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ADH1C Gene(Protein Coding)

Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide

GCID:
GC04M099336
GIFtS:
45
Genes Participants
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Aliases for ADH1C Gene

Aliases for ADH1C Gene

  • Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide 2 3 5
  • ADH3 3 4
  • Alcohol Dehydrogenase 3 (Class I), Gamma Polypeptide 3
  • Alcohol Dehydrogenase Subunit Gamma 4
  • Alcohol Dehydrogenase 1C 3
  • ADH, Gamma Subunit 3
  • Aldehyde Reductase 3
  • EC 1.1.1.1 4

External Ids for ADH1C Gene

Previous HGNC Symbols for ADH1C Gene

  • ADH3

Previous GeneCards Identifiers for ADH1C Gene

  • GC04M100504
  • GC04M100386
  • GC04M100452
  • GC04M100457
  • GC04M100614
  • GC04M100257
  • GC04M095995

Summaries for ADH1C Gene

Entrez Gene Summary for ADH1C Gene

  • This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH1C Gene

ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) is a Protein Coding gene. Diseases associated with ADH1C include Alcohol Dependence and Parkinson Disease, Late-Onset. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1B.

Gene Wiki entry for ADH1C Gene

PharmGKB "VIP" Summary for ADH1C Gene

Additional gene information for ADH1C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1C Gene

Genomics for ADH1C Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ADH1C Gene

Promoters and enhancers for ADH1C Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J099352 Promoter/Enhancer 1 EPDnew ENCODE 660 -0.2 -169 1.2 SP1 TAF1 RXRA MAX RAD21 ADH1C ADH1B ADH1A ADH5 LOC102723576
GH04J099351 Enhancer 0.3 FANTOM5 666.7 +1.5 1496 0.4 FOXA2 ADH1C ADH1B ADH6 ADH1A ADH4 PIR40463
GH04J099382 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -31.1 -31050 3.1 FOXA2 MAX RAD21 RARA YY1 EGR1 POLR2A IKZF5 HNF4G NFE2 ADH1C ADH1A MTTP ADH5 LOC102723576
GH04J099381 Enhancer 0.5 FANTOM5 27.4 -28.1 -28101 0.2 SP1 YY1 ADH1A ADH4 ADH1C ADH1B ADH6 LOC100507053 LOC102723576
GH04J099394 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 -42.5 -42464 1.9 RXRA BACH1 MAFG YY1 SP1 ZNF316 HNF4A NFE2 MAFK EMSY ADH1C LOC100507053 ADH1A RNU7-149P MTTP LOC102723576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADH1C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADH1C gene promoter:
  • FOXC1
  • CUTL1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for ADH1C Gene

Genomic Locations for ADH1C Gene
chr4:99,336,492-99,353,045
(GRCh38/hg38)
Size:
16,554 bases
Orientation:
Minus strand
chr4:100,257,649-100,274,184
(GRCh37/hg19)
Size:
16,536 bases
Orientation:
Minus strand

Genomic View for ADH1C Gene

Genes around ADH1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH1C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADH1C Gene

Proteins for ADH1C Gene

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  • Protein details for ADH1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00326-ADH1G_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1C
    Protein Accession:
    P00326
    Secondary Accessions:
    • Q4PJ18
    • Q5WRV0
    • Q6LBW4
    • Q6NWV0
    • Q6NZA7

    Protein attributes for ADH1C Gene

    Size:
    375 amino acids
    Molecular mass:
    39868 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH1C Gene

neXtProt entry for ADH1C Gene

Protein Expression for ADH1C Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADH1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADH1C Gene

Domains & Families for ADH1C Gene

Gene Families for ADH1C Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ADH1C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADH1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00326

UniProtKB/Swiss-Prot:

ADH1G_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1C: view

Function for ADH1C Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for ADH1C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A primary alcohol + NAD(+) = an aldehyde + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
A secondary alcohol + NAD(+) = a ketone + NADH.

Enzyme Numbers (IUBMB) for ADH1C Gene

Phenotypes From GWAS Catalog for ADH1C Gene

Gene Ontology (GO) - Molecular Function for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 6391957
GO:0004024 alcohol dehydrogenase activity, zinc-dependent EXP 9982
GO:0004745 retinol dehydrogenase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ADH1C: view
genes like me logo Genes that share phenotypes with ADH1C: view

Animal Models for ADH1C Gene

MGI Knock Outs for ADH1C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1C

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADH1C Gene

Localization for ADH1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1C Gene

Cytoplasm.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ADH1C: view

No data available for Subcellular locations from COMPARTMENTS for ADH1C Gene

Pathways & Interactions for ADH1C Gene

genes like me logo Genes that share pathways with ADH1C: view

Interacting Proteins for ADH1C Gene

Selected Interacting proteins: P00326-ADH1G_HUMAN for ADH1C Gene via IID

GPS-Prot Interaction Network for ADH1C

Gene Ontology (GO) - Biological Process for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH1C: view

No data available for SIGNOR curated interactions for ADH1C Gene

Drugs & Compounds for ADH1C Gene

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(30) Drugs for ADH1C Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fomepizole Approved, Vet_approved Pharma inhibitor, Target 3
Ethanol Approved Pharma Enzyme 2326
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Zinc Approved, Investigational Pharma Enzyme 2430
NADH Approved Nutra Target 0

