Aliases for ADIPOR1 Gene
External Ids for ADIPOR1 Gene
Previous GeneCards Identifiers for ADIPOR1 Gene
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
GeneCards Summary for ADIPOR1 Gene
ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include Fatty Liver Disease and Gestational Diabetes. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.
UniProtKB/Swiss-Prot Summary for ADIPOR1 Gene
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).