Aliases for ADIPOQ Gene
Aliases for ADIPOQ Gene
- Adiponectin, C1Q And Collagen Domain Containing 2 3 5
- Adipose Most Abundant Gene Transcript 1 Protein 3 4
- Adipocyte Complement-Related 30 KDa Protein 3 4
- 30 KDa Adipocyte Complement-Related Protein 3 4
- ACRP30 3 4
- GBP28 3 4
- ACDC 3 4
- APM1 3 4
- Adipocyte, C1q And Collagen Domain-Containing Protein 4
- Adipocyte, C1Q And Collagen Domain Containing 2
- Adipose Most Abundant Gene Transcript 1 2
External Ids for ADIPOQ Gene
- HGNC: 13633
- Entrez Gene: 9370
- Ensembl: ENSG00000181092
- OMIM: 605441
- UniProtKB: Q15848
Previous HGNC Symbols for ADIPOQ Gene
- ACDC
Previous GeneCards Identifiers for ADIPOQ Gene
- GC03P188044
- GC03P186560
- GC03P183969
Summaries for ADIPOQ Gene
-
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
GeneCards Summary for ADIPOQ Gene
ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include Adiponectin, Serum Level Of, Quantitative Trait Locus 1 and Fatty Liver Disease. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Adipogenesis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and signaling receptor binding. An important paralog of this gene is C1QTNF9.
UniProtKB/Swiss-Prot for ADIPOQ Gene
-
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Additional gene information for ADIPOQ Gene
- Monarch Initiative
- Search for ADIPOQ at DataMed
- Search for ADIPOQ at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOQ Gene
Genomics for ADIPOQ Gene
GeneHancer (GH) Regulatory Elements for ADIPOQ Gene
Promoters and enhancers for ADIPOQ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADIPOQ on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADIPOQ gene promoter:
Regulatory Element Products
Genomic Locations for ADIPOQ Gene
Genomic Locations for ADIPOQ Gene
- chr3:186,842,668-186,858,463
- (GRCh38/hg38)
- Size:
- 15,796 bases
- Orientation:
- Plus strand
- chr3:186,560,463-186,576,252
- (GRCh37/hg19)
Genomic View for ADIPOQ Gene
Genes around ADIPOQ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q27.3 by Entrez Gene
- 3q27.3 by HGNC
- 3q27.3 by Ensembl
ADIPOQ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADIPOQ Gene
Proteins for ADIPOQ Gene
-
Protein details for ADIPOQ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15848-ADIPO_HUMAN
- Recommended name:
- Adiponectin
- Protein Accession:
- Q15848
- Q58EX9
Protein attributes for ADIPOQ Gene
- Size:
- 244 amino acids
- Molecular mass:
- 26414 Da
- Quaternary structure:
-
- Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex) (By similarity).
- Miscellaneous:
-
- Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.
- HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.
Protein Expression for ADIPOQ Gene
Post-translational modifications for ADIPOQ Gene
- Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
- HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity).
- O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.
- Glycosylation at posLast=101101, Lys77, Lys68, Lys65, Thr22, and Thr21
- Modification sites at PhosphoSitePlus
Other Protein References for ADIPOQ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ADIPOQ (Adiponectin/Acrp30)
-
Custom Antibody ServicesOriGene Antibodies for ADIPOQ
- AM02042PU-N
- AM02042PU-S
- AM02043PU-N
- AM02043PU-S
- AM12126PU-N
- AM31880PU-N
- AM31966PU-N
- AP05253PU-N
- AP07653PU-N
- DP2004
- PP1221B1
- PP1221B2
- PP1221P1
- PP1221P2
- SM6014
- SM6014S
- SM6027
- SM6027S
- SP2182P
- TA306227
- TA306228
- TA321672
- TA327999
- TA336486
- TA349452
- TA503801
- CF503801
- TA503826
- CF503826
- TA503913
- CF503913
- TA804433
- CF804433
- TA804438
- CF804438
- TA804554
- CF804554
- TA804555
- CF804555
- TA804576
- TA804590
- CF804590
- TA804591
- CF804591
- TA804592
- CF804592
- TA804594
- CF804594
- TA804596
- CF804596
- TA804597
- CF804597
- TA804645
- CF804645
- TA804680
- CF804680
- TA804681
- CF804681
- TA804768
- CF804768
- TA804909
- CF804909
- TA805085
- CF805085
- UM570072
- TA503801S
- Novus Biologicals Antibodies for ADIPOQ
