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This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain pr... See more...
Aliases for ADH5 Gene
Aliases for ADH5 Gene
- Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
- ADHX 2 3 4
- Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
- S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
- Alcohol Dehydrogenase Class Chi Chain 3 4
- Alcohol Dehydrogenase Class-III 3 4
- S-Nitrosoglutathione Reductase 2 3
- Alcohol Dehydrogenase Class-3 3 4
- Formaldehyde Dehydrogenase 2 3
- EC 1.1.1.1 4 51
- GSH-FDH 3 4
- ADH-3 2 3
External Ids for ADH5 Gene
- HGNC: 253
- NCBI Entrez Gene: 128
- Ensembl: ENSG00000197894
- OMIM®: 103710
- UniProtKB/Swiss-Prot: P11766
Previous HGNC Symbols for ADH5 Gene
- FDH
Previous GeneCards Identifiers for ADH5 Gene
- GC04M100238
- GC04M100385
- GC04M100454
- GC04M100459
- GC04M100349
- GC04M099992
- GC04M095730
Summaries for ADH5 Gene
-
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ADH5 Gene
ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Amed Syndrome, Digenic and Methanol Poisoning. Among its related pathways are Drug metabolism - cytochrome P450 and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.
UniProtKB/Swiss-Prot Summary for ADH5 Gene
-
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).
Additional gene information for ADH5 Gene
- HGNC (253)
- NCBI Entrez Gene (128)
- Ensembl (ENSG00000197894)
- OMIM® (103710)
- UniProtKB/Swiss-Prot (P11766)
- Open Targets Platform(ENSG00000197894)
- Search for ADH5 at DataMed
- Search for ADH5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADH5 Gene
Genomics for ADH5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADH5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADH5
- Top Transcription factor binding sites by QIAGEN in the ADH5 gene promoter:
-
- aMEF-2
- AP-4
- ARP-1
- MEF-2
- MEF-2A
- MRF-2
- S8
- SREBP-1c
Genomic Locations for ADH5 Gene
Latest Assembly
- chr4:99,070,978-99,088,801
- (GRCh38/hg38)
- Size:
- 17,824 bases
- Orientation:
- Minus strand
Previous Assembly
- chr4:99,992,129-100,009,939
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 17,811 bases
- Orientation:
- Minus strand
- chr4:99,992,132-100,009,952
- (GRCh37/hg19 by Ensembl)
- Size:
- 17,821 bases
- Orientation:
- Minus strand
Genomic View for ADH5 Gene
Genes around ADH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by HGNC
- 4q23 by Entrez Gene
- 4q23 by Ensembl
ADH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH5 Gene
Proteins for ADH5 Gene
-
Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11766-ADHX_HUMAN
- Recommended name:
- Alcohol dehydrogenase class-3
- Protein Accession:
- P11766
- Q6FHR2
Protein attributes for ADH5 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 39724 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Protein Expression for ADH5 Gene
Selected DME Specific Peptides for ADH5 Gene
- P11766:
-
- EVAPPKA
- ESVGEGVT
- RFTCKGK
- GVDYSFE
- PVILGHE
- TFSEYTV
- AGASRII
- GATECINP
- WEAGKPL
- KPIQEVL
- EMTDGGV
- LGHEGAGIVES
- APLDKVC
- DINKDKF
- GIVESVG
Post-translational modifications for ADH5 Gene
Other Protein References for ADH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ADH5 Antibody
- G Biosciences Immunotag™ ADH5 Antibody
- Novus Biologicals Antibodies for ADH5
-
Abcam antibodies for ADH5
- Invitrogen Antibodies for ADH5 (AFLGC-ADH5)
-
Boster Bio Antibodies for ADH5
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH5
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH5
- Origene Custom Protein Services for ADH5
- ProSpec Recombinant Proteins for ADH5
-
Abcam proteins for ADH5
Assay products for research
- antibodies-online: Show 6 available ADH5 Elisa Kits ranked by validation data
- Compare Top ADH5 Elisa Kits
-
Quality Products:
Domains & Families for ADH5 Gene
Gene Families for ADH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH5 Gene
- InterPro:
- Blocks:
-
- Alcohol dehydrogenase GroES-like
- Zinc-containing alcohol dehydrogenase
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH5 Gene
- GenScript: Design optimal peptide antigens:
-
- S-(hydroxymethyl)glutathione dehydrogenase (ADHX_HUMAN)
- ADH5 protein (Q6FI45_HUMAN)
- cDNA, FLJ92689, highly similar to Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide(ADH5), mRNA (Q6IRT1_HUMAN)
