This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most ... See more...

Aliases for ADH7 Gene

Aliases for ADH7 Gene

  • Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide 2 3 5
  • All-Trans-Retinol Dehydrogenase [NAD(+)] ADH7 3 4
  • Alcohol Dehydrogenase Class IV Mu/Sigma Chain 3 4
  • Alcohol Dehydrogenase Class 4 Mu/Sigma Chain 3 4
  • Omega-Hydroxydecanoate Dehydrogenase ADH7 3 4
  • Gastric Alcohol Dehydrogenase 3 4
  • Retinol Dehydrogenase 3 4
  • EC 1.1.1.1 4 51
  • Class IV Sigmasigma Alcohol Dehydrogenase 3
  • Class IV Sigma-1 Alcohol Dehydrogenase 3
  • Alcohol Dehydrogenase VII 3
  • Alcohol Dehydrogenase-7 3
  • EC 1.1.1.105 4
  • EC 1.1.1.66 4
  • EC 1.1.1 51
  • ADH-4 2
  • ADH4 3
  • ADH7 5

External Ids for ADH7 Gene

Previous GeneCards Identifiers for ADH7 Gene

  • GC04M100580
  • GC04M100387
  • GC04M100455
  • GC04M100460
  • GC04M100690
  • GC04M096071
  • GC04M100333

Summaries for ADH7 Gene

Entrez Gene Summary for ADH7 Gene

  • This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for ADH7 Gene

ADH7 (Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide) is a Protein Coding gene. Diseases associated with ADH7 include Alcohol Dependence and Atrophic Gastritis. Among its related pathways are Glucose metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and retinol binding. An important paralog of this gene is ADH1A.

UniProtKB/Swiss-Prot Summary for ADH7 Gene

  • Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387).

Tocris Summary for ADH7 Gene

  • Dehydrogenases are enzymes that catalyze reduction reactions through the transfer of hydrogen ions (protons) from the substrate to an acceptor or co-enzyme. Co-enzymes are small organic molecules involved in enzyme catalysis, such as nicotinamide adenine dinucleotide (NAD+ or NADH), nicotinamide adenine dinucleotide phosphate (NADP+ or NADPH), flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).

Gene Wiki entry for ADH7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADH7 Gene

Genomics for ADH7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADH7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J099435 Promoter 0.3 EPDnew 600.7 +0.0 24 0.1 ADH7 lnc-ADH1C-3 ADH1B
GH04J099436 Promoter 0.3 EPDnew 600.7 +0.4 413 0.1 ADH7 lnc-ADH1C-3 ADH1B
GH04J099860 Enhancer 0.6 FANTOM5 dbSUPER 5.3 -425.0 -425000 0.3 ATF7 CREB1 ATF2 DAPP1 TRMT10A MTTP LAMTOR3 ADH7 RF00994-750 ENSG00000248676
GH04J099402 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +31.3 31309 3.7 SP1 GATAD2A CTCF TFE3 SOX13 NFKBIZ RCOR2 BACH1 LARP7 JUND LOC102723576 lnc-ADH7-1 ADH4 ADH6 ENSG00000246090 PCNAP1 ADH5 ADH1A ADH1B ADH1C
GH04J099446 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -11.6 -11564 1.4 IKZF2 ZNF766 HMBOX1 NFE2 ZNF316 MAFG IKZF1 JUNB MAFK IRF4 MTTP ADH7 lnc-C4orf17-1 C4orf17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADH7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADH7

Top Transcription factor binding sites by QIAGEN in the ADH7 gene promoter:
  • aMEF-2
  • AP-1
  • c-Fos
  • c-Jun
  • c-Rel
  • Cdc5
  • MEF-2
  • MEF-2A
  • RORalpha1

Genomic Locations for ADH7 Gene

Genomic Locations for ADH7 Gene
chr4:99,412,261-99,435,737
(GRCh38/hg38)
Size:
23,477 bases
Orientation:
Minus strand
chr4:100,333,418-100,356,894
(GRCh37/hg19)
Size:
23,477 bases
Orientation:
Minus strand

