Aliases for ADGRF2 Gene

Aliases for ADGRF2 Gene

  • Adhesion G Protein-Coupled Receptor F2 2 3 5
  • PGR20 2 3 4
  • Adhesion G-Protein Coupled Receptor F2 3 4
  • G Protein-Coupled Receptor 111 2 3
  • HGPCR35 2 3
  • GPR111 3 4
  • Probable G-Protein Coupled Receptor 111 3
  • G-Protein Coupled Receptor PGR20 4
  • G-Protein Coupled Receptor 111 4
  • ADGRF2 5

External Ids for ADGRF2 Gene

Previous HGNC Symbols for ADGRF2 Gene

  • GPR111

Summaries for ADGRF2 Gene

GeneCards Summary for ADGRF2 Gene

ADGRF2 (Adhesion G Protein-Coupled Receptor F2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF4.

UniProtKB/Swiss-Prot Summary for ADGRF2 Gene

Gene Wiki entry for ADGRF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF2 Gene

Genomics for ADGRF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J047656 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 278.6 0.0 -47 0.8 CEBPB MAFF KLF9 JUND ZNF316 FOSL1 ZBTB48 PKNOX1 NRF1 NFE2 ADGRF2 piR-31535-003 CD2AP
GH06J047697 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 29.8 +43.5 43476 4.9 DEK ZNF217 ELF1 ZIC2 CEBPB ZNF513 MBD2 CUX1 MAX EP300 ADGRF4 ADGRF2 lnc-ADGRF2-1 OPN5
GH06J047631 Enhancer 0.9 Ensembl ENCODE 33 -24.7 -24735 1.4 CTCF ARNT REST TRIM22 SMC3 RAD21 RFX5 DMAP1 HLTF ZSCAN5A ADGRF2 CD2AP piR-33605-377 HSALNG0050422
GH06J047475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 14.4 -178.1 -178096 5.7 CHD2 TBP ZBTB10 MXD4 MNT IKZF1 BRCA1 SMAD5 IRF2 HES1 ENSG00000270761 CD2AP ADGRF2 SLC25A27 OPN5 ENSG00000199762
GH06J047669 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 22.8 +13.9 13900 2.5 ZIC2 ZNF341 EBF1 PRDM6 ZNF2 HDAC2 FOXA1 ZNF24 RAD51 ZNF189 ADGRF2 OPN5 ADGRF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRF2

Genomic Locations for ADGRF2 Gene

Latest Assembly
41,362 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
41,323 bases
Plus strand

(GRCh37/hg19 by Ensembl)
41,362 bases
Plus strand

Genomic View for ADGRF2 Gene

Genes around ADGRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF2 Gene

Proteins for ADGRF2 Gene

  • Protein details for ADGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor F2
    Protein Accession:
    Secondary Accessions:
    • Q2PNZ1
    • Q86SL6
    • Q8NGU5
    • Q8TDT5

    Protein attributes for ADGRF2 Gene

    708 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    • Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.

    Alternative splice isoforms for ADGRF2 Gene


neXtProt entry for ADGRF2 Gene

Post-translational modifications for ADGRF2 Gene

  • Glycosylation at Asn21, Asn220, Asn252, Asn260, Asn305, Asn313, and Asn358
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF2 Gene

No data available for DME Specific Peptides for ADGRF2 Gene

Domains & Families for ADGRF2 Gene

Gene Families for ADGRF2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRF2 Gene

  • GPS domain

Suggested Antigen Peptide Sequences for ADGRF2 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR20 (GP111_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF2: view

Function for ADGRF2 Gene

Molecular function for ADGRF2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF2 Gene

Gene Ontology (GO) - Molecular Function for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view
genes like me logo Genes that share phenotypes with ADGRF2: view

Animal Models for ADGRF2 Gene

MGI Knock Outs for ADGRF2:

Animal Models for research

  • Taconic Biosciences Mouse Models for ADGRF2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF2 Gene

Localization for ADGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF2 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF2 Gene

Pathways & Interactions for ADGRF2 Gene

PathCards logo

SuperPathways for ADGRF2 Gene

No Data Available

Interacting Proteins for ADGRF2 Gene

Gene Ontology (GO) - Biological Process for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF2 Gene

Drugs & Compounds for ADGRF2 Gene

No Compound Related Data Available

Transcripts for ADGRF2 Gene

mRNA/cDNA for ADGRF2 Gene

4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF2 Gene

No ASD Table

Relevant External Links for ADGRF2 Gene

GeneLoc Exon Structure for

Expression for ADGRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRF2

mRNA Expression by UniProt/SwissProt for ADGRF2 Gene:

Tissue specificity: High expression in kidney. Up-regulated in lung adenocarcinomas and prostate cancers.
genes like me logo Genes that share expression patterns with ADGRF2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF2 Gene

Orthologs for ADGRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR111 30 31
  • 99.38 (n)
(Canis familiaris)
Mammalia GPR111 30 31
  • 85.77 (n)
(Bos Taurus)
Mammalia GPR111 30 31
  • 82.29 (n)
(Rattus norvegicus)
Mammalia Gpr111 30
  • 79.05 (n)
(Mus musculus)
Mammalia Gpr111 30 31
  • 78.86 (n)
Adgrf2 17
(Ornithorhynchus anatinus)
Mammalia GPR111 31
  • 70 (a)
(Monodelphis domestica)
Mammalia GPR111 31
  • 55 (a)
(Gallus gallus)
Aves -- 31
  • 48 (a)
(Danio rerio)
Actinopterygii CABZ01002470.1 31
  • 36 (a)
BX545917.1 31
  • 27 (a)
si:dkey-30j22.4 31
  • 25 (a)
si:dkey-30j22.12 31
  • 22 (a)
si:dkey-30j22.2 31
  • 20 (a)
si:dkey-13i15.1 31
  • 11 (a)
Species where no ortholog for ADGRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRF2 Gene

Gene Tree for ADGRF2 (if available)
Gene Tree for ADGRF2 (if available)
Evolutionary constrained regions (ECRs) for ADGRF2: view image

Paralogs for ADGRF2 Gene

Variants for ADGRF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRF2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs6907125 - p.Gln148Arg
rs9381594 - p.Ile467Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADGRF2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADGRF2 Gene

Variant ID Type Subtype PubMed ID
esv1092036 CNV deletion 17803354
esv2369895 CNV deletion 18987734
esv26618 CNV gain 19812545
esv2732041 CNV deletion 23290073
esv2732042 CNV deletion 23290073
esv2732043 CNV deletion 23290073
nsv1017113 CNV gain 25217958
nsv1117619 CNV deletion 24896259
nsv350137 CNV deletion 16902084
nsv518371 CNV loss 19592680

Variation tolerance for ADGRF2 Gene

Gene Damage Index Score: 11.42; 92.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF2 Gene

Disorders for ADGRF2 Gene

Additional Disease Information for ADGRF2

No disorders were found for ADGRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF2 Gene

Publications for ADGRF2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 3 4
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4

Products for ADGRF2 Gene

Sources for ADGRF2 Gene