Aliases for ADGRL4 Gene

Aliases for ADGRL4 Gene

  • Adhesion G Protein-Coupled Receptor L4 2 3 4 5
  • EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 1 3 4
  • EGF, Latrophilin And Seven Transmembrane Domain Containing 1 2 3
  • EGF-TM7-Latrophilin-Related Protein 3 4
  • ELTD1 3 4
  • ETL 3 4
  • ETL Protein 4
  • KPG_003 3

External Ids for ADGRL4 Gene

Previous HGNC Symbols for ADGRL4 Gene

  • ELTD1

Summaries for ADGRL4 Gene

GeneCards Summary for ADGRL4 Gene

ADGRL4 (Adhesion G Protein-Coupled Receptor L4) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL3.

UniProtKB/Swiss-Prot Summary for ADGRL4 Gene

  • Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Gene Wiki entry for ADGRL4 Gene

Additional gene information for ADGRL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRL4 Gene

Genomics for ADGRL4 Gene

GeneHancer (GH) Regulatory Elements for ADGRL4 Gene

Promoters and enhancers for ADGRL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J079005 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 750.1 +276.3 276323 3.2 JUN POLR2A ATF2 ADGRL4 lnc-ADGRL4-2 piR-34888-001
GH01J079187 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 765.7 +93.2 93223 3.4 POLR2A SMARCC1 JUN JUND EP300 BATF ADGRL4 HSALNG0004655 piR-50968-005
GH01J079075 Enhancer 1 VISTA Ensembl ENCODE 10.8 +202.6 202568 7.8 MAFK JUN ZNF140 JUND OSR2 FOS STAT1 BACH1 MAFF ADGRL4 lnc-IFI44-7 PSAT1P3
GH01J079192 Enhancer 0.6 ENCODE 15.2 +88.9 88882 1.9 POLR2A JUND IKZF1 IKZF2 CEBPB MAX DPF2 EP300 DEK JUNB ADGRL4 HSALNG0004655 piR-50968-005
GH01J079042 Enhancer 0.7 ENCODE 11.3 +239.9 239853 0.2 JUND ETV6 MAFK CREM ZBED1 BACH1 NFE2L2 JUN PKNOX1 NFE2 ADGRL4 piR-38580-011 PSAT1P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRL4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRL4 Gene

Genomic Locations for ADGRL4 Gene
392,361 bases
Minus strand
117,047 bases
Minus strand

Genomic View for ADGRL4 Gene

Genes around ADGRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL4 Gene

Proteins for ADGRL4 Gene

  • Protein details for ADGRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor L4
    Protein Accession:
    Secondary Accessions:
    • B1AR71
    • Q5KU34

    Protein attributes for ADGRL4 Gene

    690 amino acids
    Molecular mass:
    77811 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
    • Sequence=AAG33021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25721.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRL4 Gene

Post-translational modifications for ADGRL4 Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn15, Asn21, Asn64, Asn74, Asn127, Asn177, Asn188, Asn249, Asn381, and Asn395
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AGRL4_HUMAN (1915)

No data available for DME Specific Peptides for ADGRL4 Gene

Domains & Families for ADGRL4 Gene

Gene Families for ADGRL4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ADGRL4 Gene

GenScript: Design optimal peptide antigens:
  • EGF, latrophilin and seven transmembrane domain containing 1 (B1AR72_HUMAN)
  • EGF-TM7-latrophilin-related protein (ELTD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL4: view

Function for ADGRL4 Gene

Molecular function for ADGRL4 Gene

UniProtKB/Swiss-Prot Function:
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in tumor endothelial cells. Up-regulated by DLL4.

Phenotypes From GWAS Catalog for ADGRL4 Gene

Gene Ontology (GO) - Molecular Function for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,IEA 21873635
GO:0005509 calcium ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ADGRL4: view
genes like me logo Genes that share phenotypes with ADGRL4: view

Animal Models for ADGRL4 Gene

MGI Knock Outs for ADGRL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRL4

CRISPR Products

miRNA for ADGRL4 Gene

miRTarBase miRNAs that target ADGRL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL4 Gene

Localization for ADGRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
GO:0031410 cytoplasmic vesicle ISS,IEA --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRL4 Gene

Pathways & Interactions for ADGRL4 Gene

PathCards logo

SuperPathways for ADGRL4 Gene

SuperPathway Contained pathways
1 GPCRs, Class B Secretin-like
genes like me logo Genes that share pathways with ADGRL4: view