Genomic View for ADH7 Gene

Genes around ADH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH7 Gene

Proteins for ADH7 Gene

  • Protein details for ADH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40394-ADH7_HUMAN
    Recommended name:
    All-trans-retinol dehydrogenase [NAD(+)] ADH7
    Protein Accession:
    P40394
    Secondary Accessions:
    • A2RRB6
    • A8MVN9
    • B2R760
    • B4DWV6
    • Q13713

    Protein attributes for ADH7 Gene

    Size:
    386 amino acids
    Molecular mass:
    41481 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA19002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC51351.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53961.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH7 Gene

    Alternative splice isoforms for ADH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH7 Gene

Selected DME Specific Peptides for ADH7 Gene

P40394:
  • FPVIVGHEA
  • CLIGCGF
  • RFTCKGK
  • TSTFTEYTV
  • GICRTDDH
  • VFGLGGVGLSVIMGCK
  • GKVIKCKAA
  • AGASRII
  • PGDKVIPLF
  • TAGKVIKC
  • GCGFSTGYG
  • EVRIKIL

Post-translational modifications for ADH7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH7 Gene

Domains & Families for ADH7 Gene

Gene Families for ADH7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADH7 Gene

InterPro:
Blocks:
  • Alcohol dehydrogenase GroES-like
  • Zinc-containing alcohol dehydrogenase
ProtoNet:

Suggested Antigen Peptide Sequences for ADH7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51127, highly similar to Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (A8MVN9_HUMAN)
  • Retinol dehydrogenase (ADH7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40394

UniProtKB/Swiss-Prot:

ADH7_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
genes like me logo Genes that share domains with ADH7: view

Function for ADH7 Gene

Molecular function for ADH7 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH; Xref=Rhea:RHEA:20880, ChEBI:CHEBI:11305, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58022; EC=1.1.1.66; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence={ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387, ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH; Xref=Rhea:RHEA:55940, ChEBI:CHEBI:15378, ChEBI:CHEBI:28537, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132246; Evidence={ECO:0000269|PubMed:15369820};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH; Xref=Rhea:RHEA:55936, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132259, ChEBI:CHEBI:139346; Evidence={ECO:0000269|PubMed:15369820};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH; Xref=Rhea:RHEA:60632, ChEBI:CHEBI:15378, ChEBI:CHEBI:44597, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:139347; Evidence={ECO:0000269|PubMed:15369820};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH; Xref=Rhea:RHEA:60980, ChEBI:CHEBI:15378, ChEBI:CHEBI:36204, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144067; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH; Xref=Rhea:RHEA:60984, ChEBI:CHEBI:15378, ChEBI:CHEBI:55329, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144068; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexan-1-ol + NAD(+) = H(+) + hexanal + NADH; Xref=Rhea:RHEA:60972, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:87393, ChEBI:CHEBI:88528; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hex-2-en-1-ol + NAD(+) = (E)-2-hexenal + H(+) + NADH; Xref=Rhea:RHEA:60988, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:141205; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH; Xref=Rhea:RHEA:60976, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58968, ChEBI:CHEBI:142617; Evidence={ECO:0000269|PubMed:9600267};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 uM for all-trans-retinol {ECO:0000269|PubMed:15369820}; KM=15 uM for all-trans-4-hydroxyretinol {ECO:0000269|PubMed:15369820}; KM=28 uM for all-trans-3,4-didehydroretinol {ECO:0000269|PubMed:15369820}; KM=34 uM for all-trans-retinal {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:9600267}; KM=17 uM for all-trans-4-oxoretinal {ECO:0000269|PubMed:15369820}; KM=26 uM for all-trans-3,4-didehydroretinal {ECO:0000269|PubMed:15369820}; KM=0.3 uM for all-trans-retinol {ECO:0000269|PubMed:16787387}; KM=0.8 uM for all-trans-retinal {ECO:0000269|PubMed:16787387}; KM=0.1 mM for 10-OH-decanoic acid (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.17 mM for 12-OH-dodecanoic acid (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.07 mM for 12-OH-dodecanoic acid (with 0.1 M glycine/NaOH at pH 10) {ECO:0000269|PubMed:9600267}; KM=0.035 mM for 16-OH-hexadecanoic acid (with 0.1 M glycine/NaOH at pH 10) {ECO:0000269|PubMed:9600267}; KM=0.14 mM for hexanol (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.02 mM for hexanal (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.017 mM for 2-hexenol (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.025 mM for 2-hexenal (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=0.038 mM for 4-hydroxynonenal (with 0.1 M sodium phosphate at pH 7.5) {ECO:0000269|PubMed:9600267}; KM=15 uM for all-trans-retinol {ECO:0000269|PubMed:9600267}; KM=36 uM for 9-cis-retinol {ECO:0000269|PubMed:9600267}; KM=21 uM for 9-cis-retinal {ECO:0000269|PubMed:9600267};
UniProtKB/Swiss-Prot EnzymeRegulation:
Retinol oxidation is inhibited by the detergent Tween 80 (PubMed:15369820). Ethanol inhibits both all-trans-retinol and 9-cis-retinol oxidation (PubMed:9600267). 13-cis-retinol is an effective competitive inhibitor of the 9-cis-retinol oxidation (PubMed:9600267). All-trans-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). 13-cis-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). Cimetidine competitively inhibited ethanol oxidation (PubMed:9600267).
GENATLAS Biochemistry:
alcohol dehydrogenase (class IV) sigma polypeptide,expressed in stomach

