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Aliases for ADGRD2 Gene

Aliases for ADGRD2 Gene

  • Adhesion G Protein-Coupled Receptor D2 2 3 5
  • G-Protein Coupled Receptor 144 3 4
  • GPR144 3 4
  • PGR24 3 4
  • Adhesion G-Protein Coupled Receptor D2 3
  • G-Protein Coupled Receptor GPR144 3
  • G Protein-Coupled Receptor PGR24 3
  • G-Protein Coupled Receptor PGR24 4
  • G Protein-Coupled Receptor 144 2

External Ids for ADGRD2 Gene

Previous HGNC Symbols for ADGRD2 Gene

  • GPR144

Summaries for ADGRD2 Gene

GeneCards Summary for ADGRD2 Gene

ADGRD2 (Adhesion G Protein-Coupled Receptor D2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF5.

UniProtKB/Swiss-Prot for ADGRD2 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRD2 Gene

Additional gene information for ADGRD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD2 Gene

Genomics for ADGRD2 Gene

GeneHancer (GH) Regulatory Elements for ADGRD2 Gene

Promoters and enhancers for ADGRD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J124449 Enhancer 0.9 Ensembl ENCODE 654.8 -0.2 -204 2.4 CTCF SP3 SP2 KLF17 ZNF398 ZBTB8A ZNF335 GLIS2 ZNF366 POLR2A ADGRD2 LOC105376270 PSMB7
GH09J124212 Enhancer 0.5 Ensembl ENCODE 4.2 -238.4 -238424 0.9 ZFP69B NEK6 ADGRD2 GC09M124203
GH09J124453 Enhancer 0.5 ENCODE 0.7 +2.6 2630 0.2 E2F1 KLF1 POLR2A SIN3A ZFX LOC105376270 ADGRD2 NR5A1
GH09J124447 Enhancer 0.4 ENCODE 0.7 -4.0 -3990 0.2 CTCF ZNF143 RAD21 ADGRD2 LOC105376270 PSMB7
GH09J124476 Enhancer 0.8 Ensembl ENCODE 0.3 +26.9 26911 2.1 SMARCA5 BCOR PTBP1 ZMYM3 ZNF148 CBX1 KLF16 ZKSCAN8 VEZF1 ZNF143 NR5A1 ENSG00000231149 MIR181A2HG ADGRD2 LOC105376270
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRD2 Gene

Genomic Locations for ADGRD2 Gene
27,503 bases
Plus strand
25,957 bases
Plus strand

Genomic View for ADGRD2 Gene

Genes around ADGRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD2 Gene

Proteins for ADGRD2 Gene

  • Protein details for ADGRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor D2
    Protein Accession:
    Secondary Accessions:
    • Q86SL4
    • Q8NH12

    Protein attributes for ADGRD2 Gene

    963 amino acids
    Molecular mass:
    104087 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ADGRD2 Gene

Post-translational modifications for ADGRD2 Gene

  • Glycosylation at Asn634 and Asn271
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRD2 Gene

No data available for DME Specific Peptides for ADGRD2 Gene

Domains & Families for ADGRD2 Gene

Gene Families for ADGRD2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRD2: view

Function for ADGRD2 Gene

Molecular function for ADGRD2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRD2: view
genes like me logo Genes that share phenotypes with ADGRD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRD2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRD2 Gene

Localization for ADGRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRD2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRD2 Gene

Pathways & Interactions for ADGRD2 Gene

SuperPathways for ADGRD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRD2 Gene

Drugs & Compounds for ADGRD2 Gene

No Compound Related Data Available

Transcripts for ADGRD2 Gene

mRNA/cDNA for ADGRD2 Gene

(3) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRD2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD2 Gene

No ASD Table

Relevant External Links for ADGRD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRD2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRD2 Gene

Protein tissue co-expression partners for ADGRD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRD2 Gene:

genes like me logo Genes that share expression patterns with ADGRD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRD2 Gene

Orthologs for ADGRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR144 34 33
  • 98.68 (n)
(Bos Taurus)
Mammalia GPR144 34 33
  • 84.87 (n)
(Canis familiaris)
Mammalia GPR144 34 33
  • 82.67 (n)
(Monodelphis domestica)
Mammalia GPR144 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GPR144 34
  • 52 (a)
(Gallus gallus)
Aves GPR144 34 33
  • 56.67 (n)
(Anolis carolinensis)
Reptilia GPR144 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr144 33
  • 52.59 (n)
(Danio rerio)
Actinopterygii gpr144 34 33
  • 51.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 34
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
Species where no ortholog for ADGRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD2 Gene

Gene Tree for ADGRD2 (if available)
Gene Tree for ADGRD2 (if available)
Evolutionary constrained regions (ECRs) for ADGRD2: view image

Paralogs for ADGRD2 Gene

Paralogs for ADGRD2 Gene

genes like me logo Genes that share paralogs with ADGRD2: view

Variants for ADGRD2 Gene

Sequence variations from dbSNP and Humsavar for ADGRD2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000024490 -- 124,478,070(+) G/A downstream_transcript_variant
rs1000073264 -- 124,456,557(+) C/T intron_variant
rs1000207727 -- 124,472,667(+) T/A/C intron_variant
rs1000223936 -- 124,475,440(+) C/T intron_variant
rs1000288800 -- 124,469,826(+) T/A intron_variant

Variation tolerance for ADGRD2 Gene

Gene Damage Index Score: 9.71; 89.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRD2 Gene

Disorders for ADGRD2 Gene

Additional Disease Information for ADGRD2

No disorders were found for ADGRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRD2 Gene

Publications for ADGRD2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. (PMID: 15203201) Bjarnadóttir TK … Schiöth HB (Genomics 2004) 3 4 58
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for ADGRD2 Gene

Sources for ADGRD2 Gene

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