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Aliases for ADGRG5 Gene

Aliases for ADGRG5 Gene

  • Adhesion G Protein-Coupled Receptor G5 2 3 5
  • G Protein-Coupled Receptor 114 2 3
  • GPR114 3 4
  • PGR27 3 4
  • Probable G-Protein Coupled Receptor 114 3
  • Adhesion G-Protein Coupled Receptor G5 3
  • G Protein-Coupled Receptor PGR27 3
  • G-Protein Coupled Receptor PGR27 4
  • G-Protein Coupled Receptor 114 4

External Ids for ADGRG5 Gene

Previous HGNC Symbols for ADGRG5 Gene

  • GPR114

Previous GeneCards Identifiers for ADGRG5 Gene

  • GC16P057542

Summaries for ADGRG5 Gene

Entrez Gene Summary for ADGRG5 Gene

  • This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for ADGRG5 Gene

ADGRG5 (Adhesion G Protein-Coupled Receptor G5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG1.

UniProtKB/Swiss-Prot for ADGRG5 Gene

  • Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).

Gene Wiki entry for ADGRG5 Gene

Additional gene information for ADGRG5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG5 Gene

Genomics for ADGRG5 Gene

GeneHancer (GH) Regulatory Elements for ADGRG5 Gene

Promoters and enhancers for ADGRG5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I057542 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 560.2 +14.6 14625 4 HDGF PKNOX1 ATF1 SMAD1 IRF4 TCF12 ZNF766 CBX5 ZNF207 ZNF143 ADGRG5 CCDC102A DOK4 GC16P057566
GH16I057528 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 556.8 +0.3 299 4.1 HDGF ELF3 PKNOX1 ARID4B SIN3A ZBTB40 DNMT3B ZNF48 TCF12 EGR1 ADGRG5 CCDC102A DOK4 NUP93 ZNF319 PIR39147
GH16I057527 Enhancer 0.3 ENCODE 550.8 -2.0 -1999 0.2 MIER2 ADGRG5 CCDC102A PIR46688
GH16I057446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -82.0 -81993 2.4 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 CIAPIN1 COQ9 ADGRG5 GC16P057442
GH16I056859 Enhancer 1.1 Ensembl ENCODE 9.9 -667.6 -667637 4.2 HDGF SIN3A FEZF1 YBX1 ZBTB7B IRF4 TCF12 ZNF766 ZNF143 ATF7 NUP93 ADGRG5 SLC12A3 GC16P056865 MIR138-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRG5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRG5 Gene

Genomic Locations for ADGRG5 Gene
chr16:57,529,333-57,591,681
(GRCh38/hg38)
Size:
62,349 bases
Orientation:
Plus strand
chr16:57,576,333-57,625,593
(GRCh37/hg19)

Genomic View for ADGRG5 Gene

Genes around ADGRG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG5 Gene

Proteins for ADGRG5 Gene

  • Protein details for ADGRG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF4-AGRG5_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G5
    Protein Accession:
    Q8IZF4
    Secondary Accessions:
    • A0A024R6S3
    • A8K9R8
    • B3KXZ5
    • Q6ZMH7
    • Q6ZML4
    • Q86SL8
    • Q8IZ14

    Protein attributes for ADGRG5 Gene

    Size:
    528 amino acids
    Molecular mass:
    59000 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN46670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD18748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG5 Gene

Post-translational modifications for ADGRG5 Gene

  • Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.
  • Glycosylation at posLast=5858, posLast=6565, Asn146, posLast=147147, posLast=173173, posLast=179179, posLast=394394, and posLast=400400
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG5 Gene

No data available for DME Specific Peptides for ADGRG5 Gene

Domains & Families for ADGRG5 Gene

Gene Families for ADGRG5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADGRG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZF4

UniProtKB/Swiss-Prot:

AGRG5_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG5: view

Function for ADGRG5 Gene

Molecular function for ADGRG5 Gene

UniProtKB/Swiss-Prot Function:
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).

Phenotypes From GWAS Catalog for ADGRG5 Gene

Gene Ontology (GO) - Molecular Function for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with ADGRG5: view
genes like me logo Genes that share phenotypes with ADGRG5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRG5 Gene

Localization for ADGRG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG5 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with ADGRG5: view

Pathways & Interactions for ADGRG5 Gene

SuperPathways for ADGRG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRG5: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG5 Gene

Drugs & Compounds for ADGRG5 Gene

No Compound Related Data Available

Transcripts for ADGRG5 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for ADGRG5 Gene

GeneLoc Exon Structure for
ADGRG5
ECgene alternative splicing isoforms for
ADGRG5

Expression for ADGRG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRG5 Gene

Protein differential expression in normal tissues from HIPED for ADGRG5 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRG5 Gene



Protein tissue co-expression partners for ADGRG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG5 Gene:

ADGRG5

mRNA Expression by UniProt/SwissProt for ADGRG5 Gene:

Q8IZF4-AGRG5_HUMAN
Tissue specificity: Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.

Evidence on tissue expression from TISSUES for ADGRG5 Gene

  • Spleen(4.2)
  • Intestine(4.1)
  • Blood(4)
genes like me logo Genes that share expression patterns with ADGRG5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG5 Gene

Orthologs for ADGRG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR114 33 34
  • 91.77 (n)
cow
(Bos Taurus)
Mammalia GPR114 33 34
  • 82.11 (n)
dog
(Canis familiaris)
Mammalia GPR114 33 34
  • 79.44 (n)
rat
(Rattus norvegicus)
Mammalia Gpr114 33
  • 75.67 (n)
mouse
(Mus musculus)
Mammalia Gpr114 33 34
  • 75.46 (n)
Adgrg5 16
oppossum
(Monodelphis domestica)
Mammalia GPR114 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR114 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR114 33 34
  • 58.08 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr56 34
  • 20 (a)
OneToMany
Species where no ortholog for ADGRG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG5 Gene

ENSEMBL:
Gene Tree for ADGRG5 (if available)
TreeFam:
Gene Tree for ADGRG5 (if available)

Paralogs for ADGRG5 Gene

genes like me logo Genes that share paralogs with ADGRG5: view

Variants for ADGRG5 Gene

Sequence variations from dbSNP and Humsavar for ADGRG5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000082475 -- 57,545,130(+) T/A intron_variant
rs1000134873 -- 57,544,878(+) C/A intron_variant
rs1000301749 -- 57,557,434(+) T/C intron_variant
rs1000508089 -- 57,564,175(+) T/C intron_variant
rs1000596782 -- 57,551,526(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG5 Gene

Variant ID Type Subtype PubMed ID
esv2667803 CNV deletion 23128226
esv33007 CNV loss 17666407
nsv1055537 CNV loss 25217958
nsv1076435 CNV duplication 25765185
nsv833245 CNV loss 17160897
nsv952036 CNV deletion 24416366

Variation tolerance for ADGRG5 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG5 Gene

Disorders for ADGRG5 Gene

Additional Disease Information for ADGRG5

No disorders were found for ADGRG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG5 Gene

Publications for ADGRG5 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for ADGRG5 Gene

Sources for ADGRG5 Gene

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