This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located... See more...

Aliases for ADIPOR1 Gene

Aliases for ADIPOR1 Gene

  • Adiponectin Receptor 1 2 3 5
  • Progestin And AdipoQ Receptor Family Member 1 3 4
  • Progestin And AdipoQ Receptor Family Member I 3 4
  • Adiponectin Receptor Protein 1 3 4
  • TESBP1A 3 4
  • PAQR1 3 4
  • ACDCR1 3
  • CGI-45 3
  • CGI45 3

External Ids for ADIPOR1 Gene

Previous GeneCards Identifiers for ADIPOR1 Gene

  • GC01M199376
  • GC01M200198
  • GC01M199641
  • GC01M201176
  • GC01M202909
  • GC01M174075

Summaries for ADIPOR1 Gene

Entrez Gene Summary for ADIPOR1 Gene

  • This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADIPOR1 Gene

ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include Fatty Liver Disease and Gestational Diabetes. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.

UniProtKB/Swiss-Prot Summary for ADIPOR1 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Gene Wiki entry for ADIPOR1 Gene

Additional gene information for ADIPOR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADIPOR1 Gene

Genomics for ADIPOR1 Gene

GeneHancer (GH) Regulatory Elements for ADIPOR1 Gene

Promoters and enhancers for ADIPOR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADIPOR1 gene promoter:
  • CREB
  • deltaCREB
  • E47
  • Lmo2

Genomic Locations for ADIPOR1 Gene

Genomic Locations for ADIPOR1 Gene
chr1:202,940,825-202,958,572
(GRCh38/hg38)
Size:
17,748 bases
Orientation:
Minus strand
chr1:202,909,951-202,927,700
(GRCh37/hg19)
Size:
17,750 bases
Orientation:
Minus strand

Genomic View for ADIPOR1 Gene

Genes around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR1 Gene

Proteins for ADIPOR1 Gene

  • Protein details for ADIPOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A54-PAQR1_HUMAN
    Recommended name:
    Adiponectin receptor protein 1
    Protein Accession:
    Q96A54
    Secondary Accessions:
    • B3KMB0
    • Q53HS7
    • Q53YY6
    • Q9Y360

    Protein attributes for ADIPOR1 Gene

    Size:
    375 amino acids
    Molecular mass:
    42616 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR2 (PubMed:12802337). Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1. Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1 (By similarity).
    SequenceCaution:
    • Sequence=AAD34040.1; Type=Frameshift; Positions=369; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR1 Gene

neXtProt entry for ADIPOR1 Gene

Post-translational modifications for ADIPOR1 Gene

  • Ubiquitination at Lys86
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ADIPOR1

No data available for DME Specific Peptides for ADIPOR1 Gene

Domains & Families for ADIPOR1 Gene

Gene Families for ADIPOR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ADIPOR1 Gene

Suggested Antigen Peptide Sequences for ADIPOR1 Gene

GenScript: Design optimal peptide antigens:
  • Progestin and adipoQ receptor family member I (ADR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96A54

UniProtKB/Swiss-Prot:

PAQR1_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR1: view

Function for ADIPOR1 Gene

Molecular function for ADIPOR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Phenotypes From GWAS Catalog for ADIPOR1 Gene

Gene Ontology (GO) - Molecular Function for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 19233263
GO:0038023 signaling receptor activity IEA,IBA 21873635
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ADIPOR1: view
genes like me logo Genes that share phenotypes with ADIPOR1: view

Animal Models for ADIPOR1 Gene

MGI Knock Outs for ADIPOR1:

Animal Model Products

CRISPR Products

miRNA for ADIPOR1 Gene

miRTarBase miRNAs that target ADIPOR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOR1 Gene

Localization for ADIPOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADIPOR1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADIPOR1 Gene

Pathways & Interactions for ADIPOR1 Gene

genes like me logo Genes that share pathways with ADIPOR1: view

SIGNOR curated interactions for ADIPOR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0009755 hormone-mediated signaling pathway IDA 12802337
GO:0010633 negative regulation of epithelial cell migration IMP 23776679
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 23776679
genes like me logo Genes that share ontologies with ADIPOR1: view

Drugs & Compounds for ADIPOR1 Gene

(6) Drugs for ADIPOR1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AdipoRon Pharma 0

(7) Additional Compounds for ADIPOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADIPOR1 Gene

Compound Action Cas Number
AdipoRon 924416-43-3
genes like me logo Genes that share compounds with ADIPOR1: view

Transcripts for ADIPOR1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: - - -
SP11:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ADIPOR1 Gene

GeneLoc Exon Structure for
ADIPOR1
ECgene alternative splicing isoforms for
ADIPOR1

Expression for ADIPOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADIPOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIPOR1 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for ADIPOR1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADIPOR1 Gene



Protein tissue co-expression partners for ADIPOR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADIPOR1 Gene:

ADIPOR1

SOURCE GeneReport for Unigene cluster for ADIPOR1 Gene:

Hs.713729

mRNA Expression by UniProt/SwissProt for ADIPOR1 Gene:

Q96A54-PAQR1_HUMAN
Tissue specificity: Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).