- Alcohol dehydrogenase 5 (Q9H1A0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P11766UniProtKB/Swiss-Prot:
ADHX_HUMAN :- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Function for ADH5 Gene
Molecular function for ADH5 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:8460164};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:8460164};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione; Xref=Rhea:RHEA:19981, ChEBI:CHEBI:15378, ChEBI:CHEBI:57688, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence={ECO:0000269|PubMed:8460164};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione; Xref=Rhea:RHEA:19985, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57688, ChEBI:CHEBI:57945, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence={ECO:0000269|PubMed:8460164};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39803, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence={ECO:0000269|PubMed:16081420};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:39799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence={ECO:0000269|PubMed:16081420};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=21 uM for 20-HETE {ECO:0000269|PubMed:16081420};
- GENATLAS Biochemistry:
- alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
Enzyme Numbers (IUBMB) for ADH5 Gene
Phenotypes From GWAS Catalog for ADH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004022 | alcohol dehydrogenase (NAD) activity | IEA | -- |
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IBA | 21873635 |
| GO:0005504 | fatty acid binding | IDA | 8460164 |
| GO:0008270 | zinc ion binding | IEA,IDA | 6375718 |
| GO:0009055 | electron transfer activity | TAS | 8460164 |
Phenotypes for ADH5 Gene
- MGI mutant phenotypes for ADH5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ADH5:
Animal Models for ADH5 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for ADH5
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADH5 - Starting at $85 >
- * ADH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
miRNA for ADH5 Gene
- miRTarBase miRNAs that target ADH5
-
- mmu-miR-301b-3p (MIRT007812)
- hsa-miR-155-5p (MIRT020534)
- hsa-miR-106b-5p (MIRT044260)
- hsa-miR-218-5p (MIRT441262)
- hsa-miR-4709-3p (MIRT447186)
- hsa-miR-4722-5p (MIRT447187)
- hsa-miR-1286 (MIRT447188)
- hsa-miR-4635 (MIRT447189)
- hsa-miR-873-5p (MIRT447190)
- hsa-miR-5197-5p (MIRT447191)
- hsa-miR-6510-3p (MIRT450281)
- hsa-miR-4668-5p (MIRT450282)
- hsa-miR-549a (MIRT450283)
- hsa-miR-372-5p (MIRT450284)
- hsa-miR-371a-5p (MIRT450285)
- hsa-miR-616-5p (MIRT450286)
- hsa-miR-373-5p (MIRT450287)
- hsa-miR-371b-5p (MIRT450288)
- hsa-miR-3613-3p (MIRT450289)
- hsa-miR-8087 (MIRT450290)
- hsa-miR-7161-5p (MIRT450291)
- hsa-miR-548u (MIRT450292)
- hsa-miR-4715-3p (MIRT540628)
- hsa-miR-5589-3p (MIRT540629)
- hsa-miR-6715b-5p (MIRT540630)
- hsa-miR-6872-3p (MIRT540631)
- hsa-miR-4269 (MIRT540632)
- hsa-miR-5582-5p (MIRT540633)
- hsa-miR-4777-5p (MIRT620609)
- hsa-miR-526a (MIRT620610)
- hsa-miR-523-5p (MIRT620611)
- hsa-miR-522-5p (MIRT620612)
- hsa-miR-520c-5p (MIRT620613)
- hsa-miR-519c-5p (MIRT620614)
- hsa-miR-519b-5p (MIRT620615)
- hsa-miR-519a-5p (MIRT620616)
- hsa-miR-518f-5p (MIRT620617)
- hsa-miR-518e-5p (MIRT620618)
- hsa-miR-518d-5p (MIRT620619)
- hsa-miR-6088 (MIRT620620)
- hsa-miR-4770 (MIRT620621)
- hsa-miR-143-3p (MIRT620622)
- hsa-miR-520g-5p (MIRT620623)
- hsa-miR-4282 (MIRT664422)
- hsa-miR-6516-5p (MIRT695398)
- hsa-miR-455-3p (MIRT695399)
- hsa-miR-1227-3p (MIRT695400)
- hsa-miR-4451 (MIRT695401)
- hsa-miR-6799-5p (MIRT695402)
- hsa-miR-4252 (MIRT695403)
- hsa-miR-6499-3p (MIRT695404)
- hsa-miR-6086 (MIRT695405)
- hsa-miR-377-5p (MIRT695406)
- hsa-miR-98-5p (MIRT695407)
- hsa-miR-4500 (MIRT695408)
- hsa-miR-4458 (MIRT695409)
- hsa-let-7i-5p (MIRT695410)
- hsa-let-7g-5p (MIRT695411)
- hsa-let-7f-5p (MIRT695412)
- hsa-let-7e-5p (MIRT695413)
- hsa-let-7d-5p (MIRT695414)
- hsa-let-7c-5p (MIRT695415)
- hsa-let-7b-5p (MIRT695416)
- hsa-let-7a-5p (MIRT695417)
- hsa-miR-4487 (MIRT695418)
- hsa-miR-558 (MIRT695419)
- hsa-miR-3160-3p (MIRT695420)
- hsa-miR-1247-3p (MIRT695421)
- hsa-miR-6831-5p (MIRT695422)
- hsa-miR-3927-3p (MIRT695423)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
Clone products for research
