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Aliases for ADH5 Gene

Aliases for ADH5 Gene

  • Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
  • Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
  • S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
  • Alcohol Dehydrogenase Class Chi Chain 3 4
  • Alcohol Dehydrogenase Class-III 3 4
  • S-Nitrosoglutathione Reductase 2 3
  • Formaldehyde Dehydrogenase 2 3
  • EC 4 56
  • GSH-FDH 3 4
  • FALDH 3 4
  • ADHX 3 4
  • FDH 3 4
  • Alcohol Dehydrogenase (Class III), Chi Polypeptide 3
  • Epididymis Secretory Sperm Binding Protein Li 60p 3
  • Alcohol Dehydrogenase Class-3 3
  • Alcohol Dehydrogenase 5 4
  • EC 4
  • EC 1.1.1.- 4
  • HEL-S-60p 3
  • EC 1.1.1 56
  • ADH-3 3
  • GSNOR 3

External Ids for ADH5 Gene

Previous HGNC Symbols for ADH5 Gene

  • FDH

Previous GeneCards Identifiers for ADH5 Gene

  • GC04M100238
  • GC04M100385
  • GC04M100454
  • GC04M100459
  • GC04M100349
  • GC04M099992
  • GC04M095730

Summaries for ADH5 Gene

Entrez Gene Summary for ADH5 Gene

  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ADH5 Gene

ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Methanol Poisoning and Pharyngitis. Among its related pathways are Phenylalanine metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.

UniProtKB/Swiss-Prot for ADH5 Gene

  • Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Gene Wiki entry for ADH5 Gene

Additional gene information for ADH5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene

Genomics for ADH5 Gene

GeneHancer (GH) Regulatory Elements for ADH5 Gene

Promoters and enhancers for ADH5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I099086 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.4 -0.5 -480 6.5 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ADH5 LOC100507053 ENSG00000272777 ADH4 PIR42405
GH04I098994 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 11.1 +91.9 91913 5.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B METAP1 MIR3684 ENSG00000272777 LOC100507053 EIF4E ADH5 RNU7-149P ADH1A ADH4 ENSG00000263923
GH04I099143 Promoter/Enhancer 1.3 EPDnew ENCODE 12.6 -55.6 -55567 1.5 ELF3 FOXA2 RAD21 YY1 CREM THAP11 HMG20B RXRA CEBPB ELF1 ADH4 LOC100507053 ADH5 ADH1A ADH6 PIR42405
GH04I099402 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -315.7 -315661 3.6 PKNOX1 FOXA2 ARID4B DMAP1 IRF4 YY1 ARID2 ZNF207 ZNF143 ATF7 LOC102723576 ADH4 ADH6 LOC100507053 PCNAP1 ADH5 ADH1A ADH1B ADH1C
GH04I099352 Promoter/Enhancer 1 EPDnew ENCODE 5.7 -264.4 -264413 1.2 RXRA TAF1 MAX RAD21 ADH1C ADH1B ADH1A ADH5 LOC102723576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADH5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADH5 gene promoter:

Genomic Locations for ADH5 Gene

Genomic Locations for ADH5 Gene
17,824 bases
Minus strand

Genomic View for ADH5 Gene

Genes around ADH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH5 Gene

Proteins for ADH5 Gene

  • Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alcohol dehydrogenase class-3
    Protein Accession:
    Secondary Accessions:
    • Q6FHR2

    Protein attributes for ADH5 Gene

    374 amino acids
    Molecular mass:
    39724 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH5 Gene

neXtProt entry for ADH5 Gene

Selected DME Specific Peptides for ADH5 Gene


Post-translational modifications for ADH5 Gene

  • Ubiquitination at posLast=101101, Lys113, posLast=228228, Lys233, posLast=323323, and posLast=366366
  • Modification sites at PhosphoSitePlus

Other Protein References for ADH5 Gene

Domains & Families for ADH5 Gene

Gene Families for ADH5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
genes like me logo Genes that share domains with ADH5: view

Function for ADH5 Gene

Molecular function for ADH5 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity:
A primary alcohol + NAD(+) = an aldehyde + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
A secondary alcohol + NAD(+) = a ketone + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Enzyme Numbers (IUBMB) for ADH5 Gene

Phenotypes From GWAS Catalog for ADH5 Gene

Gene Ontology (GO) - Molecular Function for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IEA --
GO:0005504 fatty acid binding IDA 8460164
GO:0008270 zinc ion binding IEA,IDA 6375718
GO:0009055 electron transfer activity TAS 8460164
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ADH5: view
genes like me logo Genes that share phenotypes with ADH5: view

Animal Models for ADH5 Gene

MGI Knock Outs for ADH5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADH5

CRISPR Products

miRNA for ADH5 Gene

miRTarBase miRNAs that target ADH5

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene

Localization for ADH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH5 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with ADH5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH5 Gene

