The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008] See more...

Aliases for ADIPOR2 Gene

Aliases for ADIPOR2 Gene

  • Adiponectin Receptor 2 2 3 5
  • PAQR2 2 3 4
  • Progestin And AdipoQ Receptor Family Member II 3 4
  • Progestin And AdipoQ Receptor Family Member 2 3 4
  • Adiponectin Receptor Protein 2 3 4
  • ACDCR2 2 3
  • ADIPOR2 5

External Ids for ADIPOR2 Gene

Previous GeneCards Identifiers for ADIPOR2 Gene

  • GC12P001679
  • GC12P001801

Summaries for ADIPOR2 Gene

Entrez Gene Summary for ADIPOR2 Gene

  • The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIPOR2 Gene

ADIPOR2 (Adiponectin Receptor 2) is a Protein Coding gene. Diseases associated with ADIPOR2 include Fatty Liver Disease and Liver Disease. Among its related pathways are Integration of energy metabolism and Adipocytokine signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot Summary for ADIPOR2 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Additional gene information for ADIPOR2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADIPOR2 Gene

Genomics for ADIPOR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADIPOR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADIPOR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADIPOR2

Top Transcription factor binding sites by QIAGEN in the ADIPOR2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GR
  • GR-alpha
  • Lhx3a
  • LHX3b
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP

Genomic Locations for ADIPOR2 Gene

Genomic Locations for ADIPOR2 Gene
chr12:1,688,574-1,788,674
(GRCh38/hg38)
Size:
100,101 bases
Orientation:
Plus strand
chr12:1,797,740-1,897,845
(GRCh37/hg19)
Size:
100,106 bases
Orientation:
Plus strand

Genomic View for ADIPOR2 Gene

Genes around ADIPOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR2 Gene

Proteins for ADIPOR2 Gene

  • Protein details for ADIPOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V24-PAQR2_HUMAN
    Recommended name:
    Adiponectin receptor protein 2
    Protein Accession:
    Q86V24
    Secondary Accessions:
    • Q53YY5
    • Q9H737

    Protein attributes for ADIPOR2 Gene

    Size:
    386 amino acids
    Molecular mass:
    43884 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR1 (PubMed:12802337). Interacts with APPL2 (via BAR domain); ADIPOQ dissociates this interaction (By similarity).
    SequenceCaution:
    • Sequence=BAB15062.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR2 Gene

neXtProt entry for ADIPOR2 Gene

Post-translational modifications for ADIPOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIPOR2 Gene

No data available for DME Specific Peptides for ADIPOR2 Gene

Domains & Families for ADIPOR2 Gene

Protein Domains for ADIPOR2 Gene

InterPro:
Blocks:
  • Hly-III related proteins
ProtoNet:

Suggested Antigen Peptide Sequences for ADIPOR2 Gene

GenScript: Design optimal peptide antigens:
  • Progestin and adipoQ receptor family member II (ADR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86V24

UniProtKB/Swiss-Prot:

PAQR2_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR2: view

Function for ADIPOR2 Gene

Molecular function for ADIPOR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Phenotypes From GWAS Catalog for ADIPOR2 Gene

Gene Ontology (GO) - Molecular Function for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IEA,IBA 21873635
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0055100 adiponectin binding IDA 12802337
GO:0097003 adipokinetic hormone receptor activity IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view
genes like me logo Genes that share phenotypes with ADIPOR2: view

Animal Models for ADIPOR2 Gene

MGI Knock Outs for ADIPOR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADIPOR2

CRISPR Products

miRNA for ADIPOR2 Gene

miRTarBase miRNAs that target ADIPOR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADIPOR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOR2 Gene

Localization for ADIPOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Cell membrane. Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADIPOR2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADIPOR2 Gene

Pathways & Interactions for ADIPOR2 Gene

genes like me logo Genes that share pathways with ADIPOR2: view

SIGNOR curated interactions for ADIPOR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007507 heart development IEA --
GO:0007565 female pregnancy IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with ADIPOR2: view

Drugs & Compounds for ADIPOR2 Gene

(4) Drugs for ADIPOR2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AdipoRon Pharma 0

(5) Additional Compounds for ADIPOR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADIPOR2 Gene

Compound Action Cas Number
AdipoRon 924416-43-3
genes like me logo Genes that share compounds with ADIPOR2: view

Drug Products

Transcripts for ADIPOR2 Gene

mRNA/cDNA for ADIPOR2 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADIPOR2

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for ADIPOR2 Gene

GeneLoc Exon Structure for
ADIPOR2

Expression for ADIPOR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADIPOR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADIPOR2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADIPOR2

SOURCE GeneReport for Unigene cluster for ADIPOR2 Gene:

Hs.371642

mRNA Expression by UniProt/SwissProt for ADIPOR2 Gene:

Q86V24-PAQR2_HUMAN
Tissue specificity: Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).

