Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activi... See more...
Aliases for ADH1B Gene
Aliases for ADH1B Gene
External Ids for ADH1B Gene
- HGNC: 250
- Entrez Gene: 125
- Ensembl: ENSG00000196616
- OMIM: 103720
- UniProtKB: P00325
Previous HGNC Symbols for ADH1B Gene
- ADH2
Previous GeneCards Identifiers for ADH1B Gene
- GC04M100473
- GC04M100451
- GC04M100456
- GC04M100577
- GC04M100226
- GC04M095965
Summaries for ADH1B Gene
-
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ADH1B Gene
ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Alcoholic Liver Cirrhosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Cyclophosphamide Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.
UniProtKB/Swiss-Prot Summary for ADH1B Gene
-
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).
Additional gene information for ADH1B Gene
- Monarch Initiative
- Search for ADH1B at DataMed
- Search for ADH1B at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for ADH1B Gene
Genomics for ADH1B Gene
GeneHancer (GH) Regulatory Elements for ADH1B Gene
Promoters and enhancers for ADH1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADH1B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADH1B gene promoter:
-
- AREB6
- CP2
- GR
- GR-alpha
- Lhx3a
- LHX3b
- p53
Genomic Locations for ADH1B Gene
Genomic Locations for ADH1B Gene
- chr4:99,304,971-99,352,760
- (GRCh38/hg38)
- Size:
- 47,790 bases
- Orientation:
- Minus strand
- chr4:100,226,121-100,242,572
- (GRCh37/hg19)
- Size:
- 16,452 bases
- Orientation:
- Minus strand
Genomic View for ADH1B Gene
Genes around ADH1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q23 by HGNC
- 4q23 by Entrez Gene
- 4q23 by Ensembl
ADH1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADH1B Gene
Proteins for ADH1B Gene
-
Protein details for ADH1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P00325-ADH1B_HUMAN
- Recommended name:
- All-trans-retinol dehydrogenase [NAD(+)] ADH1B
- Protein Accession:
- P00325
- A8MYN5
- B4DRS9
- B4DVC3
- Q13711
- Q4ZGI9
- Q96KI7
Protein attributes for ADH1B Gene
- Size:
- 375 amino acids
- Molecular mass:
- 39855 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
- Miscellaneous:
-
- There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
Three dimensional structures from OCA and Proteopedia for ADH1B Gene
Protein Expression for ADH1B Gene
Selected DME Specific Peptides for ADH1B Gene
- P00325:
-
- CLIGCGF
- EVAPPKA
- FSQYTVV
- GKPIHHFLG
- KINEGFDLL
- ESVGEGVT
- ILGHEAAG
- PQCGKCR
- SVIVGVPP
- EVRIKMV
- GRTWKGA
- GICRTDDH
- GHEAAGIVES
- NKDKFAKAK
- CAVFGLGGVGLS
- CINPQDY
- GKVIKCKAA
- DFMAKKF
- PVILGHE
- LITHVLPFEKIN
- GCGFSTGYG
- AKVTPGS
- CKNPESN
- KPIQEVL
- EMTDGGV
- VMGCKAAGA
- PGDKVIPLF
- DINKDKF
- GATECINP
- TAGKVIKC
- PLEKVCL
- GIVESVG
Post-translational modifications for ADH1B Gene
Other Protein References for ADH1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Creative Biolabs
- Mouse Anti-ADH1B Recombinant Antibody (1H7)
- Mouse Anti-ADH1B Recombinant Antibody (1C3)
- Mouse Anti-ADH1B Recombinant Antibody (5D7)
- Recombinant Mouse Anti-Human ADH1B Antibody
- Hi-Affi™ Recombinant Rabbit Anti-ADH1B Monoclonal Antibody (DS79AB)
- Mouse Anti-ADH1B Recombinant Antibody (4F12)
- Mouse Anti-ADH1B Recombinant Antibody (3C12)
- Mouse Anti-ADH1B Recombinant Antibody (3F2)
- Novus Biologicals Antibodies for ADH1B
-
Abcam antibodies for ADH1B
- Invitrogen Antibodies for ADH1B (AFLGC-ADH1B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADH1B
Protein Products
- Creative Biomart Recombinant Human ADH1B 293 Cell Lysate
-
OriGene Purified Proteins for ADH1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH1B
- Origene Custom Protein Services for ADH1B
- antibodies-online: Show 7 available ADH1B Proteins ranked by validation data
- Compare Top ADH1B Proteins
-
Quality Products:
-
Abcam proteins for ADH1B
Domains & Families for ADH1B Gene
Gene Families for ADH1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ADH1B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADH1B Gene
- GenScript: Design optimal peptide antigens:
-
- Alcohol dehydrogenase subunit beta (ADH1B_HUMAN)
- cDNA, FLJ79400, highly similar to Alcohol dehydrogenase 1B (EC 1.1.1.1) (B7ZB36_HUMAN)
- cDNA FLJ51682, highly similar to Alcohol dehydrogenase 1B (EC 1.1.1.1) (F5HB16_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P00325- Family:
-
- Belongs to the zinc-containing alcohol dehydrogenase family.