Enzyme Numbers (IUBMB) for ADH7 Gene

Phenotypes From GWAS Catalog for ADH7 Gene

Gene Ontology (GO) - Molecular Function for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity TAS 8074657
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA 7876099
GO:0004031 aldehyde oxidase activity IDA 9600267
GO:0004745 retinol dehydrogenase activity IEA,IDA 7876099
GO:0008270 zinc ion binding IBA 21873635
genes like me logo Genes that share ontologies with ADH7: view
genes like me logo Genes that share phenotypes with ADH7: view

Animal Models for ADH7 Gene

MGI Knock Outs for ADH7:

Animal Model Products

CRISPR Products

miRNA for ADH7 Gene

miRTarBase miRNAs that target ADH7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH7 Gene

Localization for ADH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH7 gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ADH7: view

Pathways & Interactions for ADH7 Gene

genes like me logo Genes that share pathways with ADH7: view

Pathways by source for ADH7 Gene

1 GeneGo (Thomson Reuters) pathway for ADH7 Gene
  • Tyrosine metabolism p.1 (dopamine)

Gene Ontology (GO) - Biological Process for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IDA 9600267
GO:0006068 ethanol catabolic process IEA --
GO:0006069 ethanol oxidation TAS --
GO:0009617 response to bacterium IDA 11410738
GO:0010430 fatty acid omega-oxidation IDA 9600267
genes like me logo Genes that share ontologies with ADH7: view

No data available for SIGNOR curated interactions for ADH7 Gene

Drugs & Compounds for ADH7 Gene

(21) Drugs for ADH7 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme, substrate 3266
Vitamin A Approved, Vet_approved Nutra 685
NADH Approved Nutra Target, Enzyme, substrate 0
Chloral hydrate Approved, Illicit, Investigational, Vet_approved Pharma 18
Glycerol Approved, Investigational Pharma 197

(19) Additional Compounds for ADH7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,2,2-Trichloroethanol
  • 2,2,2-trichloro-1-Ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-trichloro-Ethanol
115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3-(4-methoxyphenyl)prop-2-en-1-ol
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxymandelic aldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • alpha,3,4-Trihydroxybenzeneacetaldehyde
  • alpha,3,4-Trihydroxyphenylacetaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
  • 1-(3,4-Dihydroxyphenyl)-1,2-ethanediol
  • 2-Hydroxy-2-(3,4-dihydroxy)phenylethanol
  • 3,4-Dihydroxyphenethyl glycol
  • 3,4-Dihydroxyphenylethyl glycol
28822-73-3

