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Aliases for ADM Gene

Aliases for ADM Gene

  • Adrenomedullin 2 3 5
  • AM 3 4
  • Proadrenomedullin N-20 Terminal Peptide 3
  • Preproadrenomedullin 3
  • PAMP 3

External Ids for ADM Gene

Previous GeneCards Identifiers for ADM Gene

  • GC11P011338
  • GC11P010896
  • GC11P010365
  • GC11P010290
  • GC11P010283
  • GC11P009999

Summaries for ADM Gene

Entrez Gene Summary for ADM Gene

  • The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

GeneCards Summary for ADM Gene

ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include Malignant Hypertension and Pheochromocytoma. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and adrenomedullin receptor binding.

UniProtKB/Swiss-Prot for ADM Gene

  • AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Wiki entry for ADM Gene

Additional gene information for ADM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM Gene

Genomics for ADM Gene

GeneHancer (GH) Regulatory Elements for ADM Gene

Promoters and enhancers for ADM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J010300 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.2 1180 10.1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 GLIS1 RCOR2 LOC105376544 SBF2 AMPD3 GC11M010302 ADM ZBED5 CTR9 ZNF143 ENSG00000255463 RPL21P97
GH11J010366 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +62.2 62230 1.7 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 DEK MCM3 SP3 ZBED5 CTR9 RPL21P97 WEE1 ADM AMPD3 LOC105376544 ENSG00000238387 EIF4G2 RNU6ATAC33P
GH11J010319 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +20.2 20200 11.3 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS SP5 REST PIR60970 LOC105376544 SBF2 ADM ENSG00000254865 MRVI1 LYVE1 ENSG00000250041 AMPD3 CAND1.11
GH11J010233 Enhancer 0.9 Ensembl ENCODE 11.9 -70.9 -70922 1.2 JUN BACH1 RAD21 BRCA1 RFX5 POLR2A NFE2 FOS NFE2L2 DEK GC11M010233 LOC105376544 SBF2 ADM AMPD3 ENSG00000250041 ENSG00000254865
GH11J010207 Enhancer 0.6 ENCODE 11.9 -96.7 -96651 0.2 CTCF JUND TRIM22 REST RAD21 RFX5 MIXL1 DEK TRIM28 SBF2 ADM LOC105376544 AMPD3 ENSG00000254865 GC11M010233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADM gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4

Genomic Locations for ADM Gene

Genomic Locations for ADM Gene
chr11:10,304,680-10,307,402
(GRCh38/hg38)
Size:
2,723 bases
Orientation:
Plus strand
chr11:10,326,227-10,328,944
(GRCh37/hg19)
Size:
2,718 bases
Orientation:
Plus strand

Genomic View for ADM Gene

Genes around ADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM Gene

Proteins for ADM Gene

  • Protein details for ADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35318-ADML_HUMAN
    Recommended name:
    ADM
    Protein Accession:
    P35318
    Secondary Accessions:
    • B2R793
    • D3DQV3
    • Q6FGW2

    Protein attributes for ADM Gene

    Size:
    185 amino acids
    Molecular mass:
    20420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM Gene

neXtProt entry for ADM Gene

Post-translational modifications for ADM Gene

  • Glycosylation at posLast=180180, Ser178, Tyr125, Thr66, and posLast=5454
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADM Gene

Domains & Families for ADM Gene

Gene Families for ADM Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ADM Gene

Suggested Antigen Peptide Sequences for ADM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35318

UniProtKB/Swiss-Prot:

ADML_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM: view

Function for ADM Gene

Molecular function for ADM Gene

UniProtKB/Swiss-Prot Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
GENATLAS Biochemistry:
adrenomedullin downregulated by cMyc

Phenotypes From GWAS Catalog for ADM Gene

Gene Ontology (GO) - Molecular Function for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8074714
GO:0005179 hormone activity IEA --
GO:0031700 adrenomedullin receptor binding IDA 20074556
genes like me logo Genes that share ontologies with ADM: view
genes like me logo Genes that share phenotypes with ADM: view

Animal Models for ADM Gene

MGI Knock Outs for ADM:
  • Adm Adm<tm1Tfjt>
  • Adm Adm<tm1Unc>
  • Adm Adm<tm1Hku>
  • Adm Adm<tm1.1Mtnz>

Animal Model Products

miRNA for ADM Gene

miRTarBase miRNAs that target ADM

Clone Products

  • Addgene plasmids for ADM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADM Gene

Localization for ADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IDA 12379507
GO:0005737 cytoplasm IDA 12379507
genes like me logo Genes that share ontologies with ADM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADM Gene

