Aliases for ADGRG7 Gene

Aliases for ADGRG7 Gene

  • Adhesion G Protein-Coupled Receptor G7 2 3 5
  • Adhesion G-Protein Coupled Receptor G7 3 4
  • G-Protein Coupled Receptor 128 3 4
  • GPR128 3 4
  • G Protein-Coupled Receptor 128 2

External Ids for ADGRG7 Gene

Previous HGNC Symbols for ADGRG7 Gene

  • GPR128

Summaries for ADGRG7 Gene

GeneCards Summary for ADGRG7 Gene

ADGRG7 (Adhesion G Protein-Coupled Receptor G7) is a Protein Coding gene. Diseases associated with ADGRG7 include Fibrogenesis Imperfecta Ossium. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB2.

UniProtKB/Swiss-Prot Summary for ADGRG7 Gene

Gene Wiki entry for ADGRG7 Gene

Additional gene information for ADGRG7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRG7 Gene

Genomics for ADGRG7 Gene

GeneHancer (GH) Regulatory Elements for ADGRG7 Gene

Promoters and enhancers for ADGRG7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100608 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.6 +2.9 2863 7.2 HLF TEAD4 IKZF1 ELF3 SP1 MLLT1 CBFA2T2 HNF1A KAT8 RNF2 ADGRG7 TFG ENSG00000252989 TOMM70 TMEM45A LNP1 HSALNG0027580
GH03J100602 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 750.4 -6.5 -6503 1.9 CTCF FOXA1 SMARCE1 NR2F6 MIXL1 RELA RAD21 SP1 MAFK BACH1 HSALNG0027579 ADGRG7 TFG TMEM45A
GH03J100628 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.2 +20.7 20690 2.6 SMARCE1 DACH1 TEAD4 MAFK CBFA2T2 SMARCA4 ZNF680 TRIM24 GMEB1 IKZF1 TFG ADGRG7 HSALNG0027580
GH03J100639 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.2 +31.7 31742 2.9 NR2F1 SP1 ZBTB33 IKZF1 RXRA TRIM22 IKZF2 FOXA2 DPF2 JUND TFG ADGRG7 TMEM45A LNP1 ENSG00000252989 HSALNG0027580
GH03J100696 Enhancer 0.8 FANTOM5 Ensembl ENCODE 8.1 +88.0 87994 4 HLF CEBPA ZSCAN4 USF1 MAFK ENSG00000252989 TFG LNP1 ADGRG7 piR-39341-253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRG7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRG7 Gene

Genomic Locations for ADGRG7 Gene
85,891 bases
Plus strand
85,891 bases
Plus strand

Genomic View for ADGRG7 Gene

Genes around ADGRG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG7 Gene

Proteins for ADGRG7 Gene

  • Protein details for ADGRG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor G7
    Protein Accession:
    Secondary Accessions:
    • Q14D94
    • Q86SQ2

    Protein attributes for ADGRG7 Gene

    797 amino acids
    Molecular mass:
    88909 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO27358.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG7 Gene

Post-translational modifications for ADGRG7 Gene

  • Glycosylation at Asn82, Asn159, Asn178, Asn191, Asn247, Asn261, Asn312, Asn316, Asn387, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG7 Gene

No data available for DME Specific Peptides for ADGRG7 Gene

Domains & Families for ADGRG7 Gene

Gene Families for ADGRG7 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRG7 Gene

Suggested Antigen Peptide Sequences for ADGRG7 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 128 (A1L441_HUMAN)
  • Probable G-protein coupled receptor 128 (GP128_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG7: view

Function for ADGRG7 Gene

Molecular function for ADGRG7 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ADGRG7: view
genes like me logo Genes that share phenotypes with ADGRG7: view

Animal Models for ADGRG7 Gene

MGI Knock Outs for ADGRG7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG7

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRG7 Gene

Localization for ADGRG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG7 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
genes like me logo Genes that share ontologies with ADGRG7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG7 Gene

Pathways & Interactions for ADGRG7 Gene

PathCards logo

SuperPathways for ADGRG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRG7: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG7 Gene

Drugs & Compounds for ADGRG7 Gene

No Compound Related Data Available

Transcripts for ADGRG7 Gene

mRNA/cDNA for ADGRG7 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG7 Gene

No ASD Table

Relevant External Links for ADGRG7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG7 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG7 Gene

Protein tissue co-expression partners for ADGRG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG7 Gene:

genes like me logo Genes that share expression patterns with ADGRG7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG7 Gene

Orthologs for ADGRG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR128 33 32
  • 99.83 (n)
(Bos Taurus)
Mammalia GPR128 33 32
  • 81.78 (n)
(Canis familiaris)
Mammalia GPR128 33 32
  • 80.6 (n)
(Rattus norvegicus)
Mammalia Gpr128 32
  • 76.93 (n)
(Mus musculus)
Mammalia Gpr128 33 32
  • 76.85 (n)
Adgrg7 17
(Monodelphis domestica)
Mammalia -- 33
  • 58 (a)
-- 33
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 55 (a)
-- 33
  • 46 (a)
(Gallus gallus)
Aves GPR128 33 32
  • 57.52 (n)
(Danio rerio)
Actinopterygii LOC101882620 32
  • 49.33 (n)
GPR128 (1 of 2) 33
  • 42 (a)
gpr128 33
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 21 (a)
Species where no ortholog for ADGRG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG7 Gene

Gene Tree for ADGRG7 (if available)
Gene Tree for ADGRG7 (if available)
Evolutionary constrained regions (ECRs) for ADGRG7: view image

Paralogs for ADGRG7 Gene

Variants for ADGRG7 Gene

Sequence variations from dbSNP and Humsavar for ADGRG7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004829 -- 100,642,986(+) T/C intron_variant
rs1000028992 -- 100,692,017(+) A/G intron_variant
rs1000032965 -- 100,616,989(+) T/A/C genic_upstream_transcript_variant, intron_variant
rs1000038121 -- 100,626,690(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000057429 -- 100,670,061(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG7 Gene

Variant ID Type Subtype PubMed ID
dgv1397e212 CNV gain 25503493
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv4830n100 CNV gain 25217958
dgv4831n100 CNV gain 25217958
dgv613n27 CNV gain 19166990
dgv614n27 CNV gain 19166990
dgv8476n54 CNV gain 21841781
dgv8477n54 CNV gain 21841781
dgv8478n54 CNV gain 21841781
dgv8479n54 CNV gain 21841781
dgv917e214 CNV gain 21293372
esv2436823 CNV insertion 19546169
esv2675173 CNV deletion 23128226
esv2751970 CNV gain 17911159
esv2763708 CNV gain 21179565
esv3597176 CNV loss 21293372
nsv1010619 CNV gain 25217958
nsv1012731 CNV gain 25217958
nsv460787 CNV gain 19166990
nsv470794 CNV gain 18288195
nsv476483 CNV novel sequence insertion 20440878
nsv516418 CNV gain 19592680
nsv591164 CNV gain 21841781
nsv822201 CNV loss 20364138

Variation tolerance for ADGRG7 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG7 Gene

Disorders for ADGRG7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRG7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
fibrogenesis imperfecta ossium
  • baker's disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRG7

genes like me logo Genes that share disorders with ADGRG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRG7 Gene

Publications for ADGRG7 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 3 4 56
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 56

Products for ADGRG7 Gene

Sources for ADGRG7 Gene