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Aliases for ADGRE1 Gene

Aliases for ADGRE1 Gene

  • Adhesion G Protein-Coupled Receptor E1 2 3 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 1 2 3
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 2 3
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 1 3 4
  • EGF-Like Module Receptor 1 3 4
  • EMR1 Hormone Receptor 3 4
  • TM7LN3 3 4
  • EMR1 3 4

External Ids for ADGRE1 Gene

Previous HGNC Symbols for ADGRE1 Gene

  • TM7LN3
  • EMR1

Summaries for ADGRE1 Gene

Entrez Gene Summary for ADGRE1 Gene

  • This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ADGRE1 Gene

ADGRE1 (Adhesion G Protein-Coupled Receptor E1) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRE2.

UniProtKB/Swiss-Prot for ADGRE1 Gene

  • Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Gene Wiki entry for ADGRE1 Gene

Additional gene information for ADGRE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE1 Gene

Genomics for ADGRE1 Gene

GeneHancer (GH) Regulatory Elements for ADGRE1 Gene

Promoters and enhancers for ADGRE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006886 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 656.7 0.0 -17 2.5 SRF ATF1 CEBPB MAFG CEBPG ZNF316 NFE2 EMSY MAFK ADGRE1 ENSG00000269680 GC19P006870
GH19J006890 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20 +4.0 4046 3 ZBTB40 ETV6 RUNX3 SMARCA5 ELF1 ZNF623 SP1 ZNF217 KDM1A MYC ADGRE1 ENSG00000269680 VAV1 GPR108 TNFSF14 DENND1C ENSG00000280091 GC19P006870
GH19J006799 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -85.6 -85577 4.8 HDGF SMAD1 SIN3A IRF4 ETS1 ZNF143 ATF7 RUNX3 REST ZNF518A KHSRP ZNF557 XAB2 ENSG00000267571 ADGRE1 TNFSF14 VAV1 DENND1C SH2D3A GPR108
GH19J006861 Enhancer 1.2 Ensembl ENCODE 8.6 -24.6 -24594 2.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 YY1 E2F8 XAB2 ENSG00000267571 ADGRE1 GC19M006869 GC19P006821
GH19J006674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -212.4 -212442 1.1 HDGF PKNOX1 SMAD1 YBX1 IRF4 ARID2 ZNF207 ZNF143 ZNF548 FOS TNFSF14 XAB2 ZNF557 KHSRP DUS3L DENND1C C3 GPR108 TRIP10 RANBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRE1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRE1 Gene

Genomic Locations for ADGRE1 Gene
52,911 bases
Plus strand
52,894 bases
Plus strand

Genomic View for ADGRE1 Gene

Genes around ADGRE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE1 Gene

Proteins for ADGRE1 Gene

  • Protein details for ADGRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor E1
    Protein Accession:
    Secondary Accessions:
    • A6NHV2
    • B7Z486
    • B7Z489
    • E7EPX9
    • E9PD45
    • H9KV79
    • Q2I7G5
    • Q6ZMN0
    • Q8NGA7

    Protein attributes for ADGRE1 Gene

    886 amino acids
    Molecular mass:
    97683 Da
    Quaternary structure:
    No Data Available
    • Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
    • Sequence=BAC06133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRE1 Gene


neXtProt entry for ADGRE1 Gene

Post-translational modifications for ADGRE1 Gene

  • Glycosylation at Asn448, posLast=375375, Asn366, Asn312, posLast=258258, posLast=232232, posLast=194194, Asn189, Asn167, posLast=127127, Asn99, and posLast=9494
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE1 Gene

Domains & Families for ADGRE1 Gene

Gene Families for ADGRE1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ADGRE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE1: view

Function for ADGRE1 Gene

Molecular function for ADGRE1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Phenotypes From GWAS Catalog for ADGRE1 Gene

Gene Ontology (GO) - Molecular Function for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with ADGRE1: view
genes like me logo Genes that share phenotypes with ADGRE1: view

Animal Models for ADGRE1 Gene

MGI Knock Outs for ADGRE1:

Animal Model Products

miRNA for ADGRE1 Gene

miRTarBase miRNAs that target ADGRE1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRE1 Gene

