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Aliases for ADGRE3 Gene

Aliases for ADGRE3 Gene

  • Adhesion G Protein-Coupled Receptor E3 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 3 2 3
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 3 3 4
  • EGF-Like Module Receptor 3 3 4
  • EMR3 3 4
  • Egf-Like Module-Containing Mucin-Like Receptor 3 3

External Ids for ADGRE3 Gene

Previous HGNC Symbols for ADGRE3 Gene

  • EMR3

Summaries for ADGRE3 Gene

Entrez Gene Summary for ADGRE3 Gene

  • This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for ADGRE3 Gene

ADGRE3 (Adhesion G Protein-Coupled Receptor E3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRE2.

UniProtKB/Swiss-Prot for ADGRE3 Gene

  • Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.

Gene Wiki entry for ADGRE3 Gene

Additional gene information for ADGRE3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE3 Gene

Genomics for ADGRE3 Gene

GeneHancer (GH) Regulatory Elements for ADGRE3 Gene

Promoters and enhancers for ADGRE3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I014689 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 26 2 PKNOX1 SMAD1 ATF1 ARID4B SIN3A YY1 ETS1 POLR2B ZNF213 E2F8 ZNF333 ADGRE3 NDUFB7
GH19I014671 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 587.5 +15.9 15879 4.9 TEAD4 TAL1 MAX EBF1 CEBPG TCF12 CTBP1 POLR2A NFE2 SOX6 ADGRE3 ZNF333 OR7C1 ADGRE5 OR7A5 PKN1 ENSG00000275432
GH19I014683 Enhancer 0.7 FANTOM5 Ensembl 31.7 +6.4 6426 0.4 CEBPB MAX MYC ADGRE3 NDUFB7 ADGRE5 PKN1 ZNF333 ENSG00000275432
GH19I014782 Enhancer 1.5 FANTOM5 Ensembl ENCODE 6.9 -94.8 -94833 4 HDGF ATF1 PKNOX1 ARNT ZNF2 ZBTB7B TCF12 ZNF121 ZNF766 CBX5 DCAF15 DDX39A RFX1 ADGRE2 AKAP8 BRD4 OR7C1 ADGRE5 ZNF333 ADGRE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRE3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRE3 Gene

Genomic Locations for ADGRE3 Gene
70,911 bases
Minus strand

Genomic View for ADGRE3 Gene

Genes around ADGRE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE3 Gene

Proteins for ADGRE3 Gene

  • Protein details for ADGRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor E3
    Protein Accession:

    Protein attributes for ADGRE3 Gene

    652 amino acids
    Molecular mass:
    72621 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).
    • Has no murine ortholog.

    Alternative splice isoforms for ADGRE3 Gene


neXtProt entry for ADGRE3 Gene

Post-translational modifications for ADGRE3 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn34, posLast=3939, posLast=145145, Asn189, Asn202, posLast=250250, Asn279, Asn327, and posLast=334334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE3 Gene

Domains & Families for ADGRE3 Gene

Gene Families for ADGRE3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADGRE3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE3: view

Function for ADGRE3 Gene

Molecular function for ADGRE3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.

Phenotypes From GWAS Catalog for ADGRE3 Gene

Gene Ontology (GO) - Molecular Function for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with ADGRE3: view
genes like me logo Genes that share phenotypes with ADGRE3: view

miRNA for ADGRE3 Gene

miRTarBase miRNAs that target ADGRE3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRE3 Gene

Localization for ADGRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE3 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 3: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRE3 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with ADGRE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRE3 Gene

Pathways & Interactions for ADGRE3 Gene

genes like me logo Genes that share pathways with ADGRE3: view

Pathways by source for ADGRE3 Gene

Interacting Proteins for ADGRE3 Gene

Gene Ontology (GO) - Biological Process for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ADGRE3: view

No data available for SIGNOR curated interactions for ADGRE3 Gene

Drugs & Compounds for ADGRE3 Gene

No Compound Related Data Available

Transcripts for ADGRE3 Gene

mRNA/cDNA for ADGRE3 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE3 Gene