- Applied Biological Materials (abm): Clones for ADH5 - Starting at $45 >
- * ADH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
Cell Lines for research
-
Horizon Cell Lines for ADH5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene
Localization for ADH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH5 Gene
Pathways & Interactions for ADH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Carbon metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Cyclophosphamide Pathway, Pharmacodynamics | ||
Pathways by source for ADH5 Gene
3 BioSystems pathways for ADH5 Gene
4 Reactome pathways for ADH5 Gene
2 PharmGKB pathways for ADH5 Gene
9 KEGG pathways for ADH5 Gene
1 GeneGo (Thomson Reuters) pathway for ADH5 Gene
- Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
Interacting Proteins for ADH5 Gene
GPS-Prot Interaction Network for ADH5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0006069 | ethanol oxidation | TAS | -- |
| GO:0010430 | fatty acid omega-oxidation | IDA | 16081420 |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | IEA | -- |
No data available for SIGNOR curated interactions for ADH5 Gene
Drugs & Compounds for ADH5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme, substrate | 3481 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| lauric acid | Approved, Experimental | Pharma | Target | 0 | ||
| Zinc | Approved, Investigational | Pharma | 1687 | |||
| Vitamin A | Approved, Vet_approved | Nutra | 732 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (2-Naphthyl)methanol |
|
|
||||
| 1-Hydroxymethylnaphthalene |
|
|
||||
| 1-Naphthaldehyde |
|
|
||||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
| 2-Naphthaldehyde |
|
|
(2) ApexBio Compounds for ADH5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Isovaleramide | 541-46-8 | |
| N6022 | GSNOR inhibitor | 1208315-24-5 |
Transcripts for ADH5 Gene
mRNA/cDNA for ADH5 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296412 2594 nts (view in UCSC)
- ENST00000502386 545 nts (view in UCSC)
- ENST00000502590 697 nts (view in UCSC)
- ENST00000503130 786 nts (view in UCSC)
- ENST00000505652 623 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADH5 - Starting at $85 >
- * ADH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
Clone products for research
- Applied Biological Materials (abm): Clones for ADH5 - Starting at $45 >
- * ADH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
Relevant External Links for ADH5 Gene
- GeneLoc Exon Structure for
- ADH5
Expression for ADH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADH5
SOURCE GeneReport for Unigene cluster for ADH5 Gene:
Hs.78989Evidence on tissue expression from TISSUES for ADH5 Gene
- Nervous system(4.8)
- Liver(4.8)
- Kidney(3.4)
- Skin(3.4)
- Heart(3.1)
- Lung(3)
- Muscle(2.8)
- Intestine(2.8)
- Eye(2.6)
- Blood(2.5)
- Stomach(2.4)
- Spleen(2.2)
- Thyroid gland(2.2)
Primer products for research
-
OriGene qPCR primer pairs for ADH5
-
OriGene qPCR primer pairs and template standards for ADH5
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH5 Gene
Orthologs for ADH5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADH5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| ADH5 30 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | ADH5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adh5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adh5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ADH5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ADH5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADH5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adh5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adh5 30 |
|
||
| zgc:77938 31 |
|
ManyToMany | |||
| zgc:63568 31 |
|
ManyToMany | |||
| adh8a 31 |
|
ManyToMany | |||
| adh8b 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010499 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Fdh 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | H24K24.3a 32 |
|
|
|
| H24K24.3b 32 |
|
|
|||
| H24K24.3 30 31 |
|
ManyToMany | |||
| Y50D4C.2 31 32 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12342g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACL148C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HOT5 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0815500 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2516 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.2742 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC13B11.04c 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06652 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14208 30 |