Pathways & Interactions for ADH5 Gene

genes like me logo Genes that share pathways with ADH5: view

Gene Ontology (GO) - Biological Process for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA --
GO:0003016 respiratory system process IEA --
GO:0006069 ethanol oxidation TAS --
GO:0018119 peptidyl-cysteine S-nitrosylation IEA --
GO:0022900 electron transport chain IEA --
genes like me logo Genes that share ontologies with ADH5: view

No data available for SIGNOR curated interactions for ADH5 Gene

Drugs & Compounds for ADH5 Gene

(23) Drugs for ADH5 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 2326
NADH Approved Nutra Target, Enzyme, substrate 0
lauric acid Approved, Experimental Pharma Agonist, Target 0
Zinc Approved, Investigational Pharma 2430
Vitamin A Approved, Vet_approved Nutra 529

(43) Additional Compounds for ADH5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol

(2) ApexBio Compounds for ADH5 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with ADH5: view

Drug Products

Transcripts for ADH5 Gene

Unigene Clusters for ADH5 Gene

Alcohol dehydrogenase 5 (class III), chi polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH5 Gene

No ASD Table

Relevant External Links for ADH5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADH5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene

Protein tissue co-expression partners for ADH5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADH5 Gene:


SOURCE GeneReport for Unigene cluster for ADH5 Gene:


Evidence on tissue expression from TISSUES for ADH5 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Kidney(3.1)
  • Lung(2.9)
  • Skin(2.6)
  • Eye(2.3)
  • Blood(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with ADH5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH5 Gene

Orthologs for ADH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADH5 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
ADH5 34 33
  • 92.6 (n)
-- 34
  • 74 (a)
(Bos Taurus)
Mammalia ADH5 33 34
  • 90.82 (n)
(Mus musculus)
Mammalia Adh5 33 16 34
  • 88.59 (n)
(Rattus norvegicus)
Mammalia Adh5 33
  • 88.24 (n)
(Monodelphis domestica)
Mammalia ADH5 34
  • 83 (a)
(Gallus gallus)
Aves ADH5 33 34
  • 79.41 (n)
(Anolis carolinensis)
Reptilia ADH5 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adh5 33
  • 76.7 (n)
(Danio rerio)
Actinopterygii adh5 33
  • 73.14 (n)
zgc:77938 34
  • 63 (a)
zgc:63568 34
  • 62 (a)
adh8a 34
  • 61 (a)
adh8b 34
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010499 33
  • 66.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fdh 35 33 34
  • 66.22 (n)
(Caenorhabditis elegans)
Secernentea H24K24.3a 35
  • 69 (a)
H24K24.3b 35
  • 68 (a)
Y50D4C.2 35 34
  • 67 (a)
H24K24.3 33 34
  • 64.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 33 34 36
  • 61.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12342g 33
  • 61.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL148C 33
  • 58.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HOT5 33
  • 64.77 (n)
(Oryza sativa)
Liliopsida Os02g0815500 33
  • 63.87 (n)
(Hordeum vulgare)
Liliopsida Hv.2516 33
(Zea mays)
Liliopsida Zm.2742 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 34
  • 71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC13B11.04c 33
  • 61.84 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06652 33
  • 59.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14208 33
Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH5 Gene

Gene Tree for ADH5 (if available)
Gene Tree for ADH5 (if available)

Paralogs for ADH5 Gene

Paralogs for ADH5 Gene

genes like me logo Genes that share paralogs with ADH5: view

Variants for ADH5 Gene

Sequence variations from dbSNP and Humsavar for ADH5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000110361 -- 99,083,370(-) C/T intron_variant
rs1000272646 -- 99,088,927(-) C/G upstream_transcript_variant
rs1000646028 -- 99,088,821(-) T/C upstream_transcript_variant
rs1000838146 -- 99,078,841(-) G/A intron_variant
rs1000876694 -- 99,078,181(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADH5 Gene

Variant ID Type Subtype PubMed ID
nsv1002927 CNV gain 25217958
nsv1136894 CNV deletion 24896259

Variation tolerance for ADH5 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene

Disorders for ADH5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADH5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
methanol poisoning
  • acute sore throat
alcohol dependence
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards
Search ADH5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADH5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene

Publications for ADH5 Gene

  1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur MW … Edenberg HJ (Gene 1992) 2 3 4 22 58
  2. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H … London SJ (The Journal of allergy and clinical immunology 2007) 3 22 44 58
  3. Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang ZN … Hurley TD (Journal of molecular biology 1997) 3 4 22 58
  4. Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K … Vallee BL (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
  5. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B … Vallee BL (Biochemistry 1993) 3 4 22 58

Products for ADH5 Gene

Sources for ADH5 Gene

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