Aliases for ADH5 Gene
Aliases for ADH5 Gene
- Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
- Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
- S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
- Alcohol Dehydrogenase Class Chi Chain 3 4
- Alcohol Dehydrogenase Class-III 3 4
- S-Nitrosoglutathione Reductase 2 3
- Alcohol Dehydrogenase Class-3 3 4
- Formaldehyde Dehydrogenase 2 3
- EC 1.1.1.1 4 56
- GSH-FDH 3 4
- FALDH 3 4
- ADHX 3 4
External Ids for ADH5 Gene
- HGNC: 253
- Entrez Gene: 128
- Ensembl: ENSG00000197894
- OMIM: 103710
- UniProtKB: P11766
Previous HGNC Symbols for ADH5 Gene
- FDH
Previous GeneCards Identifiers for ADH5 Gene
- GC04M100238
- GC04M100385
- GC04M100454
- GC04M100459
- GC04M100349
- GC04M099992
- GC04M095730
Summaries for ADH5 Gene
-
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ADH5 Gene
ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Methanol Poisoning and Pharyngitis. Among its related pathways are Amino Acid metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is ADH1A.
UniProtKB/Swiss-Prot for ADH5 Gene
-
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene
Genomics for ADH5 Gene
GeneHancer (GH) Regulatory Elements for ADH5 Gene
Promoters and enhancers for ADH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADH5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADH5 gene promoter:
-
- aMEF-2
- AP-4
- ARP-1
- MEF-2
- MEF-2A
- MRF-2
- S8
- SREBP-1c
Genomic Locations for ADH5 Gene
Genomic Locations for ADH5 Gene
- chr4:99,070,978-99,088,801
- (GRCh38/hg38)
- Size:
- 17,824 bases
- Orientation:
- Minus strand
- chr4:99,992,129-100,009,952
- (GRCh37/hg19)
- Size:
- 17,824 bases
- Orientation:
- Minus strand
Genomic View for ADH5 Gene
Genes around ADH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by HGNC
- 4q23 by Entrez Gene
- 4q23 by Ensembl
ADH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH5 Gene
Proteins for ADH5 Gene
-
Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11766-ADHX_HUMAN
- Recommended name:
- Alcohol dehydrogenase class-3
- Protein Accession:
- P11766
- Q6FHR2
Protein attributes for ADH5 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 39724 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Protein Expression for ADH5 Gene
Selected DME Specific Peptides for ADH5 Gene
- P11766:
-
- EVAPPKA
- ESVGEGVT
- RFTCKGK
- GVDYSFE
- PVILGHE
- TFSEYTV
- AGASRII
- GATECINP
- WEAGKPL
- KPIQEVL
- EMTDGGV
- LGHEGAGIVES
- APLDKVC
- DINKDKF
- GIVESVG
Post-translational modifications for ADH5 Gene
Other Protein References for ADH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-ADH5 Antibody (HPA044578) and Anti-ADH5 Antibody (HPA061919)
- Novus Biologicals Antibodies for ADH5
-
Abcam antibodies for ADH5
- Invitrogen Antibodies for ADH5 (AFLGC-ADH5)
-
Boster Bio Antibodies for ADH5
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH5
Protein Products
- Atlas Antibodies PrEST Antigen ADH5 (APrEST79877) and PrEST Antigen ADH5 (APrEST88493)
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH5
- Origene Custom Protein Services for ADH5
- ProSpec Recombinant Proteins for ADH5
-
Abcam proteins for ADH5
Assay Products
- antibodies-online: Search results for 4 available ADH5 Elisa Kits ranked by validation data
- Compare Top ADH5 Elisa Kits
-
Quality Products:
Domains & Families for ADH5 Gene
Gene Families for ADH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH5 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH5 Gene
- GenScript: Design optimal peptide antigens:
-
- S-(hydroxymethyl)glutathione dehydrogenase (ADHX_HUMAN)
- ADH5 protein (Q6FI45_HUMAN)
- cDNA, FLJ92689, highly similar to Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide(ADH5), mRNA (Q6IRT1_HUMAN)
- Alcohol dehydrogenase 5 (Q9H1A0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P11766UniProtKB/Swiss-Prot:
ADHX_HUMAN :- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Function for ADH5 Gene
Molecular function for ADH5 Gene
- UniProtKB/Swiss-Prot Function:
- Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione; Xref=Rhea:RHEA:19981, ChEBI:CHEBI:15378, ChEBI:CHEBI:57688, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione; Xref=Rhea:RHEA:19985, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57688, ChEBI:CHEBI:57945, ChEBI:CHEBI:58758; EC=1.1.1.284; Evidence=. ;.
