This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain pr... See more...

Aliases for ADH5 Gene

Aliases for ADH5 Gene

  • Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
  • ADHX 2 3 4
  • Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
  • S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
  • Alcohol Dehydrogenase Class Chi Chain 3 4
  • Alcohol Dehydrogenase Class-III 3 4
  • S-Nitrosoglutathione Reductase 2 3
  • Alcohol Dehydrogenase Class-3 3 4
  • Formaldehyde Dehydrogenase 2 3
  • EC 1.1.1.1 4 51
  • GSH-FDH 3 4
  • ADH-3 2 3
  • FALDH 3 4
  • GSNOR 2 3
  • FDH 3 4
  • Alcohol Dehydrogenase (Class III), Chi Polypeptide 3
  • Epididymis Secretory Sperm Binding Protein Li 60p 3
  • Alcohol Dehydrogenase 5 4
  • EC 1.1.1.284 4
  • EC 1.1.1.- 4
  • HEL-S-60p 3
  • EC 1.1.1 51
  • ADH5 5

External Ids for ADH5 Gene

Previous HGNC Symbols for ADH5 Gene

  • FDH

Previous GeneCards Identifiers for ADH5 Gene

  • GC04M100238
  • GC04M100385
  • GC04M100454
  • GC04M100459
  • GC04M100349
  • GC04M099992
  • GC04M095730

Summaries for ADH5 Gene

Entrez Gene Summary for ADH5 Gene

  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ADH5 Gene

ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Methanol Poisoning and Proliferative Type Fibrocystic Change Of Breast. Among its related pathways are Glucose metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.

UniProtKB/Swiss-Prot Summary for ADH5 Gene

  • Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).

Gene Wiki entry for ADH5 Gene

Additional gene information for ADH5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADH5 Gene

Genomics for ADH5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADH5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADH5

Top Transcription factor binding sites by QIAGEN in the ADH5 gene promoter:
  • aMEF-2
  • AP-4
  • ARP-1
  • MEF-2
  • MEF-2A
  • MRF-2
  • S8
  • SREBP-1c

Genomic Locations for ADH5 Gene

Genomic Locations for ADH5 Gene
chr4:99,070,978-99,088,801
(GRCh38/hg38)
Size:
17,824 bases
Orientation:
Minus strand
chr4:99,992,129-100,009,952
(GRCh37/hg19)
Size:
17,824 bases
Orientation:
Minus strand

Genomic View for ADH5 Gene

Genes around ADH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH5 Gene

Proteins for ADH5 Gene

  • Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11766-ADHX_HUMAN
    Recommended name:
    Alcohol dehydrogenase class-3
    Protein Accession:
    P11766
    Secondary Accessions:
    • Q6FHR2

    Protein attributes for ADH5 Gene

    Size:
    374 amino acids
    Molecular mass:
    39724 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH5 Gene

neXtProt entry for ADH5 Gene

Selected DME Specific Peptides for ADH5 Gene

P11766:
  • EVAPPKA
  • ESVGEGVT
  • RFTCKGK
  • GVDYSFE
  • PVILGHE
  • TFSEYTV
  • AGASRII
  • GATECINP
  • WEAGKPL
  • KPIQEVL
  • EMTDGGV
  • LGHEGAGIVES
  • APLDKVC
  • DINKDKF
  • GIVESVG

Post-translational modifications for ADH5 Gene

  • Ubiquitination at Lys101, Lys113, Lys228, Lys233, Lys323, and Lys366
  • Modification sites at PhosphoSitePlus

Other Protein References for ADH5 Gene

Domains & Families for ADH5 Gene

Gene Families for ADH5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ADH5 Gene

InterPro:
Blocks:
  • Alcohol dehydrogenase GroES-like
  • Zinc-containing alcohol dehydrogenase
ProtoNet:

Suggested Antigen Peptide Sequences for ADH5 Gene

GenScript: Design optimal peptide antigens:
  • S-(hydroxymethyl)glutathione dehydrogenase (ADHX_HUMAN)
  • ADH5 protein (Q6FI45_HUMAN)
  • cDNA, FLJ92689, highly similar to Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide(ADH5), mRNA (Q6IRT1_HUMAN)
  • Alcohol dehydrogenase 5 (Q9H1A0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11766

