This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence ... See more...

Aliases for ADGRE4P Gene

Aliases for ADGRE4P Gene

  • Adhesion G Protein-Coupled Receptor E4, Pseudogene 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 Pseudogene 2 3
  • G Protein-Coupled Receptor 127 2 3
  • GPR127 3 4
  • EMR4P 3 4
  • PGR16 3 4
  • EMR4 3 4
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 2
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 4 4
  • Putative Adhesion G Protein-Coupled Receptor E4P 4
  • G-Protein Coupled Receptor PGR16 4
  • G-Protein Coupled Receptor 127 4
  • EGF-Like Module Receptor 4 4
  • EGF-TM7 Receptor EMR4 3
  • FIRE 3

External Ids for ADGRE4P Gene

Previous HGNC Symbols for ADGRE4P Gene

  • GPR127
  • EMR4
  • EMR4P

Summaries for ADGRE4P Gene

Entrez Gene Summary for ADGRE4P Gene

  • This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ADGRE4P Gene

ADGRE4P (Adhesion G Protein-Coupled Receptor E4, Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for ADGRE4P Gene

  • May mediate the cellular interaction between myeloid cells and B-cells.

Additional gene information for ADGRE4P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRE4P Gene

Genomics for ADGRE4P Gene

GeneHancer (GH) Regulatory Elements for ADGRE4P Gene

Promoters and enhancers for ADGRE4P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006997 Promoter 0.8 Ensembl 526.9 +0.2 171 3.4 EZH2 FOS CEBPG SRF CEBPB MEF2B NBN SPI1 NFE2 JUND ADGRE4P INSR RF00017-2778
GH19J007007 Enhancer 0.7 Ensembl 14.2 -11.2 -11229 3.8 RELA TRIM22 BCL11A MEF2B NBN SPI1 IKZF1 E2F8 NR2F1 NFATC3 ENSG00000268845 ADGRE4P FLJ25758 ENSG00000283679 lnc-MBD3L2B-2
GH19J007004 Enhancer 0.4 Ensembl 21.8 -6.6 -6629 0.6 CTCF SMC3 RAD21 ENSG00000269761 FLJ25758 RF00017-2779 lnc-MBD3L2B-2 piR-50880 ADGRE4P SLC25A23
GH19J006987 Enhancer 0.7 Ensembl 8.9 +8.6 8572 3.4 ZBTB40 MEF2B BATF IRF4 EBF1 IKZF1 NR2F1 NFATC3 TBX21 PAX5 ARHGEF18 ADGRE4P SLC25A23 RF00017-2778
GH19J006849 Enhancer 0.5 Ensembl 5 +147.8 147772 0.6 MEF2C ZNF316 MAFF MAFK ZNF146 MEF2A RUNX3 EMSY ADGRE4P hsa-miR-5095-261 piR-36100-009 VAV1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRE4P on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRE4P Gene

Genomic Locations for ADGRE4P Gene
chr19:6,952,500-6,997,872
(GRCh38/hg38)
Size:
45,373 bases
Orientation:
Minus strand
chr19:6,952,511-6,990,857
(GRCh37/hg19)
Size:
38,347 bases
Orientation:
Minus strand

Genomic View for ADGRE4P Gene

Genes around ADGRE4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE4P Gene

Proteins for ADGRE4P Gene

  • Protein details for ADGRE4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SQ3-AGRE4_HUMAN
    Recommended name:
    Putative adhesion G protein-coupled receptor E4P
    Protein Accession:
    Q86SQ3
    Secondary Accessions:
    • Q86SP1

    Protein attributes for ADGRE4P Gene

    Size:
    457 amino acids
    Molecular mass:
    50903 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).
    Miscellaneous:
    • [Isoform 2]: Due to a frameshift mutation in exon 8 would result in a truncated soluble form.

    Alternative splice isoforms for ADGRE4P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE4P Gene

Post-translational modifications for ADGRE4P Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn26, Asn106, Asn162, and Asn245
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE4P Gene

Domains & Families for ADGRE4P Gene

Gene Families for ADGRE4P Gene

Protein Domains for ADGRE4P Gene

Blocks:
  • Type I EGF
  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain
  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRE4P Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR16 (EMR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SQ3

UniProtKB/Swiss-Prot:

AGRE4_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE4P: view

Function for ADGRE4P Gene

Molecular function for ADGRE4P Gene

UniProtKB/Swiss-Prot Function:
May mediate the cellular interaction between myeloid cells and B-cells.