- GENATLAS Biochemistry:
- alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
Enzyme Numbers (IUBMB) for ADH5 Gene
Phenotypes From GWAS Catalog for ADH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004022 | alcohol dehydrogenase (NAD) activity | IEA | -- |
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IBA | 21873635 |
| GO:0005504 | fatty acid binding | IDA | 8460164 |
| GO:0008270 | zinc ion binding | IDA,IEA | 6375718 |
| GO:0009055 | electron transfer activity | TAS | 8460164 |
Phenotypes for ADH5 Gene
- MGI mutant phenotypes for ADH5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ADH5:
Animal Models for ADH5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ADH5
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADH5
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADH5 - Now 50% OFF >
- * ADH5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH5 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- genomics-online: gRNA clones - Search results for available ADH5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
miRNA for ADH5 Gene
- miRTarBase miRNAs that target ADH5
-
- hsa-mir-155-5p (MIRT020534)
- hsa-mir-106b-5p (MIRT044260)
- hsa-mir-218-5p (MIRT441262)
- hsa-mir-4709-3p (MIRT447186)
- hsa-mir-4722-5p (MIRT447187)
- hsa-mir-1286 (MIRT447188)
- hsa-mir-4635 (MIRT447189)
- hsa-mir-873-5p (MIRT447190)
- hsa-mir-5197-5p (MIRT447191)
- hsa-mir-6510-3p (MIRT450281)
- hsa-mir-4668-5p (MIRT450282)
- hsa-mir-549a (MIRT450283)
- hsa-mir-372-5p (MIRT450284)
- hsa-mir-371a-5p (MIRT450285)
- hsa-mir-616-5p (MIRT450286)
- hsa-mir-373-5p (MIRT450287)
- hsa-mir-371b-5p (MIRT450288)
- hsa-mir-3613-3p (MIRT450289)
- hsa-mir-8087 (MIRT450290)
- hsa-mir-7161-5p (MIRT450291)
- hsa-mir-548u (MIRT450292)
- hsa-mir-4715-3p (MIRT540628)
- hsa-mir-5589-3p (MIRT540629)
- hsa-mir-6715b-5p (MIRT540630)
- hsa-mir-6872-3p (MIRT540631)
- hsa-mir-4269 (MIRT540632)
- hsa-mir-5582-5p (MIRT540633)
- hsa-mir-4777-5p (MIRT620609)
- hsa-mir-526a (MIRT620610)
- hsa-mir-523-5p (MIRT620611)
- hsa-mir-522-5p (MIRT620612)
- hsa-mir-520c-5p (MIRT620613)
- hsa-mir-519c-5p (MIRT620614)
- hsa-mir-519b-5p (MIRT620615)
- hsa-mir-519a-5p (MIRT620616)
- hsa-mir-518f-5p (MIRT620617)
- hsa-mir-518e-5p (MIRT620618)
- hsa-mir-518d-5p (MIRT620619)
- hsa-mir-6088 (MIRT620620)
- hsa-mir-4770 (MIRT620621)
- hsa-mir-143-3p (MIRT620622)
- hsa-mir-520g-5p (MIRT620623)
- hsa-mir-4282 (MIRT664422)
- hsa-mir-6516-5p (MIRT695398)
- hsa-mir-455-3p (MIRT695399)
- hsa-mir-1227-3p (MIRT695400)
- hsa-mir-4451 (MIRT695401)
- hsa-mir-6799-5p (MIRT695402)
- hsa-mir-4252 (MIRT695403)
- hsa-mir-6499-3p (MIRT695404)
- hsa-mir-6086 (MIRT695405)
- hsa-mir-377-5p (MIRT695406)
- hsa-mir-98-5p (MIRT695407)
- hsa-mir-4500 (MIRT695408)
- hsa-mir-4458 (MIRT695409)
- hsa-let-7i-5p (MIRT695410)
- hsa-let-7g-5p (MIRT695411)
- hsa-let-7f-5p (MIRT695412)
- hsa-let-7e-5p (MIRT695413)
- hsa-let-7d-5p (MIRT695414)
- hsa-let-7c-5p (MIRT695415)
- hsa-let-7b-5p (MIRT695416)
- hsa-let-7a-5p (MIRT695417)
- hsa-mir-4487 (MIRT695418)
- hsa-mir-558 (MIRT695419)
- hsa-mir-3160-3p (MIRT695420)
- hsa-mir-1247-3p (MIRT695421)
- hsa-mir-6831-5p (MIRT695422)
- hsa-mir-3927-3p (MIRT695423)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- genomics-online: shRNA clones - Search results for available ADH5 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ADH5 - Now 50% OFF >
- * ADH5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG222327
- MR222327
- MR222327L1
- MR222327L1V
- MR222327L2
- MR222327L2V
- MR222327L3
- MR222327L3V
- MR222327L4
- MR222327L4V
- MR228796
- RC204903
- RC204903L1
- RC204903L1V
- RC204903L2
- RC204903L2V
- RC204903L3
- RC204903L3V
- RC204903L4
- RC204903L4V
- RC504903
- RG204903
- RR211769
- RR211769L1
- RR211769L1V
- RR211769L2
- RR211769L2V
- RR211769L3
- RR211769L3V
- RR211769L4
- RR211769L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
- genomics-online: cdna clones - Search results for available ADH5 gene related products
- orf clones - Search results for available ADH5 gene related products
Cell Line Products
-
Horizon Cell Lines for ADH5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene
Localization for ADH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 3 |
| nucleus | 1 |
| plasma membrane | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADH5 Gene
Pathways & Interactions for ADH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Carbon metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Cyclophosphamide Pathway, Pharmacodynamics | ||
Pathways by source for ADH5 Gene
3 BioSystems pathways for ADH5 Gene
4 Reactome pathways for ADH5 Gene
2 PharmGKB pathways for ADH5 Gene
9 KEGG pathways for ADH5 Gene
