ADGRF3 Gene (Protein Coding)

Adhesion G Protein-Coupled Receptor F3

GC02M026308
GIFtS:
33

Aliases for ADGRF3 Gene

Aliases for ADGRF3 Gene

  • Adhesion G Protein-Coupled Receptor F3 2 3 5
  • Adhesion G-Protein Coupled Receptor F3 3 4
  • G Protein-Coupled Receptor 113 2 3
  • GPR113 3 4
  • PGR23 3 4
  • Probable G-Protein Coupled Receptor 113 3
  • Seven Transmembrane Helix Receptor 3
  • G Protein-Coupled Receptor PGR23 3
  • G-Protein Coupled Receptor PGR23 4
  • G-Protein Coupled Receptor 113 4

External Ids for ADGRF3 Gene

Previous HGNC Symbols for ADGRF3 Gene

  • GPR113

Summaries for ADGRF3 Gene

GeneCards Summary for ADGRF3 Gene

ADGRF3 (Adhesion G Protein-Coupled Receptor F3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF5.

UniProtKB/Swiss-Prot Summary for ADGRF3 Gene

Gene Wiki entry for ADGRF3 Gene

Additional gene information for ADGRF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF3 Gene

Genomics for ADGRF3 Gene

GeneHancer (GH) Regulatory Elements for ADGRF3 Gene

Promoters and enhancers for ADGRF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J026342 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.6 +1.0 1047 6.3 SIN3A SP1 SREBF1 MLX RBPJ SMARCE1 POLR2A CTBP1 NR2F1 ATF1 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5 CAD ASXL2 GTF3C2-AS1 AGBL5 TMEM214 KIF3C
GH02J026319 Promoter/Enhancer 0.7 EPDnew Ensembl 776.8 +27.7 27717 0.6 PRDM1 ZNF366 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5
GH02J026298 Promoter/Enhancer 1.9 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 18.6 +47.0 47004 3.4 ETV6 MAX ZNF652 SP1 BCL6B PRDM1 EGR1 IKZF1 RFX1 IKZF2 ENSG00000286707 LOC105374334 lnc-SELENOI-1 SELENOI HADHB HADHA ADGRF3 ASXL2 ATRAID CAD
GH02J026353 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.3 -8.8 -8783 8 ZBTB40 GATA3 SMARCE1 POLR2A TCF7L2 ZNF217 ZNF362 CC2D1A HLF L3MBTL2 ADGRF3 ATRAID EMILIN1 HADHA OST4 SELENOI CENPA piR-53431-369
GH02J026401 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -55.2 -55249 1.5 ZNF121 ZBTB8A RFX1 POLR2A ZNF692 ZFX ZBTB48 BMI1 ZBTB17 ZNF217 DRC1 ADGRF3 piR-50437-363
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRF3 Gene

Genomic Locations for ADGRF3 Gene
chr2:26,308,173-26,346,817
(GRCh38/hg38)
Size:
38,645 bases
Orientation:
Minus strand
chr2:26,531,041-26,569,685
(GRCh37/hg19)
Size:
38,645 bases
Orientation:
Minus strand

Genomic View for ADGRF3 Gene

Genes around ADGRF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRF3 Gene

Proteins for ADGRF3 Gene

Products:

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  • Protein details for ADGRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF5-AGRF3_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor F3
    Protein Accession:
    Q8IZF5
    Secondary Accessions:
    • B4DF15
    • E9PEV1
    • Q53TA5
    • Q6UXT7
    • Q6UXX3
    • Q86SL7
    • Q8IXD8
    • Q8TDT3

    Protein attributes for ADGRF3 Gene

    Size:
    1079 amino acids
    Molecular mass:
    116341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB89332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC45265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRF3 Gene

Protein Expression for ADGRF3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRF3 Gene

  • Glycosylation at Asn188, Asn382, Asn264, Asn301, Asn441, and Asn648
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRF3 Gene

Domains & Families for ADGRF3 Gene

Gene Families for ADGRF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADGRF3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRF3 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 113, isoform CRA_b (D6W540_HUMAN)
  • G-protein coupled receptor PGR23 (GP113_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZF5

UniProtKB/Swiss-Prot:

AGRF3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF3: view

Function for ADGRF3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for ADGRF3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF3 Gene

Gene Ontology (GO) - Molecular Function for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF3: view
genes like me logo Genes that share phenotypes with ADGRF3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF3 Gene

Localization for ADGRF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF3 Gene

Pathways & Interactions for ADGRF3 Gene

PathCards logo

SuperPathways for ADGRF3 Gene

No Data Available

Interacting Proteins for ADGRF3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000307831 Q8IZF5-AGRF3_HUMAN for ADGRF3 Gene via STRING IID

GPS-Prot Interaction Network for ADGRF3

Gene Ontology (GO) - Biological Process for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF3 Gene

Drugs & Compounds for ADGRF3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRF3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADGRF3 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF3 Gene

No ASD Table

Relevant External Links for ADGRF3 Gene

GeneLoc Exon Structure for
ADGRF3
ECgene alternative splicing isoforms for
ADGRF3

Expression for ADGRF3 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRF3 Gene

mRNA expression in normal human tissues for ADGRF3 Gene
mRNA expression by GTEx for ADGRF3 Gene

Protein differential expression in normal tissues from HIPED for ADGRF3 Gene

This gene is overexpressed in Plasma (58.9) and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRF3 Gene



Protein tissue co-expression partners for ADGRF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRF3 Gene:

ADGRF3

Evidence on tissue expression from TISSUES for ADGRF3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADGRF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF3 Gene

Orthologs for ADGRF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR113 33 32
  • 98.95 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia GPR113 33 32
  • 81.76 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPR113 33 32
  • 81.42 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpr113 33 32
  • 74.52 (n)
 OneToOne
Adgrf3 17
rat
(Rattus norvegicus)
 Mammalia Gpr113 32
  • 74.47 (n)
oppossum
(Monodelphis domestica)
 Mammalia GPR113 33
  • 60 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 59 (a)
 OneToMany
-- 33
  • 56 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia GPR113 33
  • 40 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gpr113 32
  • 48.09 (n)
zebrafish
(Danio rerio)
 Actinopterygii GPR113 33
  • 21 (a)
 OneToMany
Species where no ortholog for ADGRF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF3 Gene

ENSEMBL:
Gene Tree for ADGRF3 (if available)
TreeFam:
Gene Tree for ADGRF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRF3: view image

Paralogs for ADGRF3 Gene

Variants for ADGRF3 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ADGRF3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000038941 -- 26,326,369(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000044547 -- 26,331,320(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000075620 -- 26,331,607(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000137158 -- 26,340,694(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000163151 -- 26,333,208(-) A/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRF3 Gene

Variant ID Type Subtype PubMed ID
esv1009939 CNV insertion 20482838
esv1067506 CNV insertion 17803354
esv33316 CNV loss 17666407
esv3370059 CNV duplication 20981092
esv3590117 CNV loss 21293372
esv3590118 CNV loss 21293372
nsv2649 CNV insertion 18451855
nsv2650 CNV insertion 18451855
nsv508832 CNV insertion 20534489
nsv953758 CNV deletion 24416366

Variation tolerance for ADGRF3 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF3 Gene

Disorders for ADGRF3 Gene

Additional Disease Information for ADGRF3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADGRF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF3 Gene

Publications for ADGRF3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 56
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 56

ExternalLinks

View latest publications for ADGRF3 gene in Mastermind

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Sources for ADGRF3 Gene