Function for ADH1B Gene
Molecular function for ADH1B Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21285; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH; Xref=Rhea:RHEA:55936, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132259, ChEBI:CHEBI:139346; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55937; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH; Xref=Rhea:RHEA:60632, ChEBI:CHEBI:15378, ChEBI:CHEBI:44597, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:139347; Evidence=. ;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4 uM for all-trans-4-hydroxyretinol (in allele ADH1B*1) {ECO:0000269 PubMed:15369820}; KM=25 uM for all-trans-4-oxoretinal (in allele ADH1B*1) {ECO:0000269 PubMed:15369820}; KM=11 uM for all-trans-4-hydroxyretinol (in allele ADH1B*2) {ECO:0000269 PubMed:15369820}; KM=27 uM for all-trans-4-oxoretinal (in allele ADH1B*2) {ECO:0000269 PubMed:15369820}; KM=24 uM for all-trans-3,4-didehydroretinol(in allele ADH1B*2) {ECO:0000269 PubMed:15369820}; KM=25 uM for all-trans-3,4-didehydroretinal(in allele ADH1B*2) {ECO:0000269 PubMed:15369820}; KM=0.4 uM for all-trans-retinaldehyde (in allele ADH1B*2) {ECO:0000269 PubMed:16787387}; KM=0.3 uM for all-trans-retinol (in allele ADH1B*2) {ECO:0000269 PubMed:16787387};
Enzyme Numbers (IUBMB) for ADH1B Gene
Phenotypes From GWAS Catalog for ADH1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | IDA | 9982 |
| GO:0004745 | retinol dehydrogenase activity | IBA | 21873635 |
| GO:0008270 | zinc ion binding | IEA,IDA | 9982 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ADH1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for ADH1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- Applied Biological Materials (abm): CRISPR Clones for ADH1B - Select products 50% OFF >
- * ADH1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH1B CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
miRNA for ADH1B Gene
- miRTarBase miRNAs that target ADH1B
-
- hsa-mir-1277-5p (MIRT504583)
- hsa-mir-190a-3p (MIRT504584)
- hsa-mir-4758-3p (MIRT504585)
- hsa-mir-3189-5p (MIRT504586)
- hsa-mir-5699-5p (MIRT504587)
- hsa-mir-5011-5p (MIRT504588)
- hsa-mir-4280 (MIRT504589)
- hsa-mir-98-3p (MIRT518099)
- hsa-let-7f-1-3p (MIRT518100)
- hsa-let-7b-3p (MIRT518101)
- hsa-let-7a-3p (MIRT518102)
- hsa-mir-4705 (MIRT518103)
- hsa-mir-4666a-3p (MIRT518104)
- hsa-mir-5580-3p (MIRT518105)
- hsa-mir-34b-3p (MIRT518106)
- hsa-mir-381-3p (MIRT518107)
- hsa-mir-300 (MIRT518108)
- hsa-mir-3149 (MIRT551501)
- hsa-mir-297 (MIRT551502)
- hsa-mir-568 (MIRT551503)
- hsa-mir-3924 (MIRT551504)
- hsa-mir-223-5p (MIRT551505)
- hsa-mir-567 (MIRT551506)
- hsa-mir-511-3p (MIRT551507)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- Applied Biological Materials (abm): Clones for ADH1B - Select products 50% OFF >
- * ADH1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH1B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for ADH1B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH1B Gene
Localization for ADH1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADH1B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for ADH1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Metabolism |
.40
|
|
| 4 | Phenylalanine metabolism | ||
| 5 | Cyclophosphamide Pathway, Pharmacodynamics | ||
Pathways by source for ADH1B Gene
6 BioSystems pathways for ADH1B Gene
4 Reactome pathways for ADH1B Gene
8 KEGG pathways for ADH1B Gene
1 GeneGo (Thomson Reuters) pathway for ADH1B Gene
1 Cell Signaling Technology pathway for ADH1B Gene
Interacting Proteins for ADH1B Gene
GPS-Prot Interaction Network for ADH1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006069 | ethanol oxidation | TAS | -- |
| GO:0042572 | retinol metabolic process | IBA | 21873635 |
| GO:0042573 | retinoic acid metabolic process | IBA | 21873635 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for ADH1B Gene
