ADGRL4 Gene (Protein Coding)

Adhesion G Protein-Coupled Receptor L4

GC01M078889
GIFtS:
39

Aliases for ADGRL4 Gene

Aliases for ADGRL4 Gene

  • Adhesion G Protein-Coupled Receptor L4 2 3 4 5
  • EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 1 3 4
  • EGF, Latrophilin And Seven Transmembrane Domain Containing 1 2 3
  • EGF-TM7-Latrophilin-Related Protein 3 4
  • ELTD1 3 4
  • ETL 3 4
  • HSALNG0004641 167
  • NONHSAG001887 92
  • Lnc-ADGRL4-2 168
  • ETL Protein 4
  • KPG_003 3

External Ids for ADGRL4 Gene

Previous HGNC Symbols for ADGRL4 Gene

  • ELTD1

Summaries for ADGRL4 Gene

GeneCards Summary for ADGRL4 Gene

ADGRL4 (Adhesion G Protein-Coupled Receptor L4) is a Protein Coding gene. Diseases associated with ADGRL4 include Epilepsy, Familial Temporal Lobe, 8 and Epilepsy, Familial Temporal Lobe, 2. Among its related pathways are GPCRs, Class B Secretin-like. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL3.

UniProtKB/Swiss-Prot Summary for ADGRL4 Gene

  • Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Gene Wiki entry for ADGRL4 Gene

Additional gene information for ADGRL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRL4 Gene

Genomics for ADGRL4 Gene

GeneHancer (GH) Regulatory Elements for ADGRL4 Gene

Promoters and enhancers for ADGRL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J079005 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.1 +276.3 276323 3.2 HDAC2 POLR2A YY1 STAT3 FOS ATF2 JUN TAF1 TBP CTBP2 ADGRL4 piR-38580-011 piR-34888-001
GH01J079187 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 515.7 +93.2 93223 3.4 EP300 NFYB SMARCC1 FOS JUN ELK4 BATF JUND TBP TAF1 ADGRL4 HSALNG0004655 piR-50968-005
GH01J079075 Enhancer 1.1 VISTA Ensembl ENCODE 10.8 +202.6 202568 7.8 JUND FOS TRIM28 OSR2 REST JUN MAFK FOXP2 STAT1 POLR2A ADGRL4 lnc-IFI44-7 PSAT1P3
GH01J079192 Enhancer 0.7 ENCODE 15.2 +88.9 88882 1.9 JUND EP300 POLR2A DEK FOS SRF CEBPB TCF12 BATF MAX ADGRL4 HSALNG0004655 piR-50968-005
GH01J079040 Enhancer 0.7 FANTOM5 11.3 +241.4 241436 0.3 JUND MEF2C OSR2 BCL11A SRF BATF ZNF189 STAT5A ATF2 FEZF1 ADGRL4 IFI44 piR-38580-011 PSAT1P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRL4

Genomic Locations for ADGRL4 Gene

Genomic Locations for ADGRL4 Gene
chr1:78,889,764-79,282,124
(GRCh38/hg38)
Size:
392,361 bases
Orientation:
Minus strand
chr1:79,355,449-79,472,495
(GRCh37/hg19)
Size:
117,047 bases
Orientation:
Minus strand

Genomic View for ADGRL4 Gene

Genes around ADGRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRL4 Gene

Proteins for ADGRL4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBW9-AGRL4_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L4
    Protein Accession:
    Q9HBW9
    Secondary Accessions:
    • B1AR71
    • Q5KU34

    Protein attributes for ADGRL4 Gene

    Size:
    690 amino acids
    Molecular mass:
    77811 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
    SequenceCaution:
    • Sequence=AAG33021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25721.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRL4 Gene

Protein Expression for ADGRL4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRL4 Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn15, Asn21, Asn64, Asn74, Asn127, Asn177, Asn188, Asn249, Asn381, and Asn395
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AGRL4_HUMAN (1915)

Other Protein References for ADGRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRL4 Gene

Domains & Families for ADGRL4 Gene

Gene Families for ADGRL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ADGRL4 Gene

Blocks:
  • Type I EGF
  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRL4 Gene

GenScript: Design optimal peptide antigens:
  • EGF, latrophilin and seven transmembrane domain containing 1 (B1AR72_HUMAN)
  • EGF-TM7-latrophilin-related protein (ELTD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBW9

UniProtKB/Swiss-Prot:

AGRL4_HUMAN :
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL4: view

Function for ADGRL4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ADGRL4 Gene

UniProtKB/Swiss-Prot Function:
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in tumor endothelial cells. Up-regulated by DLL4.

