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Aliases for ADH1B Gene

Aliases for ADH1B Gene

  • Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide 2 3 5
  • Alcohol Dehydrogenase Subunit Beta 3 4
  • ADH2 3 4
  • Alcohol Dehydrogenase 2 (Class I), Beta Polypeptide 3
  • Epididymis Secretory Protein Li 117 3
  • Alcohol Dehydrogenase 1B 3
  • Aldehyde Reductase 3
  • ADH, Beta Subunit 3
  • EC 4
  • HEL-S-117 3

External Ids for ADH1B Gene

Previous HGNC Symbols for ADH1B Gene

  • ADH2

Previous GeneCards Identifiers for ADH1B Gene

  • GC04M100473
  • GC04M100451
  • GC04M100456
  • GC04M100577
  • GC04M100226
  • GC04M095965

Summaries for ADH1B Gene

Entrez Gene Summary for ADH1B Gene

  • The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ADH1B Gene

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Alcoholic Liver Cirrhosis. Among its related pathways are Drug metabolism - cytochrome P450 and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH1B Gene

PharmGKB "VIP" Summary for ADH1B Gene

Additional gene information for ADH1B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1B Gene

Genomics for ADH1B Gene

GeneHancer (GH) Regulatory Elements for ADH1B Gene

Promoters and enhancers for ADH1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J099352 Promoter/Enhancer 1 EPDnew ENCODE 650.7 -0.5 -454 1.2 SP1 TAF1 RXRA MAX RAD21 ADH1C ADH1B ADH1A ADH5 LOC102723576
GH04J099322 Promoter 0.9 EPDnew 650.3 +31.3 31339 0.1 FOXA2 TAF1 RXRA HLF MAX REST RAD21 FOXA1 YY1 SP1 ADH1B PIR40463
GH04J099351 Enhancer 0.3 FANTOM5 660.9 +1.2 1211 0.4 FOXA2 ADH1C ADH1B ADH6 ADH1A ADH4 PIR40463
GH04J099381 Enhancer 0.5 FANTOM5 22.2 -28.4 -28386 0.2 SP1 YY1 ADH1A ADH4 ADH1C ADH1B ADH6 LOC100507053 LOC102723576
GH04J099571 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 4.1 -223.2 -223178 9 FOXA2 ARID4B DMAP1 YY1 RXRA MXD4 MIER2 REST PPARG KAT8 MTTP TRMT10A LOC100507053 ADH1B ENSG00000248676
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADH1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADH1B gene promoter:

Genomic Locations for ADH1B Gene

Genomic Locations for ADH1B Gene
47,797 bases
Minus strand

Genomic View for ADH1B Gene

Genes around ADH1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1B Gene

Proteins for ADH1B Gene

  • Protein details for ADH1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alcohol dehydrogenase 1B
    Protein Accession:
    Secondary Accessions:
    • A8MYN5
    • B4DRS9
    • B4DVC3
    • Q13711
    • Q4ZGI9
    • Q96KI7

    Protein attributes for ADH1B Gene

    375 amino acids
    Molecular mass:
    39855 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH1B Gene

    Alternative splice isoforms for ADH1B Gene


neXtProt entry for ADH1B Gene

Post-translational modifications for ADH1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1B Gene

No data available for DME Specific Peptides for ADH1B Gene

Domains & Families for ADH1B Gene

Gene Families for ADH1B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family.
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1B: view

Function for ADH1B Gene

Molecular function for ADH1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A primary alcohol + NAD(+) = an aldehyde + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
A secondary alcohol + NAD(+) = a ketone + NADH.

Enzyme Numbers (IUBMB) for ADH1B Gene

Phenotypes From GWAS Catalog for ADH1B Gene

Gene Ontology (GO) - Molecular Function for ADH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA 9982
GO:0008270 zinc ion binding IEA,IDA 9982
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADH1B: view
genes like me logo Genes that share phenotypes with ADH1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH1B Gene

Localization for ADH1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH1B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ADH1B: view

Pathways & Interactions for ADH1B Gene

genes like me logo Genes that share pathways with ADH1B: view

Interacting Proteins for ADH1B Gene

Gene Ontology (GO) - Biological Process for ADH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH1B: view

No data available for SIGNOR curated interactions for ADH1B Gene

Drugs & Compounds for ADH1B Gene

(21) Drugs for ADH1B Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 2326
Fomepizole Approved, Vet_approved Pharma inhibitor, Target 3
Glycerol Approved, Investigational Pharma Target 175
NADH Approved Nutra Target, Enzyme, substrate 0
Vitamin A Approved, Vet_approved Nutra 529