Pathways & Interactions for ADM Gene

genes like me logo Genes that share pathways with ADM: view

Gene Ontology (GO) - Biological Process for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IDA 16964401
GO:0001666 response to hypoxia IEA --
GO:0001843 neural tube closure IEA --
GO:0002026 regulation of the force of heart contraction IEA --
GO:0002031 G-protein coupled receptor internalization IDA 10882736
genes like me logo Genes that share ontologies with ADM: view

No data available for SIGNOR curated interactions for ADM Gene

Drugs & Compounds for ADM Gene

(56) Drugs for ADM Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 236
Aldosterone Experimental, Investigational Pharma Agonist 0
Adrenomedullin (1-12), human Pharma Vasodilator 0

(57) Additional Compounds for ADM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADM: view

Transcripts for ADM Gene

mRNA/cDNA for ADM Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(424) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADM Gene

Adrenomedullin:
Representative Sequences:

Clone Products

  • Addgene plasmids for ADM

Alternative Splicing Database (ASD) splice patterns (SP) for ADM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADM Gene

GeneLoc Exon Structure for
ADM
ECgene alternative splicing isoforms for
ADM

Expression for ADM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADM Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ADM Gene

This gene is overexpressed in Adipocyte (51.0) and Peripheral blood mononuclear cells (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADM Gene



Protein tissue co-expression partners for ADM Gene

NURSA nuclear receptor signaling pathways regulating expression of ADM Gene:

ADM

SOURCE GeneReport for Unigene cluster for ADM Gene:

Hs.441047

mRNA Expression by UniProt/SwissProt for ADM Gene:

P35318-ADML_HUMAN
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Evidence on tissue expression from TISSUES for ADM Gene

  • Nervous system(4.8)
  • Kidney(4.6)
  • Liver(4.5)
  • Heart(3.4)
  • Blood(3.3)
  • Muscle(3.3)
  • Adrenal gland(3)
  • Lung(2.9)
  • Intestine(2.4)
  • Eye(2.2)
  • Skin(2.2)
  • Stomach(2.1)
  • Pancreas(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ADM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADM Gene

Orthologs for ADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADM 34 33
  • 86.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADM 33
  • 84.29 (n)
bta-mir-6518 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adm 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Adm 16 34 33
  • 75.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ADM 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADM 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADM 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adm 33
  • 56.55 (n)
Str.12882 33
zebrafish
(Danio rerio)
Actinopterygii adma 34
  • 28 (a)
OneToOne
Species where no ortholog for ADM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM Gene

ENSEMBL:
Gene Tree for ADM (if available)
TreeFam:
Gene Tree for ADM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADM: view image

Paralogs for ADM Gene

No data available for Paralogs for ADM Gene

Variants for ADM Gene

Sequence variations from dbSNP and Humsavar for ADM Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000068140 -- 10,304,362(+) C/T upstream_transcript_variant
rs1000453457 -- 10,305,646(+) G/T intron_variant
rs1000505179 -- 10,305,431(+) T/A intron_variant
rs1002195794 -- 10,303,858(+) A/C upstream_transcript_variant
rs1003676074 -- 10,307,667(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADM Gene

Variant ID Type Subtype PubMed ID
nsv483076 CNV gain+loss 15286789

Variation tolerance for ADM Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADM Gene

Human Gene Mutation Database (HGMD)
ADM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM Gene

Disorders for ADM Gene

MalaCards: The human disease database

(20) MalaCards diseases for ADM Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant hypertension
  • hypertension malignant
pheochromocytoma
  • pheochromocytoma, susceptibility to
congestive heart failure
  • cardiac failure congestive
renal hypertension
  • hypertension renal
pulmonary hypertension
  • primary pulmonary hypertension
- elite association - COSMIC cancer census association via MalaCards
Search ADM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM Gene

Publications for ADM Gene

  1. Proadrenomedullin-derived peptides. (PMID: 9578982) Samson WK (Frontiers in neuroendocrinology 1998) 3 4 22 58
  2. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PMID: 7688224) Kitamura K … Eto T (Biochemical and biophysical research communications 1993) 2 3 4 58
  3. A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese. (PMID: 21075100) Ong KL … Lam KS (Clinica chimica acta; international journal of clinical chemistry 2011) 3 44 58
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 44 58
  5. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) International Consortium for Blood Pressure Genome-Wide Association Studies … Johnson T (Nature 2011) 3 44 58

Products for ADM Gene

  • Addgene plasmids for ADM

Sources for ADM Gene

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