UniProtKB/Swiss-Prot:

ADHX_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
genes like me logo Genes that share domains with ADH5: view

Function for ADH5 Gene

Molecular function for ADH5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:8460164};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:8460164};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione; Xref=Rhea:RHEA:19981, ChEBI:CHEBI:15378, ChEBI:CHEBI:57688, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence={ECO:0000269|PubMed:8460164};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione; Xref=Rhea:RHEA:19985, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57688, ChEBI:CHEBI:57945, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence={ECO:0000269|PubMed:8460164};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39803, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence={ECO:0000269|PubMed:16081420};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:39799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence={ECO:0000269|PubMed:16081420};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for 20-HETE {ECO:0000269|PubMed:16081420};
GENATLAS Biochemistry:
alcohol dehydrogenase (class III),chi polypeptide (see ADH@)

Enzyme Numbers (IUBMB) for ADH5 Gene

Phenotypes From GWAS Catalog for ADH5 Gene

Gene Ontology (GO) - Molecular Function for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IEA --
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IBA 21873635
GO:0005504 fatty acid binding IDA 8460164
GO:0008270 zinc ion binding IEA,IDA 6375718
GO:0009055 electron transfer activity TAS 8460164
genes like me logo Genes that share ontologies with ADH5: view
genes like me logo Genes that share phenotypes with ADH5: view

Animal Models for ADH5 Gene

MGI Knock Outs for ADH5:
  • Adh5 Adh5<tm1Stam>
  • Adh5 Adh5<tm1b(EUCOMM)Wtsi>
  • Adh5 Adh5<tm1Gdu>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADH5

CRISPR Products

miRNA for ADH5 Gene

miRTarBase miRNAs that target ADH5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene

Localization for ADH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH5 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 3
plasma membrane 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ADH5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH5 Gene

Pathways & Interactions for ADH5 Gene

genes like me logo Genes that share pathways with ADH5: view

Pathways by source for ADH5 Gene

1 GeneGo (Thomson Reuters) pathway for ADH5 Gene
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Gene Ontology (GO) - Biological Process for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA --
GO:0003016 respiratory system process IEA --
GO:0006069 ethanol oxidation TAS --
GO:0010430 fatty acid omega-oxidation IDA 16081420
GO:0018119 peptidyl-cysteine S-nitrosylation IEA --
genes like me logo Genes that share ontologies with ADH5: view

No data available for SIGNOR curated interactions for ADH5 Gene

Drugs & Compounds for ADH5 Gene

(31) Drugs for ADH5 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme, substrate 3266
NADH Approved Nutra Target, Enzyme, substrate 0
lauric acid Approved, Experimental Pharma Agonist, Target 0
Zinc Approved, Investigational Pharma 1594
Vitamin A Approved, Vet_approved Nutra 685

(38) Additional Compounds for ADH5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2-Naphthyl)methanol
  • 2-Hydroxymethylnaphthalene
  • 2-Naphthalenemethanol
  • Naphthalen-2-yl-methanol
1-Hydroxymethylnaphthalene
  • 1-Menaphthyl alcohol
  • 1-Naphthalenemethanol
  • 1-Naphthylmethyl alcohol
  • Naphthalene-1-methanol
1-Naphthaldehyde
  • 1-Formylnaphthalene
  • 1-Naphthalenecarboxaldehyde
  • alpha-Naphthal
  • Alphaalpha-naphthaldehyde
  • a-Naphthal
2,2,2-Trichloroethanol
  • 2,2,2-trichloro-1-Ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-trichloro-Ethanol
115-20-8
2-Naphthaldehyde
  • 2-Formylnaphthalene
  • 2-Naphthalenecarboxaldehyde
  • beta-Formylnaphthalene
  • beta-Naphthaldehyde
  • b-Formylnaphthalene

(2) ApexBio Compounds for ADH5 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with ADH5: view

