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This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
ADGRL2 (Adhesion G Protein-Coupled Receptor L2) is a Protein Coding gene. Diseases associated with ADGRL2 include Rhombencephalosynapsis and Microcephaly. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
GO:0016524 | latrotoxin receptor activity | NAS | 10030676 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS,NAS | 10030676 |
GO:0043005 | neuron projection | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | GPCRs, Class B Secretin-like | ||
2 | GPCRs, Other |
Symbol | External ID(s) | Details |
---|---|---|
SHANK1 | ||
CDH1 | ||
ENSG00000126500 | ||
IRF3 | ||
SHANK2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS,NAS | 10030676 |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0007420 | brain development | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c | · | 29d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | ||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||
SP11: | - | - | - | - | - | ||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LPHN2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LPHN2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LPHN2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-7431 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LPHN2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lphn2 30 31 |
|
OneToOne | |
Adgrl2 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Lphn2 30 |
|
||
Chicken (Gallus gallus) |
Aves | LPHN2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LPHN2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lphn2 30 |
|
||
Str.1058 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16778 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01074906.1 31 |
|
ManyToMany | |
lphn2a 30 31 |
|
ManyToMany | |||
CU467642.1 31 |
|
ManyToMany | |||
CABZ01096573.1 31 |
|
ManyToMany | |||
FP245444.1 31 |
|
ManyToMany | |||
wufb72a08 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | lat-1 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
740851 | Likely Benign: not provided | 81,950,367(+) | A/G | SYNONYMOUS_VARIANT | |
743281 | Likely Benign: not provided | 81,966,555(+) | G/A | SYNONYMOUS_VARIANT | |
779220 | Likely Benign: not provided | 81,952,012(+) | A/G | MISSENSE_VARIANT | |
784951 | Benign: not provided | 81,990,617(+) | G/A | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
VAR_077836 | - | p.Arg467Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1159587 | CNV | deletion | 17803354 |
esv2659412 | CNV | deletion | 23128226 |
esv3307207 | CNV | mobile element insertion | 20981092 |
esv3308604 | CNV | mobile element insertion | 20981092 |
esv3323603 | CNV | insertion | 20981092 |
esv3380260 | CNV | insertion | 20981092 |
esv3564837 | CNV | deletion | 23714750 |
esv3577986 | CNV | loss | 25503493 |
esv3586619 | CNV | loss | 21293372 |
esv3586621 | CNV | loss | 21293372 |
esv3586622 | CNV | gain | 21293372 |
esv3586623 | CNV | loss | 21293372 |
esv3586624 | CNV | loss | 21293372 |
nsv437226 | CNV | loss | 16327808 |
nsv437590 | CNV | loss | 16327808 |
nsv473455 | CNV | novel sequence insertion | 20440878 |
nsv506937 | OTHER | sequence alteration | 20534489 |
nsv823331 | CNV | loss | 20364138 |
nsv830359 | CNV | gain | 17160897 |
nsv946023 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rhombencephalosynapsis |
|
|
microcephaly |
|
|