No ASD Table

Relevant External Links for ADGRE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRE3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRE3 Gene

Protein tissue co-expression partners for ADGRE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRE3 Gene:


mRNA Expression by UniProt/SwissProt for ADGRE3 Gene:

Tissue specificity: Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.
genes like me logo Genes that share expression patterns with ADGRE3: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRE3 Gene

Orthologs for ADGRE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EMR3 33 34
  • 96.48 (n)
(Bos Taurus)
Mammalia EMR3 33 34
  • 81.79 (n)
(Canis familiaris)
Mammalia EMR3 33 34
  • 80.49 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
-- 34
  • 44 (a)
(Mus musculus)
Mammalia Emr4 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
(Danio rerio)
Actinopterygii si:dkey-29n3.1 34
  • 38 (a)
si:ch73-341p18.5 34
  • 38 (a)
si:ch73-341p18.6 34
  • 34 (a)
si:dkey-9c18.12 34
  • 33 (a)
si:dkey-9c18.4 34
  • 32 (a)
si:dkey-9c18.9 34
  • 32 (a)
si:dkey-9c18.10 34
  • 29 (a)
si:dkey-9c18.1 34
  • 24 (a)
si:ch73-341p18.7 34
  • 24 (a)
Species where no ortholog for ADGRE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE3 Gene

Gene Tree for ADGRE3 (if available)
Gene Tree for ADGRE3 (if available)

Paralogs for ADGRE3 Gene

Paralogs for ADGRE3 Gene Pseudogenes for ADGRE3 Gene

genes like me logo Genes that share paralogs with ADGRE3: view

Variants for ADGRE3 Gene

Sequence variations from dbSNP and Humsavar for ADGRE3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000024725 -- 14,615,645(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000043822 -- 14,649,263(-) TCTCT/TCT intron_variant
rs1000087526 -- 14,609,399(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000108708 -- 14,655,632(-) TTTTTTTTTTT/TTTTTTTTTT/TTTTTTTTTTTT intron_variant
rs1000140352 -- 14,625,316(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRE3 Gene

Variant ID Type Subtype PubMed ID
dgv1717n106 CNV tandem duplication 24896259
dgv1718n106 CNV deletion 24896259
dgv6280n54 CNV loss 21841781
dgv6281n54 CNV loss 21841781
esv1027269 CNV deletion 17803354
esv1975584 CNV deletion 18987734
esv2534308 CNV deletion 19546169
esv2718218 CNV deletion 23290073
esv2718219 CNV deletion 23290073
esv28692 CNV gain+loss 19812545
esv3094901 CNV deletion 24192839
esv3556072 CNV deletion 23714750
esv3893167 CNV gain 25118596
esv5910 CNV loss 19470904
esv995429 CNV deletion 20482838
esv995771 CNV loss 20482838
nsv1071149 CNV deletion 25765185
nsv1116303 CNV deletion 24896259
nsv1127655 CNV deletion 24896259
nsv1146895 CNV deletion 26484159
nsv512565 CNV loss 21212237
nsv578664 CNV loss 21841781
nsv578665 CNV loss 21841781
nsv578666 CNV gain+loss 21841781
nsv578667 CNV loss 21841781
nsv578676 CNV loss 21841781
nsv578679 CNV loss 21841781
nsv820830 CNV deletion 20802225
nsv930502 CNV deletion 23359205
nsv953981 CNV deletion 24416366
nsv956575 CNV deletion 24416366

Variation tolerance for ADGRE3 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.47; 82.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRE3 Gene

Disorders for ADGRE3 Gene

Additional Disease Information for ADGRE3

No disorders were found for ADGRE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE3 Gene

Publications for ADGRE3 Gene

  1. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. (PMID: 11279179) Stacey M … McKnight AJ (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  4. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J … Akyüz L (PloS one 2013) 3 58
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58

Products for ADGRE3 Gene

Sources for ADGRE3 Gene

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