Aliases for ADGRF5 Gene

Aliases for ADGRF5 Gene

  • Adhesion G Protein-Coupled Receptor F5 2 3 4 5
  • G-Protein Coupled Receptor 116 3 4
  • KIAA0758 2 4
  • GPR116 3 4
  • Probable G-Protein Coupled Receptor 116 3
  • G Protein-Coupled Receptor 116 2
  • Ig-Hepta Homolog 3
  • DKFZp564O1923 2
  • KPG_001 3
  • ADGRF5 5

External Ids for ADGRF5 Gene

Previous HGNC Symbols for ADGRF5 Gene

  • GPR116

Summaries for ADGRF5 Gene

GeneCards Summary for ADGRF5 Gene

ADGRF5 (Adhesion G Protein-Coupled Receptor F5) is a Protein Coding gene. Diseases associated with ADGRF5 include Vibratory Urticaria. Among its related pathways are Surfactant metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF1.

UniProtKB/Swiss-Prot Summary for ADGRF5 Gene

  • Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.

Gene Wiki entry for ADGRF5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF5 Gene

Genomics for ADGRF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRF5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J046953 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 250.7 +1.5 1453 3 ZIC2 ZNF335 ADGRF5 PLA2G7 HSALNG0050387 MEP1A
GH06J046917 Promoter/Enhancer 0.9 EPDnew Ensembl dbSUPER 261.8 +34.4 34353 5.2 POLR2A ADGRF5 LOC105375080 ADGRF5-AS1 SLC25A27 MEP1A
GH06J047046 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -92.5 -92547 1.8 ZNF654 ATF2 KLF9 CEBPA JUND ZBTB10 REST CEBPB DEK TRIM22 TNFRSF21 ADGRF5 PLA2G7 piR-39858-558 ADGRF1 lnc-ADGRF5-2 HSALNG0050392
GH06J047074 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9.3 -121.7 -121664 3.5 SSRP1 ZMYM3 KLF9 CEBPA CHD4 MXD4 KLF11 ZFP64 HOMEZ KMT2B TNFRSF21 PLA2G7 ADGRF5 RF00017-5092 piR-39858-558 ADGRF1 HSALNG0050392
GH06J046925 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.9 +28.5 28454 3 CEBPA CEBPB TEAD3 CEBPG CREB1 FOS NR2F2 TEAD1 ADGRF5 ADGRF5-AS1 PLA2G7 LOC105375080 HSALNG0050387 MEP1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRF5

Genomic Locations for ADGRF5 Gene

Latest Assembly
102,433 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
102,418 bases
Minus strand

(GRCh37/hg19 by Ensembl)
102,432 bases
Minus strand

Genomic View for ADGRF5 Gene

Genes around ADGRF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF5 Gene

Proteins for ADGRF5 Gene

  • Protein details for ADGRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor F5
    Protein Accession:
    Secondary Accessions:
    • O94858
    • Q5TF06
    • Q6RGN2
    • Q86SP0
    • Q9Y3Z2

    Protein attributes for ADGRF5 Gene

    1346 amino acids
    Molecular mass:
    149457 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N-terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD.
    • Sequence=BAA34478.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAB43394.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF5 Gene


neXtProt entry for ADGRF5 Gene

Post-translational modifications for ADGRF5 Gene

  • Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin.
  • Highly glycosylated.
  • Glycosylation at Asn73, Asn94, Asn106, Asn188, Asn256, Asn272, Asn301, Asn315, Asn328, Asn472, Asn339, Asn487, Asn505, Asn398, Asn540, Asn627, Asn649, Asn666, Asn718, Asn820, Asn931, Asn963, Asn982, and Asn1160
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AGRF5_HUMAN (1914)

No data available for DME Specific Peptides for ADGRF5 Gene

Domains & Families for ADGRF5 Gene

Gene Families for ADGRF5 Gene

Protein Domains for ADGRF5 Gene

  • Immunoglobulin C-2 type
  • SEA domain
  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain
  • Ig-hepta receptor signature

Suggested Antigen Peptide Sequences for ADGRF5 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 116 (GP116_HUMAN)
  • GPR116 protein (Q4G0K7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF5: view

Function for ADGRF5 Gene

Molecular function for ADGRF5 Gene

UniProtKB/Swiss-Prot Function:
Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.

