Aliases for ADGRG3 Gene

Aliases for ADGRG3 Gene

  • Adhesion G Protein-Coupled Receptor G3 2 3 4 5
  • G-Protein Coupled Receptor PGR26 3 4
  • G Protein-Coupled Receptor 97 2 3
  • GPR97 3 4
  • PGR26 3 4
  • Probable G-Protein Coupled Receptor 97 3
  • G-Protein Coupled Receptor 97 4
  • PB99 3

External Ids for ADGRG3 Gene

Previous HGNC Symbols for ADGRG3 Gene

  • GPR97

Summaries for ADGRG3 Gene

GeneCards Summary for ADGRG3 Gene

ADGRG3 (Adhesion G Protein-Coupled Receptor G3) is a Protein Coding gene. Diseases associated with ADGRG3 include Polymicrogyria, Bilateral Frontoparietal. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG1.

UniProtKB/Swiss-Prot Summary for ADGRG3 Gene

  • Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Wiki entry for ADGRG3 Gene

Additional gene information for ADGRG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRG3 Gene

Genomics for ADGRG3 Gene

GeneHancer (GH) Regulatory Elements for ADGRG3 Gene

Promoters and enhancers for ADGRG3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRG3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRG3 Gene

Genomic Locations for ADGRG3 Gene
chr16:57,668,192-57,689,378
(GRCh38/hg38)
Size:
21,187 bases
Orientation:
Plus strand
chr16:57,702,099-57,723,975
(GRCh37/hg19)
Size:
21,877 bases
Orientation:
Plus strand

Genomic View for ADGRG3 Gene

Genes around ADGRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG3 Gene

Proteins for ADGRG3 Gene

  • Protein details for ADGRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y34-AGRG3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor G3
    Protein Accession:
    Q86Y34
    Secondary Accessions:
    • Q6ZMF4
    • Q86SL9
    • Q8IZF1

    Protein attributes for ADGRG3 Gene

    Size:
    549 amino acids
    Molecular mass:
    60861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18774.1; Type=Frameshift; Positions=492; Evidence={ECO:0000305};

neXtProt entry for ADGRG3 Gene

Post-translational modifications for ADGRG3 Gene

  • Glycosylation at Asn98, Asn144, Asn210, and Asn413
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRG3 Gene

Domains & Families for ADGRG3 Gene

Gene Families for ADGRG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRG3 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR26 (GPR97_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86Y34

UniProtKB/Swiss-Prot:

AGRG3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG3: view

Function for ADGRG3 Gene

Molecular function for ADGRG3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Ontology (GO) - Molecular Function for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with ADGRG3: view
genes like me logo Genes that share phenotypes with ADGRG3: view

Animal Models for ADGRG3 Gene

MGI Knock Outs for ADGRG3:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRG3 Gene

Localization for ADGRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG3 Gene

Pathways & Interactions for ADGRG3 Gene

PathCards logo

SuperPathways for ADGRG3 Gene

genes like me logo Genes that share pathways with ADGRG3: view

Pathways by source for ADGRG3 Gene

3 Reactome pathways for ADGRG3 Gene

Interacting Proteins for ADGRG3 Gene

Gene Ontology (GO) - Biological Process for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,IDA 22575658
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0030183 B cell differentiation IEA,ISS --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for SIGNOR curated interactions for ADGRG3 Gene

Drugs & Compounds for ADGRG3 Gene

(1) Drugs for ADGRG3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beclomethasone dipropionate Approved, Investigational Pharma Corticosteroid used for asthma and rhinitis 0
genes like me logo Genes that share compounds with ADGRG3: view

Transcripts for ADGRG3 Gene

mRNA/cDNA for ADGRG3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3: -

Relevant External Links for ADGRG3 Gene

GeneLoc Exon Structure for
ADGRG3
ECgene alternative splicing isoforms for
ADGRG3

Expression for ADGRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG3 Gene

This gene is overexpressed in Neutrophil (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG3 Gene



Protein tissue co-expression partners for ADGRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG3 Gene:

ADGRG3

mRNA Expression by UniProt/SwissProt for ADGRG3 Gene:

Q86Y34-AGRG3_HUMAN
Tissue specificity: Expressed in cultured primary dermal lymphatic endothelial cells.

Evidence on tissue expression from TISSUES for ADGRG3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ADGRG3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG3 Gene

Orthologs for ADGRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR97 33 32
  • 89.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR97 33 32
  • 77.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR97 33 32
  • 76.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr97 32
  • 76.14 (n)
mouse
(Mus musculus)
Mammalia Gpr97 33 32
  • 75.76 (n)
OneToOne
Adgrg3 17
oppossum
(Monodelphis domestica)
Mammalia GPR97 33
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR97 33
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR97 33 32
  • 56.04 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC799479 32
  • 51.31 (n)
GPR97 33
  • 28 (a)
OneToOne
Species where no ortholog for ADGRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG3 Gene

ENSEMBL:
Gene Tree for ADGRG3 (if available)
TreeFam:
Gene Tree for ADGRG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRG3: view image

Paralogs for ADGRG3 Gene

Variants for ADGRG3 Gene

Sequence variations from dbSNP and Humsavar for ADGRG3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs111939130 conflicting-interpretations-of-pathogenicity, uncertain-significance, not specified, not provided 57,663,501(+) T/C/G upstream_transcript_variant
rs587783657 pathogenic, Polymicrogyria, bilateral frontoparietal 57,663,470(+) G/A upstream_transcript_variant
rs761336676 likely-benign, not specified 57,663,448(+) G/A/T upstream_transcript_variant
rs766775940 likely-benign, not specified 57,663,630(+) C/A/T upstream_transcript_variant
rs768017345 uncertain-significance, not provided 57,663,575(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG3 Gene

Variant ID Type Subtype PubMed ID
nsv1065634 CNV gain 25217958
nsv833246 CNV loss 17160897

Variation tolerance for ADGRG3 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG3 Gene

Disorders for ADGRG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRG3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
polymicrogyria, bilateral frontoparietal
  • bfpp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRG3

genes like me logo Genes that share disorders with ADGRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRG3 Gene

Publications for ADGRG3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 56
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 56
  3. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. (PMID: 24178298) Valtcheva N … Detmar M (The Journal of biological chemistry 2013) 3 4 56
  4. Signaling property study of adhesion G-protein-coupled receptors. (PMID: 22575658) Gupte J … Wu X (FEBS letters 2012) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for ADGRG3 Gene

Sources for ADGRG3 Gene