Drugs & Compounds for ADH1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Enzyme | 3120 | ||
| Fomepizole | Approved, Vet_approved | Pharma | Target, inhibitor | 4 | ||
| Glycerol | Approved, Investigational | Pharma | Target | 202 | ||
| NADH | Approved | Nutra | Target, Enzyme, substrate | 0 | ||
| Vitamin A | Approved, Vet_approved | Nutra | 636 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 2,2,2-Trichloroethanol |
|
115-20-8 |
|
|||
| 2-Phenyl-1,3-propanediol monocarbamate |
|
|
||||
| 3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
Drug Products
- Creative Biomart Recombinant Human ADH1B 293 Cell Lysate
Transcripts for ADH1B Gene
mRNA/cDNA for ADH1B Gene
- (2) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000305046 4067 bps (ENST00000305046.12)
- ENST00000515694 3820 bps (ENST00000515694.4)
- ENST00000506651 1667 bps (ENST00000506651.5)
- ENST00000632775 5363 bps (ENST00000632775.1)
- ENST00000504498 694 bps (ENST00000504498.1)
CRISPR Products
-
OriGene CRISPR knockouts for ADH1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- Applied Biological Materials (abm): CRISPR Clones for ADH1B - Select products 50% OFF >
- * ADH1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH1B CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- Applied Biological Materials (abm): Clones for ADH1B - Select products 50% OFF >
- * ADH1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ADH1B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for ADH1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Adipose (Muscoskeletal System)
- Lung (Respiratory System)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ADH1B Gene
This gene is overexpressed in Liver (x7.6), Adipose - Subcutaneous (x7.1), Adipose - Visceral (Omentum) (x6.3), and Breast - Mammary Tissue (x4.2).
This gene is overexpressed in Nasopharynx (18.6), Liver (10.7), Liver, secretome (9.8), and Gallbladder (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1B Gene
NURSA nuclear receptor signaling pathways regulating expression of ADH1B Gene:
ADH1BSOURCE GeneReport for Unigene cluster for ADH1B Gene:
Hs.4Evidence on tissue expression from TISSUES for ADH1B Gene
- Liver(5)
- Intestine(4.7)
- Lung(3.6)
- Heart(3.5)
- Stomach(2.4)
- Kidney(2.3)
- Gall bladder(2.1)
- Nervous system(2.1)
- Adrenal gland(2)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for ADH1B
-
OriGene qPCR primer pairs and template standards for ADH1B
- genomics-online: primer clones - Search results for available ADH1B gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH1B Gene
Orthologs for ADH1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADH1B 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Adh1 33 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adh6 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68507 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:63568 33 |
|
ManyToMany | |
| zgc:77938 33 |
|
ManyToMany | |||
| adh8a 33 |
|
ManyToMany | |||
| adh8b 33 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Fdh 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H24K24.3 33 |
|
ManyToMany | |
| Y50D4C.2 33 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SFA1 33 |
|
OneToMany | |
| ADH1 35 |
|
|
|||
| wheat (Triticum aestivum) |
Liliopsida | Ta.10015 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1497 33 |
|
OneToMany |
- Species where no ortholog for ADH1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ADH1B Gene
- ENSEMBL:
- Gene Tree for ADH1B (if available)
- TreeFam:
- Gene Tree for ADH1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADH1B: view image
Paralogs for ADH1B Gene
Paralogs for ADH1B Gene
(7) SIMAP similar genes for ADH1B Gene using alignment to 3 proteins:
- ADH1B_HUMAN
- A8MYN5_HUMAN
- D6RHZ6_HUMAN
Variants for ADH1B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1B Gene
- ADH1B_HUMAN-P00325
- Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIM:103720].
