Aliases for ADH5 Gene
Aliases for ADH5 Gene
- Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
- Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
- S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
- Alcohol Dehydrogenase Class Chi Chain 3 4
- Alcohol Dehydrogenase Class-III 3 4
- S-Nitrosoglutathione Reductase 2 3
- Formaldehyde Dehydrogenase 2 3
- GSH-FDH 3 4
- FALDH 3 4
- ADHX 3 4
- FDH 3 4
External Ids for ADH5 Gene
- HGNC: 253
- Entrez Gene: 128
- Ensembl: ENSG00000197894
- OMIM: 103710
- UniProtKB: P11766
Previous HGNC Symbols for ADH5 Gene
- FDH
Previous GeneCards Identifiers for ADH5 Gene
- GC04M100238
- GC04M100385
- GC04M100454
- GC04M100459
- GC04M100349
- GC04M099992
- GC04M095730
Summaries for ADH5 Gene
-
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ADH5 Gene
ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Methanol Poisoning and Pharyngitis. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.
UniProtKB/Swiss-Prot for ADH5 Gene
-
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene
Genomics for ADH5 Gene
GeneHancer (GH) Regulatory Elements for ADH5 Gene
Promoters and enhancers for ADH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADH5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADH5 Gene
Genomic Locations for ADH5 Gene
- chr4:99,070,978-99,088,801
- (GRCh38/hg38)
- Size:
- 17,824 bases
- Orientation:
- Minus strand
- chr4:99,992,129-100,009,952
- (GRCh37/hg19)
Genomic View for ADH5 Gene
Genes around ADH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by Entrez Gene
- 4q23 by HGNC
- 4q23 by Ensembl
ADH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH5 Gene
Proteins for ADH5 Gene
-
Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11766-ADHX_HUMAN
- Recommended name:
- Alcohol dehydrogenase class-3
- Protein Accession:
- P11766
- Q6FHR2
Protein attributes for ADH5 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 39724 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Protein Expression for ADH5 Gene
Post-translational modifications for ADH5 Gene
Other Protein References for ADH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ADH5
- Invitrogen Antibodies for ADH5
- GeneTex ADH5 Antibody for ADH5
-
Boster Bio Antibodies for ADH5
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH5
Protein Products
-
OriGene Purified Proteins for ADH5
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH5
- Origene Custom Protein Services for ADH5
- ProSpec Recombinant Proteins for ADH5
- Search GeneTex for Proteins for ADH5
Assay Products
- antibodies-online: Search results for 4 available ADH5 Elisa Kits ranked by validation data
- Compare Top ADH5 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ADH5 Gene
Domains & Families for ADH5 Gene
Gene Families for ADH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH5 Gene
Graphical View of Domain Structure for InterPro Entry
P11766UniProtKB/Swiss-Prot:
ADHX_HUMAN :- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Function for ADH5 Gene
Molecular function for ADH5 Gene
- UniProtKB/Swiss-Prot Function:
- Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A primary alcohol + NAD(+) = an aldehyde + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A secondary alcohol + NAD(+) = a ketone + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
- GENATLAS Biochemistry:
- alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
Enzyme Numbers (IUBMB) for ADH5 Gene
Phenotypes From GWAS Catalog for ADH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004022 | alcohol dehydrogenase (NAD) activity | IEA | -- |
| GO:0005504 | fatty acid binding | IDA | 8460164 |
| GO:0008270 | zinc ion binding | IEA,IDA | 6375718 |
| GO:0009055 | electron transfer activity | TAS | 8460164 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for ADH5 Gene
- MGI mutant phenotypes for ADH5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ADH5:
Animal Models for ADH5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ADH5
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADH5
-
CRISPR Products
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- genomics-online: gRNA clones - Search results for available ADH5 gene related products
- Applied Biological Materials CRISPR for ADH5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
- GenScript: Design CRISPR guide RNA sequences for ADH5
miRNA for ADH5 Gene
- miRTarBase miRNAs that target ADH5
-
- hsa-mir-155-5p (MIRT020534)
- hsa-mir-106b-5p (MIRT044260)
- hsa-mir-218-5p (MIRT441262)
- hsa-mir-4709-3p (MIRT447186)
- hsa-mir-4722-5p (MIRT447187)
- hsa-mir-1286 (MIRT447188)
- hsa-mir-4635 (MIRT447189)
- hsa-mir-873-5p (MIRT447190)
- hsa-mir-5197-5p (MIRT447191)
- hsa-mir-6510-3p (MIRT450281)
- hsa-mir-4668-5p (MIRT450282)
- hsa-mir-549a (MIRT450283)
- hsa-mir-372-5p (MIRT450284)
- hsa-mir-371a-5p (MIRT450285)
- hsa-mir-616-5p (MIRT450286)
- hsa-mir-373-5p (MIRT450287)
- hsa-mir-371b-5p (MIRT450288)