Evidence on tissue expression from TISSUES for ADIPOR2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Intestine(4.6)
  • Muscle(3.2)
  • Skin(3.2)
  • Lung(3)
  • Heart(2.9)
  • Pancreas(2.9)
  • Blood(2.8)
  • Adrenal gland(2.6)
  • Kidney(2.6)
  • Stomach(2.5)
  • Thyroid gland(2.4)
  • Lymph node(2.2)
  • Spleen(2.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with ADIPOR2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIPOR2 Gene

Orthologs for ADIPOR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADIPOR2 30 31
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADIPOR2 30 31
  • 92.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adipor2 30
  • 89.72 (n)
Mouse
(Mus musculus)
Mammalia Adipor2 30 17 31
  • 89.64 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADIPOR2 31
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ADIPOR2 30 31
  • 86.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR2 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADIPOR2 30 31
  • 77.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADIPOR2 31
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4802 30
Zebrafish
(Danio rerio)
Actinopterygii adipor2 30 31
  • 72.89 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11010 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004486 30
  • 59.35 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5315 31
  • 45 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea paqr-1 31
  • 39 (a)
ManyToMany
paqr-2 31
  • 29 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH2 31 33
  • 36 (a)
ManyToMany
IZH1 31
  • 30 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons HHP4 30
  • 48.86 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0232900 30
  • 49.32 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8140 31
  • 50 (a)
OneToMany
Species where no ortholog for ADIPOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ADIPOR2 Gene

ENSEMBL:
Gene Tree for ADIPOR2 (if available)
TreeFam:
Gene Tree for ADIPOR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADIPOR2: view image

Paralogs for ADIPOR2 Gene

Paralogs for ADIPOR2 Gene

(2) SIMAP similar genes for ADIPOR2 Gene using alignment to 1 proteins:

  • ADR2_HUMAN

Pseudogenes.org Pseudogenes for ADIPOR2 Gene

genes like me logo Genes that share paralogs with ADIPOR2: view

Variants for ADIPOR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADIPOR2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
785390 Benign: not provided 1,786,042(+) C/T SYNONYMOUS_VARIANT
rs12298275 - p.Gln39Arg

Additional dbSNP identifiers (rs#s) for ADIPOR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADIPOR2 Gene

Variant ID Type Subtype PubMed ID
dgv751n106 CNV deletion 24896259
esv1263717 CNV deletion 17803354
esv2586584 CNV deletion 19546169
esv2662489 CNV deletion 23128226
esv2745395 CNV deletion 23290073
esv2745396 CNV deletion 23290073
esv2745398 CNV deletion 23290073
esv3309167 CNV mobile element insertion 20981092
esv3391809 CNV insertion 20981092
esv3548628 CNV deletion 23714750
esv3628291 CNV loss 21293372
esv3628293 CNV loss 21293372
esv3783 CNV loss 18987735
esv994937 CNV deletion 20482838
nsv1045312 CNV loss 25217958
nsv1071001 CNV deletion 25765185
nsv1145579 CNV deletion 24896259
nsv510285 OTHER sequence alteration 20534489
nsv53173 CNV deletion 16902084
nsv556996 CNV gain 21841781
nsv832304 CNV gain 17160897
nsv832305 CNV gain 17160897
nsv832306 CNV loss 17160897
nsv952786 CNV duplication 24416366
nsv957269 CNV deletion 24416366
nsv973980 CNV duplication 23825009
nsv983262 CNV duplication 23825009

Variation tolerance for ADIPOR2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADIPOR2 Gene

Human Gene Mutation Database (HGMD)
ADIPOR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIPOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Disorders for ADIPOR2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for ADIPOR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • steatosis of liver
liver disease
  • disorder of liver
non-alcoholic fatty liver disease
  • nafld
meconium ileus
  • ileus
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADIPOR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADIPOR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR2 Gene

Publications for ADIPOR2 Gene

  1. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson JF … Roche HM (The American journal of clinical nutrition 2010) 3 23 41
  2. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. (PMID: 20178558) Halvatsiotis I … Raptis SA (Cardiovascular diabetology 2010) 3 23 41
  3. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PMID: 19208777) Kotronen A … Fisher RM (European journal of endocrinology 2009) 3 23 41
  4. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 41
  5. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PMID: 19037660) Rasmussen-Torvik LJ … Sinaiko AR (Human genetics 2009) 3 23 41

Products for ADIPOR2 Gene

Sources for ADIPOR2 Gene