ADH6 Gene (Protein Coding)

Alcohol Dehydrogenase 6 (Class V)

GC04M099202
GIFtS:
41
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response ele... See more...

Aliases for ADH6 Gene

Aliases for ADH6 Gene

  • Alcohol Dehydrogenase 6 (Class V) 2 3 5
  • Alcohol Dehydrogenase 6 3 4
  • EC 1.1.1.1 4 52
  • Aldehyde Reductase 3
  • EC 1.1.1 52
  • ADH-5 3

External Ids for ADH6 Gene

Previous GeneCards Identifiers for ADH6 Gene

  • GC04M100373
  • GC04M100516
  • GC04M100584
  • GC04M100480
  • GC04M100123
  • GC04M095861

Summaries for ADH6 Gene

Entrez Gene Summary for ADH6 Gene

  • This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH6 Gene

ADH6 (Alcohol Dehydrogenase 6 (Class V)) is a Protein Coding gene. Diseases associated with ADH6 include Fetal Alcohol Spectrum Disorder and Breast Intraductal Proliferative Lesion. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1A.

Gene Wiki entry for ADH6 Gene

Additional gene information for ADH6 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADH6 Gene

Genomics for ADH6 Gene

GeneHancer (GH) Regulatory Elements for ADH6 Gene

Promoters and enhancers for ADH6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADH6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADH6

Top Transcription factor binding sites by QIAGEN in the ADH6 gene promoter:
  • AML1a
  • Hlf
  • Lmo2
  • LyF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • TBP
  • TFIID

Genomic Locations for ADH6 Gene

Genomic Locations for ADH6 Gene
chr4:99,202,638-99,219,537
(GRCh38/hg38)
Size:
16,900 bases
Orientation:
Minus strand
chr4:100,123,795-100,140,694
(GRCh37/hg19)
Size:
16,900 bases
Orientation:
Minus strand

Genomic View for ADH6 Gene

Genes around ADH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADH6 Gene

Proteins for ADH6 Gene

Products:

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  • Protein details for ADH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28332-ADH6_HUMAN
    Recommended name:
    Alcohol dehydrogenase 6
    Protein Accession:
    P28332
    Secondary Accessions:
    • A0A0A0MS56
    • B3KS45
    • Q58F53

    Protein attributes for ADH6 Gene

    Size:
    368 amino acids
    Molecular mass:
    39073 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Alternative splice isoforms for ADH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH6 Gene

Protein Expression for ADH6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ADH6 Gene

P28332:
  • EVAPPKA
  • RFTCKGK
  • CAVFGLGGVGLS
  • EEVEVAPP
  • AKVTPGS
  • KPIQEVL
  • DPLITHTL
  • LGHEGAGIVES
  • VMGCKAAGA
  • KGSVFGG
  • PLEKVCL

Post-translational modifications for ADH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADH6 Gene

Gene Families for ADH6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADH6 Gene

Blocks:
  • Zinc-containing alcohol dehydrogenase
  • Alcohol dehydrogenase GroES-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADH6 Gene

GenScript: Design optimal peptide antigens:
  • Alcohol dehydrogenase 6 (ADH6_HUMAN)
  • cDNA, FLJ79225, highly similar to Alcohol dehydrogenase 6 (EC 1.1.1.1) (B7ZAL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28332

UniProtKB/Swiss-Prot:

ADH6_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
genes like me logo Genes that share domains with ADH6: view

Function for ADH6 Gene

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Molecular function for ADH6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;.

Enzyme Numbers (IUBMB) for ADH6 Gene

Phenotypes From GWAS Catalog for ADH6 Gene

Gene Ontology (GO) - Molecular Function for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 1755855
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IBA 21873635
GO:0004745 retinol dehydrogenase activity IBA 21873635
GO:0008270 zinc ion binding NAS,IEA 1593644
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ADH6: view
genes like me logo Genes that share phenotypes with ADH6: view

Animal Model Products

CRISPR Products

miRNA for ADH6 Gene

miRTarBase miRNAs that target ADH6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH6 Gene

Localization for ADH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH6 gene
Compartment Confidence
cytosol 4
plasma membrane 2
mitochondrion 2
peroxisome 2
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ADH6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH6 Gene

Pathways & Interactions for ADH6 Gene

genes like me logo Genes that share pathways with ADH6: view

Gene Ontology (GO) - Biological Process for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0042572 retinol metabolic process IBA 21873635
GO:0042573 retinoic acid metabolic process IBA 21873635
GO:0045471 response to ethanol IDA 1755855
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH6: view

