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This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
ADH6 (Alcohol Dehydrogenase 6 (Class V)) is a Protein Coding gene. Diseases associated with ADH6 include Fetal Alcohol Spectrum Disorder and Breast Intraductal Proliferative Lesion. Among its related pathways are Glucose metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004022 | alcohol dehydrogenase (NAD) activity | IEA,IDA | 1755855 |
GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IBA | 21873635 |
GO:0004745 | retinol dehydrogenase activity | IBA | 21873635 |
GO:0008270 | zinc ion binding | IEA,NAS | 1593644 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Cytochrome P450 - arranged by substrate type | ||
3 | Metabolism |
.40
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4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
5 | superpathway of tryptophan utilization |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006069 | ethanol oxidation | TAS | -- |
GO:0042572 | retinol metabolic process | IBA | 21873635 |
GO:0042573 | retinoic acid metabolic process | IBA | 21873635 |
GO:0045471 | response to ethanol | IDA | 1755855 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Enzyme, substrate | 3266 | ||
Abacavir | Approved, Investigational | Pharma | Enzyme, substrate | 231 | ||
NADH | Approved | Nutra | Enzyme, substrate, activator | 0 | ||
Chloral hydrate | Approved, Illicit, Investigational, Vet_approved | Pharma | 18 | |||
Glycerol | Approved, Investigational | Pharma | 197 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1-Hexanol |
|
111-27-3 |
|
|||
1-Pentanol |
|
71-41-0 |
|
|||
2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
2-Phenyl-1,3-propanediol monocarbamate |
|
|
||||
3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ADH6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ADH6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Adh6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ADH6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ADH6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ADH6 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Adh6a 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | ADH6 30 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487939 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:77938 31 |
|
ManyToMany | |
adh8a 31 |
|
ManyToMany | |||
zgc:63568 31 |
|
ManyToMany | |||
adh8b 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Fdh 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 31 |
|
ManyToMany | |
Y50D4C.2 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 31 |
|
OneToMany | |
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.80 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs28720152 | - | p.Cys102Gly | |||
rs28720153 | - | p.Ile114Val | |||
rs34582580 | - | p.Thr151Pro |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5345n100 | CNV | gain | 25217958 |
nsv1002574 | CNV | loss | 25217958 |
nsv1002927 | CNV | gain | 25217958 |
nsv1128084 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fetal alcohol spectrum disorder |
|
|
breast intraductal proliferative lesion |
|
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proliferative type fibrocystic change of breast |
|
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drug dependence |
|
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alcohol dependence |
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