Aliases for ADGRL2 Gene
External Ids for ADGRL2 Gene
Previous HGNC Symbols for ADGRL2 Gene
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for ADGRL2 Gene
ADGRL2 (Adhesion G Protein-Coupled Receptor L2) is a Protein Coding gene. Diseases associated with ADGRL2 include Rhombencephalosynapsis. Among its related pathways are GPCRs, Class B Secretin-like and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL1.
UniProtKB/Swiss-Prot Summary for ADGRL2 Gene
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.