Aliases for ADGRG7 Gene

Aliases for ADGRG7 Gene

  • Adhesion G Protein-Coupled Receptor G7 2 3 5
  • Adhesion G-Protein Coupled Receptor G7 3 4
  • G-Protein Coupled Receptor 128 3 4
  • GPR128 3 4
  • G Protein-Coupled Receptor 128 2
  • FLJ14454 2
  • ADGRG7 5

External Ids for ADGRG7 Gene

Previous HGNC Symbols for ADGRG7 Gene

  • GPR128

Summaries for ADGRG7 Gene

GeneCards Summary for ADGRG7 Gene

ADGRG7 (Adhesion G Protein-Coupled Receptor G7) is a Protein Coding gene. Diseases associated with ADGRG7 include Fibrogenesis Imperfecta Ossium. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL3.

UniProtKB/Swiss-Prot Summary for ADGRG7 Gene

Gene Wiki entry for ADGRG7 Gene

Additional gene information for ADGRG7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRG7 Gene

Genomics for ADGRG7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRG7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100608 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +2.9 2851 7.2 RNF2 REST RBFOX2 RXRB IRF2 SP1 HDAC1 DPF2 CEBPB FOXA2 ADGRG7 TFG ENSG00000252989 SENP7 TOMM70 TMEM45A LNP1 HSALNG0027580
GH03J100602 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 600.4 -6.5 -6515 1.9 GATAD2A CTCF ZNF512 SOX13 IKZF1 JUND FOXA1 STAT3 RELA RAD21 HSALNG0027579 ADGRG7 TFG TMEM45A
GH03J100628 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.2 +20.7 20678 2.6 IKZF1 JUND PKNOX1 DPF2 SOX6 EP300 NFE2 HDAC2 CEBPB ZNF316 TFG ADGRG7 HSALNG0027580
GH03J100639 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.2 +31.7 31730 2.9 TCF12 IKZF2 SP1 TRIM22 DPF2 RELB RUNX3 GATAD2B FOXA2 ZNF592 TFG ADGRG7 TMEM45A LNP1 ENSG00000252989 HSALNG0027580
GH03J100696 Enhancer 0.8 FANTOM5 Ensembl ENCODE 8.1 +88.0 87982 4 ZSCAN4 CEBPA USF1 MAFK HLF CEBPB ENSG00000252989 TFG LNP1 ADGRG7 piR-39341-253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRG7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRG7

Genomic Locations for ADGRG7 Gene

Genomic Locations for ADGRG7 Gene
chr3:100,609,601-100,696,174
(GRCh38/hg38)
Size:
86,574 bases
Orientation:
Plus strand
chr3:100,328,433-100,414,323
(GRCh37/hg19)
Size:
85,891 bases
Orientation:
Plus strand

Genomic View for ADGRG7 Gene

Genes around ADGRG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG7 Gene

Proteins for ADGRG7 Gene

  • Protein details for ADGRG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K78-AGRG7_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G7
    Protein Accession:
    Q96K78
    Secondary Accessions:
    • Q14D94
    • Q86SQ2

    Protein attributes for ADGRG7 Gene

    Size:
    797 amino acids
    Molecular mass:
    88909 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO27358.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG7 Gene

Post-translational modifications for ADGRG7 Gene

  • Glycosylation at Asn82, Asn159, Asn178, Asn191, Asn247, Asn261, Asn312, Asn316, Asn387, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG7 Gene

No data available for DME Specific Peptides for ADGRG7 Gene

Domains & Families for ADGRG7 Gene

Gene Families for ADGRG7 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRG7 Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRG7 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 128 (A1L441_HUMAN)
  • Probable G-protein coupled receptor 128 (GP128_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96K78

UniProtKB/Swiss-Prot:

AGRG7_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG7: view

Function for ADGRG7 Gene

Molecular function for ADGRG7 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRG7 Gene

Gene Ontology (GO) - Molecular Function for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ADGRG7: view
genes like me logo Genes that share phenotypes with ADGRG7: view

Animal Models for ADGRG7 Gene

MGI Knock Outs for ADGRG7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRG7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRG7 Gene

Localization for ADGRG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG7 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG7 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
genes like me logo Genes that share ontologies with ADGRG7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG7 Gene

Pathways & Interactions for ADGRG7 Gene

PathCards logo

SuperPathways for ADGRG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRG7: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG7 Gene

Drugs & Compounds for ADGRG7 Gene

No Compound Related Data Available

Transcripts for ADGRG7 Gene

mRNA/cDNA for ADGRG7 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRG7

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG7 Gene

No ASD Table

Relevant External Links for ADGRG7 Gene

GeneLoc Exon Structure for
ADGRG7

Expression for ADGRG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG7 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG7 Gene



Protein tissue co-expression partners for ADGRG7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRG7

genes like me logo Genes that share expression patterns with ADGRG7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG7 Gene

Orthologs for ADGRG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR128 30 31
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR128 30 31
  • 81.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR128 30 31
  • 80.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr128 30
  • 76.93 (n)
Mouse
(Mus musculus)
Mammalia Gpr128 30 31
  • 76.85 (n)
OneToOne
Adgrg7 17
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 55 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GPR128 30 31
  • 57.52 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC101882620 30
  • 49.33 (n)
GPR128 (1 of 2) 31
  • 42 (a)
OneToMany
gpr128 31
  • 38 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToOne
Species where no ortholog for ADGRG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRG7 Gene

ENSEMBL:
Gene Tree for ADGRG7 (if available)
TreeFam:
Gene Tree for ADGRG7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRG7: view image

Paralogs for ADGRG7 Gene

Variants for ADGRG7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRG7 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
716103 Benign: not provided 100,609,889(+) G/C SYNONYMOUS_VARIANT
716846 Benign: not provided 100,694,874(+) G/A MISSENSE_VARIANT
730290 Likely Benign: not provided 100,694,910(+) C/A MISSENSE_VARIANT
730291 Likely Benign: not provided 100,694,916(+) A/G MISSENSE_VARIANT
738678 Likely Benign: not provided 100,643,519(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ADGRG7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRG7 Gene

Variant ID Type Subtype PubMed ID
dgv1397e212 CNV gain 25503493
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv4830n100 CNV gain 25217958
dgv4831n100 CNV gain 25217958
dgv613n27 CNV gain 19166990
dgv614n27 CNV gain 19166990
dgv8476n54 CNV gain 21841781
dgv8477n54 CNV gain 21841781
dgv8478n54 CNV gain 21841781
dgv8479n54 CNV gain 21841781
dgv917e214 CNV gain 21293372
esv2436823 CNV insertion 19546169
esv2675173 CNV deletion 23128226
esv2751970 CNV gain 17911159
esv2763708 CNV gain 21179565
esv3597176 CNV loss 21293372
nsv1010619 CNV gain 25217958
nsv1012731 CNV gain 25217958
nsv460787 CNV gain 19166990
nsv470794 CNV gain 18288195
nsv476483 CNV novel sequence insertion 20440878
nsv516418 CNV gain 19592680
nsv591164 CNV gain 21841781
nsv822201 CNV loss 20364138

Variation tolerance for ADGRG7 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG7 Gene

Human Gene Mutation Database (HGMD)
ADGRG7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG7 Gene

Disorders for ADGRG7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRG7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fibrogenesis imperfecta ossium
  • baker's disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ADGRG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRG7 Gene

Publications for ADGRG7 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ADGRG7 Gene

Sources for ADGRG7 Gene