- hsa-mir-3613-3p (MIRT450289)
- hsa-mir-8087 (MIRT450290)
- hsa-mir-7161-5p (MIRT450291)
- hsa-mir-548u (MIRT450292)
- hsa-mir-4715-3p (MIRT540628)
- hsa-mir-5589-3p (MIRT540629)
- hsa-mir-6715b-5p (MIRT540630)
- hsa-mir-6872-3p (MIRT540631)
- hsa-mir-4269 (MIRT540632)
- hsa-mir-5582-5p (MIRT540633)
- hsa-mir-4777-5p (MIRT620609)
- hsa-mir-526a (MIRT620610)
- hsa-mir-523-5p (MIRT620611)
- hsa-mir-522-5p (MIRT620612)
- hsa-mir-520c-5p (MIRT620613)
- hsa-mir-519c-5p (MIRT620614)
- hsa-mir-519b-5p (MIRT620615)
- hsa-mir-519a-5p (MIRT620616)
- hsa-mir-518f-5p (MIRT620617)
- hsa-mir-518e-5p (MIRT620618)
- hsa-mir-518d-5p (MIRT620619)
- hsa-mir-6088 (MIRT620620)
- hsa-mir-4770 (MIRT620621)
- hsa-mir-143-3p (MIRT620622)
- hsa-mir-520g-5p (MIRT620623)
- hsa-mir-4282 (MIRT664422)
- hsa-mir-6516-5p (MIRT695398)
- hsa-mir-455-3p (MIRT695399)
- hsa-mir-1227-3p (MIRT695400)
- hsa-mir-4451 (MIRT695401)
- hsa-mir-6799-5p (MIRT695402)
- hsa-mir-4252 (MIRT695403)
- hsa-mir-6499-3p (MIRT695404)
- hsa-mir-6086 (MIRT695405)
- hsa-mir-377-5p (MIRT695406)
- hsa-mir-98-5p (MIRT695407)
- hsa-mir-4500 (MIRT695408)
- hsa-mir-4458 (MIRT695409)
- hsa-let-7i-5p (MIRT695410)
- hsa-let-7g-5p (MIRT695411)
- hsa-let-7f-5p (MIRT695412)
- hsa-let-7e-5p (MIRT695413)
- hsa-let-7d-5p (MIRT695414)
- hsa-let-7c-5p (MIRT695415)
- hsa-let-7b-5p (MIRT695416)
- hsa-let-7a-5p (MIRT695417)
- hsa-mir-4487 (MIRT695418)
- hsa-mir-558 (MIRT695419)
- hsa-mir-3160-3p (MIRT695420)
- hsa-mir-1247-3p (MIRT695421)
- hsa-mir-6831-5p (MIRT695422)
- hsa-mir-3927-3p (MIRT695423)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- genomics-online: shRNA clones - Search results for available ADH5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADH5
- VectorBuilder custom plasmid, inducible vectors for ADH5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADH5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
- genomics-online: cdna clones - Search results for available ADH5 gene related products
- orf clones - Search results for available ADH5 gene related products
- Applied Biological Materials Clones for ADH5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADH5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene
Localization for ADH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH5 Gene
Pathways & Interactions for ADH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Carbon metabolism | ||
| 4 | Metabolism |
.37
|
|
| 5 | Cyclophosphamide Pathway, Pharmacodynamics | ||
Pathways by source for ADH5 Gene
3 BioSystems pathways for ADH5 Gene
4 Reactome pathways for ADH5 Gene
2 PharmGKB pathways for ADH5 Gene
9 KEGG pathways for ADH5 Gene
1 GeneGo (Thomson Reuters) pathway for ADH5 Gene
Interacting Proteins for ADH5 Gene
GPS-Prot Interaction Network for ADH5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0006069 | ethanol oxidation | TAS | -- |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | IEA | -- |
| GO:0022900 | electron transport chain | IEA | -- |
No data available for SIGNOR curated interactions for ADH5 Gene
Drugs & Compounds for ADH5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme | 2326 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| lauric acid | Approved, Experimental | Pharma | Agonist, Target | 0 | ||
| Zinc | Approved, Investigational | Pharma | 2430 | |||
| Vitamin A | Approved, Vet_approved | Nutra | 529 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| (2-Naphthyl)methanol |
|
|
||||
| 1-Hydroxymethylnaphthalene |
|
|
|
|||
| 1-Naphthaldehyde |
|
|
||||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
(2) ApexBio Compounds for ADH5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Isovaleramide | 541-46-8 | |
| N6022 | GSNOR inhibitor | 1208315-24-5 |
Transcripts for ADH5 Gene
mRNA/cDNA for ADH5 Gene
- (570) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000296412 2615 bps (uc003hui.5)
- ENST00000502386 545 bps (uc062ykd.1)
- ENST00000502590 697 bps (uc062yjx.1)
- ENST00000503130 786 bps (uc062yjw.1)
- ENST00000505652 623 bps (uc062yka.1)
Unigene Clusters for ADH5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- genomics-online: gRNA clones - Search results for available ADH5 gene related products
- Applied Biological Materials CRISPR for ADH5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
- GenScript: Design CRISPR guide RNA sequences for ADH5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- genomics-online: shRNA clones - Search results for available ADH5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADH5
- VectorBuilder custom plasmid, inducible vectors for ADH5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADH5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
- genomics-online: cdna clones - Search results for available ADH5 gene related products
- orf clones - Search results for available ADH5 gene related products
- Applied Biological Materials Clones for ADH5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADH5 Gene:
