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ADH4 Gene(Protein Coding)

Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide

GCID:
GC04M099123
GIFtS:
52
Genes Participants
UDN Logo

Aliases for ADH4 Gene

Aliases for ADH4 Gene

  • Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide 2 3 5
  • Alcohol Dehydrogenase Class II Pi Chain 3 4
  • EC 1.1.1.1 4 56
  • Epididymis Secretory Protein Li 4 3
  • Alcohol Dehydrogenase 4 3
  • Aldehyde Reductase 3
  • EC 1.1.1 56
  • HEL-S-4 3
  • ADH-2 3

External Ids for ADH4 Gene

Previous GeneCards Identifiers for ADH4 Gene

  • GC04M100290
  • GC04M100453
  • GC04M100458
  • GC04M100401
  • GC04M100044
  • GC04M095782

Summaries for ADH4 Gene

Entrez Gene Summary for ADH4 Gene

  • This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH4 Gene

ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide) is a Protein Coding gene. Diseases associated with ADH4 include Alcohol Dependence and Substance Dependence. Among its related pathways are Phenylalanine metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is ADH5.

Gene Wiki entry for ADH4 Gene

Additional gene information for ADH4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH4 Gene

Genomics for ADH4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ADH4 Gene

Promoters and enhancers for ADH4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I099143 Promoter/Enhancer 1.3 EPDnew ENCODE 567.5 +13.4 13424 1.5 ELF3 FOXA2 RAD21 YY1 CREM THAP11 HMG20B RXRA CEBPB ELF1 ADH4 LOC100507053 ADH5 ADH1A ADH6 PIR42405
GH04I099157 Enhancer 0.9 ENCODE 550.8 +0.2 193 0.2 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 ATF7 RXRA SP5 NFYC ADH4 ENSG00000272777 PIR42405 LOC100507053
GH04I099086 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.7 +68.5 68511 6.5 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ADH5 LOC100507053 ENSG00000272777 ADH4 PIR42405
GH04I099402 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -246.7 -246670 3.6 PKNOX1 FOXA2 ARID4B DMAP1 IRF4 YY1 ARID2 ZNF207 ZNF143 ATF7 LOC102723576 ADH4 ADH6 LOC100507053 PCNAP1 ADH5 ADH1A ADH1B ADH1C
GH04I099381 Enhancer 0.4 FANTOM5 34.8 -223.4 -223354 0.2 YY1 ADH1A ADH4 ADH1C ADH1B ADH6 LOC100507053 LOC102723576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADH4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADH4 gene promoter:

Genomic Locations for ADH4 Gene

Genomic Locations for ADH4 Gene
chr4:99,123,657-99,157,792
(GRCh38/hg38)
Size:
34,136 bases
Orientation:
Minus strand
chr4:100,044,808-100,078,949
(GRCh37/hg19)

Genomic View for ADH4 Gene

Genes around ADH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADH4 Gene

Proteins for ADH4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08319-ADH4_HUMAN
    Recommended name:
    Alcohol dehydrogenase 4
    Protein Accession:
    P08319
    Secondary Accessions:
    • A8K470
    • B4DIE7
    • C9J4A9
    • Q8TCD7

    Protein attributes for ADH4 Gene

    Size:
    380 amino acids
    Molecular mass:
    40222 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH4 Gene

    Alternative splice isoforms for ADH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH4 Gene

Protein Expression for ADH4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ADH4 Gene

P08319:
  • FPVIVGHEA
  • EVAPPKA
  • RFTCKGK
  • GHEAAGIVES
  • CAVFGLGGVGLS
  • GKVIKCKAA
  • MGCKAAGASRII
  • AGASRII
  • LGATDCLNP
  • FSQYTVV
  • EEVEVAPP
  • TFFGGWKSV
  • TSLCHTD
  • GCGFSTGYG
  • WEAGKPL
  • AKVTPGS
  • VMGCKAAGA

Post-translational modifications for ADH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADH4 Gene

Gene Families for ADH4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ADH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08319

UniProtKB/Swiss-Prot:

ADH4_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
genes like me logo Genes that share domains with ADH4: view

Function for ADH4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ADH4 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class II),pi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity:
A primary alcohol + NAD(+) = an aldehyde + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
A secondary alcohol + NAD(+) = a ketone + NADH.

Enzyme Numbers (IUBMB) for ADH4 Gene

Phenotypes From GWAS Catalog for ADH4 Gene

Gene Ontology (GO) - Molecular Function for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity ISS --
GO:0004022 alcohol dehydrogenase (NAD) activity IDA,IEA 3466164
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA,IEA 10407146
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IEA --
GO:0004745 retinol dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with ADH4: view
genes like me logo Genes that share phenotypes with ADH4: view

Animal Model Products

Clone Products

  • Addgene plasmids for ADH4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH4 Gene

Localization for ADH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH4 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with ADH4: view

Pathways & Interactions for ADH4 Gene

genes like me logo Genes that share pathways with ADH4: view

Gene Ontology (GO) - Biological Process for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IDA 15369820
GO:0006066 alcohol metabolic process IDA 3466164
GO:0006067 ethanol metabolic process IEA --
GO:0006069 ethanol oxidation TAS,IEA --
GO:0006081 cellular aldehyde metabolic process IDA 3466164
genes like me logo Genes that share ontologies with ADH4: view

