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This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a ... See more...
Aliases for ADH4 Gene
Aliases for ADH4 Gene
External Ids for ADH4 Gene
- HGNC: 252
- NCBI Entrez Gene: 127
- Ensembl: ENSG00000198099
- OMIM®: 103740
- UniProtKB/Swiss-Prot: P08319
Previous GeneCards Identifiers for ADH4 Gene
- GC04M100290
- GC04M100453
- GC04M100458
- GC04M100401
- GC04M100044
- GC04M095782
Summaries for ADH4 Gene
-
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADH4 Gene
ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide) is a Protein Coding gene. Diseases associated with ADH4 include Alcohol Dependence and Substance Dependence. Among its related pathways are Signaling by GPCR and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is ADH5.
UniProtKB/Swiss-Prot Summary for ADH4 Gene
-
Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444).
Additional gene information for ADH4 Gene
- HGNC (252)
- NCBI Entrez Gene (127)
- Ensembl (ENSG00000198099)
- OMIM® (103740)
- UniProtKB/Swiss-Prot (P08319)
- Open Targets Platform(ENSG00000198099)
- Monarch Initiative
- Search for ADH4 at DataMed
- Search for ADH4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADH4 Gene
Genomics for ADH4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADH4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADH4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADH4
- Top Transcription factor binding sites by QIAGEN in the ADH4 gene promoter:
-
- AML1a
- AP-1
- c-Fos
- E2F
- E2F-1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- RSRFC4
- S8
Genomic Locations for ADH4 Gene
Latest Assembly
- chr4:99,123,657-99,157,792
- (GRCh38/hg38)
- Size:
- 34,136 bases
- Orientation:
- Minus strand
Previous Assembly
- chr4:100,044,809-100,065,448
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,640 bases
- Orientation:
- Minus strand
- chr4:100,044,808-100,078,949
- (GRCh37/hg19 by Ensembl)
- Size:
- 34,142 bases
- Orientation:
- Minus strand
Genomic View for ADH4 Gene
Genes around ADH4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by HGNC
- 4q23 by Entrez Gene
- 4q23 by Ensembl
ADH4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH4 Gene
Proteins for ADH4 Gene
-
Protein details for ADH4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08319-ADH4_HUMAN
- Recommended name:
- All-trans-retinol dehydrogenase [NAD(+)] ADH4
- Protein Accession:
- P08319
- A8K470
- B4DIE7
- C9J4A9
- Q8TCD7
Protein attributes for ADH4 Gene
- Size:
- 380 amino acids
- Molecular mass:
- 40222 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Protein Expression for ADH4 Gene
Selected DME Specific Peptides for ADH4 Gene
- P08319:
-
- FPVIVGHEA
- EVAPPKA
- RFTCKGK
- GHEAAGIVES
- CAVFGLGGVGLS
- GKVIKCKAA
- MGCKAAGASRII
- AGASRII
- LGATDCLNP
- FSQYTVV
- EEVEVAPP
- TFFGGWKSV
- TSLCHTD
- GCGFSTGYG
- WEAGKPL
- AKVTPGS
- VMGCKAAGA
Post-translational modifications for ADH4 Gene
Other Protein References for ADH4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for ADH4
-
Abcam antibodies for ADH4
- Invitrogen Antibodies for ADH4 (AFLGC-ADH4)
-
Boster Bio Antibodies for ADH4
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH4
- Sino Biological Antibodies for ADH4
Protein products for research
-
OriGene Purified Proteins for ADH4
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH4
- Origene Custom Protein Services for ADH4
-
Abcam proteins for ADH4
Assay products for research
- antibodies-online: Search results for available ADH4 related products ranked by validation data
Domains & Families for ADH4 Gene
Gene Families for ADH4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH4 Gene
- InterPro:
- Blocks:
-
- Alcohol dehydrogenase GroES-like
- Zinc-containing alcohol dehydrogenase
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH4 Gene
- GenScript: Design optimal peptide antigens:
-
- Alcohol dehydrogenase class II pi chain (ADH4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08319UniProtKB/Swiss-Prot:
ADH4_HUMAN :- Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
Function for ADH4 Gene
Molecular function for ADH4 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence={ECO:0000269|PubMed:17279314};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence={ECO:0000269|PubMed:17279314};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39803, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76645, ChEBI:CHEBI:76647; Evidence={ECO:0000269|PubMed:16081420};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:39799, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76624, ChEBI:CHEBI:76645; Evidence={ECO:0000269|PubMed:16081420};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+); Xref=Rhea:RHEA:60660, ChEBI:CHEBI:15378, ChEBI:CHEBI:16509, ChEBI:CHEBI:17594, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:10514444};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.14 uM for all-trans-retinol {ECO:0000269|PubMed:17279314}; KM=0.29 uM for all-trans-retinaldehyde {ECO:0000269|PubMed:17279314}; KM=0.054 uM for 9-cis-retinol {ECO:0000269|PubMed:17279314}; KM=0.21 uM for 9-cis-retinaldehyde {ECO:0000269|PubMed:17279314}; KM=9.5 uM for 20-HETE {ECO:0000269|PubMed:16081420}; KM=0.088 mM for 1,4-benzoquinone {ECO:0000269|PubMed:10514444};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Oxydation of 20-HETE is inhibited by low concentrations of N-heptylformamide (PubMed:16081420). Oxydation of 20-HETE is a decreased by 55-65% by either all-trans-retinol or all-trans-retinoic acid. Strongly inhibited by omega-hydroxy fatty acids (By similarity).
