Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternativ... See more...

Aliases for ADGRF4 Gene

Aliases for ADGRF4 Gene

  • Adhesion G Protein-Coupled Receptor F4 2 3 4 5
  • G-Protein Coupled Receptor PGR18 3 4
  • GPR115 3 4
  • PGR18 3 4
  • Probable G-Protein Coupled Receptor 115 3
  • Seven Transmembrane Helix Receptor 3
  • G-Protein Coupled Receptor 115 4
  • G Protein-Coupled Receptor 115 2

External Ids for ADGRF4 Gene

Previous HGNC Symbols for ADGRF4 Gene

  • GPR115

Summaries for ADGRF4 Gene

Entrez Gene Summary for ADGRF4 Gene

  • Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

GeneCards Summary for ADGRF4 Gene

ADGRF4 (Adhesion G Protein-Coupled Receptor F4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF2.

UniProtKB/Swiss-Prot Summary for ADGRF4 Gene

Gene Wiki entry for ADGRF4 Gene

Additional gene information for ADGRF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF4 Gene

Genomics for ADGRF4 Gene

GeneHancer (GH) Regulatory Elements for ADGRF4 Gene

Promoters and enhancers for ADGRF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J047697 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 750.4 +14.0 14048 4.9 TCF7L2 USF2 ZNF217 ELF1 MNT NCOA3 SP7 ZSCAN21 SMARCA4 CEBPG ADGRF4 ADGRF2 lnc-ADGRF2-1 RF00100-127 RN7SKP116
GH06J047741 Enhancer 0.9 Ensembl ENCODE 5.3 +56.1 56148 1.2 ETV6 CREM ZBED1 FOSL2 IKZF1 TRIM22 IKZF2 JUN JUND DPF2 ENSG00000226594 ADGRF4 lnc-PTCHD4-3 RPL27AP7
GH06J047518 Enhancer 0.9 Ensembl ENCODE 4.6 -166.6 -166597 8.5 NR2F6 CREB1 MIXL1 ELF3 CEBPG ZNF644 GATAD2A RCOR2 SOX13 TCF7 ADGRF2 CD2AP ENSG00000270761 OPN5 ADGRF4 lnc-TNFRSF21-1 piR-52438-098
GH06J047357 Enhancer 0.5 Ensembl 4.7 -327.3 -327264 2.4 POU5F1 IKZF1 IKZF2 BCL11A RUNX3 BMI1 NR2F1 NANOG TNFRSF21 CD2AP ADGRF4 piR-31199-310 lnc-CD2AP-3 B3GNTL1P2 RF00017-5588
GH06J046814 Enhancer 0.5 FANTOM5 Ensembl ENCODE 4.1 -869.7 -869716 2.8 PLA2G7 ENSG00000225730 SLC25A27 MEP1A ADGRF4 HSALNG0050373 lnc-PLA2G7-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRF4 Gene

Genomic Locations for ADGRF4 Gene
chr6:47,685,864-47,722,021
(GRCh38/hg38)
Size:
36,158 bases
Orientation:
Plus strand
chr6:47,653,600-47,689,757
(GRCh37/hg19)
Size:
36,158 bases
Orientation:
Plus strand

Genomic View for ADGRF4 Gene

Genes around ADGRF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF4 Gene

Proteins for ADGRF4 Gene

  • Protein details for ADGRF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF3-AGRF4_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor F4
    Protein Accession:
    Q8IZF3
    Secondary Accessions:
    • B3KTD0
    • Q2PNZ0
    • Q5T5B5
    • Q5T5B6
    • Q86SN9
    • Q8IXE6

    Protein attributes for ADGRF4 Gene

    Size:
    695 amino acids
    Molecular mass:
    77719 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.
    SequenceCaution:
    • Sequence=AAN46671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC45257.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ADGRF4 Gene

Post-translational modifications for ADGRF4 Gene

  • Glycosylation at Asn61, Asn169, Asn177, Asn209, Asn229, Asn250, Asn257, Asn263, Asn264, Asn286, Asn309, Asn340, and Asn379
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF4 Gene

No data available for DME Specific Peptides for ADGRF4 Gene

Domains & Families for ADGRF4 Gene

Gene Families for ADGRF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRF4 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR18 (GP115_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZF3

UniProtKB/Swiss-Prot:

AGRF4_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF4: view

Function for ADGRF4 Gene

Molecular function for ADGRF4 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF4 Gene

Gene Ontology (GO) - Molecular Function for ADGRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF4: view
genes like me logo Genes that share phenotypes with ADGRF4: view

Animal Models for ADGRF4 Gene

MGI Knock Outs for ADGRF4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF4

CRISPR Products

miRNA for ADGRF4 Gene

miRTarBase miRNAs that target ADGRF4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF4 Gene

Localization for ADGRF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF4 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADGRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF4: view

Pathways & Interactions for ADGRF4 Gene

PathCards logo

SuperPathways for ADGRF4 Gene

No Data Available

Interacting Proteins for ADGRF4 Gene

Gene Ontology (GO) - Biological Process for ADGRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF4: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF4 Gene

Drugs & Compounds for ADGRF4 Gene

No Compound Related Data Available

Transcripts for ADGRF4 Gene

mRNA/cDNA for ADGRF4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:

Relevant External Links for ADGRF4 Gene

GeneLoc Exon Structure for
ADGRF4
ECgene alternative splicing isoforms for
ADGRF4

Expression for ADGRF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRF4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRF4 Gene



Protein tissue co-expression partners for ADGRF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRF4 Gene:

ADGRF4
genes like me logo Genes that share expression patterns with ADGRF4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF4 Gene

Orthologs for ADGRF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR115 33 32
  • 99.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR115 33 32
  • 87.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR115 33 32
  • 85.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr115 32
  • 75.93 (n)
mouse
(Mus musculus)
Mammalia Gpr115 33 32
  • 75.69 (n)
OneToOne
Adgrf4 17
oppossum
(Monodelphis domestica)
Mammalia GPR115 33
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR115 33
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01002470.1 33
  • 42 (a)
ManyToMany
BX545917.1 33
  • 28 (a)
ManyToMany
si:dkey-30j22.4 33
  • 27 (a)
ManyToMany
si:dkey-30j22.12 33
  • 25 (a)
ManyToMany
si:dkey-30j22.2 33
  • 22 (a)
ManyToMany
si:dkey-13i15.1 33
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 24 (a)
ManyToMany
Species where no ortholog for ADGRF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF4 Gene

ENSEMBL:
Gene Tree for ADGRF4 (if available)
TreeFam:
Gene Tree for ADGRF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRF4: view image

Paralogs for ADGRF4 Gene

Variants for ADGRF4 Gene

Sequence variations from dbSNP and Humsavar for ADGRF4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs572583506 A breast cancer sample 47,717,338(+) C/T coding_sequence_variant, missense_variant
rs386352312 uncertain-significance, not provided 47,714,668(+) G/T coding_sequence_variant, missense_variant
rs1000004754 -- 47,717,110(+) A/C intron_variant
rs1000023765 -- 47,701,980(+) A/T intron_variant
rs1000256603 -- 47,696,717(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRF4 Gene

Variant ID Type Subtype PubMed ID
nsv1017113 CNV gain 25217958
nsv480369 CNV novel sequence insertion 20440878
nsv507328 OTHER sequence alteration 20534489

Variation tolerance for ADGRF4 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF4 Gene

Human Gene Mutation Database (HGMD)
ADGRF4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF4 Gene

Disorders for ADGRF4 Gene

Additional Disease Information for ADGRF4

No disorders were found for ADGRF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF4 Gene

Publications for ADGRF4 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 56
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 56

Products for ADGRF4 Gene

Sources for ADGRF4 Gene