No data available for SIGNOR curated interactions for ADH4 Gene

Drugs & Compounds for ADH4 Gene

Products:

  1. Drug

(12) Drugs for ADH4 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 2326
NADH Approved Nutra Target, Enzyme, substrate 0
Vitamin A Approved, Vet_approved Nutra 529
Chloral hydrate Approved, Illicit, Investigational, Vet_approved Pharma 17
Isopropyl alcohol Approved, Investigational Pharma 0

(16) Additional Compounds for ADH4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
 111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
 71-41-0
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
 115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
 13023-73-9

(1) ApexBio Compounds for ADH4 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
genes like me logo Genes that share compounds with ADH4: view

Drug Products

Transcripts for ADH4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADH4 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(75) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADH4 Gene

Alcohol dehydrogenase 4 (class II), pi polypeptide:
Representative Sequences:

Clone Products

  • Addgene plasmids for ADH4

Alternative Splicing Database (ASD) splice patterns (SP) for ADH4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for ADH4 Gene

GeneLoc Exon Structure for
ADH4
ECgene alternative splicing isoforms for
ADH4

Expression for ADH4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADH4 Gene

mRNA expression in normal human tissues for ADH4 Gene
mRNA expression by BioGPS for ADH4 GenemRNA expression by GTEx for ADH4 Gene

mRNA differential expression in normal tissues according to GTEx for ADH4 Gene

This gene is overexpressed in Liver (x50.9).

Protein differential expression in normal tissues from HIPED for ADH4 Gene

This gene is overexpressed in Liver, secretome (46.4) and Liver (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADH4 Gene:

ADH4

SOURCE GeneReport for Unigene cluster for ADH4 Gene:

Hs.1219

Evidence on tissue expression from TISSUES for ADH4 Gene

  • Liver(4.9)
  • Nervous system(4.2)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with ADH4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH4 Gene

Orthologs for ADH4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ADH4 33 34
  • 99.39 (n)
dog
(Canis familiaris)
 Mammalia ADH4 34 33
  • 86.72 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ADH4 33 34
  • 84.56 (n)
rat
(Rattus norvegicus)
 Mammalia Adh4 33
  • 80.19 (n)
mouse
(Mus musculus)
 Mammalia Adh4 33 16 34
  • 78.43 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 60 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia adh4 33
  • 68.68 (n)
zebrafish
(Danio rerio)
 Actinopterygii adh5 34
  • 64 (a)
 ManyToMany
zgc:77938 34
  • 57 (a)
 ManyToMany
zgc:63568 34
  • 56 (a)
 ManyToMany
adh8a 34
  • 54 (a)
 ManyToMany
adh8b 34
  • 53 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Fdh 34
  • 55 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea H24K24.3 34
  • 51 (a)
 ManyToMany
Y50D4C.2 34
  • 32 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SFA1 34
  • 46 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons ADH1 33
  • 54.04 (n)
rice
(Oryza sativa)
 Liliopsida Os11g0210500 33
  • 52.42 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1497 34
  • 56 (a)
 OneToMany
Species where no ortholog for ADH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH4 Gene

ENSEMBL:
Gene Tree for ADH4 (if available)
TreeFam:
Gene Tree for ADH4 (if available)

Paralogs for ADH4 Gene

Paralogs for ADH4 Gene

(6) SIMAP similar genes for ADH4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ADH4 Gene

genes like me logo Genes that share paralogs with ADH4: view

Variants for ADH4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ADH4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000224044 -- 99,131,679(-) G/A coding_sequence_variant, missense_variant
rs1000444510 -- 99,128,813(-) /C intron_variant
rs1000451530 -- 99,137,878(-) A/G intron_variant
rs1000454489 -- 99,142,620(-) G/C intron_variant
rs1000467131 -- 99,145,323(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADH4 Gene

Variant ID Type Subtype PubMed ID
nsv1002574 CNV loss 25217958
nsv1002927 CNV gain 25217958

Variation tolerance for ADH4 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH4 Gene

Human Gene Mutation Database (HGMD)
ADH4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH4 Gene

Disorders for ADH4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ADH4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcoholism
substance dependence
hypocalciuric hypercalcemia, familial, type ii
  • hhc2
alcoholic neuropathy
  • alcohol-related polyneuropathy
alcoholic liver cirrhosis
  • alcoholic cirrhosis
- elite association - COSMIC cancer census association via MalaCards
Search ADH4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADH4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH4 Gene

Publications for ADH4 Gene

  1. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. (PMID: 19925625) Rainero I … Pinessi L (Headache 2010) 3 22 44 58
  2. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PMID: 15863808) Guindalini C … Zatz M (The American journal of psychiatry 2005) 3 22 44 58
  3. Alcohol dehydrogenase alleles in Parkinson's disease. (PMID: 11009184) Buervenich S … Olson L (Movement disorders : official journal of the Movement Disorder Society 2000) 3 22 44 58
  4. Cloning and characterization of the human ADH4 gene. (PMID: 1889753) von Bahr-Lindström H … Höög JO (Gene 1991) 3 4 22 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for ADH4 Gene

  • Addgene plasmids for ADH4

Sources for ADH4 Gene

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