Aliases for ADH1B Gene
Aliases for ADH1B Gene
External Ids for ADH1B Gene
- HGNC: 250
- Entrez Gene: 125
- Ensembl: ENSG00000196616
- OMIM: 103720
- UniProtKB: P00325
Previous HGNC Symbols for ADH1B Gene
- ADH2
Previous GeneCards Identifiers for ADH1B Gene
- GC04M100473
- GC04M100451
- GC04M100456
- GC04M100577
- GC04M100226
- GC04M095965
Summaries for ADH1B Gene
-
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ADH1B Gene
ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Alcoholic Liver Cirrhosis. Among its related pathways are Drug metabolism - cytochrome P450 and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.
Additional gene information for ADH1B Gene
- Monarch Initiative
- Search for ADH1B at DataMed
- Search for ADH1B at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1B Gene
Genomics for ADH1B Gene
GeneHancer (GH) Regulatory Elements for ADH1B Gene
Promoters and enhancers for ADH1B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J099352 | Promoter/Enhancer | 1 | EPDnew ENCODE | 650.7 | -0.5 | -454 | 1.2 | SP1 TAF1 RXRA MAX RAD21 | ADH1C ADH1B ADH1A ADH5 LOC102723576 | |
| GH04J099322 | Promoter | 0.9 | EPDnew | 650.3 | +31.3 | 31339 | 0.1 | FOXA2 TAF1 RXRA HLF MAX REST RAD21 FOXA1 YY1 SP1 | ADH1B PIR40463 | |
| GH04J099351 | Enhancer | 0.3 | FANTOM5 | 660.9 | +1.2 | 1211 | 0.4 | FOXA2 | ADH1C ADH1B ADH6 ADH1A ADH4 PIR40463 | |
| GH04J099381 | Enhancer | 0.5 | FANTOM5 | 22.2 | -28.4 | -28386 | 0.2 | SP1 YY1 | ADH1A ADH4 ADH1C ADH1B ADH6 LOC100507053 LOC102723576 | |
| GH04J099571 | Promoter/Enhancer | 1.6 | EPDnew ENCODE dbSUPER | 4.1 | -223.2 | -223178 | 9 | FOXA2 ARID4B DMAP1 YY1 RXRA MXD4 MIER2 REST PPARG KAT8 | MTTP TRMT10A LOC100507053 ADH1B ENSG00000248676 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADH1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADH1B Gene
Genomic Locations for ADH1B Gene
- chr4:99,304,964-99,352,760
- (GRCh38/hg38)
- Size:
- 47,797 bases
- Orientation:
- Minus strand
- chr4:100,226,121-100,242,572
- (GRCh37/hg19)
Genomic View for ADH1B Gene
Genes around ADH1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by Entrez Gene
- 4q23 by HGNC
- 4q23 by Ensembl
ADH1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH1B Gene
Proteins for ADH1B Gene
-
Protein details for ADH1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P00325-ADH1B_HUMAN
- Recommended name:
- Alcohol dehydrogenase 1B
- Protein Accession:
- P00325
- A8MYN5
- B4DRS9
- B4DVC3
- Q13711
- Q4ZGI9
- Q96KI7
Protein attributes for ADH1B Gene
- Size:
- 375 amino acids
- Molecular mass:
- 39855 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
- Miscellaneous:
-
- There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Three dimensional structures from OCA and Proteopedia for ADH1B Gene
Protein Expression for ADH1B Gene
Post-translational modifications for ADH1B Gene
Other Protein References for ADH1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ADH1B
- Invitrogen Antibodies for ADH1B
- GeneTex ADH1B Antibody for ADH1B
-
Boster Bio Antibodies for ADH1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH1B
Protein Products
-
OriGene Purified Proteins for ADH1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH1B
- Origene Custom Protein Services for ADH1B
- antibodies-online: Search results for 10 available ADH1B Proteins ranked by validation data
- Compare Top ADH1B Proteins
-
Quality Products:
- Search GeneTex for Proteins for ADH1B
Assay Products
- antibodies-online: Search results for 1 available ADH1B Elisa Kits ranked by validation data
- Compare Top ADH1B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ADH1B Gene
Domains & Families for ADH1B Gene
Gene Families for ADH1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH1B Gene
Graphical View of Domain Structure for InterPro Entry
P00325- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family.
Function for ADH1B Gene
Molecular function for ADH1B Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- A primary alcohol + NAD(+) = an aldehyde + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A secondary alcohol + NAD(+) = a ketone + NADH.
Enzyme Numbers (IUBMB) for ADH1B Gene
Phenotypes From GWAS Catalog for ADH1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IDA | 9982 |
| GO:0008270 | zinc ion binding | IEA,IDA | 9982 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ADH1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADH1B
-
CRISPR Products
-
OriGene CRISPR knockouts for ADH1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- Applied Biological Materials CRISPR for ADH1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
- GenScript: Design CRISPR guide RNA sequences for ADH1B
miRNA for ADH1B Gene
- miRTarBase miRNAs that target ADH1B
-
- hsa-mir-1277-5p (MIRT504583)
- hsa-mir-190a-3p (MIRT504584)
- hsa-mir-4758-3p (MIRT504585)
- hsa-mir-3189-5p (MIRT504586)
- hsa-mir-5699-5p (MIRT504587)
- hsa-mir-5011-5p (MIRT504588)
- hsa-mir-4280 (MIRT504589)
- hsa-mir-98-3p (MIRT518099)
- hsa-let-7f-1-3p (MIRT518100)
- hsa-let-7b-3p (MIRT518101)
- hsa-let-7a-3p (MIRT518102)
- hsa-mir-4705 (MIRT518103)
- hsa-mir-4666a-3p (MIRT518104)
- hsa-mir-5580-3p (MIRT518105)
- hsa-mir-34b-3p (MIRT518106)
- hsa-mir-381-3p (MIRT518107)
- hsa-mir-300 (MIRT518108)
- hsa-mir-3149 (MIRT551501)
- hsa-mir-297 (MIRT551502)
- hsa-mir-568 (MIRT551503)
- hsa-mir-3924 (MIRT551504)
- hsa-mir-223-5p (MIRT551505)
- hsa-mir-567 (MIRT551506)
- hsa-mir-511-3p (MIRT551507)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADH1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADH1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- Applied Biological Materials Clones for ADH1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADH1B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH1B Gene
Localization for ADH1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH1B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for ADH1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Metabolism |
.37
|
|
| 4 | Phenylalanine metabolism | ||
| 5 | Cyclophosphamide Pathway, Pharmacodynamics | ||
Pathways by source for ADH1B Gene
6 BioSystems pathways for ADH1B Gene
4 Reactome pathways for ADH1B Gene
8 KEGG pathways for ADH1B Gene
1 GeneGo (Thomson Reuters) pathway for ADH1B Gene
1 Cell Signaling Technology pathway for ADH1B Gene
Interacting Proteins for ADH1B Gene
GPS-Prot Interaction Network for ADH1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006069 | ethanol oxidation | TAS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for ADH1B Gene
Drugs & Compounds for ADH1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme | 2326 | ||
| Fomepizole | Approved, Vet_approved | Pharma | inhibitor, Target | 3 | ||
| Glycerol | Approved, Investigational | Pharma | Target | 175 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| Vitamin A | Approved, Vet_approved | Nutra | 529 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
| 2-Phenyl-1,3-propanediol monocarbamate |
|
|
||||
| 3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
Transcripts for ADH1B Gene
mRNA/cDNA for ADH1B Gene
- (475) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000305046 4072 bps (uc003hus.6)
- ENST00000504498 694 bps (uc062ylc.1)
- ENST00000506651 1667 bps (uc062ylb.2)
- ENST00000515694 3820 bps (uc062yla.1)
- ENST00000625860 4059 bps (uc062ykz.1)
Unigene Clusters for ADH1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADH1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- Applied Biological Materials CRISPR for ADH1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
- GenScript: Design CRISPR guide RNA sequences for ADH1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADH1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADH1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- Applied Biological Materials Clones for ADH1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADH1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
- Lung (Respiratory System)
-
Hair
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Ovary (Reproductive System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for ADH1B Gene
This gene is overexpressed in Liver (x7.6), Adipose - Subcutaneous (x7.1), Adipose - Visceral (Omentum) (x6.3), and Breast - Mammary Tissue (x4.2).
This gene is overexpressed in Nasopharynx (18.6), Liver (10.7), Liver, secretome (9.8), and Gallbladder (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1B Gene
NURSA nuclear receptor signaling pathways regulating expression of ADH1B Gene:
ADH1BSOURCE GeneReport for Unigene cluster for ADH1B Gene:
Hs.4Evidence on tissue expression from TISSUES for ADH1B Gene
- Liver(5)
- Intestine(4.7)
- Lung(3.6)
- Heart(3.5)
- Stomach(2.4)
- Kidney(2.3)
- Gall bladder(2.1)
- Nervous system(2.1)
- Adrenal gland(2)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADH1B
-
OriGene qPCR primer pairs for ADH1B
- genomics-online: primer clones - Search results for available ADH1B gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH1B Gene
Orthologs for ADH1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADH1B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Adh1 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adh6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68507 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:63568 34 |
|
ManyToMany | |
| zgc:77938 34 |
|
ManyToMany | |||
| adh8a 34 |
|
ManyToMany | |||
| adh8b 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Fdh 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 34 |
|
ManyToMany | |
| Y50D4C.2 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 34 |
|
OneToMany | |
| ADH1 36 |
|
|
|||
| wheat (Triticum aestivum) |
Liliopsida | Ta.10015 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 34 |
|
OneToMany |
- Species where no ortholog for ADH1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ADH1B Gene
- ENSEMBL:
- Gene Tree for ADH1B (if available)
- TreeFam:
- Gene Tree for ADH1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH1B: view image
Paralogs for ADH1B Gene
Variants for ADH1B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1B Gene
- ADH1B_HUMAN-P00325
- Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIM:103720].
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1229984 | protective, Alcohol dependence, Aerodigestive tract cancer, squamous cell, alcohol-related, protection against | 99,318,162(-) | T/C | coding_sequence_variant, missense_variant | |
| rs2066702 | protective, Alcohol dependence | 99,307,860(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000003992 | -- | 99,306,430(-) | G/C | 3_prime_UTR_variant | |
| rs1000102884 | -- | 99,308,659(-) | G/A | intron_variant | |
| rs1000312910 | -- | 99,319,187(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5345n100 | CNV | gain | 25217958 |
| esv2659036 | CNV | deletion | 23128226 |
| nsv1002809 | CNV | gain | 25217958 |
| nsv966300 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.03;
68.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH1B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ADH1B Gene
(9) MalaCards diseases for ADH1B Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alcohol dependence |
|
|
| alcoholic liver cirrhosis |
|
|
| fetal alcohol syndrome |
|
|
| alcoholic pancreatitis |
|
|
| aspartylglucosaminuria |
|
|
Search ADH1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1B Gene
Publications for ADH1B Gene
- Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. (PMID: 20010786) Ding JH … Yao GH (Journal of human genetics 2010) 3 22 44 58
- CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B … Soucek P (Pancreas 2010) 3 22 44 58
- Alcohol dehydrogenase 2 genotype and risk for migraine. (PMID: 19486361) García-Martín E … Jiménez-Jiménez FJ (Headache 2010) 3 22 44 58
- Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura FT … Saijoh K (Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2009) 3 25 44 58
- Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. (PMID: 19667493) Kawase T … Tajima K (Journal of epidemiology 2009) 3 22 44 58
Products for ADH1B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ADH1B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ADH1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH1B
- Origene Custom Protein Services for ADH1B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- OriGene qPCR primer pairs and template standards for ADH1B
- OriGene qPCR primer pairs for ADH1B
- OriGene CRISPR knockouts for ADH1B
- OriGene ORF clones in human for ADH1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADH1B
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADH1B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADH1B
- GenScript Custom Assay Services for ADH1B
- GenScript Custom overexpressing Cell Line Services for ADH1B
- GenScript: Design CRISPR guide RNA sequences for ADH1B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADH1B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ADH1B
- Novus Biologicals proteins and lysates for ADH1B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ADH1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADH1B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 57 available ADH1B Antibodies ranked by validation data
- Compare Top ADH1B Antibodies
- antibodies-online: Search results for 1 available ADH1B Elisa Kits ranked by validation data
- Compare Top ADH1B Elisa Kits
- Quality Products:
- antibodies-online: Search results for 10 available ADH1B Proteins ranked by validation data
- Compare Top ADH1B Proteins
- Quality Products:
- GeneTex ADH1B Antibody for ADH1B
- Search GeneTex for Proteins for ADH1B
- Santa Cruz Biotechnology (SCBT) Antibodies for ADH1B
- Search Santa Cruz Biotechnology (SCBT) for ADH1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
- Horizon Cell Lines for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- genomics-online: primer clones - Search results for available ADH1B gene related products
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- GeneCopoeia miRNA 3'UTR Target clone products for ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
- Boster Bio Antibodies for ADH1B
- Browse Boster Bio ELISA Kits
Sources for ADH1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio