Aliases for ADM Gene
External Ids for ADM Gene
Previous GeneCards Identifiers for ADM Gene
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
GeneCards Summary for ADM Gene
ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include Pheochromocytoma and Malignant Hypertension. Among its related pathways are Signaling by GPCR and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and adrenomedullin receptor binding. An important paralog of this gene is ADM2.
UniProtKB/Swiss-Prot Summary for ADM Gene
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.