Aliases for ADGRD2 Gene

Aliases for ADGRD2 Gene

  • Adhesion G Protein-Coupled Receptor D2 2 3 5
  • PGR24 2 3 4
  • Adhesion G-Protein Coupled Receptor D2 3 4
  • G-Protein Coupled Receptor 144 3 4
  • GPR144 3 4
  • G-Protein Coupled Receptor GPR144 3
  • G Protein-Coupled Receptor PGR24 3
  • G-Protein Coupled Receptor PGR24 4
  • G Protein-Coupled Receptor 144 2
  • ADGRD2 5

External Ids for ADGRD2 Gene

Previous HGNC Symbols for ADGRD2 Gene

  • GPR144

Summaries for ADGRD2 Gene

GeneCards Summary for ADGRD2 Gene

ADGRD2 (Adhesion G Protein-Coupled Receptor D2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF3.

UniProtKB/Swiss-Prot Summary for ADGRD2 Gene

Gene Wiki entry for ADGRD2 Gene

Additional gene information for ADGRD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRD2 Gene

Genomics for ADGRD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J124450 Enhancer 0.6 ENCODE 604.7 -0.6 -590 0.2 ZNF629 POLR2A EZH2 KLF9 SP2 ZBTB17 YY1 WT1 ZNF335 KLF17 ADGRD2 LOC105376270 HSALNG0074337 RF00017-7884 PSMB7
GH09J124449 Enhancer 0.3 ENCODE 600.7 -1.0 -970 0.2 VEZF1 ADGRD2 HSALNG0074337 LOC105376270 RF00017-7884 PSMB7
GH09J124445 Enhancer 0.3 Ensembl 6 -5.2 -5186 0.2 PKNOX1 MEIS2 RF00017-7884 ADGRD2 HSALNG0074337 PSMB7
GH09J124428 Enhancer 0.3 Ensembl 5.1 -22.1 -22086 0.4 HNRNPL GATA2 ADGRD2 PSMB7 piR-33511 RF00017-7884
GH09J124212 Enhancer 0.3 ENCODE 4.2 -238.4 -238424 0.9 ZFP69B RF00017-7882 NEK6 ADGRD2 HSALNG0074323 LHX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRD2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ADGRD2 Gene

Genomic Locations for ADGRD2 Gene
27,503 bases
Plus strand
25,957 bases
Plus strand

Genomic View for ADGRD2 Gene

Genes around ADGRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD2 Gene

Proteins for ADGRD2 Gene

  • Protein details for ADGRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor D2
    Protein Accession:
    Secondary Accessions:
    • Q86SL4
    • Q8NH12

    Protein attributes for ADGRD2 Gene

    963 amino acids
    Molecular mass:
    104087 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ADGRD2 Gene

Post-translational modifications for ADGRD2 Gene

  • Glycosylation at Asn271 and Asn634
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRD2 Gene

No data available for DME Specific Peptides for ADGRD2 Gene

Domains & Families for ADGRD2 Gene

Gene Families for ADGRD2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADGRD2 Gene

  • G-protein coupled receptors family 2 (secretin-like)
  • Pentaxin
  • GPS domain

Suggested Antigen Peptide Sequences for ADGRD2 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 144 (A1E4E8_HUMAN)
  • G protein-coupled receptor 144 (A1E4E9_HUMAN)
  • G protein-coupled receptor 144 splice variant (A1E4F0_HUMAN)
  • G-protein coupled receptor PGR24 (GP144_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRD2: view

Function for ADGRD2 Gene

Molecular function for ADGRD2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRD2 Gene

Gene Ontology (GO) - Molecular Function for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with ADGRD2: view
genes like me logo Genes that share phenotypes with ADGRD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRD2 Gene

Localization for ADGRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRD2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 15203201
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRD2 Gene

Pathways & Interactions for ADGRD2 Gene

PathCards logo

SuperPathways for ADGRD2 Gene

No Data Available

Interacting Proteins for ADGRD2 Gene

Gene Ontology (GO) - Biological Process for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS 15203201
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRD2 Gene

Drugs & Compounds for ADGRD2 Gene

No Compound Related Data Available

Transcripts for ADGRD2 Gene

mRNA/cDNA for ADGRD2 Gene

7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRD2

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD2 Gene

No ASD Table

Relevant External Links for ADGRD2 Gene

GeneLoc Exon Structure for

Expression for ADGRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRD2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRD2 Gene

Protein tissue co-expression partners for ADGRD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRD2

genes like me logo Genes that share expression patterns with ADGRD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRD2 Gene

Orthologs for ADGRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR144 30 31
  • 98.68 (n)
(Bos Taurus)
Mammalia GPR144 30 31
  • 84.87 (n)
(Canis familiaris)
Mammalia GPR144 30 31
  • 82.67 (n)
(Monodelphis domestica)
Mammalia GPR144 31
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GPR144 31
  • 52 (a)
(Gallus gallus)
Aves GPR144 30 31
  • 56.67 (n)
(Anolis carolinensis)
Reptilia GPR144 31
  • 54 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr144 30
  • 52.59 (n)
(Danio rerio)
Actinopterygii gpr144 30 31
  • 51.29 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Cirl 31
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 31
  • 10 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 13 (a)
Species where no ortholog for ADGRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADGRD2 Gene

Gene Tree for ADGRD2 (if available)
Gene Tree for ADGRD2 (if available)
Evolutionary constrained regions (ECRs) for ADGRD2: view image

Paralogs for ADGRD2 Gene

Variants for ADGRD2 Gene

Additional dbSNP identifiers (rs#s) for ADGRD2 Gene

Variation tolerance for ADGRD2 Gene

Gene Damage Index Score: 9.71; 89.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ADGRD2 Gene

Disorders for ADGRD2 Gene

No disorders were found for ADGRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRD2 Gene

Publications for ADGRD2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. (PMID: 15203201) Bjarnadóttir TK … Schiöth HB (Genomics 2004) 3 4
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ADGRD2 Gene

Sources for ADGRD2 Gene