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This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Amed Syndrome, Digenic and Methanol Poisoning. Among its related pathways are Drug metabolism - cytochrome P450 and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004022 | alcohol dehydrogenase (NAD) activity | IEA | -- |
GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IBA | 21873635 |
GO:0005504 | fatty acid binding | IDA | 8460164 |
GO:0008270 | zinc ion binding | IEA,IDA | 6375718 |
GO:0009055 | electron transfer activity | TAS | 8460164 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Cytochrome P450 - arranged by substrate type | ||
3 | Carbon metabolism | ||
4 | Metabolism |
.40
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5 | Cyclophosphamide Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | IEA | -- |
GO:0003016 | respiratory system process | IEA | -- |
GO:0006069 | ethanol oxidation | TAS | -- |
GO:0010430 | fatty acid omega-oxidation | IDA | 16081420 |
GO:0018119 | peptidyl-cysteine S-nitrosylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Enzyme, substrate | 3481 | ||
NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
lauric acid | Approved, Experimental | Pharma | Target | 0 | ||
Zinc | Approved, Investigational | Pharma | 1687 | |||
Vitamin A | Approved, Vet_approved | Nutra | 732 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(2-Naphthyl)methanol |
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1-Hydroxymethylnaphthalene |
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1-Naphthaldehyde |
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2,2,2-Trichloroethanol |
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115-20-8 |
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2-Naphthaldehyde |
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Compound | Action | Cas Number |
---|---|---|
Isovaleramide | 541-46-8 | |
N6022 | GSNOR inhibitor | 1208315-24-5 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ADH5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
ADH5 30 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | ADH5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Adh5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Adh5 30 |
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||
Oppossum (Monodelphis domestica) |
Mammalia | ADH5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ADH5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ADH5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adh5 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | adh5 30 |
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zgc:77938 31 |
|
ManyToMany | |||
zgc:63568 31 |
|
ManyToMany | |||
adh8a 31 |
|
ManyToMany | |||
adh8b 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010499 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | Fdh 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | H24K24.3a 32 |
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H24K24.3b 32 |
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H24K24.3 30 31 |
|
ManyToMany | |||
Y50D4C.2 31 32 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12342g 30 |
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A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACL148C 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HOT5 30 |
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Rice (Oryza sativa) |
Liliopsida | Os02g0815500 30 |
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Barley (Hordeum vulgare) |
Liliopsida | Hv.2516 30 |
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Corn (Zea mays) |
Liliopsida | Zm.2742 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC13B11.04c 30 |
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||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06652 30 |
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Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14208 30 |
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SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
995825 | Pathogenic: AMED SYNDROME, DIGENIC | 99,072,706(-) |
TC/T NM_000671.4(ADH5):c.966del (p.Gly321_Trp322insTer) |
NONSENSE | |
995826 | Pathogenic: AMED SYNDROME, DIGENIC | 99,076,703(-) |
C/T NM_000671.4(ADH5):c.564+1G>A |
SPLICE_DONOR | |
995827 | Pathogenic: AMED SYNDROME, DIGENIC | 99,075,043(-) |
C/G NM_000671.4(ADH5):c.832G>C (p.Ala278Pro) |
MISSENSE | |
rs16996593 | - |
p.Asp353Glu |
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rs28730623 | - |
p.Leu163Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1002927 | CNV | gain | 25217958 |
nsv1136894 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
amed syndrome, digenic |
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methanol poisoning |
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proliferative type fibrocystic change of breast |
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focal dermal hypoplasia |
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alcohol dependence |
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