- GENATLAS Biochemistry:
- alcohol dehydrogenase (class II),pi polypeptide (see ADH@)
Enzyme Numbers (IUBMB) for ADH4 Gene
Phenotypes From GWAS Catalog for ADH4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003960 | NADPH:quinone reductase activity | ISS | -- |
| GO:0004022 | alcohol dehydrogenase (NAD) activity | IDA | 3466164 |
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IEA,IDA | 10407146 |
| GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | IEA | -- |
| GO:0004745 | retinol dehydrogenase activity | IEA,IDA | 10514444 |
Phenotypes for ADH4 Gene
- GenomeRNAi human phenotypes for ADH4:
-
- Decreased viability
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased hepcidin::fluc mRNA expression
- Increased homologous recombination repair frequency
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADH4 - Starting at $85 >
- * ADH4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADH4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH4
miRNA for ADH4 Gene
- miRTarBase miRNAs that target ADH4
-
- hsa-miR-4666a-5p (MIRT549898)
- hsa-miR-8068 (MIRT549899)
- hsa-miR-143-5p (MIRT549900)
- hsa-miR-3944-5p (MIRT549901)
- hsa-miR-5087 (MIRT549902)
- hsa-miR-4764-5p (MIRT549903)
- hsa-miR-657 (MIRT549904)
- hsa-miR-3665 (MIRT549905)
- hsa-miR-4722-5p (MIRT549906)
- hsa-miR-1286 (MIRT549907)
- hsa-miR-873-5p (MIRT549908)
- hsa-miR-4748 (MIRT549909)
- hsa-miR-4464 (MIRT549910)
- hsa-miR-6841-5p (MIRT549911)
- hsa-miR-1265 (MIRT549912)
- hsa-miR-376c-3p (MIRT549913)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH4
- Browse OriGene Inhibitory RNA Products For ADH4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH4
Clone products for research
- Applied Biological Materials (abm): Clones for ADH4 - Starting at $45 >
- * ADH4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADH4
- Addgene plasmids for ADH4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH4
Cell Lines for research
-
Horizon Cell Lines for ADH4
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH4 Gene
Localization for ADH4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for ADH4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Metabolism |
.40
|
|
| 4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
| 5 | Signaling by Retinoic Acid | ||
Pathways by source for ADH4 Gene
4 BioSystems pathways for ADH4 Gene
7 Reactome pathways for ADH4 Gene
2 PharmGKB pathways for ADH4 Gene
8 KEGG pathways for ADH4 Gene
Interacting Proteins for ADH4 Gene
Selected Interacting proteins:
P08319-ADH4_HUMAN
ENSP00000265512
for ADH4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ADH4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | IDA | 15369820 |
| GO:0006066 | alcohol metabolic process | IDA | 3466164 |
| GO:0006067 | ethanol metabolic process | IEA | -- |
| GO:0006069 | ethanol oxidation | IEA,TAS | -- |
| GO:0006081 | cellular aldehyde metabolic process | IDA | 3466164 |
No data available for SIGNOR curated interactions for ADH4 Gene
Drugs & Compounds for ADH4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme, substrate | 3481 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| Vitamin A | Approved, Vet_approved | Nutra | 732 | |||
| Chloral hydrate | Approved, Illicit, Investigational, Vet_approved | Pharma | 18 | |||
| Isopropyl alcohol | Approved, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
| 2-Phenyl-1,3-propanediol monocarbamate |
|
|
||||
| 3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
(1) ApexBio Compounds for ADH4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Isovaleramide | 541-46-8 |
Transcripts for ADH4 Gene
mRNA/cDNA for ADH4 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000265512 2002 nts (view in UCSC)
- ENST00000503416 708 nts (view in UCSC)
- ENST00000503944 304 nts (view in UCSC)
- ENST00000504125 665 nts (view in UCSC)
- ENST00000504581 315 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADH4 - Starting at $85 >
- * ADH4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADH4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH4
- Browse OriGene Inhibitory RNA Products For ADH4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH4
Clone products for research
- Applied Biological Materials (abm): Clones for ADH4 - Starting at $45 >
- * ADH4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADH4
- Addgene plasmids for ADH4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH4
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for ADH4 Gene
- GeneLoc Exon Structure for
- ADH4
Expression for ADH4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
-
Peripheral Nervous System (Nervous System)
mRNA differential expression in normal tissues according to GTEx for ADH4 Gene
This gene is overexpressed in Liver (x50.9).
