Aliases for ADH7 Gene
External Ids for ADH7 Gene
Previous GeneCards Identifiers for ADH7 Gene
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for ADH7 Gene
ADH7 (Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide) is a Protein Coding gene. Diseases associated with ADH7 include Atrophic Gastritis and Alcohol Dependence. Among its related pathways are Cytochrome P450 - arranged by substrate type and Cyclophosphamide Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and retinol binding. An important paralog of this gene is ADH1A.
UniProtKB/Swiss-Prot Summary for ADH7 Gene
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
Dehydrogenases are enzymes that catalyze reduction reactions through the transfer of hydrogen ions (protons) from the substrate to an acceptor or co-enzyme. Co-enzymes are small organic molecules involved in enzyme catalysis, such as nicotinamide adenine dinucleotide (NAD+ or NADH), nicotinamide adenine dinucleotide phosphate (NADP+ or NADPH), flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).