Phenotypes From GWAS Catalog for ADGRL4 Gene

Gene Ontology (GO) - Molecular Function for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,IEA 21873635
GO:0005509 calcium ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ADGRL4: view
genes like me logo Genes that share phenotypes with ADGRL4: view

Animal Models for ADGRL4 Gene

MGI Knock Outs for ADGRL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRL4

CRISPR Products

miRNA for ADGRL4 Gene

miRTarBase miRNAs that target ADGRL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL4 Gene

Localization for ADGRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
GO:0031410 cytoplasmic vesicle IEA,ISS --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRL4 Gene

Pathways & Interactions for ADGRL4 Gene

PathCards logo

SuperPathways for ADGRL4 Gene

SuperPathway Contained pathways
1 GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
-
genes like me logo Genes that share pathways with ADGRL4: view

Pathways by source for ADGRL4 Gene

1 BioSystems pathway for ADGRL4 Gene

Gene Ontology (GO) - Biological Process for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for SIGNOR curated interactions for ADGRL4 Gene

Drugs & Compounds for ADGRL4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRL4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADGRL4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
5 RNACentral transcripts :
1 NONCODE transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL4 Gene

No ASD Table

Relevant External Links for ADGRL4 Gene

GeneLoc Exon Structure for
ADGRL4

Expression for ADGRL4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRL4 Gene

mRNA expression in normal human tissues for ADGRL4 Gene
mRNA expression by GTEx for ADGRL4 Gene

Protein differential expression in normal tissues from HIPED for ADGRL4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRL4 Gene



Protein tissue co-expression partners for ADGRL4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRL4

mRNA Expression by UniProt/SwissProt for ADGRL4 Gene:

Q9HBW9-AGRL4_HUMAN
Tissue specificity: Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.

Evidence on tissue expression from TISSUES for ADGRL4 Gene

  • Bone marrow(4)
  • Pancreas(4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ADGRL4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRL4 Gene

Orthologs for ADGRL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ELTD1 31 30
  • 99.18 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ELTD1 31 30
  • 90.14 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ELTD1 31 30
  • 89.4 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Eltd1 31 30
  • 78.68 (n)
 OneToOne
Adgrl4 17
rat
(Rattus norvegicus)
 Mammalia Eltd1 30
  • 77.34 (n)
oppossum
(Monodelphis domestica)
 Mammalia ELTD1 31
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ELTD1 31
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ELTD1 31 30
  • 71.4 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ELTD1 31
  • 60 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101731473 30
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC68819 30
zebrafish
(Danio rerio)
 Actinopterygii eltd1 31 30
  • 60.25 (n)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea lat-1 31
  • 18 (a)
 OneToMany
Species where no ortholog for ADGRL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL4 Gene

ENSEMBL:
Gene Tree for ADGRL4 (if available)
TreeFam:
Gene Tree for ADGRL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRL4: view image

Paralogs for ADGRL4 Gene

Variants for ADGRL4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRL4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
787750 Benign: not provided 78,936,332(-) A/G SYNONYMOUS_VARIANT
rs12754818 - p.Val300Leu
rs1968956 - p.His599Gln
rs2275902 - p.Ala620Gly

Additional dbSNP identifiers (rs#s) for ADGRL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRL4 Gene

Variant ID Type Subtype PubMed ID
dgv331n54 CNV loss 21841781
dgv332n54 CNV loss 21841781
dgv333n54 CNV loss 21841781
esv1001130 CNV deletion 20482838
esv2156352 CNV deletion 18987734
esv21924 CNV loss 19812545
esv2551231 CNV deletion 19546169
esv2661629 CNV deletion 23128226
esv2750229 CNV deletion 23290073
esv2750240 CNV deletion 23290073
esv2750252 CNV deletion 23290073
esv3564571 CNV deletion 23714750
esv3586563 CNV loss 21293372
esv3586564 CNV loss 21293372
esv4207 CNV loss 18987735
esv9047 CNV loss 19470904
nsv1001291 CNV loss 25217958
nsv1010441 CNV loss 25217958
nsv1077959 CNV deletion 25765185
nsv1122370 CNV deletion 24896259
nsv1147665 CNV deletion 26484159
nsv462139 CNV loss 19166990
nsv470720 CNV loss 18288195
nsv526221 CNV loss 19592680
nsv528328 CNV loss 19592680
nsv546619 CNV loss 21841781
nsv546621 CNV loss 21841781
nsv546623 CNV loss 21841781
nsv546629 CNV loss 21841781
nsv957236 CNV deletion 24416366

Variation tolerance for ADGRL4 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL4 Gene

Disorders for ADGRL4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ADGRL4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRL4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADGRL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRL4 Gene

Publications for ADGRL4 Gene

  1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. (PMID: 11050079) Nechiporuk T … Keating MT (The Journal of biological chemistry 2001) 2 3 4 23 54
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 54
  3. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. (PMID: 23871637) Masiero M … Buffa FM (Cancer cell 2013) 3 4 54
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

View latest publications for ADGRL4 gene in Mastermind

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