Pathways by source for ADGRL4 Gene

1 BioSystems pathway for ADGRL4 Gene

Gene Ontology (GO) - Biological Process for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for SIGNOR curated interactions for ADGRL4 Gene

Drugs & Compounds for ADGRL4 Gene

No Compound Related Data Available

Transcripts for ADGRL4 Gene

mRNA/cDNA for ADGRL4 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL4 Gene

No ASD Table

Relevant External Links for ADGRL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRL4 Gene

Protein differential expression in normal tissues from HIPED for ADGRL4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRL4 Gene

Protein tissue co-expression partners for ADGRL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRL4 Gene:


mRNA Expression by UniProt/SwissProt for ADGRL4 Gene:

Tissue specificity: Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.

Evidence on tissue expression from TISSUES for ADGRL4 Gene

  • Bone marrow(4)
  • Pancreas(4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ADGRL4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRL4 Gene

Orthologs for ADGRL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ELTD1 33 32
  • 99.18 (n)
(Canis familiaris)
Mammalia ELTD1 33 32
  • 90.14 (n)
(Bos Taurus)
Mammalia ELTD1 33 32
  • 89.4 (n)
(Mus musculus)
Mammalia Eltd1 33 32
  • 78.68 (n)
Adgrl4 17
(Rattus norvegicus)
Mammalia Eltd1 32
  • 77.34 (n)
(Monodelphis domestica)
Mammalia ELTD1 33
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ELTD1 33
  • 67 (a)
(Gallus gallus)
Aves ELTD1 33 32
  • 71.4 (n)
(Anolis carolinensis)
Reptilia ELTD1 33
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731473 32
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68819 32
(Danio rerio)
Actinopterygii eltd1 33 32
  • 60.25 (n)
(Caenorhabditis elegans)
Secernentea lat-1 33
  • 18 (a)
Species where no ortholog for ADGRL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL4 Gene

Gene Tree for ADGRL4 (if available)
Gene Tree for ADGRL4 (if available)
Evolutionary constrained regions (ECRs) for ADGRL4: view image

Paralogs for ADGRL4 Gene

Variants for ADGRL4 Gene

Sequence variations from dbSNP and Humsavar for ADGRL4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000010971 -- 78,901,233(-) T/A intron_variant
rs1000093521 -- 78,980,527(-) T/C intron_variant
rs1000097858 -- 78,932,948(-) A/T intron_variant
rs1000113063 -- 79,000,908(-) C/A intron_variant
rs1000118557 -- 78,963,583(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRL4 Gene

Variant ID Type Subtype PubMed ID
dgv331n54 CNV loss 21841781
dgv332n54 CNV loss 21841781
dgv333n54 CNV loss 21841781
esv1001130 CNV deletion 20482838
esv2156352 CNV deletion 18987734
esv21924 CNV loss 19812545
esv2551231 CNV deletion 19546169
esv2661629 CNV deletion 23128226
esv2750229 CNV deletion 23290073
esv2750240 CNV deletion 23290073
esv2750252 CNV deletion 23290073
esv3564571 CNV deletion 23714750
esv3586563 CNV loss 21293372
esv3586564 CNV loss 21293372
esv4207 CNV loss 18987735
esv9047 CNV loss 19470904
nsv1001291 CNV loss 25217958
nsv1010441 CNV loss 25217958
nsv1077959 CNV deletion 25765185
nsv1122370 CNV deletion 24896259
nsv1147665 CNV deletion 26484159
nsv462139 CNV loss 19166990
nsv470720 CNV loss 18288195
nsv526221 CNV loss 19592680
nsv528328 CNV loss 19592680
nsv546619 CNV loss 21841781
nsv546621 CNV loss 21841781
nsv546623 CNV loss 21841781
nsv546629 CNV loss 21841781
nsv957236 CNV deletion 24416366

Variation tolerance for ADGRL4 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL4 Gene

Disorders for ADGRL4 Gene

Additional Disease Information for ADGRL4

No disorders were found for ADGRL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRL4 Gene

Publications for ADGRL4 Gene

  1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. (PMID: 11050079) Nechiporuk T … Keating MT (The Journal of biological chemistry 2001) 2 3 4 23 56
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 56
  3. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. (PMID: 23871637) Masiero M … Buffa FM (Cancer cell 2013) 3 4 56
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for ADGRL4 Gene

Sources for ADGRL4 Gene