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Aliases for ADGRG4 Gene

Aliases for ADGRG4 Gene

  • Adhesion G Protein-Coupled Receptor G4 2 3 5
  • G Protein-Coupled Receptor 112 2 3
  • GPR112 3 4
  • Probable G-Protein Coupled Receptor 112 3
  • Adhesion G-Protein Coupled Receptor G4 3
  • G-Protein Coupled Receptor 112 4
  • RP1-299I16 3
  • PGR17 3

External Ids for ADGRG4 Gene

Previous HGNC Symbols for ADGRG4 Gene

  • GPR112

Summaries for ADGRG4 Gene

Entrez Gene Summary for ADGRG4 Gene

  • This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

GeneCards Summary for ADGRG4 Gene

ADGRG4 (Adhesion G Protein-Coupled Receptor G4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG6.

UniProtKB/Swiss-Prot for ADGRG4 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRG4 Gene

Additional gene information for ADGRG4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG4 Gene

Genomics for ADGRG4 Gene

GeneHancer (GH) Regulatory Elements for ADGRG4 Gene

Promoters and enhancers for ADGRG4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ136305 Promoter 0.5 EPDnew 650.4 +5.0 5035 0.1 ADGRG4 GC0XP136355
GH0XJ136908 Promoter/Enhancer 1.5 Ensembl ENCODE 12.1 +609.2 609152 2.6 HDGF PKNOX1 ARNT NEUROD1 SIN3A YBX1 ZBTB7B POLR2B MCM3 SP3 LOC100420958 SRRM1P3 RBMX MAP7D3 ADGRG4 RNU6-972P CD40LG RPL22P23
GH0XJ136352 Enhancer 0.5 ENCODE 13.4 +53.2 53160 2.4 JUND RFX1 JUN CEBPB FOS EP300 TCF7L2 GC0XP136355 ADGRG4 STK24P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRG4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRG4 Gene

Genomic Locations for ADGRG4 Gene
115,945 bases
Plus strand

Genomic View for ADGRG4 Gene

Genes around ADGRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG4 Gene

Proteins for ADGRG4 Gene

  • Protein details for ADGRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor G4
    Protein Accession:
    Secondary Accessions:
    • A2A2J1
    • A2A2J2
    • Q5EGP2
    • Q86SM6

    Protein attributes for ADGRG4 Gene

    3080 amino acids
    Molecular mass:
    333368 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADGRG4 Gene


neXtProt entry for ADGRG4 Gene

Post-translational modifications for ADGRG4 Gene

  • Glycosylation at Asn2640, Asn2361, posLast=15191519, posLast=10201020, posLast=899899, Asn836, Asn487, and Asn233
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG4 Gene

No data available for DME Specific Peptides for ADGRG4 Gene

Domains & Families for ADGRG4 Gene

Gene Families for ADGRG4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG4: view

Function for ADGRG4 Gene

Molecular function for ADGRG4 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with ADGRG4: view
genes like me logo Genes that share phenotypes with ADGRG4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG4

miRNA for ADGRG4 Gene

miRTarBase miRNAs that target ADGRG4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRG4 Gene

Localization for ADGRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG4 Gene

Pathways & Interactions for ADGRG4 Gene

SuperPathways for ADGRG4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRG4: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG4 Gene

Drugs & Compounds for ADGRG4 Gene

No Compound Related Data Available

Transcripts for ADGRG4 Gene

mRNA/cDNA for ADGRG4 Gene

(3) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG4 Gene

No ASD Table

Relevant External Links for ADGRG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRG4 Gene

Protein differential expression in normal tissues from HIPED for ADGRG4 Gene

This gene is overexpressed in Serum (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG4 Gene

Protein tissue co-expression partners for ADGRG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG4 Gene:


mRNA Expression by UniProt/SwissProt for ADGRG4 Gene:

Tissue specificity: Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.

Evidence on tissue expression from TISSUES for ADGRG4 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ADGRG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG4 Gene

Orthologs for ADGRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GPR112 34 33
  • 82.27 (n)
(Mus musculus)
Mammalia Gpr112 34 33
  • 75.22 (n)
Adgrg4 16
(Rattus norvegicus)
Mammalia Gpr112l 33
  • 74.68 (n)
(Ornithorhynchus anatinus)
Mammalia GPR112 34
  • 73 (a)
(Monodelphis domestica)
Mammalia GPR112 34
  • 59 (a)
(Gallus gallus)
Aves GPR112 34 33
  • 57.02 (n)
(Anolis carolinensis)
Reptilia GPR112 34
  • 54 (a)
(Danio rerio)
Actinopterygii LOC793963 33
  • 51.27 (n)
gpr112b 34
  • 45 (a)
GPR112 (1 of 2) 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 34
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for ADGRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADGRG4 Gene

Gene Tree for ADGRG4 (if available)
Gene Tree for ADGRG4 (if available)
Evolutionary constrained regions (ECRs) for ADGRG4: view image

Paralogs for ADGRG4 Gene

Paralogs for ADGRG4 Gene

genes like me logo Genes that share paralogs with ADGRG4: view

Variants for ADGRG4 Gene

Sequence variations from dbSNP and Humsavar for ADGRG4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000030419 -- 136,373,484(+) A/G intron_variant
rs1000041487 -- 136,311,897(+) G/A intron_variant
rs1000067605 -- 136,408,604(+) T/C intron_variant
rs1000144040 -- 136,373,989(+) A/C intron_variant
rs1000155684 -- 136,311,370(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG4 Gene

Variant ID Type Subtype PubMed ID
dgv2476e212 CNV loss 25503493
dgv2477e212 CNV gain 25503493

Variation tolerance for ADGRG4 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.42; 97.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG4 Gene

Disorders for ADGRG4 Gene

Additional Disease Information for ADGRG4

No disorders were found for ADGRG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG4 Gene

Publications for ADGRG4 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. (PMID: 18953328) Leja J … Giandomenico V (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009) 3 4 22 58
  3. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 58
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. (PMID: 26823453) Peeters MC … Schwartz TW (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58

Products for ADGRG4 Gene

Sources for ADGRG4 Gene

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