Drug Products

Transcripts for ADH5 Gene

mRNA/cDNA for ADH5 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5

Alternative Splicing Database (ASD) splice patterns (SP) for ADH5 Gene

No ASD Table

Relevant External Links for ADH5 Gene

GeneLoc Exon Structure for
ADH5

Expression for ADH5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene



Protein tissue co-expression partners for ADH5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADH5

SOURCE GeneReport for Unigene cluster for ADH5 Gene:

Hs.78989

Evidence on tissue expression from TISSUES for ADH5 Gene

  • Nervous system(4.8)
  • Liver(4.8)
  • Kidney(3.5)
  • Skin(3.5)
  • Heart(3.3)
  • Lung(3.2)
  • Muscle(2.9)
  • Intestine(2.9)
  • Eye(2.7)
  • Blood(2.7)
  • Stomach(2.5)
  • Spleen(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.1)
  • Adrenal gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ADH5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH5 Gene

Orthologs for ADH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADH5 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 94 (a)
OneToMany
ADH5 30 31
  • 92.6 (n)
OneToMany
-- 31
  • 74 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia ADH5 30 31
  • 90.82 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adh5 30 17 31
  • 88.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adh5 30
  • 88.24 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADH5 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADH5 30 31
  • 79.41 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADH5 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adh5 30
  • 76.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii adh5 30
  • 73.14 (n)
zgc:77938 31
  • 63 (a)
ManyToMany
zgc:63568 31
  • 62 (a)
ManyToMany
adh8a 31
  • 61 (a)
ManyToMany
adh8b 31
  • 56 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010499 30
  • 66.76 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Fdh 30 31 32
  • 66.22 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea H24K24.3a 32
  • 69 (a)
H24K24.3b 32
  • 68 (a)
H24K24.3 30 31
  • 64.24 (n)
ManyToMany
Y50D4C.2 31 32
  • 43 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 30 31 33
  • 61.32 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12342g 30
  • 61.13 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACL148C 30
  • 58.08 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons HOT5 30
  • 64.77 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0815500 30
  • 63.87 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.2516 30
Corn
(Zea mays)
Liliopsida Zm.2742 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1497 31
  • 71 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC13B11.04c 30
  • 61.84 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06652 30
  • 59.3 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14208 30
Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADH5 Gene

ENSEMBL:
Gene Tree for ADH5 (if available)
TreeFam:
Gene Tree for ADH5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADH5: view image

Paralogs for ADH5 Gene

(6) SIMAP similar genes for ADH5 Gene using alignment to 9 proteins:

  • ADHX_HUMAN
  • D6R9G2_HUMAN
  • D6RAY0_HUMAN
  • D6RD54_HUMAN
  • D6RFE4_HUMAN
  • H0YAG8_HUMAN
  • Q6FI45_HUMAN
  • Q6IRT1_HUMAN
  • Q9H1A0_HUMAN
genes like me logo Genes that share paralogs with ADH5: view

Variants for ADH5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADH5 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs16996593 - p.Asp353Glu
rs28730623 - p.Leu163Ser
rs28730628 - p.Val309Ile

Additional dbSNP identifiers (rs#s) for ADH5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADH5 Gene

Variant ID Type Subtype PubMed ID
nsv1002927 CNV gain 25217958
nsv1136894 CNV deletion 24896259

Variation tolerance for ADH5 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH5 Gene

Human Gene Mutation Database (HGMD)
ADH5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene

Disorders for ADH5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADH5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
methanol poisoning
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
focal dermal hypoplasia
  • fdh
pharyngitis
  • acute sore throat
alcohol dependence
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards
Search ADH5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADH5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene

Publications for ADH5 Gene

  1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur MW … Edenberg HJ (Gene 1992) 2 3 4 23
  2. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H … London SJ (The Journal of allergy and clinical immunology 2007) 3 23 41
  3. Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang ZN … Hurley TD (Journal of molecular biology 1997) 3 4 23
  4. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B … Vallee BL (Biochemistry 1993) 3 4 23
  5. Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K … Vallee BL (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 23

Products for ADH5 Gene

Sources for ADH5 Gene