Aliases for ADGRL1 Gene
External Ids for ADGRL1 Gene
Previous HGNC Symbols for ADGRL1 Gene
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
GeneCards Summary for ADGRL1 Gene
ADGRL1 (Adhesion G Protein-Coupled Receptor L1) is a Protein Coding gene. Diseases associated with ADGRL1 include Vibratory Urticaria and Louping Ill. Among its related pathways are GPCRs, Class B Secretin-like. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL2.
UniProtKB/Swiss-Prot Summary for ADGRL1 Gene
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).