No data available for SIGNOR curated interactions for ADH6 Gene

Drugs & Compounds for ADH6 Gene

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  1. Drug

(15) Drugs for ADH6 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme, substrate 3220
Abacavir Approved, Investigational Pharma Enzyme, substrate 231
NADH Approved Nutra Enzyme, substrate, activator 0
Chloral hydrate Approved, Illicit, Investigational, Vet_approved Pharma 17
Glycerol Approved, Investigational Pharma 208

(18) Additional Compounds for ADH6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
 111-27-3
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
 71-41-0
2,2,2-Trichloroethanol
  • 2,2,2-trichloro-1-Ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-trichloro-Ethanol
 115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxymandelic aldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • alpha,3,4-Trihydroxybenzeneacetaldehyde
  • alpha,3,4-Trihydroxyphenylacetaldehyde
 13023-73-9
genes like me logo Genes that share compounds with ADH6: view

Transcripts for ADH6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADH6 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for ADH6 Gene

GeneLoc Exon Structure for
ADH6

Expression for ADH6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADH6 Gene

mRNA expression in normal human tissues for ADH6 Gene
mRNA expression by BioGPS for ADH6 GenemRNA expression by GTEx for ADH6 Gene

mRNA differential expression in normal tissues according to GTEx for ADH6 Gene

This gene is overexpressed in Liver (x41.0).

Protein differential expression in normal tissues from HIPED for ADH6 Gene

This gene is overexpressed in Liver (36.4) and Liver, secretome (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADH6

SOURCE GeneReport for Unigene cluster for ADH6 Gene:

Hs.586161

mRNA Expression by UniProt/SwissProt for ADH6 Gene:

P28332-ADH6_HUMAN
Tissue specificity: Stomach and liver.

Evidence on tissue expression from TISSUES for ADH6 Gene

  • Liver(4.8)
  • Intestine(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ADH6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH6 Gene

Orthologs for ADH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ADH6 31 30
  • 99.82 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ADH6 31 30
  • 84.58 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Adh6 30
  • 74.4 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ADH6 31
  • 62 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ADH6 31
  • 59 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ADH6 31
  • 57 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Adh6a 31
  • 55 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves ADH6 31 30
  • 64.71 (n)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 61 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487939 30
  • 62.47 (n)
zebrafish
(Danio rerio)
 Actinopterygii zgc:77938 31
  • 53 (a)
 ManyToMany
adh8a 31
  • 52 (a)
 ManyToMany
zgc:63568 31
  • 51 (a)
 ManyToMany
adh8b 31
  • 49 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Fdh 31
  • 50 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea H24K24.3 31
  • 47 (a)
 ManyToMany
Y50D4C.2 31
  • 30 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SFA1 31
  • 42 (a)
 OneToMany
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.80 30
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1497 31
  • 51 (a)
 OneToMany
Species where no ortholog for ADH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH6 Gene

ENSEMBL:
Gene Tree for ADH6 (if available)
TreeFam:
Gene Tree for ADH6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADH6: view image

Paralogs for ADH6 Gene

Paralogs for ADH6 Gene

(7) SIMAP similar genes for ADH6 Gene using alignment to 7 proteins:

  • ADH6_HUMAN
  • B7ZAL1_HUMAN
  • D6RDN5_HUMAN
  • D6RH17_HUMAN
  • E9PBI1_HUMAN
  • H0Y8U2_HUMAN
  • L8E8M5_HUMAN

Pseudogenes.org Pseudogenes for ADH6 Gene

genes like me logo Genes that share paralogs with ADH6: view

Variants for ADH6 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADH6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs28720152 - p.Cys102Gly
rs28720153 - p.Ile114Val
rs34582580 - p.Thr151Pro

Additional dbSNP identifiers (rs#s) for ADH6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADH6 Gene

Variant ID Type Subtype PubMed ID
dgv5345n100 CNV gain 25217958
nsv1002574 CNV loss 25217958
nsv1002927 CNV gain 25217958
nsv1128084 CNV deletion 24896259

Variation tolerance for ADH6 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH6 Gene

Disorders for ADH6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADH6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fetal alcohol spectrum disorder
  • fetal alcohol syndrome
breast intraductal proliferative lesion
  • intraductal proliferative lesion
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
drug dependence
alcohol dependence
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards
Search ADH6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADH6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH6 Gene

Publications for ADH6 Gene

  1. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. (PMID: 1881901) Yasunami M … Yoshida A (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23 54
  2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X … Gelernter J (American journal of human genetics 2006) 3 23 41 54
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41 54
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41 54
  5. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 41 54

ExternalLinks

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