Aliases for ADGRG5 Gene
External Ids for ADGRG5 Gene
Previous HGNC Symbols for ADGRG5 Gene
Previous GeneCards Identifiers for ADGRG5 Gene
This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for ADGRG5 Gene
ADGRG5 (Adhesion G Protein-Coupled Receptor G5) is a Protein Coding gene. Diseases associated with ADGRG5 include Alveoli Adenoma and Bronchial Neoplasm. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF3.
UniProtKB/Swiss-Prot Summary for ADGRG5 Gene
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).