Phenotypes From GWAS Catalog for ADGRF5 Gene

Gene Ontology (GO) - Molecular Function for ADGRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ADGRF5: view
genes like me logo Genes that share phenotypes with ADGRF5: view

Animal Models for ADGRF5 Gene

MGI Knock Outs for ADGRF5:

Animal Models for research

miRNA for ADGRF5 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF5 Gene

Localization for ADGRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADGRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 23684610
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
GO:0031410 cytoplasmic vesicle IDA 23684610
genes like me logo Genes that share ontologies with ADGRF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF5 Gene

Pathways & Interactions for ADGRF5 Gene

PathCards logo

SuperPathways for ADGRF5 Gene

genes like me logo Genes that share pathways with ADGRF5: view

Pathways by source for ADGRF5 Gene

1 BioSystems pathway for ADGRF5 Gene
2 Reactome pathways for ADGRF5 Gene

Interacting Proteins for ADGRF5 Gene

Gene Ontology (GO) - Biological Process for ADGRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003094 glomerular filtration IEA --
GO:0006112 energy reserve metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF5: view

No data available for SIGNOR curated interactions for ADGRF5 Gene

Drugs & Compounds for ADGRF5 Gene

No Compound Related Data Available

Transcripts for ADGRF5 Gene

mRNA/cDNA for ADGRF5 Gene

18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF5

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: -

ExUns: 25b · 25c

Relevant External Links for ADGRF5 Gene

GeneLoc Exon Structure for

Expression for ADGRF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRF5 Gene

Protein differential expression in normal tissues from HIPED for ADGRF5 Gene

This gene is overexpressed in Serum (54.9) and Plasma (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRF5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRF5

Evidence on tissue expression from TISSUES for ADGRF5 Gene

  • Nervous system(4.5)
  • Bone marrow(4)
  • Lung(2.5)
  • Kidney(2.4)
  • Heart(2.4)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ADGRF5: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF5 Gene

Orthologs for ADGRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR116 29 30
  • 99.43 (n)
(Canis familiaris)
Mammalia GPR116 29 30
  • 84.52 (n)
(Bos Taurus)
Mammalia GPR116 29 30
  • 81.42 (n)
(Rattus norvegicus)
Mammalia Gpr116 29
  • 78.3 (n)
(Mus musculus)
Mammalia Gpr116 29 30
  • 78.05 (n)
Adgrf5 16
(Monodelphis domestica)
Mammalia GPR116 30
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia GPR116 30
  • 60 (a)
(Gallus gallus)
Aves GPR116 29 30
  • 55.4 (n)
(Anolis carolinensis)
Reptilia GPR116 30
  • 43 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr116 29
  • 50.25 (n)
(Danio rerio)
Actinopterygii si:dkey-30j22.5 30
  • 24 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 22 (a)
Species where no ortholog for ADGRF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRF5 Gene

Gene Tree for ADGRF5 (if available)
Gene Tree for ADGRF5 (if available)
Evolutionary constrained regions (ECRs) for ADGRF5: view image
Alliance of Genome Resources:
Additional Orthologs for ADGRF5

Paralogs for ADGRF5 Gene

Variants for ADGRF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRF5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs547499 -- p.Met856Thr
rs586024 -- p.Thr604Met
rs9395218 -- p.Val801Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADGRF5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADGRF5 Gene

Variant ID Type Subtype PubMed ID
dgv389e215 CNV deletion 23714750
esv24845 CNV gain 19812545
esv2759425 CNV gain+loss 17122850
esv3608888 CNV loss 21293372
esv996927 CNV deletion 20482838
nsv1017113 CNV gain 25217958
nsv428147 CNV gain 18775914
nsv521031 CNV gain 19592680
nsv7895 CNV gain 18304495
nsv823683 CNV gain 20364138
nsv830654 CNV gain 17160897
nsv965723 CNV duplication 23825009

Variation tolerance for ADGRF5 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF5 Gene

Disorders for ADGRF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRF5 Gene - From: COP

Disorder Aliases PubMed IDs
vibratory urticaria
  • vbu
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRF5

genes like me logo Genes that share disorders with ADGRF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRF5 Gene

Publications for ADGRF5 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4

Products for ADGRF5 Gene

Sources for ADGRF5 Gene