Aliases for ADGRF2 Gene

Aliases for ADGRF2 Gene

  • Adhesion G Protein-Coupled Receptor F2 2 3 5
  • PGR20 2 3 4
  • Adhesion G-Protein Coupled Receptor F2 3 4
  • G Protein-Coupled Receptor 111 2 3
  • HGPCR35 2 3
  • GPR111 3 4
  • Probable G-Protein Coupled Receptor 111 3
  • G-Protein Coupled Receptor PGR20 4
  • G-Protein Coupled Receptor 111 4
  • ADGRF2 5

External Ids for ADGRF2 Gene

Previous HGNC Symbols for ADGRF2 Gene

  • GPR111

Summaries for ADGRF2 Gene

GeneCards Summary for ADGRF2 Gene

ADGRF2 (Adhesion G Protein-Coupled Receptor F2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF4.

UniProtKB/Swiss-Prot Summary for ADGRF2 Gene

Gene Wiki entry for ADGRF2 Gene

Additional gene information for ADGRF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRF2 Gene

Genomics for ADGRF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J047656 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 628.6 0.0 -47 0.8 CREB1 JUND PRDM1 PKNOX1 PATZ1 ZNF600 ZBTB44 KLF9 CTBP1 CEBPB ADGRF2 piR-31535-003 CD2AP
GH06J047697 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 29.8 +43.5 43476 4.9 CEBPG CREB1 PRDM10 ZNF629 ZNF692 JUND FOXA1 ZIC2 ZSCAN4 ZNF24 ADGRF4 ADGRF2 RF00100-127 RN7SKP116 lnc-ADGRF2-1 OPN5
GH06J047631 Enhancer 0.9 Ensembl ENCODE 33 -24.7 -24694 1.3 CTCF ZNF629 KDM1A RCOR2 PKNOX1 REST RAD21 TRIM22 SCRT2 CBX3 ADGRF2 CD2AP piR-33605-377 LOC100421517
GH06J047475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 14.4 -178.1 -178096 5.7 BRCA1 ARHGAP35 CREB1 GATAD2A HNRNPL ATF7 PRDM10 REST ZNF629 LEF1 ENSG00000270761 CD2AP ADGRF2 SLC25A27 OPN5 ENSG00000199762
GH06J047651 Enhancer 1 FANTOM5 Ensembl ENCODE 29 -4.9 -4935 2.2 PKNOX1 MGA CEBPB JUND FOSL1 ATF4 ZFP91 ATF3 JUN FOS ADGRF2 OPN5 piR-31535-003 CD2AP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRF2

Genomic Locations for ADGRF2 Gene

Genomic Locations for ADGRF2 Gene
chr6:47,656,436-47,697,797
(GRCh38/hg38)
Size:
41,362 bases
Orientation:
Plus strand
chr6:47,624,172-47,665,533
(GRCh37/hg19)
Size:
41,362 bases
Orientation:
Plus strand

Genomic View for ADGRF2 Gene

Genes around ADGRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF2 Gene

Proteins for ADGRF2 Gene

  • Protein details for ADGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF7-AGRF2_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor F2
    Protein Accession:
    Q8IZF7
    Secondary Accessions:
    • Q2PNZ1
    • Q86SL6
    • Q8NGU5
    • Q8TDT5

    Protein attributes for ADGRF2 Gene

    Size:
    708 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.

    Alternative splice isoforms for ADGRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRF2 Gene

Post-translational modifications for ADGRF2 Gene

  • Glycosylation at Asn21, Asn220, Asn252, Asn260, Asn305, Asn313, and Asn358
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF2 Gene

No data available for DME Specific Peptides for ADGRF2 Gene

Domains & Families for ADGRF2 Gene

Gene Families for ADGRF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRF2 Gene

InterPro:
Blocks:
  • GPS domain
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRF2 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR20 (GP111_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZF7

UniProtKB/Swiss-Prot:

AGRF2_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF2: view

Function for ADGRF2 Gene

Molecular function for ADGRF2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF2 Gene

Gene Ontology (GO) - Molecular Function for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view
genes like me logo Genes that share phenotypes with ADGRF2: view

Animal Models for ADGRF2 Gene

MGI Knock Outs for ADGRF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF2 Gene

Localization for ADGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF2 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF2 Gene

Pathways & Interactions for ADGRF2 Gene

PathCards logo

SuperPathways for ADGRF2 Gene

No Data Available

Interacting Proteins for ADGRF2 Gene

Gene Ontology (GO) - Biological Process for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF2 Gene

Drugs & Compounds for ADGRF2 Gene

No Compound Related Data Available

Transcripts for ADGRF2 Gene

mRNA/cDNA for ADGRF2 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF2 Gene

No ASD Table

Relevant External Links for ADGRF2 Gene

GeneLoc Exon Structure for
ADGRF2

Expression for ADGRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRF2

mRNA Expression by UniProt/SwissProt for ADGRF2 Gene:

Q8IZF7-AGRF2_HUMAN
Tissue specificity: High expression in kidney. Up-regulated in lung adenocarcinomas and prostate cancers.
genes like me logo Genes that share expression patterns with ADGRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF2 Gene

Orthologs for ADGRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR111 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR111 30 31
  • 85.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR111 30 31
  • 82.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr111 30
  • 79.05 (n)
Mouse
(Mus musculus)
Mammalia Gpr111 30 31
  • 78.86 (n)
OneToOne
Adgrf2 17
Platypus
(Ornithorhynchus anatinus)
Mammalia GPR111 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR111 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 48 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii CABZ01002470.1 31
  • 36 (a)
ManyToMany
BX545917.1 31
  • 27 (a)
ManyToMany
si:dkey-30j22.4 31
  • 25 (a)
ManyToMany
si:dkey-30j22.12 31
  • 22 (a)
ManyToMany
si:dkey-30j22.2 31
  • 20 (a)
ManyToMany
si:dkey-13i15.1 31
  • 11 (a)
ManyToMany
Species where no ortholog for ADGRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRF2 Gene

ENSEMBL:
Gene Tree for ADGRF2 (if available)
TreeFam:
Gene Tree for ADGRF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRF2: view image

Paralogs for ADGRF2 Gene

Variants for ADGRF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRF2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs6907125 - p.Gln148Arg
rs9381594 - p.Ile467Val

Additional dbSNP identifiers (rs#s) for ADGRF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRF2 Gene

Variant ID Type Subtype PubMed ID
esv1092036 CNV deletion 17803354
esv2369895 CNV deletion 18987734
esv26618 CNV gain 19812545
esv2732041 CNV deletion 23290073
esv2732042 CNV deletion 23290073
esv2732043 CNV deletion 23290073
nsv1017113 CNV gain 25217958
nsv1117619 CNV deletion 24896259
nsv350137 CNV deletion 16902084
nsv518371 CNV loss 19592680

Variation tolerance for ADGRF2 Gene

Gene Damage Index Score: 11.42; 92.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF2 Gene

Disorders for ADGRF2 Gene

No disorders were found for ADGRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF2 Gene

Publications for ADGRF2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 3 4
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  5. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3

Products for ADGRF2 Gene

Sources for ADGRF2 Gene