Aliases for ADGRF3 Gene

Aliases for ADGRF3 Gene

  • Adhesion G Protein-Coupled Receptor F3 2 3 5
  • PGR23 2 3 4
  • Adhesion G-Protein Coupled Receptor F3 3 4
  • G Protein-Coupled Receptor 113 2 3
  • GPR113 3 4
  • Probable G-Protein Coupled Receptor 113 3
  • Seven Transmembrane Helix Receptor 3
  • G Protein-Coupled Receptor PGR23 3
  • G-Protein Coupled Receptor PGR23 4
  • G-Protein Coupled Receptor 113 4
  • HGPCR37 2
  • ADGRF3 5

External Ids for ADGRF3 Gene

Previous HGNC Symbols for ADGRF3 Gene

  • GPR113

Summaries for ADGRF3 Gene

GeneCards Summary for ADGRF3 Gene

ADGRF3 (Adhesion G Protein-Coupled Receptor F3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB1.

UniProtKB/Swiss-Prot Summary for ADGRF3 Gene

Gene Wiki entry for ADGRF3 Gene

Additional gene information for ADGRF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF3 Gene

Genomics for ADGRF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026342 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 611.6 +1.0 1047 6.3 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5 CAD TMEM214 ENSG00000272148 KIF3C GAREM2 ATRAID
GH02J026319 Promoter/Enhancer 0.7 EPDnew Ensembl 626.8 +27.7 27717 0.6 PRDM1 ZNF366 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5
GH02J026298 Promoter/Enhancer 2 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 18.6 +47.0 47004 3.4 RFX1 ZNF143 PRDM1 IRF2 IKZF2 POLR2A KMT2B EED RELB EGR1 ENSG00000286707 LOC105374334 SELENOI HADHB HADHA TMEM214 ADGRF3 CAD ATRAID RPS2P15
GH02J026353 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.3 -8.8 -8783 8 CREB1 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 ZHX2 JUND PRDM1 MTA2 ADGRF3 ATRAID HADHA OST4 SELENOI CENPA piR-53431-369 DRC1
GH02J026401 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -55.2 -55249 1.5 KDM1A ZNF692 RFX1 POLR2A ZFX BMI1 ZBTB48 ZBTB26 MYNN ZBTB17 DRC1 ADGRF3 piR-50437-363 OTOF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRF3

Genomic Locations for ADGRF3 Gene

Genomic Locations for ADGRF3 Gene
38,645 bases
Minus strand
38,645 bases
Minus strand

Genomic View for ADGRF3 Gene

Genes around ADGRF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF3 Gene

Proteins for ADGRF3 Gene

  • Protein details for ADGRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor F3
    Protein Accession:
    Secondary Accessions:
    • B4DF15
    • E9PEV1
    • Q53TA5
    • Q6UXT7
    • Q6UXX3
    • Q86SL7
    • Q8IXD8
    • Q8TDT3

    Protein attributes for ADGRF3 Gene

    1079 amino acids
    Molecular mass:
    116341 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB89332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC45265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF3 Gene


neXtProt entry for ADGRF3 Gene

Post-translational modifications for ADGRF3 Gene

  • Glycosylation at Asn188, Asn382, Asn264, Asn301, Asn441, and Asn648
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRF3 Gene

Domains & Families for ADGRF3 Gene

Gene Families for ADGRF3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADGRF3 Gene

  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain

Suggested Antigen Peptide Sequences for ADGRF3 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 113, isoform CRA_b (D6W540_HUMAN)
  • G-protein coupled receptor PGR23 (GP113_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF3: view

Function for ADGRF3 Gene

Molecular function for ADGRF3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF3 Gene

Gene Ontology (GO) - Molecular Function for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF3: view
genes like me logo Genes that share phenotypes with ADGRF3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF3 Gene

Localization for ADGRF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF3 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF3 Gene

Pathways & Interactions for ADGRF3 Gene

PathCards logo

SuperPathways for ADGRF3 Gene

No Data Available

Interacting Proteins for ADGRF3 Gene

Gene Ontology (GO) - Biological Process for ADGRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF3 Gene

Drugs & Compounds for ADGRF3 Gene

No Compound Related Data Available

Transcripts for ADGRF3 Gene

mRNA/cDNA for ADGRF3 Gene

10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF3 Gene

No ASD Table

Relevant External Links for ADGRF3 Gene

GeneLoc Exon Structure for

Expression for ADGRF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRF3 Gene

Protein differential expression in normal tissues from HIPED for ADGRF3 Gene

This gene is overexpressed in Plasma (58.9) and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRF3 Gene

Protein tissue co-expression partners for ADGRF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRF3

Evidence on tissue expression from TISSUES for ADGRF3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ADGRF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF3 Gene

Orthologs for ADGRF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR113 30 31
  • 98.95 (n)
(Bos Taurus)
Mammalia GPR113 30 31
  • 81.76 (n)
(Canis familiaris)
Mammalia GPR113 30 31
  • 81.42 (n)
(Mus musculus)
Mammalia Gpr113 30 31
  • 74.52 (n)
Adgrf3 17
(Rattus norvegicus)
Mammalia Gpr113 30
  • 74.47 (n)
(Monodelphis domestica)
Mammalia GPR113 31
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
-- 31
  • 56 (a)
(Anolis carolinensis)
Reptilia GPR113 31
  • 40 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr113 30
  • 48.09 (n)
(Danio rerio)
Actinopterygii GPR113 31
  • 21 (a)
Species where no ortholog for ADGRF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRF3 Gene

Gene Tree for ADGRF3 (if available)
Gene Tree for ADGRF3 (if available)
Evolutionary constrained regions (ECRs) for ADGRF3: view image

Paralogs for ADGRF3 Gene

Variants for ADGRF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRF3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs2052937 - p.Ala404Thr

Additional dbSNP identifiers (rs#s) for ADGRF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRF3 Gene

Variant ID Type Subtype PubMed ID
esv1009939 CNV insertion 20482838
esv1067506 CNV insertion 17803354
esv33316 CNV loss 17666407
esv3370059 CNV duplication 20981092
esv3590117 CNV loss 21293372
esv3590118 CNV loss 21293372
nsv2649 CNV insertion 18451855
nsv2650 CNV insertion 18451855
nsv508832 CNV insertion 20534489
nsv953758 CNV deletion 24416366

Variation tolerance for ADGRF3 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF3 Gene

Disorders for ADGRF3 Gene

No disorders were found for ADGRF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF3 Gene

Publications for ADGRF3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4

Products for ADGRF3 Gene

Sources for ADGRF3 Gene