Aliases for ADIPOR2 Gene
External Ids for ADIPOR2 Gene
Previous GeneCards Identifiers for ADIPOR2 Gene
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ADIPOR2 Gene
ADIPOR2 (Adiponectin Receptor 2) is a Protein Coding gene. Diseases associated with ADIPOR2 include Fatty Liver Disease and Liver Disease. Among its related pathways are Longevity regulating pathway and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is ADIPOR1.
UniProtKB/Swiss-Prot Summary for ADIPOR2 Gene
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).