1 GeneGo (Thomson Reuters) pathway for ADH5 Gene
Interacting Proteins for ADH5 Gene
GPS-Prot Interaction Network for ADH5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0006069 | ethanol oxidation | TAS | -- |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | IEA | -- |
| GO:0022900 | electron transport chain | IEA | -- |
No data available for SIGNOR curated interactions for ADH5 Gene
Drugs & Compounds for ADH5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme | 3035 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| lauric acid | Approved, Experimental | Pharma | Agonist, Target | 0 | ||
| Zinc | Approved, Investigational | Pharma | 2681 | |||
| Vitamin A | Approved, Vet_approved | Nutra | 619 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| (2-Naphthyl)methanol |
|
|
||||
| 1-Hydroxymethylnaphthalene |
|
|
||||
| 1-Naphthaldehyde |
|
|
||||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
(2) ApexBio Compounds for ADH5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Isovaleramide | 541-46-8 | |
| N6022 | GSNOR inhibitor | 1208315-24-5 |
Drug Products
- Atlas Antibodies PrEST Antigen ADH5 (APrEST79877) and PrEST Antigen ADH5 (APrEST88493)
- ApexBio compounds for ADH5
Transcripts for ADH5 Gene
mRNA/cDNA for ADH5 Gene
- (1) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (570) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296412 2594 bps (ENST00000296412.12)
- ENST00000512621 1475 bps (ENST00000512621.5)
- ENST00000512659 822 bps (ENST00000512659.5)
- ENST00000508511 1909 bps (ENST00000508511.5)
- ENST00000503130 786 bps (ENST00000503130.5)
Unigene Clusters for ADH5 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADH5 - Now 50% OFF >
- * ADH5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH5 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ADH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- genomics-online: gRNA clones - Search results for available ADH5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADH5
- Browse OriGene Inhibitory RNA Products For ADH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- genomics-online: shRNA clones - Search results for available ADH5 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ADH5 - Now 50% OFF >
- * ADH5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG222327
- MR222327
- MR222327L1
- MR222327L1V
- MR222327L2
- MR222327L2V
- MR222327L3
- MR222327L3V
- MR222327L4
- MR222327L4V
- MR228796
- RC204903
- RC204903L1
- RC204903L1V
- RC204903L2
- RC204903L2V
- RC204903L3
- RC204903L3V
- RC204903L4
- RC204903L4V
- RC504903
- RG204903
- RR211769
- RR211769L1
- RR211769L1V
- RR211769L2
- RR211769L2V
- RR211769L3
- RR211769L3V
- RR211769L4
- RR211769L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
- genomics-online: cdna clones - Search results for available ADH5 gene related products
- orf clones - Search results for available ADH5 gene related products
Expression for ADH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADH5 Gene:
ADH5SOURCE GeneReport for Unigene cluster for ADH5 Gene:
Hs.78989Evidence on tissue expression from TISSUES for ADH5 Gene
- Liver(4.8)
- Nervous system(4.8)
- Kidney(3.1)
- Lung(2.9)
- Skin(2.6)
- Eye(2.3)
- Intestine(2.3)
- Blood(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for ADH5
-
OriGene qPCR primer pairs and template standards for ADH5
- genomics-online: primer clones - Search results for available ADH5 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH5 Gene
Orthologs for ADH5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADH5 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| ADH5 35 34 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ADH5 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adh5 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adh5 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADH5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADH5 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADH5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adh5 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adh5 34 34 |
|
||
| zgc:77938 35 |
|
ManyToMany | |||
| zgc:63568 35 |
|
ManyToMany | |||
| adh8a 35 |
|
ManyToMany | |||
| adh8b 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010499 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fdh 35 36 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H24K24.3a 36 |
|
|
|
| H24K24.3b 36 |
|
|
|||
| H24K24.3 35 34 |
|
ManyToMany | |||
| Y50D4C.2 35 36 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 37 35 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12342g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL148C 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HOT5 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0815500 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.2742 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2516 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 35 |
