This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expresse... See more...

Aliases for ADGRG4 Gene

Aliases for ADGRG4 Gene

  • Adhesion G Protein-Coupled Receptor G4 2 3 5
  • Adhesion G-Protein Coupled Receptor G4 3 4
  • G Protein-Coupled Receptor 112 2 3
  • RP1-299I16 2 3
  • GPR112 3 4
  • PGR17 2 3
  • Probable G-Protein Coupled Receptor 112 3
  • G-Protein Coupled Receptor 112 4
  • ADGRG4 5

External Ids for ADGRG4 Gene

Previous HGNC Symbols for ADGRG4 Gene

  • GPR112

Summaries for ADGRG4 Gene

Entrez Gene Summary for ADGRG4 Gene

  • This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

GeneCards Summary for ADGRG4 Gene

ADGRG4 (Adhesion G Protein-Coupled Receptor G4) is a Protein Coding gene. Diseases associated with ADGRG4 include Neuroendocrine Carcinoma. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG6.

UniProtKB/Swiss-Prot Summary for ADGRG4 Gene

Gene Wiki entry for ADGRG4 Gene

Additional gene information for ADGRG4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRG4 Gene

Genomics for ADGRG4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ136305 Promoter 0.3 EPDnew 600.4 +5.0 5035 0.1 ADGRG4 RF00017-8753 BRS3
GH0XJ136908 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 12.1 +609.3 609338 3.4 RNF2 ARHGAP35 PRDM10 ZNF512 RFX1 LEF1 IKZF1 ZNF692 BACH1 TARDBP ENSG00000234062 lnc-CD40LG-2 lnc-RBMX-2 SRRM1P3 RBMX MAP7D3 ADGRG4 RNU6-972P CD40LG ARHGEF6
GH0XJ136352 Enhancer 0.7 Ensembl ENCODE 13.4 +53.0 52992 2.7 RFX1 CEBPB JUN JUND EP300 CTCF TCF7L2 FOS STK24P1 ADGRG4 RF00017-8753 BRS3
GH0XJ136268 Enhancer 0.6 Ensembl 13.3 -31.5 -31463 2.2 CTCF REST RAD21 TRIM22 CEBPB BCLAF1 SMC3 GATA3 ZNF335 ZNF654 STK24P1 ADGRG4 MAP7D3
GH0XJ136270 Enhancer 0.4 Ensembl 13.3 -29.4 -29362 1.6 CTCF SPI1 HNF4A ADGRG4 STK24P1 MAP7D3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRG4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRG4

Genomic Locations for ADGRG4 Gene

Genomic Locations for ADGRG4 Gene
chrX:136,300,963-136,416,890
(GRCh38/hg38)
Size:
115,928 bases
Orientation:
Plus strand
chrX:135,383,122-135,519,215
(GRCh37/hg19)
Size:
136,094 bases
Orientation:
Plus strand

Genomic View for ADGRG4 Gene

Genes around ADGRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG4 Gene

Proteins for ADGRG4 Gene

  • Protein details for ADGRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF6-AGRG4_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G4
    Protein Accession:
    Q8IZF6
    Secondary Accessions:
    • A2A2J1
    • A2A2J2
    • Q5EGP2
    • Q86SM6

    Protein attributes for ADGRG4 Gene

    Size:
    3080 amino acids
    Molecular mass:
    333368 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADGRG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRG4 Gene

Post-translational modifications for ADGRG4 Gene

  • Glycosylation at Asn233, Asn487, Asn836, Asn899, Asn1020, Asn1519, Asn2361, and Asn2640
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG4 Gene

No data available for DME Specific Peptides for ADGRG4 Gene

Domains & Families for ADGRG4 Gene

Gene Families for ADGRG4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ADGRG4 Gene

Suggested Antigen Peptide Sequences for ADGRG4 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 112 (GP112_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZF6

UniProtKB/Swiss-Prot:

AGRG4_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG4: view

Function for ADGRG4 Gene

Molecular function for ADGRG4 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRG4 Gene

Gene Ontology (GO) - Molecular Function for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with ADGRG4: view
genes like me logo Genes that share phenotypes with ADGRG4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG4

CRISPR Products

miRNA for ADGRG4 Gene

miRTarBase miRNAs that target ADGRG4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRG4 Gene

Localization for ADGRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG4 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG4 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 15203201
genes like me logo Genes that share ontologies with ADGRG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG4 Gene

Pathways & Interactions for ADGRG4 Gene

PathCards logo

SuperPathways for ADGRG4 Gene

No Data Available

Interacting Proteins for ADGRG4 Gene

Gene Ontology (GO) - Biological Process for ADGRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRG4: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG4 Gene

Drugs & Compounds for ADGRG4 Gene

No Compound Related Data Available

Transcripts for ADGRG4 Gene

mRNA/cDNA for ADGRG4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRG4

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG4 Gene

No ASD Table

Relevant External Links for ADGRG4 Gene

GeneLoc Exon Structure for
ADGRG4

Expression for ADGRG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRG4 Gene

Protein differential expression in normal tissues from HIPED for ADGRG4 Gene

This gene is overexpressed in Serum (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG4 Gene



Protein tissue co-expression partners for ADGRG4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRG4

mRNA Expression by UniProt/SwissProt for ADGRG4 Gene:

Q8IZF6-AGRG4_HUMAN
Tissue specificity: Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.

Evidence on tissue expression from TISSUES for ADGRG4 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ADGRG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG4 Gene

Orthologs for ADGRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia GPR112 30 31
  • 82.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpr112 30 31
  • 75.22 (n)
OneToOne
Adgrg4 17
Rat
(Rattus norvegicus)
Mammalia Gpr112l 30
  • 74.68 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GPR112 31
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR112 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR112 30 31
  • 57.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR112 31
  • 54 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC793963 30
  • 51.27 (n)
gpr112b 31
  • 45 (a)
OneToMany
GPR112 (1 of 2) 31
  • 35 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Cirl 31
  • 9 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lat-2 31
  • 12 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for ADGRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ADGRG4 Gene

ENSEMBL:
Gene Tree for ADGRG4 (if available)
TreeFam:
Gene Tree for ADGRG4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRG4: view image

Paralogs for ADGRG4 Gene

Variants for ADGRG4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRG4 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
711173 Benign: not provided 136,347,975(+) A/G SYNONYMOUS_VARIANT
rs4829829 - p.Ile276Met
rs4829830 - p.Thr1213Asn
rs5930931 - p.Pro368His
rs5930932 - p.Phe1791Leu

Additional dbSNP identifiers (rs#s) for ADGRG4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRG4 Gene

Variant ID Type Subtype PubMed ID
dgv2476e212 CNV loss 25503493
dgv2477e212 CNV gain 25503493

Variation tolerance for ADGRG4 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.42; 97.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG4 Gene

Human Gene Mutation Database (HGMD)
ADGRG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG4 Gene

Disorders for ADGRG4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRG4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroendocrine carcinoma
  • neuroendocrine cancer
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ADGRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRG4 Gene

Publications for ADGRG4 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. (PMID: 18953328) Leja J … Giandomenico V (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009) 3 4 23
  3. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  5. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. (PMID: 26823453) Peeters MC … Schwartz TW (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3

Products for ADGRG4 Gene

Sources for ADGRG4 Gene