(1) Tocris Compounds for ADH7 Gene

Compound Action Cas Number
JK 184 Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway 315703-52-7

(1) ApexBio Compounds for ADH7 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
genes like me logo Genes that share compounds with ADH7: view

Transcripts for ADH7 Gene

mRNA/cDNA for ADH7 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH7

Alternative Splicing Database (ASD) splice patterns (SP) for ADH7 Gene

No ASD Table

Relevant External Links for ADH7 Gene

GeneLoc Exon Structure for
ADH7

Expression for ADH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH7 Gene

This gene is overexpressed in Esophagus - Mucosa (x44.6) and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for ADH7 Gene

This gene is overexpressed in Nasal epithelium (52.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADH7

SOURCE GeneReport for Unigene cluster for ADH7 Gene:

Hs.389

mRNA Expression by UniProt/SwissProt for ADH7 Gene:

P40394-ADH7_HUMAN
Tissue specificity: Preferentially expressed in stomach.

Evidence on tissue expression from TISSUES for ADH7 Gene

  • Stomach(4.6)
  • Liver(2.8)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with ADH7: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH7 Gene

Orthologs for ADH7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADH7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADH7 30
  • 99.4 (n)
Mouse
(Mus musculus)
Mammalia Adh7 30 17 31
  • 85.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADH7 30 31
  • 84.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adh7 30
  • 84.58 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ADH7 31
  • 62 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 61 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 66 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.15510 30
Zebrafish
(Danio rerio)
Actinopterygii zgc:77938 31
  • 52 (a)
ManyToMany
zgc:63568 31
  • 51 (a)
ManyToMany
adh8a 31
  • 51 (a)
ManyToMany
adh8b 31
  • 49 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Fdh 31
  • 52 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea H24K24.3 31
  • 49 (a)
ManyToMany
Y50D4C.2 31
  • 32 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 31
  • 44 (a)
OneToMany
ADH2 33
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1497 31
  • 52 (a)
OneToMany
Species where no ortholog for ADH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADH7 Gene

ENSEMBL:
Gene Tree for ADH7 (if available)
TreeFam:
Gene Tree for ADH7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADH7: view image

Paralogs for ADH7 Gene

(6) SIMAP similar genes for ADH7 Gene using alignment to 3 proteins:

  • ADH7_HUMAN
  • C9JP14_HUMAN
  • E9PFG0_HUMAN
genes like me logo Genes that share paralogs with ADH7: view

Variants for ADH7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADH7 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
776001 Benign: not provided 99,420,682(-) T/C MISSENSE_VARIANT
rs1573496 - p.Gly92Ala

Additional dbSNP identifiers (rs#s) for ADH7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADH7 Gene

Variant ID Type Subtype PubMed ID
dgv50e213 CNV gain 24956385
dgv5345n100 CNV gain 25217958
esv3584519 CNV gain 24956385
nsv517344 CNV gain 19592680

Variation tolerance for ADH7 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH7 Gene

Human Gene Mutation Database (HGMD)
ADH7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH7 Gene

Disorders for ADH7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADH7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcoholism
atrophic gastritis
  • gastric atrophy
gastritis
  • acute gastric mucosal erosion
drug dependence
fetal alcohol syndrome
  • alcohol-related neurodevelopmental disorder
- elite association - COSMIC cancer census association via MalaCards
Search ADH7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADH7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH7 Gene

Publications for ADH7 Gene

  1. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. (PMID: 8195208) Satre MA … Duester G (The Journal of biological chemistry 1994) 2 3 4 23
  2. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. (PMID: 17918242) Luo X … Gelernter J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  3. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. (PMID: 16787387) Gallego O … Kedishvili NY (The Biochemical journal 2006) 3 4 23
  4. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X … Gelernter J (American journal of human genetics 2006) 3 23 41
  5. Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80. (PMID: 15369820) Martras S … Parés X (Archives of biochemistry and biophysics 2004) 3 4 23

Products for ADH7 Gene

Sources for ADH7 Gene