Evidence on tissue expression from TISSUES for ADIPOR1 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Skin(4.6)
  • Kidney(3.6)
  • Muscle(3.6)
  • Intestine(3.4)
  • Liver(3.3)
  • Pancreas(3.2)
  • Blood(3.1)
  • Heart(2.8)
genes like me logo Genes that share expression patterns with ADIPOR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIPOR1 Gene

Orthologs for ADIPOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOR1 33 32
  • 99.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIPOR1 33
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIPOR1 33 32
  • 95.47 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adipor1 32
  • 91.82 (n)
mouse
(Mus musculus)
Mammalia Adipor1 17 33 32
  • 90.93 (n)
cow
(Bos Taurus)
Mammalia ADIPOR1 33 32
  • 87.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR1 33
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADIPOR1 33 32
  • 80.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADIPOR1 33
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adipor1 32
  • 76.64 (n)
Str.15110 32
African clawed frog
(Xenopus laevis)
Amphibia adipor1-prov 32
zebrafish
(Danio rerio)
Actinopterygii adipor1a 33
  • 82 (a)
OneToMany
adipor1b 33 32
  • 73.2 (n)
OneToMany
Dr.4053 32
fruit fly
(Drosophila melanogaster)
Insecta CG5315 33 32
  • 58.38 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea paqr-1 33 32
  • 58.73 (n)
ManyToMany
paqr-2 33
  • 29 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL002C 32
  • 45.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01331g 32
  • 45.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH2 33 32
  • 44.9 (n)
ManyToMany
IZH1 33
  • 30 (a)
ManyToMany
IZH3 35
rice
(Oryza sativa)
Liliopsida Os12g0511200 32
  • 48.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8140 33
  • 51 (a)
OneToMany
Cin.4089 32
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.09c 32
  • 47.88 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04987 32
  • 47.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4089 32
Species where no ortholog for ADIPOR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADIPOR1 Gene

ENSEMBL:
Gene Tree for ADIPOR1 (if available)
TreeFam:
Gene Tree for ADIPOR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADIPOR1: view image

Paralogs for ADIPOR1 Gene

Paralogs for ADIPOR1 Gene

(2) SIMAP similar genes for ADIPOR1 Gene using alignment to 4 proteins:

  • ADR1_HUMAN
  • C9J0W7_HUMAN
  • C9JNM5_HUMAN
  • F8W782_HUMAN

Pseudogenes.org Pseudogenes for ADIPOR1 Gene

genes like me logo Genes that share paralogs with ADIPOR1: view

Variants for ADIPOR1 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs886039240 uncertain-significance, not provided 202,951,040(-) G/ 5_prime_UTR_variant, coding_sequence_variant, frameshift
rs1000027834 -- 202,942,466(-) A/G intron_variant
rs1000080392 -- 202,944,440(-) C/T intron_variant
rs1000264710 -- 202,950,501(-) G/A intron_variant
rs1000546318 -- 202,941,952(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADIPOR1 Gene

Variant ID Type Subtype PubMed ID
nsv1068426 CNV deletion 25765185

Variation tolerance for ADIPOR1 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADIPOR1 Gene

Human Gene Mutation Database (HGMD)
ADIPOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIPOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Disorders for ADIPOR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADIPOR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • steatosis of liver
gestational diabetes
  • gdm
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
non-alcoholic fatty liver disease
  • nafld
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADIPOR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADIPOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR1 Gene

Publications for ADIPOR1 Gene

  1. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson JF … Roche HM (The American journal of clinical nutrition 2010) 3 23 43 56
  2. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PMID: 19208777) Kotronen A … Fisher RM (European journal of endocrinology 2009) 3 23 43 56
  3. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. (PMID: 19723917) Teras LR … Feigelson HS (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 43 56
  4. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PMID: 19037660) Rasmussen-Torvik LJ … Sinaiko AR (Human genetics 2009) 3 23 43 56
  5. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. (PMID: 18294218) Ruchat SM … Pérusse L (Diabetic medicine : a journal of the British Diabetic Association 2008) 3 23 43 56

Products for ADIPOR1 Gene

Sources for ADIPOR1 Gene