Aliases for ADGRE3 Gene
External Ids for ADGRE3 Gene
Previous HGNC Symbols for ADGRE3 Gene
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
GeneCards Summary for ADGRE3 Gene
ADGRE3 (Adhesion G Protein-Coupled Receptor E3) is a Protein Coding gene. Diseases associated with ADGRE3 include Inflammatory Bowel Disease 3 and Folic Acid Deficiency Anemia. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRE2.
UniProtKB/Swiss-Prot Summary for ADGRE3 Gene
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.