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This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide) is a Protein Coding gene. Diseases associated with ADH4 include Alcohol Dependence and Substance Dependence. Among its related pathways are Signaling by GPCR and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is ADH5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003960 | NADPH:quinone reductase activity | ISS | -- |
GO:0004022 | alcohol dehydrogenase (NAD) activity | IDA | 3466164 |
GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IEA,IDA | 10407146 |
GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | IEA | -- |
GO:0004745 | retinol dehydrogenase activity | IEA,IDA | 10514444 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Cytochrome P450 - arranged by substrate type | ||
3 | Metabolism |
.40
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4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
5 | Signaling by Retinoic Acid |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | IDA | 15369820 |
GO:0006066 | alcohol metabolic process | IDA | 3466164 |
GO:0006067 | ethanol metabolic process | IEA | -- |
GO:0006069 | ethanol oxidation | IEA,TAS | -- |
GO:0006081 | cellular aldehyde metabolic process | IDA | 3466164 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Enzyme, substrate | 3481 | ||
NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
Vitamin A | Approved, Vet_approved | Nutra | 732 | |||
Chloral hydrate | Approved, Illicit, Investigational, Vet_approved | Pharma | 18 | |||
Isopropyl alcohol | Approved, Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1-Hexanol |
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111-27-3 |
|
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1-Pentanol |
|
71-41-0 |
|
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2,2,2-Trichloroethanol |
|
115-20-8 |
|
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2-Phenyl-1,3-propanediol monocarbamate |
|
|
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3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
Compound | Action | Cas Number |
---|---|---|
Isovaleramide | 541-46-8 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ADH4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Adh4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Adh4 30 17 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adh4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | adh5 31 |
|
ManyToMany | |
zgc:77938 31 |
|
ManyToMany | |||
zgc:63568 31 |
|
ManyToMany | |||
adh8a 31 |
|
ManyToMany | |||
adh8b 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Fdh 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 31 |
|
ManyToMany | |
Y50D4C.2 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ADH1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os11g0210500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1579406737 | Not Provided: CIC-DUX Sarcoma | 99,142,747(-) |
C/CT NM_000670.4(ADH4):c.51dup (p.Ala18fs) |
FRAMESHIFT | |
rs1126671 | - |
p.Ile309Val |
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rs1126673 | - |
p.Val374Ile |
|||
rs29001219 | - |
p.Arg318His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1002574 | CNV | loss | 25217958 |
nsv1002927 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alcohol dependence |
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substance dependence |
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alcohol-related birth defect |
|
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cluster headache |
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hypocalciuric hypercalcemia, familial, type ii |
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