Localization for ADGRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 7601460
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRE1 Gene

Pathways & Interactions for ADGRE1 Gene

genes like me logo Genes that share pathways with ADGRE1: view

Interacting Proteins for ADGRE1 Gene

Gene Ontology (GO) - Biological Process for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007155 cell adhesion TAS 7601460
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRE1: view

No data available for SIGNOR curated interactions for ADGRE1 Gene

Drugs & Compounds for ADGRE1 Gene

No Compound Related Data Available

Transcripts for ADGRE1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for ADGRE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ADGRE1 Gene:


mRNA Expression by UniProt/SwissProt for ADGRE1 Gene:

Tissue specificity: Expression is restricted to eosinophils.

Evidence on tissue expression from TISSUES for ADGRE1 Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with ADGRE1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRE1 Gene

Orthologs for ADGRE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EMR1 34 33
  • 98.8 (n)
(Bos Taurus)
Mammalia EMR1 34 33
  • 80.17 (n)
(Canis familiaris)
Mammalia EMR1 34 33
  • 75.36 (n)
(Mus musculus)
Mammalia Emr1 34 33
  • 71.89 (n)
Adgre1 16
(Rattus norvegicus)
Mammalia Emr1 33
  • 71.15 (n)
(Ornithorhynchus anatinus)
Mammalia EMR1 34
  • 58 (a)
(Monodelphis domestica)
Mammalia EMR1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730714 33
  • 63.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18311 33
(Danio rerio)
Actinopterygii si:ch73-268p17.1 34
  • 28 (a)
Species where no ortholog for ADGRE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE1 Gene

Gene Tree for ADGRE1 (if available)
Gene Tree for ADGRE1 (if available)
Evolutionary constrained regions (ECRs) for ADGRE1: view image

Paralogs for ADGRE1 Gene

Paralogs for ADGRE1 Gene Pseudogenes for ADGRE1 Gene

genes like me logo Genes that share paralogs with ADGRE1: view

Variants for ADGRE1 Gene

Sequence variations from dbSNP and Humsavar for ADGRE1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000016432 -- 6,900,686(+) A/T intron_variant
rs1000070191 -- 6,911,471(+) T/C intron_variant
rs1000072940 -- 6,933,169(+) C/T intron_variant
rs1000182442 -- 6,931,764(+) C/T intron_variant
rs1000200283 -- 6,892,246(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRE1 Gene

Variant ID Type Subtype PubMed ID
nsv978763 CNV duplication 23825009
nsv833729 CNV loss 17160897
nsv517794 CNV gain+loss 19592680
nsv510752 CNV deletion 20534489
nsv1056442 CNV gain 25217958
nsv1056194 CNV gain 25217958
esv3643573 CNV loss 21293372
esv3643571 CNV gain 21293372
esv3643570 CNV gain 21293372
esv3583216 CNV loss 25503493
esv3574297 CNV gain 25503493
esv33729 CNV gain+loss 17666407
esv2762977 CNV gain+loss 21179565
esv2751809 CNV gain 17911159
esv2678266 CNV deletion 23128226
esv1597449 CNV insertion 17803354
dgv6237n54 CNV gain 21841781
dgv6236n54 CNV gain 21841781
dgv393n27 CNV gain 19166990
dgv392n27 CNV gain 19166990
dgv3421n100 CNV gain 25217958
dgv14e196 CNV duplication 17116639
dgv136e55 CNV gain 17911159
dgv1016e212 CNV loss 25503493

Variation tolerance for ADGRE1 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRE1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRE1 Gene

Disorders for ADGRE1 Gene

Additional Disease Information for ADGRE1

No disorders were found for ADGRE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE1 Gene

Publications for ADGRE1 Gene

  1. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. (PMID: 7601460) Baud V … Lipinski M (Genomics 1995) 2 3 4 22 58
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  3. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. (PMID: 17823986) Hamann J … Kwakkenbos MJ (European journal of immunology 2007) 3 4 22 58
  4. The EGF-TM7 family: unusual structures at the leukocyte surface. (PMID: 9500513) McKnight AJ … Gordon S (Journal of leukocyte biology 1998) 2 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ADGRE1 Gene

Sources for ADGRE1 Gene

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