APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008] See more...

Aliases for ADIRF Gene

Aliases for ADIRF Gene

  • Adipogenesis Regulatory Factor 2 3 4 5
  • Adipogenesis Factor Rich In Obesity 2 3 4
  • Adipose Most Abundant Gene Transcript 2 Protein 3 4
  • Adipose-Specific Protein 2 3 4
  • Adipose Specific 2 2 3
  • C10orf116 3 4
  • ApM-2 3 4
  • AFRO 3 4
  • APM2 3 4
  • Adipose Most Abundant Gene Transcript 2 2
  • Chromosome 10 Open Reading Frame 116 2

External Ids for ADIRF Gene

Previous HGNC Symbols for ADIRF Gene

  • C10orf116

Previous GeneCards Identifiers for ADIRF Gene

  • GC10P088728

Summaries for ADIRF Gene

Entrez Gene Summary for ADIRF Gene

  • APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADIRF Gene

ADIRF (Adipogenesis Regulatory Factor) is a Protein Coding gene. Diseases associated with ADIRF include Vagina Leiomyosarcoma and Dystonia 9. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

UniProtKB/Swiss-Prot Summary for ADIRF Gene

  • Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.

Additional gene information for ADIRF Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADIRF Gene

Genomics for ADIRF Gene

GeneHancer (GH) Regulatory Elements for ADIRF Gene

Promoters and enhancers for ADIRF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J086965 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +1.6 1639 7.8 SP1 CTCF POLR2A USF2 MYC RELA L3MBTL2 RAD21 MAX MNT ADIRF-AS1 ADIRF AGAP11 ENSG00000273413 MMRN2 NONHSAG006426.2 lnc-ADIRF-1 SNCG ENSG00000261011 BMS1P3
GH10J087503 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 19.4 +537.6 537603 5.4 ZBTB40 CTCF MLX RBPJ POLR2A MIXL1 ELF1 MAX RAD21 ZNF121 ENSG00000286445 MINPP1 MIR4678 lnc-ATAD1-5 WAPL NUTM2A-AS1 RPL11P3 FAM25A ADIRF SHLD2
GH10J086224 Enhancer 1 FANTOM5 Ensembl ENCODE 12.4 -740.0 -739992 7.6 MAFK BACH1 IKZF1 CREB1 ZNF316 NFE2 SCRT2 YBX1 EED EGR1 WAPL ADIRF MIR346 piR-55627-017 piR-46501-009 GRID1
GH10J086770 Enhancer 1.1 Ensembl ENCODE 11 -196.5 -196491 10.6 MLX SMARCE1 NR2F6 ATF1 CREB1 MIXL1 CC2D1A ETV6 L3MBTL2 TEAD4 BMPR1A SNCG MMRN2 ADIRF NUTM2A BMS1P3 piR-50443-047 RPAP2P1
GH10J086939 Enhancer 0.9 ENCODE 13.3 -28.8 -28818 0.7 CTCF ZNF362 MAX RAD21 GTF2F1 ZNF384 MLLT1 SP7 ZNF24 REST ADIRF MMRN2 ENSG00000151303 SNCG HSALNG0079420 lnc-GLUD1-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADIRF on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADIRF Gene

Genomic Locations for ADIRF Gene
chr10:86,968,192-86,983,934
(GRCh38/hg38)
Size:
15,743 bases
Orientation:
Plus strand
chr10:88,727,949-88,743,691
(GRCh37/hg19)
Size:
15,743 bases
Orientation:
Plus strand

Genomic View for ADIRF Gene

Genes around ADIRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIRF Gene

Proteins for ADIRF Gene

  • Protein details for ADIRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15847-ADIRF_HUMAN
    Recommended name:
    Adipogenesis regulatory factor
    Protein Accession:
    Q15847

    Protein attributes for ADIRF Gene

    Size:
    76 amino acids
    Molecular mass:
    7855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIRF Gene

Post-translational modifications for ADIRF Gene

  • Glycosylation at Thr57
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIRF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADIRF Gene

Domains & Families for ADIRF Gene

Gene Families for ADIRF Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ADIRF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADIRF Gene

GenScript: Design optimal peptide antigens:
  • Adipose most abundant gene transcript 2 protein (APM2_HUMAN)
genes like me logo Genes that share domains with ADIRF: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADIRF Gene

Function for ADIRF Gene

Molecular function for ADIRF Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.