ADH5SOURCE GeneReport for Unigene cluster for ADH5 Gene:
Hs.78989Evidence on tissue expression from TISSUES for ADH5 Gene
- Liver(4.8)
- Nervous system(4.8)
- Kidney(3.1)
- Lung(2.9)
- Skin(2.6)
- Eye(2.3)
- Intestine(2.3)
- Blood(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADH5
-
OriGene qPCR primer pairs for ADH5
- genomics-online: primer clones - Search results for available ADH5 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH5 Gene
Orthologs for ADH5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADH5 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| ADH5 34 33 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ADH5 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adh5 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adh5 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADH5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADH5 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADH5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adh5 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adh5 33 33 |
|
||
| zgc:77938 34 |
|
ManyToMany | |||
| zgc:63568 34 |
|
ManyToMany | |||
| adh8a 34 |
|
ManyToMany | |||
| adh8b 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010499 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fdh 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H24K24.3a 35 |
|
|
|
| H24K24.3b 35 |
|
|
|||
| H24K24.3 34 33 |
|
ManyToMany | |||
| Y50D4C.2 34 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12342g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL148C 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HOT5 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0815500 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.2742 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2516 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 34 |
|
OneToMany | |
| Cin.14208 33 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC13B11.04c 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06652 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14208 33 |
|
- Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADH5 Gene
- ENSEMBL:
- Gene Tree for ADH5 (if available)
- TreeFam:
- Gene Tree for ADH5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH5: view image
Paralogs for ADH5 Gene
(6) SIMAP similar genes for ADH5 Gene using alignment to 9 proteins:
- ADHX_HUMAN
- D6R9G2_HUMAN
- D6RAY0_HUMAN
- D6RD54_HUMAN
- D6RFE4_HUMAN
- H0YAG8_HUMAN
- Q6FI45_HUMAN
- Q6IRT1_HUMAN
- Q9H1A0_HUMAN
Pseudogenes.org Pseudogenes for ADH5 Gene
Variants for ADH5 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000110361 | -- | 99,083,370(-) | C/T | intron_variant | |
| rs1000272646 | -- | 99,088,927(-) | C/G | upstream_transcript_variant | |
| rs1000646028 | -- | 99,088,821(-) | T/C | upstream_transcript_variant | |
| rs1000838146 | -- | 99,078,841(-) | G/A | intron_variant | |
| rs1000876694 | -- | 99,078,181(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1002927 | CNV | gain | 25217958 |
| nsv1136894 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.61;
30.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene
Disorders for ADH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| methanol poisoning |
|
|
| pharyngitis |
|
|
| alcohol dependence |
|
|
Search ADH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene
Publications for ADH5 Gene
- Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur MW … Edenberg HJ (Gene 1992) 2 3 4 22 58
- Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H … London SJ (The Journal of allergy and clinical immunology 2007) 3 22 44 58
- Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang ZN … Hurley TD (Journal of molecular biology 1997) 3 4 22 58
- Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B … Vallee BL (Biochemistry 1993) 3 4 22 58
- Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K … Vallee BL (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
Products for ADH5 Gene
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- antibodies-online: Search results for 98 available ADH5 Antibodies ranked by validation data
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- antibodies-online: Search results for 36 available ADH5 Proteins ranked by validation data
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- GeneTex ADH5 Antibody for ADH5
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- genomics-online: cdna clones - Search results for available ADH5 gene related products
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- Boster Bio Antibodies for ADH5
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Sources for ADH5 Gene
- (1) GeneCards
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- (28) ASD
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- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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