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The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Alcoholic Liver Cirrhosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Cyclophosphamide Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IDA | 9982 |
GO:0004745 | retinol dehydrogenase activity | IBA | 21873635 |
GO:0008270 | zinc ion binding | IEA,IDA | 9982 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Cytochrome P450 - arranged by substrate type | ||
3 | Metabolism |
.40
|
|
4 | Phenylalanine metabolism | ||
5 | Cyclophosphamide Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006069 | ethanol oxidation | TAS | -- |
GO:0042572 | retinol metabolic process | IBA | 21873635 |
GO:0042573 | retinoic acid metabolic process | IBA | 21873635 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Enzyme | 3120 | ||
Fomepizole | Approved, Vet_approved | Pharma | Target, inhibitor | 4 | ||
Glycerol | Approved, Investigational | Pharma | Target | 202 | ||
NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
Vitamin A | Approved, Vet_approved | Nutra | 636 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1-Hexanol |
|
111-27-3 |
|
|||
1-Pentanol |
|
71-41-0 |
|
|||
2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
2-Phenyl-1,3-propanediol monocarbamate |
|
|
||||
3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ADH1B 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
mouse (Mus musculus) |
Mammalia | Adh1 33 |
|
OneToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
cow (Bos Taurus) |
Mammalia | -- 33 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | adh6 32 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68507 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | zgc:63568 33 |
|
ManyToMany | |
zgc:77938 33 |
|
ManyToMany | |||
adh8a 33 |
|
ManyToMany | |||
adh8b 33 |
|
ManyToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | Fdh 33 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 33 |
|
ManyToMany | |
Y50D4C.2 33 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 33 |
|
OneToMany | |
ADH1 35 |
|
|
|||
wheat (Triticum aestivum) |
Liliopsida | Ta.10015 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 33 |
|
OneToMany |
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1229984 | protective, Alcohol dependence, Aerodigestive tract cancer, squamous cell, alcohol-related, protection against, - | 99,318,162(-) | T/C/G | coding_sequence_variant, missense_variant | |
rs2066702 | protective, Alcohol dependence, - | 99,307,860(-) | G/A | coding_sequence_variant, missense_variant | |
rs1000003992 | -- | 99,306,430(-) | G/C | 3_prime_UTR_variant | |
rs1000102884 | -- | 99,308,659(-) | G/A | intron_variant | |
rs1000312910 | -- | 99,319,187(-) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5345n100 | CNV | gain | 25217958 |
esv2659036 | CNV | deletion | 23128226 |
nsv1002809 | CNV | gain | 25217958 |
nsv966300 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alcohol dependence |
|
|
alcoholic liver cirrhosis |
|
|
fetal alcohol syndrome |
|
|
alcoholic pancreatitis |
|
|
alcohol use disorder |
|
|