Aliases for ADGRD1 Gene
External Ids for ADGRD1 Gene
Previous HGNC Symbols for ADGRD1 Gene
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]
GeneCards Summary for ADGRD1 Gene
ADGRD1 (Adhesion G Protein-Coupled Receptor D1) is a Protein Coding gene. Diseases associated with ADGRD1 include Brachial Plexus Lesion. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL1.
UniProtKB/Swiss-Prot Summary for ADGRD1 Gene
Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701).