Phenotypes From GWAS Catalog for ADIRF Gene

Gene Ontology (GO) - Molecular Function for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ADIRF: view
genes like me logo Genes that share phenotypes with ADIRF: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADIRF Gene

Localization for ADIRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIRF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADIRF gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 23239344
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ADIRF: view

Pathways & Interactions for ADIRF Gene

genes like me logo Genes that share pathways with ADIRF: view

Pathways by source for ADIRF Gene

Interacting Proteins for ADIRF Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q15847-ADIRF_HUMAN ENSP00000361083 for ADIRF Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IBA,IDA 23239344
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 23239344
GO:0071478 cellular response to radiation IDA 23239344
GO:0072719 cellular response to cisplatin IDA 23239344
genes like me logo Genes that share ontologies with ADIRF: view

No data available for SIGNOR curated interactions for ADIRF Gene

Drugs & Compounds for ADIRF Gene

No Compound Related Data Available

Transcripts for ADIRF Gene

mRNA/cDNA for ADIRF Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIRF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ADIRF Gene

GeneLoc Exon Structure for
ADIRF
ECgene alternative splicing isoforms for
ADIRF

Expression for ADIRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADIRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIRF Gene

This gene is overexpressed in Artery - Tibial (x6.5), Artery - Coronary (x4.3), Adipose - Subcutaneous (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for ADIRF Gene

This gene is overexpressed in Nasal epithelium (10.7), Nasopharynx (9.3), Cerebral cortex (9.1), and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADIRF Gene



NURSA nuclear receptor signaling pathways regulating expression of ADIRF Gene:

ADIRF

SOURCE GeneReport for Unigene cluster for ADIRF Gene:

Hs.642660

mRNA Expression by UniProt/SwissProt for ADIRF Gene:

Q15847-ADIRF_HUMAN
Tissue specificity: Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.

Evidence on tissue expression from TISSUES for ADIRF Gene

  • Liver(4.3)
  • Pancreas(4.2)
  • Kidney(2.3)
  • Muscle(2.2)
  • Lung(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ADIRF: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIRF Gene

Orthologs for ADIRF Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10ORF116 33
  • 100 (a)
OneToOne
C10H10orf116 32
  • 98.81 (n)
cow
(Bos Taurus)
Mammalia C28H10orf116 32
  • 88.16 (n)
C28H10ORF116 33
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H10orf116 32
  • 86.94 (n)
oppossum
(Monodelphis domestica)
Mammalia ADIRF 33
  • 66 (a)
OneToOne
Species where no ortholog for ADIRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIRF Gene

ENSEMBL:
Gene Tree for ADIRF (if available)
TreeFam:
Gene Tree for ADIRF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADIRF: view image

Paralogs for ADIRF Gene

No data available for Paralogs for ADIRF Gene

Variants for ADIRF Gene

Sequence variations from dbSNP and Humsavar for ADIRF Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000350462 -- 86,970,264(+) T/G splice_donor_variant
rs1000405007 -- 86,968,267(+) T/C upstream_transcript_variant
rs1000736340 -- 86,967,239(+) C/T upstream_transcript_variant
rs1000768864 -- 86,967,447(+) G/A/C upstream_transcript_variant
rs1001188440 -- 86,967,986(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADIRF Gene

Variant ID Type Subtype PubMed ID
esv2759774 CNV gain+loss 17122850
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv470969 CNV loss 18288195
nsv517487 CNV gain+loss 19592680

Variation tolerance for ADIRF Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADIRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIRF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIRF Gene

Disorders for ADIRF Gene

MalaCards: The human disease database

(22) MalaCards diseases for ADIRF Gene - From: DISEASES

Disorder Aliases PubMed IDs
vagina leiomyosarcoma
  • leiomyosarcoma of the vagina
dystonia 9
  • dyt9
vagina sarcoma
  • sarcoma of the vagina
acute inferolateral myocardial infarction
  • acute myocardial infarction of inferolateral wall
dermatosis papulosa nigra
- elite association - COSMIC cancer census association via MalaCards
Search ADIRF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADIRF

genes like me logo Genes that share disorders with ADIRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIRF Gene

Publications for ADIRF Gene

  1. A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARγ and C/EBPα. (PMID: 23239344) Ni Y … Guo X (Journal of bioenergetics and biomembranes 2013) 2 3 4 56
  2. APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status. (PMID: 19444912) Scott BJ … Ng CE (International journal of cancer 2009) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). (PMID: 8619847) Maeda K … Matsubara K (Biochemical and biophysical research communications 1996) 2 3 56
  5. C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance. (PMID: 29084195) Meng J … Lu Y (Medical science monitor : international medical journal of experimental and clinical research 2017) 3 56

Products for ADIRF Gene

Sources for ADIRF Gene