This gene is overexpressed in Liver, secretome (46.4) and Liver (20.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADH4
SOURCE GeneReport for Unigene cluster for ADH4 Gene:
Hs.1219Evidence on tissue expression from TISSUES for ADH4 Gene
- Liver(4.9)
- Nervous system(4.4)
- Intestine(2.8)
- Skin(2.2)
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for ADH4
-
OriGene qPCR primer pairs and template standards for ADH4
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH4 Gene
Orthologs for ADH4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adh4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Adh4 30 17 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adh4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adh5 31 |
|
ManyToMany | |
| zgc:77938 31 |
|
ManyToMany | |||
| zgc:63568 31 |
|
ManyToMany | |||
| adh8a 31 |
|
ManyToMany | |||
| adh8b 31 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Fdh 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 31 |
|
ManyToMany | |
| Y50D4C.2 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ADH1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os11g0210500 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 31 |
|
OneToMany |
- Species where no ortholog for ADH4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADH4 Gene
- ENSEMBL:
- Gene Tree for ADH4 (if available)
- TreeFam:
- Gene Tree for ADH4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH4: view image
Paralogs for ADH4 Gene
Paralogs for ADH4 Gene
(6) SIMAP similar genes for ADH4 Gene using alignment to 5 proteins:
- ADH4_HUMAN
- D6R9K8_HUMAN
- D6RF43_HUMAN
- D6RIB1_HUMAN
- H0Y9N0_HUMAN
Pseudogenes.org Pseudogenes for ADH4 Gene
Variants for ADH4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADH4 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1579406737 | Not Provided: CIC-DUX Sarcoma | 99,142,747(-) |
C/CT NM_000670.4(ADH4):c.51dup (p.Ala18fs) |
FRAMESHIFT | |
| rs1126671 | - |
p.Ile309Val |
|||
| rs1126673 | - |
p.Val374Ile |
|||
| rs29001219 | - |
p.Arg318His |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1002574 | CNV | loss | 25217958 |
| nsv1002927 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.14;
51.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH4 Gene
Disorders for ADH4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alcohol dependence |
|
|
| substance dependence |
|
|
| alcohol-related birth defect |
|
|
| cluster headache |
|
|
| hypocalciuric hypercalcemia, familial, type ii |
|
|
Search ADH4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH4 Gene
Publications for ADH4 Gene
- Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. (PMID: 19925625) Rainero I … Pinessi L (Headache 2010) 3 23 41
- Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. (PMID: 16081420) Collins XH … Spector AA (The Journal of biological chemistry 2005) 3 4 23
- Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PMID: 15863808) Guindalini C … Zatz M (The American journal of psychiatry 2005) 3 23 41
- Alcohol dehydrogenase alleles in Parkinson's disease. (PMID: 11009184) Buervenich S … Olson L (Movement disorders : official journal of the Movement Disorder Society 2000) 3 23 41
- Cloning and characterization of the human ADH4 gene. (PMID: 1889753) von Bahr-Lindström H … Höög JO (Gene 1991) 3 4 23
ExternalLinks
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Sources for ADH4 Gene
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