- Invitrogen Antibodies for ADIPOQ
- GeneTex ADIPOQ Antibody for ADIPOQ
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADIPOQ
- Sino Biological Antibodies for ADIPOQ
Protein Products
- R&D Systems Proteins and Enzymes for ADIPOQ (Adiponectin/Acrp30)
- R&D Systems Proteins and Enzymes for ADIPOQ (gAdiponectin/gAcrp30)
- Search Origene for MassSpec and Protein Over-expression Lysates for ADIPOQ
- Origene Custom Protein Services for ADIPOQ
- Sino Biological Cell Lysates for ADIPOQ
- Sino Biological Recombinant Proteins for ADIPOQ
- ProSpec Recombinant Proteins for ADIPOQ
- GeneTex Proteins for ADIPOQ
-
ProSci Proteins for ADIPOQ
- adiponectin, C1Q and collagen domain containing [96-015]
- adiponectin, C1Q and collagen domain containing [90-002]
- adiponectin, C1Q and collagen domain containing [90-240]
- adiponectin, C1Q and collagen domain containing [91-501]
- adiponectin, C1Q and collagen domain containing [92-243]
- adiponectin, C1Q and collagen domain containing [92-392]
- adiponectin, C1Q and collagen domain containing [40-326]
- adiponectin, C1Q and collagen domain containing [40-327]
- adiponectin, C1Q and collagen domain containing [40-328]
- adiponectin, C1Q and collagen domain containing [40-487]
- adiponectin, C1Q and collagen domain containing [40-614]
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for ADIPOQ (Adiponectin/Acrp30)
- Novus Biologicals ELISA Kits for ADIPOQ
No data available for DME Specific Peptides for ADIPOQ Gene
Domains & Families for ADIPOQ Gene
Gene Families for ADIPOQ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for ADIPOQ Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADIPOQ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15848- Domain:
-
- The C1q domain is commonly called the globular domain.
Function for ADIPOQ Gene
Molecular function for ADIPOQ Gene
- UniProtKB/Swiss-Prot Function:
- Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Phenotypes From GWAS Catalog for ADIPOQ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | ISS | 12368907 |
| GO:0005125 | cytokine activity | NAS | 12611609 |
| GO:0005179 | hormone activity | IDA | 11222466 |
| GO:0005515 | protein binding | IPI | 12070119 |
| GO:0033691 | sialic acid binding | IDA | 19855092 |
Phenotypes for ADIPOQ Gene
- MGI mutant phenotypes for ADIPOQ:
-
inferred from 5 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ADIPOQ:
Animal Models for ADIPOQ Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ADIPOQ
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADIPOQ
-
CRISPR Products
-
OriGene CRISPR knockouts for ADIPOQ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADIPOQ
- genomics-online: gRNA clones - Search results for available ADIPOQ gene related products
- Applied Biological Materials CRISPR for ADIPOQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADIPOQ
- GenScript: Design CRISPR guide RNA sequences for ADIPOQ
miRNA for ADIPOQ Gene
- miRTarBase miRNAs that target ADIPOQ
-
- hsa-mir-6513-5p (MIRT691096)
- hsa-mir-887-5p (MIRT691097)
- hsa-mir-3913-5p (MIRT691098)
- hsa-mir-3122 (MIRT691099)
- hsa-mir-450a-1-3p (MIRT691100)
- hsa-mir-6780a-5p (MIRT691101)
- hsa-mir-6779-5p (MIRT691102)
- hsa-mir-3689c (MIRT691103)
- hsa-mir-3689b-3p (MIRT691104)
- hsa-mir-3689a-3p (MIRT691105)
- hsa-mir-30b-3p (MIRT691106)
- hsa-mir-1273h-5p (MIRT691107)
- hsa-mir-6788-5p (MIRT691108)
- hsa-mir-30c-2-3p (MIRT691109)
- hsa-mir-30c-1-3p (MIRT691110)
- hsa-mir-6514-3p (MIRT691111)
- hsa-mir-3165 (MIRT691112)
- hsa-mir-6745 (MIRT691113)
- hsa-mir-363-5p (MIRT691114)
- hsa-mir-6799-5p (MIRT691115)
- hsa-mir-6883-5p (MIRT691116)
- hsa-mir-6785-5p (MIRT691117)
- hsa-mir-4728-5p (MIRT691118)
- hsa-mir-149-3p (MIRT691119)
- hsa-mir-7106-5p (MIRT691120)
- hsa-mir-3656 (MIRT691121)
- hsa-mir-6811-3p (MIRT691122)
- hsa-mir-214-5p (MIRT691123)
- hsa-mir-6087 (MIRT691124)
- hsa-mir-383-3p (MIRT691125)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADIPOQ
- Browse OriGene Inhibitory RNA Products For ADIPOQ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADIPOQ
- genomics-online: shRNA clones - Search results for available ADIPOQ gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADIPOQ
- VectorBuilder custom plasmid, inducible vectors for ADIPOQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADIPOQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADIPOQ
- genomics-online: cdna clones - Search results for available ADIPOQ gene related products
- orf clones - Search results for available ADIPOQ gene related products
- Applied Biological Materials Clones for ADIPOQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ADIPOQ (Adiponectin/Acrp30)
Cell Line Products
-
Horizon Cell Lines for ADIPOQ
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOQ Gene
Localization for ADIPOQ Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADIPOQ Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| peroxisome | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| golgi apparatus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005615 | extracellular space | IEA,IDA | 10403784 |
| GO:0005783 | endoplasmic reticulum | IEA,ISS | -- |
| GO:0009986 | cell surface | IDA | 10982546 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADIPOQ Gene
Pathways & Interactions for ADIPOQ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Type II diabetes mellitus | ||
| 3 | Integration of energy metabolism | ||
| 4 | Adipocytokine signaling pathway | ||
| 5 | Longevity regulating pathway | ||
Pathways by source for ADIPOQ Gene
1 Sino Biological pathway for ADIPOQ Gene
6 BioSystems pathways for ADIPOQ Gene
6 KEGG pathways for ADIPOQ Gene
1 R&D Systems pathway for ADIPOQ Gene
1 Cell Signaling Technology pathway for ADIPOQ Gene
Interacting Proteins for ADIPOQ Gene
Selected Interacting proteins:
Q15848-ADIPO_HUMAN
ENSP00000320709
for ADIPOQ Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for ADIPOQ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 18431508 |
| GO:0006006 | glucose metabolic process | ISS,IEA | 12368907 |
| GO:0006091 | generation of precursor metabolites and energy | TAS | 10095105 |
| GO:0006635 | fatty acid beta-oxidation | ISS | 12368907 |
Transcripts for ADIPOQ Gene
mRNA/cDNA for ADIPOQ Gene
- (45) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000320741 4562 bps (uc003fra.4)
- ENST00000444204 4599 bps (uc010hyy.4)
Unigene Clusters for ADIPOQ Gene
- Adiponectin, C1Q and collagen domain containing:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADIPOQ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADIPOQ
- genomics-online: gRNA clones - Search results for available ADIPOQ gene related products
- Applied Biological Materials CRISPR for ADIPOQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADIPOQ
- GenScript: Design CRISPR guide RNA sequences for ADIPOQ
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADIPOQ
- Browse OriGene Inhibitory RNA Products For ADIPOQ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADIPOQ
- genomics-online: shRNA clones - Search results for available ADIPOQ gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADIPOQ
- VectorBuilder custom plasmid, inducible vectors for ADIPOQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADIPOQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADIPOQ
- genomics-online: cdna clones - Search results for available ADIPOQ gene related products
- orf clones - Search results for available ADIPOQ gene related products
- Applied Biological Materials Clones for ADIPOQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ADIPOQ (Adiponectin/Acrp30)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Expression for ADIPOQ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells
- Bone (Muscoskeletal System)
- Neurons (Uncategorized)
- Uncategorized
- NULL (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for ADIPOQ Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x19.9), Adipose - Subcutaneous (x18.8), and Breast - Mammary Tissue (x8.2).
This gene is overexpressed in Uterus (14.6), Synovial fluid (11.7), Serum (7.3), Nasopharynx (6.7), and Heart (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADIPOQ Gene
NURSA nuclear receptor signaling pathways regulating expression of ADIPOQ Gene:
ADIPOQSOURCE GeneReport for Unigene cluster for ADIPOQ Gene:
Hs.80485mRNA Expression by UniProt/SwissProt for ADIPOQ Gene:
Q15848-ADIPO_HUMAN
Tissue specificity:
Synthesized exclusively by adipocytes and secreted into plasma.
Evidence on tissue expression from TISSUES for ADIPOQ Gene
- Muscle(3.9)
- Heart(3.7)
- Blood(3.6)
- Kidney(3.4)
- Intestine(3.3)
- Skin(3.1)
- Liver(3)
- Nervous system(2.8)
- Pancreas(2.6)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADIPOQ
-
OriGene qPCR primer pairs for ADIPOQ
- genomics-online: primer clones - Search results for available ADIPOQ gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIPOQ Gene
Orthologs for ADIPOQ Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADIPOQ 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADIPOQ 33 |
|
||
| APM1 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | ADIPOQ 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Adipoq 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Adipoq 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADIPOQ 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADIPOQ 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADIPOQ 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADIPOQ 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adipoq 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adipoqb 34 33 |
|
OneToMany | |
| adipoqa 34 |
|
OneToMany |
- Species where no ortholog for ADIPOQ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ADIPOQ Gene
- ENSEMBL:
- Gene Tree for ADIPOQ (if available)
- TreeFam:
- Gene Tree for ADIPOQ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADIPOQ: view image
Paralogs for ADIPOQ Gene
Paralogs for ADIPOQ Gene
(16) SIMAP similar genes for ADIPOQ Gene using alignment to 2 proteins:
- ADIPO_HUMAN
- A8K660_HUMAN
Variants for ADIPOQ Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOQ Gene
- ADIPO_HUMAN-Q15848
- Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556].
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121917815 | pathogenic, Hypoadiponectinemia, Adiponectin deficiency (ADPND) [MIM:612556] | 186,854,303(+) | C/T | coding_sequence_variant, missense_variant | |
| rs876661321 | risk-factor, Serum level of adiponectin 1 | 186,841,714(+) | G/T | upstream_transcript_variant | |
| rs147185738 | uncertain-significance, not specified | 186,853,249(+) | A/G | coding_sequence_variant, missense_variant | |
| rs1000490867 | -- | 186,842,571(+) | A/G | upstream_transcript_variant | |
| rs1000733570 | -- | 186,842,822(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759206 | CNV | loss | 17122850 |
| esv34136 | CNV | loss | 18971310 |
| esv3598999 | CNV | gain | 21293372 |
| esv3893839 | CNV | gain | 25118596 |
| nsv1001111 | CNV | gain | 25217958 |
| nsv1010626 | CNV | loss | 25217958 |
| nsv1012615 | CNV | gain | 25217958 |
| nsv246 | CNV | deletion | 15895083 |
| nsv4155 | CNV | deletion | 18451855 |
| nsv508263 | CNV | deletion | 20534489 |
Residual Variation Intolerance Score:
76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.75;
46.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADIPOQ Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ADIPOQ Gene
(52) MalaCards diseases for ADIPOQ Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adiponectin, serum level of, quantitative trait locus 1 |
|
|
| fatty liver disease |
|
|
| glucose intolerance |
|
|
| gestational diabetes |
|
|
| acquired generalized lipodystrophy |
|
Search ADIPOQ in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADIPO_HUMAN- Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin. {ECO:0000269 PubMed:10918532}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for ADIPOQ
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ADIPOQ Gene
Publications for ADIPOQ Gene
- Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study. (PMID: 19761474) Menzaghi C … Trischitta V (Journal of internal medicine 2010) 3 22 44 58
- Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. (PMID: 19855092) Richards AA … Whitehead JP (Molecular endocrinology (Baltimore, Md.) 2010) 3 4 22 58
- Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson JF … Roche HM (The American journal of clinical nutrition 2010) 3 22 44 58
- Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PMID: 19267370) Wang MH … Platz EA (The Prostate 2009) 3 22 44 58
- ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity. (PMID: 19543786) Ntalla I … Talmud PJ (European journal of nutrition 2009) 3 22 44 58
Products for ADIPOQ Gene
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- adiponectin, C1Q and collagen domain containing [96-015]
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Sources for ADIPOQ Gene
- (1) GeneCards
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