Phenotypes From GWAS Catalog for ADGRE4P Gene

Phenotypes for ADGRE4P Gene

genes like me logo Genes that share phenotypes with ADGRE4P: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRE4P

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRE4P Gene

Localization for ADGRE4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE4P Gene

[Isoform 1]: Cell membrane; Multi-pass membrane protein.
[Isoform 2]: Secreted.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ADGRE4P Gene

Pathways & Interactions for ADGRE4P Gene

PathCards logo

SuperPathways for ADGRE4P Gene

No Data Available

Interacting Proteins for ADGRE4P Gene

Selected Interacting proteins: Q86SQ3-AGRE4_HUMAN for ADGRE4P Gene via IID

Symbol External ID(s) Details
YWHAQ
;

Gene Ontology (GO) - Biological Process for ADGRE4P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRE4P Gene

Drugs & Compounds for ADGRE4P Gene

No Compound Related Data Available

Transcripts for ADGRE4P Gene

mRNA/cDNA for ADGRE4P Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRE4P

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE4P Gene

No ASD Table

Relevant External Links for ADGRE4P Gene

GeneLoc Exon Structure for
ADGRE4P

Expression for ADGRE4P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRE4P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRE4P

genes like me logo Genes that share expression patterns with ADGRE4P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRE4P Gene

Orthologs for ADGRE4P Gene

Evolution for ADGRE4P Gene

ENSEMBL:
Gene Tree for ADGRE4P (if available)
TreeFam:
Gene Tree for ADGRE4P (if available)

No data available for Orthologs for ADGRE4P Gene

Paralogs for ADGRE4P Gene

No data available for Paralogs for ADGRE4P Gene

Variants for ADGRE4P Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRE4P Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv14e196 CNV duplication 17116639
dgv3421n100 CNV gain 25217958
dgv3422n100 CNV loss 25217958
dgv392n27 CNV gain 19166990
dgv393n27 CNV gain 19166990
dgv394n27 CNV loss 19166990
dgv6236n54 CNV gain 21841781
dgv6237n54 CNV gain 21841781
dgv6238n54 CNV loss 21841781
dgv6239n54 CNV loss 21841781
dgv6240n54 CNV loss 21841781
esv2425378 CNV deletion 19546169
esv2662906 CNV deletion 23128226
esv2668680 CNV deletion 23128226
esv2718080 CNV deletion 23290073
esv27190 CNV loss 19812545
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2751811 CNV loss 17911159
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3555956 CNV deletion 23714750
esv3574297 CNV gain 25503493
esv3583219 CNV loss 25503493
esv3583220 CNV loss 25503493
esv3643571 CNV gain 21293372
esv3643574 CNV loss 21293372
esv3643575 CNV gain 21293372
nsv1056194 CNV gain 25217958
nsv1056442 CNV gain 25217958
nsv1057286 CNV loss 25217958
nsv1061916 CNV gain 25217958
nsv1063661 CNV gain 25217958
nsv1072852 CNV deletion 25765185
nsv1127646 CNV deletion 24896259
nsv1130727 CNV deletion 24896259
nsv517794 CNV gain+loss 19592680
nsv578476 CNV loss 21841781
nsv578477 CNV loss 21841781
nsv833729 CNV loss 17160897
nsv956611 CNV deletion 24416366

Additional Variant Information for ADGRE4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRE4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for ADGRE4P Gene

Disorders for ADGRE4P Gene

Additional Disease Information for ADGRE4P

No disorders were found for ADGRE4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE4P Gene

Publications for ADGRE4P Gene

  1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 2 3 4 23 54
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 54
  3. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. (PMID: 12731063) Hamann J … van Lier RA (European journal of immunology 2003) 3 4 23 54
  4. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. (PMID: 16753812) Caminschi I … Wright MD (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 4 54
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 54

Products for ADGRE4P Gene

Sources for ADGRE4P Gene