(23) Additional Compounds for ADH1B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
  • 2,2,2-trichloro-1-Ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-trichloro-Ethanol
2-Phenyl-1,3-propanediol monocarbamate
  • 3,4-Dihydroxymandelic aldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • alpha,3,4-Trihydroxybenzeneacetaldehyde
  • alpha,3,4-Trihydroxyphenylacetaldehyde
genes like me logo Genes that share compounds with ADH1B: view

Transcripts for ADH1B Gene

mRNA/cDNA for ADH1B Gene

Unigene Clusters for ADH1B Gene

Alcohol dehydrogenase 1B (class I), beta polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1B Gene

No ASD Table

Relevant External Links for ADH1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADH1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADH1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH1B Gene

This gene is overexpressed in Liver (x7.6), Adipose - Subcutaneous (x7.1), Adipose - Visceral (Omentum) (x6.3), and Breast - Mammary Tissue (x4.2).

Protein differential expression in normal tissues from HIPED for ADH1B Gene

This gene is overexpressed in Nasopharynx (18.6), Liver (10.7), Liver, secretome (9.8), and Gallbladder (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1B Gene

Protein tissue co-expression partners for ADH1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADH1B Gene:


SOURCE GeneReport for Unigene cluster for ADH1B Gene:


Evidence on tissue expression from TISSUES for ADH1B Gene

  • Liver(5)
  • Intestine(4.7)
  • Lung(3.6)
  • Heart(3.5)
  • Stomach(2.4)
  • Kidney(2.3)
  • Gall bladder(2.1)
  • Nervous system(2.1)
  • Adrenal gland(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with ADH1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH1B Gene

Orthologs for ADH1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADH1B 34 33
  • 99.2 (n)
(Canis familiaris)
Mammalia -- 34
  • 86 (a)
(Mus musculus)
Mammalia Adh1 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
(Bos Taurus)
Mammalia -- 34
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
-- 34
  • 71 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
-- 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adh6 33
  • 67.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68507 33
(Danio rerio)
Actinopterygii zgc:63568 34
  • 57 (a)
zgc:77938 34
  • 57 (a)
adh8a 34
  • 55 (a)
adh8b 34
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fdh 34
  • 53 (a)
(Caenorhabditis elegans)
Secernentea H24K24.3 34
  • 51 (a)
Y50D4C.2 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 34
  • 46 (a)
ADH1 36
(Triticum aestivum)
Liliopsida Ta.10015 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 34
  • 55 (a)
Species where no ortholog for ADH1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ADH1B Gene

Gene Tree for ADH1B (if available)
Gene Tree for ADH1B (if available)
Evolutionary constrained regions (ECRs) for ADH1B: view image

Paralogs for ADH1B Gene

Paralogs for ADH1B Gene

(7) SIMAP similar genes for ADH1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADH1B: view

Variants for ADH1B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1B Gene

Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIM:103720].

Sequence variations from dbSNP and Humsavar for ADH1B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1229984 protective, Alcohol dependence, Aerodigestive tract cancer, squamous cell, alcohol-related, protection against 99,318,162(-) T/C coding_sequence_variant, missense_variant
rs2066702 protective, Alcohol dependence 99,307,860(-) G/A coding_sequence_variant, missense_variant
rs1000003992 -- 99,306,430(-) G/C 3_prime_UTR_variant
rs1000102884 -- 99,308,659(-) G/A intron_variant
rs1000312910 -- 99,319,187(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADH1B Gene

Variant ID Type Subtype PubMed ID
dgv5345n100 CNV gain 25217958
esv2659036 CNV deletion 23128226
nsv1002809 CNV gain 25217958
nsv966300 CNV duplication 23825009

Variation tolerance for ADH1B Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADH1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for ADH1B Gene

MalaCards: The human disease database

(9) MalaCards diseases for ADH1B Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcoholism
alcoholic liver cirrhosis
  • alcoholic cirrhosis
fetal alcohol syndrome
  • alcohol-related neurodevelopmental disorder
alcoholic pancreatitis
  • pancreatitis alcoholic
  • agu
- elite association - COSMIC cancer census association via MalaCards
Search ADH1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADH1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADH1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1B Gene

Publications for ADH1B Gene

  1. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. (PMID: 20010786) Ding JH … Yao GH (Journal of human genetics 2010) 3 22 44 58
  2. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B … Soucek P (Pancreas 2010) 3 22 44 58
  3. Alcohol dehydrogenase 2 genotype and risk for migraine. (PMID: 19486361) García-Martín E … Jiménez-Jiménez FJ (Headache 2010) 3 22 44 58
  4. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura FT … Saijoh K (Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2009) 3 25 44 58
  5. Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. (PMID: 19667493) Kawase T … Tajima K (Journal of epidemiology 2009) 3 22 44 58

Products for ADH1B Gene

Sources for ADH1B Gene

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