Aliases for ADH1C Gene
External Ids for ADH1C Gene
Previous HGNC Symbols for ADH1C Gene
Previous GeneCards Identifiers for ADH1C Gene
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]
GeneCards Summary for ADH1C Gene
ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) is a Protein Coding gene. Diseases associated with ADH1C include Alcohol Dependence and Parkinson Disease, Late-Onset. Among its related pathways are Signaling by GPCR and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1B.