Aliases for ADH1A Gene
External Ids for ADH1A Gene
Previous HGNC Symbols for ADH1A Gene
Previous GeneCards Identifiers for ADH1A Gene
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
GeneCards Summary for ADH1A Gene
ADH1A (Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ADH1A include Substance Dependence and Methanol Poisoning. Among its related pathways are Drug metabolism - cytochrome P450 and Fatty acid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1B.