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1229984 | protective, Alcohol dependence, Aerodigestive tract cancer, squamous cell, alcohol-related, protection against, - | 99,318,162(-) | T/C/G | coding_sequence_variant, missense_variant | |
| rs2066702 | protective, Alcohol dependence, - | 99,307,860(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000003992 | -- | 99,306,430(-) | G/C | 3_prime_UTR_variant | |
| rs1000102884 | -- | 99,308,659(-) | G/A | intron_variant | |
| rs1000312910 | -- | 99,319,187(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5345n100 | CNV | gain | 25217958 |
| esv2659036 | CNV | deletion | 23128226 |
| nsv1002809 | CNV | gain | 25217958 |
| nsv966300 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.03;
68.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADH1B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ADH1B Gene
(16) MalaCards diseases for ADH1B Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alcohol dependence |
|
|
| alcoholic liver cirrhosis |
|
|
| fetal alcohol syndrome |
|
|
| alcoholic pancreatitis |
|
|
| alcohol use disorder |
|
|
Search ADH1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADH1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1B Gene
Publications for ADH1B Gene
- CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B … Soucek P (Pancreas 2010) 3 23 43 56
- Alcohol dehydrogenase 2 genotype and risk for migraine. (PMID: 19486361) García-Martín E … Jiménez-Jiménez FJ (Headache 2010) 3 23 43 56
- Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. (PMID: 20010786) Ding JH … Yao GH (Journal of human genetics 2010) 3 23 43 56
- Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura FT … Saijoh K (Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2009) 3 26 43 56
- Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males. (PMID: 19452585) Ding JH … Yao GH (World journal of gastroenterology 2009) 3 23 43 56
ExternalLinks
Products for ADH1B Gene
- Custom Antibody ServicesOriGene Antibodies for ADH1B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ADH1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ADH1B
- Origene Custom Protein Services for ADH1B
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADH1B
- Browse OriGene Inhibitory RNA Products For ADH1B
- OriGene qPCR primer pairs for ADH1B
- OriGene qPCR primer pairs and template standards for ADH1B
- OriGene CRISPR knockouts for ADH1B
- OriGene ORF clones in human for ADH1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADH1B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ADH1B
- Novus Biologicals proteins and lysates for ADH1B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ADH1B
- Abcam proteins for ADH1B
- Abcam assays for ADH1B
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ADH1B (AFLGC-ADH1B)
- antibodies-online: Show 50 available ADH1B Antibodies ranked by validation data
- Compare Top ADH1B Antibodies
- antibodies-online: Search results for available ADH1B related products ranked by validation data
- antibodies-online: Show 7 available ADH1B Proteins ranked by validation data
- Compare Top ADH1B Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ADH1B
- Search Santa Cruz Biotechnology (SCBT) for ADH1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADH1B
- Horizon Cell Lines for ADH1B
- genomics-online: cdna clones - Search results for available ADH1B gene related products
- orf clones - Search results for available ADH1B gene related products
- genomics-online: gRNA clones - Search results for available ADH1B gene related products
- genomics-online: primer clones - Search results for available ADH1B gene related products
- genomics-online: shRNA clones - Search results for available ADH1B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADH1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADH1B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ADH1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADH1B
Sources for ADH1B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource