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Aliases for ADIG Gene

Aliases for ADIG Gene

  • Adipogenin 2 3 3 5
  • Adipogenesis Associated 2 3
  • Small Adipocyte Factor 1 (SMAF1) 3
  • Small Adipocyte Factor 1 2
  • SMAF1 3

External Ids for ADIG Gene

Previous GeneCards Identifiers for ADIG Gene

  • GC20P036645
  • GC20P037209
  • GC20P033946

Summaries for ADIG Gene

Entrez Gene Summary for ADIG Gene

  • ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIG Gene

ADIG (Adipogenin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ADIG Gene

  • Plays a role in stimulating adipocyte differentiation and development.

Additional gene information for ADIG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIG Gene

Genomics for ADIG Gene

GeneHancer (GH) Regulatory Elements for ADIG Gene

Promoters and enhancers for ADIG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I038581 Promoter 0.8 EPDnew 550.8 0.0 -17 0.1 NFIL3 ZNF449 GLIS1 HLF ZNF629 ZNF600 TEAD3 ADIG RPS3P2
GH20I038604 Enhancer 0.9 ENCODE 11.5 +23.9 23898 0.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 ATF7 FOS SP5 ADIG ARHGAP40 LOC391247
GH20I038536 Enhancer 0.2 ENCODE 10.8 -44.6 -44585 1.2 RPS3P2 ADIG ARHGAP40 ENSG00000224635 MIR548O2 RALGAPB
GH20I038600 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 0.3 +20.4 20395 1.2 CTCF BCOR KLF1 ARID4B KLF17 ZMYM3 ZIC2 RAD21 ZKSCAN1 TEAD3 ARHGAP40 ADIG
GH20I038598 Enhancer 0.7 ENCODE 0.4 +18.2 18232 1.2 ELF3 NFIB ZIC2 ZNF644 ZNF48 TEAD3 ZNF121 GATA3 GLIS2 ELK1 ARHGAP40 ADIG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADIG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADIG gene promoter:

Genomic Locations for ADIG Gene

Genomic Locations for ADIG Gene
7,269 bases
Plus strand

Genomic View for ADIG Gene

Genes around ADIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIG Gene

Proteins for ADIG Gene

  • Protein details for ADIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ADIG Gene

    80 amino acids
    Molecular mass:
    9465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIG Gene

Post-translational modifications for ADIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIG Gene

No data available for DME Specific Peptides for ADIG Gene

Domains & Families for ADIG Gene

Gene Families for ADIG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ADIG Gene


Suggested Antigen Peptide Sequences for ADIG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adipogenin family.
  • Belongs to the adipogenin family.
genes like me logo Genes that share domains with ADIG: view

Function for ADIG Gene

Molecular function for ADIG Gene

UniProtKB/Swiss-Prot Function:
Plays a role in stimulating adipocyte differentiation and development.
genes like me logo Genes that share phenotypes with ADIG: view

Animal Model Products

CRISPR Products

miRNA for ADIG Gene

miRTarBase miRNAs that target ADIG

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADIG Gene

Localization for ADIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIG Gene

Membrane; Single-pass membrane protein. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADIG gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 15567149
GO:0005737 cytoplasm ISS,IEA 15567149
GO:0005811 lipid droplet IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADIG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADIG Gene

Pathways & Interactions for ADIG Gene

No Data Available

Interacting Proteins for ADIG Gene

Gene Ontology (GO) - Biological Process for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0045444 fat cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IEA,ISS 15567149
GO:0050872 white fat cell differentiation IEA,ISS 15567149
GO:0050873 brown fat cell differentiation IEA,ISS 15567149
genes like me logo Genes that share ontologies with ADIG: view

No data available for Pathways by source and SIGNOR curated interactions for ADIG Gene

Drugs & Compounds for ADIG Gene

No Compound Related Data Available

Transcripts for ADIG Gene

mRNA/cDNA for ADIG Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADIG Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIG Gene

No ASD Table

Relevant External Links for ADIG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADIG Gene

mRNA differential expression in normal tissues according to GTEx for ADIG Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for ADIG Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADIG Gene

Protein tissue co-expression partners for ADIG Gene

NURSA nuclear receptor signaling pathways regulating expression of ADIG Gene:


SOURCE GeneReport for Unigene cluster for ADIG Gene:

genes like me logo Genes that share expression patterns with ADIG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIG Gene

Orthologs for ADIG Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADIG 33 34
  • 98.75 (n)
(Canis familiaris)
Mammalia ADIG 33
  • 85 (n)
(Bos Taurus)
Mammalia ADIG 33 34
  • 82.7 (n)
(Rattus norvegicus)
Mammalia Adig 33
  • 78.79 (n)
(Mus musculus)
Mammalia Adig 34
  • 61 (a)
Species where no ortholog for ADIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIG Gene

Gene Tree for ADIG (if available)
Gene Tree for ADIG (if available)

Paralogs for ADIG Gene

No data available for Paralogs for ADIG Gene

Variants for ADIG Gene

Sequence variations from dbSNP and Humsavar for ADIG Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000540364 -- 38,584,031(+) C/T intron_variant
rs1001472540 -- 38,584,444(+) C/T intron_variant
rs1001652478 -- 38,580,312(+) AGATAG/AG upstream_transcript_variant
rs1001808115 -- 38,583,025(+) C/T intron_variant
rs1002041950 -- 38,581,851(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADIG Gene

Variant ID Type Subtype PubMed ID
nsv1058457 CNV loss 25217958
nsv3372 CNV insertion 18451855

Variation tolerance for ADIG Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADIG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIG Gene

Disorders for ADIG Gene

Additional Disease Information for ADIG

No disorders were found for ADIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADIG Gene

Publications for ADIG Gene

  1. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. (PMID: 15567149) Kim JY … Smas CM (Biochemical and biophysical research communications 2005) 2 3 58
  2. Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (PMID: 16132694) Hong YH … Sasaki S (Molecular and cellular biochemistry 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 4 58

Products for ADIG Gene

Sources for ADIG Gene

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