Aliases for ADGRL3 Gene
External Ids for ADGRL3 Gene
Previous HGNC Symbols for ADGRL3 Gene
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADGRL3 Gene
ADGRL3 (Adhesion G Protein-Coupled Receptor L3) is a Protein Coding gene. Diseases associated with ADGRL3 include Hereditary Lymphedema Ii and Argentine Hemorrhagic Fever. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL2.
UniProtKB/Swiss-Prot Summary for ADGRL3 Gene
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.