|
- Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADH5 Gene
- ENSEMBL:
- Gene Tree for ADH5 (if available)
- TreeFam:
- Gene Tree for ADH5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH5: view image
Paralogs for ADH5 Gene
Paralogs for ADH5 Gene
(6) SIMAP similar genes for ADH5 Gene using alignment to 9 proteins:
- ADHX_HUMAN
- D6R9G2_HUMAN
- D6RAY0_HUMAN
- D6RD54_HUMAN
- D6RFE4_HUMAN
- H0YAG8_HUMAN
- Q6FI45_HUMAN
- Q6IRT1_HUMAN
- Q9H1A0_HUMAN
Pseudogenes.org Pseudogenes for ADH5 Gene
Variants for ADH5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADH5 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 995825 | Pathogenic: AMED SYNDROME, DIGENIC | 99,072,706(-) |
TC/T NM_000671.4(ADH5):c.966del (p.Gly321_Trp322insTer) |
NONSENSE | |
| 995826 | Pathogenic: AMED SYNDROME, DIGENIC | 99,076,703(-) |
C/T NM_000671.4(ADH5):c.564+1G>A |
SPLICE_DONOR | |
| 995827 | Pathogenic: AMED SYNDROME, DIGENIC | 99,075,043(-) |
C/G NM_000671.4(ADH5):c.832G>C (p.Ala278Pro) |
MISSENSE | |
| rs16996593 | - |
p.Asp353Glu |
|||
| rs28730623 | - |
p.Leu163Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1002927 | CNV | gain | 25217958 |
| nsv1136894 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.61;
30.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene
Disorders for ADH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amed syndrome, digenic |
|
|
| methanol poisoning |
|
|
| proliferative type fibrocystic change of breast |
|
|
| focal dermal hypoplasia |
|
|
| alcohol dependence |
|
|
Search ADH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene
Publications for ADH5 Gene
- Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur MW … Edenberg HJ (Gene 1992) 2 3 4 23
- Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H … London SJ (The Journal of allergy and clinical immunology 2007) 3 23 41
- Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang ZN … Hurley TD (Journal of molecular biology 1997) 3 4 23
- Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B … Vallee BL (Biochemistry 1993) 3 4 23
- Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K … Vallee BL (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 23
ExternalLinks
Products for ADH5 Gene
- Custom Antibody ServicesOriGene Antibodies for ADH5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH5
- Origene Custom Protein Services for ADH5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- OriGene qPCR primer pairs for ADH5
- OriGene qPCR primer pairs and template standards for ADH5
- OriGene CRISPR knockouts for ADH5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADH5
- Sino Biological Human cDNA Clone for ADH5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ADH5
- Novus Biologicals proteins and lysates for ADH5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for ADH5
- Abcam proteins for ADH5
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for ADH5
- Taconic Biosciences Mouse Models for ADH5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ADH5 (AFLGC-ADH5)
- ApexBio compounds for ADH5
- VectorBuilder Custom and pre-made DNA vectors for ADH5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ADH5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ADH5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ADH5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ADH5
- antibodies-online: Show 33 available ADH5 Antibodies ranked by validation data
- Compare Top ADH5 Antibodies
- antibodies-online: Show 6 available ADH5 Elisa Kits ranked by validation data
- Compare Top ADH5 Elisa Kits
- Quality Products:
- antibodies-online: Show 31 available ADH5 Proteins ranked by validation data
- Compare Top ADH5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ADH5
- Search Santa Cruz Biotechnology (SCBT) for ADH5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
- Horizon Cell Lines for ADH5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- Boster Bio Antibodies for ADH5
- Browse Boster Bio ELISA Kits
Sources for ADH5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB