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Aliases for ADGRF2 Gene

Aliases for ADGRF2 Gene

  • Adhesion G Protein-Coupled Receptor F2 2 3 5
  • G Protein-Coupled Receptor 111 2 3
  • GPR111 3 4
  • PGR20 3 4
  • Probable G-Protein Coupled Receptor 111 3
  • Adhesion G-Protein Coupled Receptor F2 3
  • G-Protein Coupled Receptor PGR20 4
  • G-Protein Coupled Receptor 111 4
  • HGPCR35 3

External Ids for ADGRF2 Gene

Previous HGNC Symbols for ADGRF2 Gene

  • GPR111

Summaries for ADGRF2 Gene

GeneCards Summary for ADGRF2 Gene

ADGRF2 (Adhesion G Protein-Coupled Receptor F2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF4.

UniProtKB/Swiss-Prot for ADGRF2 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRF2 Gene

Additional gene information for ADGRF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF2 Gene

Genomics for ADGRF2 Gene

GeneHancer (GH) Regulatory Elements for ADGRF2 Gene

Promoters and enhancers for ADGRF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J047656 Promoter/Enhancer 1.2 EPDnew ENCODE 677.4 0.0 -36 0.2 MEIS2 PKNOX1 JUN ZKSCAN1 FOSL1 ZNF335 CTBP1 ZBTB48 PATZ1 FOSL2 ADGRF2 GC06M047647
GH06J047697 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 29.7 +43.5 43476 4.9 PKNOX1 NEUROD1 ATF7 FOS RUNX3 DEK JUNB TSHZ1 ZNF518A ATF4 ADGRF4 ADGRF2 RN7SKP116
GH06J047475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.4 -178.3 -178307 5.3 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ENSG00000270761 CD2AP ADGRF2 OPN5 GC06P047489
GH06J047651 Enhancer 1 FANTOM5 Ensembl ENCODE 29 -4.8 -4801 1.1 JUN CEBPB FOSL1 JUND ATF4 IKZF1 ZFP91 FOS MGA ADGRF2 OPN5 GC06M047647
GH06J047669 Enhancer 1.2 FANTOM5 Ensembl ENCODE 22.7 +13.9 13888 2.5 HDAC1 MEIS2 USF1 ZSCAN4 ZNF384 EBF1 ZIC2 ZNF2 ZNF335 ZNF213 ADGRF2 OPN5 ADGRF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRF2 Gene

Genomic Locations for ADGRF2 Gene
41,362 bases
Plus strand
41,362 bases
Plus strand

Genomic View for ADGRF2 Gene

Genes around ADGRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF2 Gene

Proteins for ADGRF2 Gene

  • Protein details for ADGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor F2
    Protein Accession:
    Secondary Accessions:
    • Q2PNZ1
    • Q86SL6
    • Q8NGU5
    • Q8TDT5

    Protein attributes for ADGRF2 Gene

    708 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    No Data Available
    • Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.
    • Sequence=BAC05907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF2 Gene


neXtProt entry for ADGRF2 Gene

Post-translational modifications for ADGRF2 Gene

  • Glycosylation at posLast=358358, Asn313, Asn305, posLast=260260, posLast=252252, Asn220, and Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF2 Gene

No data available for DME Specific Peptides for ADGRF2 Gene

Domains & Families for ADGRF2 Gene

Gene Families for ADGRF2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRF2 Gene


Suggested Antigen Peptide Sequences for ADGRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF2: view

Function for ADGRF2 Gene

Molecular function for ADGRF2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRF2 Gene

Gene Ontology (GO) - Molecular Function for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF2: view
genes like me logo Genes that share phenotypes with ADGRF2: view

Animal Models for ADGRF2 Gene

MGI Knock Outs for ADGRF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF2 Gene

Localization for ADGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF2 Gene

Pathways & Interactions for ADGRF2 Gene

SuperPathways for ADGRF2 Gene

No Data Available

Interacting Proteins for ADGRF2 Gene

Gene Ontology (GO) - Biological Process for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF2 Gene

Drugs & Compounds for ADGRF2 Gene

No Compound Related Data Available

Transcripts for ADGRF2 Gene

mRNA/cDNA for ADGRF2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRF2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF2 Gene

No ASD Table

Relevant External Links for ADGRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRF2 Gene:


mRNA Expression by UniProt/SwissProt for ADGRF2 Gene:

Tissue specificity: High expression in kidney. Up-regulated in lung adenocarcinomas and prostate cancers.
genes like me logo Genes that share expression patterns with ADGRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF2 Gene

Orthologs for ADGRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR111 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia GPR111 34 33
  • 85.77 (n)
(Bos Taurus)
Mammalia GPR111 34 33
  • 82.29 (n)
(Rattus norvegicus)
Mammalia Gpr111 33
  • 79.05 (n)
(Mus musculus)
Mammalia Gpr111 34 33
  • 78.86 (n)
Adgrf2 16
(Ornithorhynchus anatinus)
Mammalia GPR111 34
  • 70 (a)
(Monodelphis domestica)
Mammalia GPR111 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii CABZ01002470.1 34
  • 36 (a)
BX545917.1 34
  • 27 (a)
si:dkey-30j22.4 34
  • 25 (a)
si:dkey-30j22.12 34
  • 22 (a)
si:dkey-30j22.2 34
  • 20 (a)
si:dkey-13i15.1 34
  • 11 (a)
Species where no ortholog for ADGRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF2 Gene

Gene Tree for ADGRF2 (if available)
Gene Tree for ADGRF2 (if available)
Evolutionary constrained regions (ECRs) for ADGRF2: view image

Paralogs for ADGRF2 Gene

Paralogs for ADGRF2 Gene

genes like me logo Genes that share paralogs with ADGRF2: view

Variants for ADGRF2 Gene

Sequence variations from dbSNP and Humsavar for ADGRF2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000016301 -- 47,664,508(+) A/G intron_variant
rs1000139295 -- 47,670,716(+) G/A/T intron_variant
rs1000144681 -- 47,657,640(+) A/C intron_variant
rs1000175783 -- 47,680,589(+) A/G intron_variant
rs1000181306 -- 47,686,142(+) AAA/AA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRF2 Gene

Variant ID Type Subtype PubMed ID
nsv518371 CNV loss 19592680
nsv350137 CNV deletion 16902084
nsv1117619 CNV deletion 24896259
nsv1017113 CNV gain 25217958
esv2732043 CNV deletion 23290073
esv2732042 CNV deletion 23290073
esv2732041 CNV deletion 23290073
esv26618 CNV gain 19812545
esv2369895 CNV deletion 18987734
esv1092036 CNV deletion 17803354

Variation tolerance for ADGRF2 Gene

Gene Damage Index Score: 11.42; 92.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF2 Gene

Disorders for ADGRF2 Gene

Additional Disease Information for ADGRF2

No disorders were found for ADGRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF2 Gene

Publications for ADGRF2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 3 4 58
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 58

Products for ADGRF2 Gene

Sources for ADGRF2 Gene

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