(20) Additional Compounds for ADH1C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Piperidinecarboxaldehyde
  • 1-Formyl-piperidine
  • 1-Formylpiperidine
  • 1-Piperidinecarbaldehyde
  • Formylpiperidine
  • FPI
 2591-86-8
2,2,2-Trichloroethanol
  • 2,2,2-trichloro-1-Ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-trichloro-Ethanol
 115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxymandelic aldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • alpha,3,4-Trihydroxybenzeneacetaldehyde
  • alpha,3,4-Trihydroxyphenylacetaldehyde
 13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
  • 1-(3,4-Dihydroxyphenyl)-1,2-ethanediol
  • 2-Hydroxy-2-(3,4-dihydroxy)phenylethanol
  • 3,4-Dihydroxyphenethyl glycol
  • 3,4-Dihydroxyphenylethyl glycol
 28822-73-3
genes like me logo Genes that share compounds with ADH1C: view

Transcripts for ADH1C Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADH1C Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(475) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADH1C Gene

Alcohol dehydrogenase 1C (class I), gamma polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1C Gene

No ASD Table

Relevant External Links for ADH1C Gene

GeneLoc Exon Structure for
ADH1C
ECgene alternative splicing isoforms for
ADH1C

Expression for ADH1C Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADH1C Gene

mRNA expression in normal human tissues for ADH1C Gene
mRNA expression by GTEx for ADH1C GenemRNA expression by BioGPS for ADH1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH1C Gene

This gene is overexpressed in Liver (x21.9), Colon - Transverse (x10.0), and Stomach (x5.4).

Protein differential expression in normal tissues from HIPED for ADH1C Gene

This gene is overexpressed in Liver, secretome (18.6), Gallbladder (9.5), Liver (8.5), and Stomach (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1C Gene



Protein tissue co-expression partners for ADH1C Gene

NURSA nuclear receptor signaling pathways regulating expression of ADH1C Gene:

ADH1C

SOURCE GeneReport for Unigene cluster for ADH1C Gene:

Hs.654537
genes like me logo Genes that share expression patterns with ADH1C: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH1C Gene

Orthologs for ADH1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ADH1C 33
  • 99.38 (n)
dog
(Canis familiaris)
 Mammalia -- 34
  • 86 (a)
 OneToMany
LOC100856533 33
  • 85.96 (n)
cow
(Bos Taurus)
 Mammalia ADH1C 33
  • 85.51 (n)
-- 34
  • 74 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Adh1 16 34 33
  • 82.22 (n)
rat
(Rattus norvegicus)
 Mammalia Adh1 33
  • 81.16 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 76 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 70 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 34
  • 71 (a)
 OneToMany
ADH1C 33
  • 70.4 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 74 (a)
 ManyToMany
-- 34
  • 72 (a)
 ManyToMany
-- 34
  • 68 (a)
 ManyToMany
-- 34
  • 68 (a)
 ManyToMany
-- 34
  • 67 (a)
 ManyToMany
-- 34
  • 66 (a)
 ManyToMany
-- 34
  • 66 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia adh1c 33
  • 66.31 (n)
zebrafish
(Danio rerio)
 Actinopterygii zgc:63568 34
  • 56 (a)
 ManyToMany
zgc:77938 34
  • 56 (a)
 ManyToMany
adh8a 34
  • 54 (a)
 ManyToMany
adh8b 34
  • 51 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Fdh 34
  • 52 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea H24K24.3 34
  • 50 (a)
 ManyToMany
Y50D4C.2 34
  • 32 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SFA1 34
  • 45 (a)
 OneToMany
corn
(Zea mays)
 Liliopsida Zm.2859 33
rice
(Oryza sativa)
 Liliopsida Os.12591 33
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1497 34
  • 54 (a)
 OneToMany
Species where no ortholog for ADH1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH1C Gene

ENSEMBL:
Gene Tree for ADH1C (if available)
TreeFam:
Gene Tree for ADH1C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADH1C: view image

Paralogs for ADH1C Gene

Paralogs for ADH1C Gene

(6) SIMAP similar genes for ADH1C Gene using alignment to 1 proteins:

  • ADH1G_HUMAN
genes like me logo Genes that share paralogs with ADH1C: view

Variants for ADH1C Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1C Gene

ADH1G_HUMAN-P00326
Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate.

Sequence variations from dbSNP and Humsavar for ADH1C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1693482 protective, Alcohol dependence 99,342,808(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs283413 benign, risk-factor, not specified, Parkinson disease, mitochondrial 99,347,033(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained
rs698 protective, Alcohol dependence 99,339,632(-) T/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000177059 -- 99,354,773(-) C/T upstream_transcript_variant
rs1000410422 -- 99,350,389(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADH1C Gene

Variant ID Type Subtype PubMed ID
nsv980234 CNV duplication 23825009
nsv966301 CNV duplication 23825009
nsv528518 CNV loss 19592680
nsv293592 CNV deletion 16902084
nsv1002809 CNV gain 25217958
esv2659036 CNV deletion 23128226
dgv5345n100 CNV gain 25217958

Additional Variant Information for ADH1C Gene

Human Gene Mutation Database (HGMD)
ADH1C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH1C

SNP Genotyping and Copy Number Assay Products

No data available for Variation tolerance for ADH1C Gene

Disorders for ADH1C Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADH1C Gene - From: HGMD, OMIM, ClinVar, GTR, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADH1C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH1C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADH1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1C Gene

Publications for ADH1C Gene

  1. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B … Soucek P (Pancreas 2010) 3 22 44 58
  2. Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. (PMID: 20401433) Cichoz-Lach H … Lis E (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2010) 3 22 44 58
  3. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura FT … Saijoh K (Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2009) 3 25 44 58
  4. Genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors: results from the IMMIDIET study. (PMID: 19447389) Latella MC … European Collaborative Group of the IMMIDIET Project (Atherosclerosis 2009) 3 22 44 58
  5. Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism. (PMID: 19120062) Homann N … Seitz HK (Alcoholism, clinical and experimental research 2009) 3 22 44 58

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