(3.4)
  • Blood(3.3)
  • Muscle(3.3)
  • Adrenal gland(3)
  • Lung(2.9)
  • Intestine(2.4)
  • Eye(2.2)
  • Skin(2.2)
  • Stomach(2.1)
  • Pancreas(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ADM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADM Gene

Orthologs for ADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADM 31 30
  • 86.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADM 30
  • 84.29 (n)
bta-mir-6518 31
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adm 30
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Adm 17 31 30
  • 75.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ADM 31
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADM 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADM 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adm 30
  • 56.55 (n)
Str.12882 30
zebrafish
(Danio rerio)
Actinopterygii adma 31
  • 28 (a)
OneToOne
Species where no ortholog for ADM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM Gene

ENSEMBL:
Gene Tree for ADM (if available)
TreeFam:
Gene Tree for ADM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADM: view image

Paralogs for ADM Gene

Paralogs for ADM Gene

genes like me logo Genes that share paralogs with ADM: view

Variants for ADM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADM Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2228573 - p.Pro85Arg
rs5005 - p.Ser50Arg

Additional dbSNP identifiers (rs#s) for ADM Gene

Structural Variations from Database of Genomic Variants (DGV) for ADM Gene

Variant ID Type Subtype PubMed ID
nsv483076 CNV gain+loss 15286789

Variation tolerance for ADM Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADM Gene

Human Gene Mutation Database (HGMD)
ADM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM Gene

Disorders for ADM Gene

MalaCards: The human disease database

(43) MalaCards diseases for ADM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pcc
malignant hypertension
  • hypertension malignant
congestive heart failure
  • cardiac failure congestive
pulmonary hypertension
  • primary pulmonary hypertension
renal hypertension
  • hypertension renal
- elite association - COSMIC cancer census association via MalaCards
Search ADM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM Gene

Publications for ADM Gene

  1. Proadrenomedullin-derived peptides. (PMID: 9578982) Samson WK (Frontiers in neuroendocrinology 1998) 3 4 23 54
  2. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PMID: 7688224) Kitamura K … Eto T (Biochemical and biophysical research communications 1993) 2 3 4 54
  3. A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese. (PMID: 21075100) Ong KL … Lam KS (Clinica chimica acta; international journal of clinical chemistry 2011) 3 41 54
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 41 54
  5. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) International Consortium for Blood Pressure Genome-Wide Association Studies … Johnson T (Nature 2011) 3 41 54

Products for ADM Gene

  • Addgene plasmids for ADM

Sources for ADM Gene