|
OneToMany | |
| Cin.14208 34 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC13B11.04c 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06652 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14208 34 |
|
- Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADH5 Gene
- ENSEMBL:
- Gene Tree for ADH5 (if available)
- TreeFam:
- Gene Tree for ADH5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH5: view image
Paralogs for ADH5 Gene
Paralogs for ADH5 Gene
(6) SIMAP similar genes for ADH5 Gene using alignment to 9 proteins:
- ADHX_HUMAN
- D6R9G2_HUMAN
- D6RAY0_HUMAN
- D6RD54_HUMAN
- D6RFE4_HUMAN
- H0YAG8_HUMAN
- Q6FI45_HUMAN
- Q6IRT1_HUMAN
- Q9H1A0_HUMAN
Pseudogenes.org Pseudogenes for ADH5 Gene
Variants for ADH5 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000110361 | -- | 99,083,370(-) | C/T | intron_variant | |
| rs1000272646 | -- | 99,088,927(-) | C/G | upstream_transcript_variant | |
| rs1000646028 | -- | 99,088,821(-) | T/C | upstream_transcript_variant | |
| rs1000838146 | -- | 99,078,841(-) | G/A | intron_variant | |
| rs1000876694 | -- | 99,078,181(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1002927 | CNV | gain | 25217958 |
| nsv1136894 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.61;
30.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene
Disorders for ADH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| methanol poisoning |
|
|
| pharyngitis |
|
|
| alcohol dependence |
|
|
Search ADH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene
Publications for ADH5 Gene
- Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur MW … Edenberg HJ (Gene 1992) 2 3 4 23 58
- Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H … London SJ (The Journal of allergy and clinical immunology 2007) 3 23 45 58
- Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang ZN … Hurley TD (Journal of molecular biology 1997) 3 4 23 58
- Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K … Vallee BL (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 23 58
- Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B … Vallee BL (Biochemistry 1993) 3 4 23 58
ExternalLinks
Products for ADH5 Gene
- Custom Antibody ServicesOriGene Antibodies for ADH5
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- OriGene qPCR primer pairs for ADH5
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- RC504903
- RG204903
- RR211769
- RR211769L1
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- RR211769L2
- RR211769L2V
- RR211769L3
- RR211769L3V
- RR211769L4
- RR211769L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for ADH5
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for ADH5
- Novus Biologicals proteins and lysates for ADH5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for ADH5
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for ADH5
- Taconic Biosciences Mouse Models for ADH5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ADH5 (AFLGC-ADH5)
- antibodies-online: Search results for 98 available ADH5 Antibodies ranked by validation data
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- Quality Products:
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- Santa Cruz Biotechnology (SCBT) Antibodies for ADH5
- Search Santa Cruz Biotechnology (SCBT) for ADH5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADH5
- Horizon Cell Lines for ADH5
- genomics-online: cdna clones - Search results for available ADH5 gene related products
- orf clones - Search results for available ADH5 gene related products
- genomics-online: gRNA clones - Search results for available ADH5 gene related products
- genomics-online: primer clones - Search results for available ADH5 gene related products
- genomics-online: shRNA clones - Search results for available ADH5 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH5
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH5
- Boster Bio Antibodies for ADH5
- Browse Boster Bio ELISA Kits
Sources for ADH5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
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- (117) Disease Ontology
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- (123) NCBI Bookshelf
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- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
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- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
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- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind